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| 1 | Adverse events with bismuth salts for Helicobacter pylori eradication:Systematic review and meta-analysis显示文摘AIM: To assess the safety of bismuth used in Helico- bacter pylori (H pylori) eradication therapy regimens. METHODS: We conducted a systematic review and meta-analysis. MEDLINE and EMBASE were searched (up to October 2007) to identify randomised controlled tri- als comparing bismuth with placebo or no treatment, or bismuth salts in combination with antibiotics as part of eradication therapy with the same dose and duration of antibiotics alone or, in combination, with acid suppres- sion. Total numbers of adverse events were recorded. Data were pooled and expressed as relative risks with 95% confidence intervals (CI). RESULTS: We identified 35 randomised controlled tri- als containing 4763 patients. There were no serious adverse events occurring with bismuth therapy. There was no statistically significant difference detected in total adverse events with bismuth [relative risk (RR) = 1.01; 95% CI: 0.87-1.16], specific individual adverse events, with the exception of dark stools (RR = 5.06; 95% CI: 1.59-16.12), or adverse events leading to withdrawal of therapy (RR = 0.86; 95% CI: 0.54-1.37). CONCLUSION: Bismuth for the treatment of H pylori is safe and well-tolerated. The only adverse event oc- curring significantly more commonly was dark stools. | Alexander C Ford Peter Malfertheiner Monique Giguère José Santana Mostafizur Khan Paul Moayyedi | 2008 | World Journal of Gastroenterology2008，14，48： | 62 |
| 2 | Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments显示文摘Therapeutic management of hepatocellular carcinoma(HCC) is quite complex owing to the underlying cirrhosis and portal vein hypertension. Different scores or classification systems based on liver function and tumoral stages have been published in the recent years. If none of them is currently 'universally' recognized, the Barcelona Clinic Liver Cancer(BCLC) staging system has become the reference classification system in Western countries. Based on a robust treatment algorithm associated with stage stratification, it relies on a high level of evidence. However, BCLC stage B and C HCC include a broad spectrum of tumors but are only matched with a single therapeutic option. Some experts have thus suggested to extend the indications for surgery or for transarterial chemoembolization. In clinical practice, many patients are already treated beyond the scope of recommendations. Additional alternative prognostic scores that could be applied to any therapeutic modality have been recently proposed. They could represent complementary tools to the BCLC staging system and improve the stratification of HCC patients enrolled in clinical trials, as illustrated by the NIACE score. Prospective studies are needed to compare these scores and refine their role in the decision making process. | Xavier Adhoute Guillaume Penaranda Jean Luc Raoul Patrice Le Treut Emilie Bollon Jean Hardwigsen Paul Castellani Hervé Perrier Marc Bourlière | 2016 | World Journal of Hepatology2016，8，17： | 7 |
| 3 | Archaea and the human gut:New beginning of an old story显示文摘Methanogenic archaea are known as human gut inhabitants since more than 30 years ago through the detection of methane in the breath and isolation of two methanogenic species belonging to the order Methanobacteriales,Methanobrevibacter smithii and Methanosphaera stadtmanae.During the last decade,diversity of archaea encountered in the human gastrointestinal tract(GIT)has been extended by sequence identification and culturing of new strains.Here we provide an updated census of the archaeal diversity associatedwith the human GIT and their possible role in the gut physiology and health.We particularly focus on the still poorly characterized 7th order of methanogens,the Methanomassiliicoccales,associated to aged population.While also largely distributed in non-GIT environments,our actual knowledge on this novel order of methanogens has been mainly revealed through GIT inhabitants.They enlarge the number of final electron acceptors of the gut metabolites to mono-di-and trimethylamine.Trimethylamine is exclusively a microbiota-derived product of nutrients(lecithin,choline,TMAO,L-carnitine)from normal diet,from which seems originate two diseases,trimethylaminuria(or Fish-Odor Syndrome)and cardiovascular disease through the proatherogenic property of its oxidized liver-derived form.This therefore supports interest on these methanogenic species and its use as archaebiotics,a term coined from the notion of archaea-derived probiotics. | Nadia Gaci Guillaume Borrel William Tottey Paul William O’Toole Jean-Fran?ois Brugère | 2014 | World Journal of Gastroenterology2014，20，43： | 5 |
| 4 | Efficacy of Radiofrequency Ablation Combined With Endoscopic Resection for Barrett’s Esophagus With Early Neoplasia显示文摘 | Roos E. Pouw Katja Wirths Pierre Eisendrath Carine M. Sondermeijer Fiebo J. Ten Kate Paul Fockens Jacques Devière Horst Neuhaus Jacques J. Bergman | 2010 | Clinical Gastroenterology and Hepatology2010，，： | 2 |
| 5 | Effects of extracts from Hibiscus macranthus and Basella alba mixture on testosterone production in vitro in adult rat testes slices显示文摘瞄准:为了为生男性征的测量发现一个在试管内系统,芙蓉 macranthus (锦葵科) 和 Basella 白长袍的不同摘录完成一(Basellaceae ) 。方法:从片在二媒介,包含0.5%牛的血清白蛋白( BSA )的任何一个 Krebs-Henseleit 缓冲区或 Dubecco 孵化了的睾丸的睾丸激素的生产是修改的鹰的 medium-F12 火腿滋养的混合( DME/Ham F12 ),在5%的混合物下面,在95%空中的 CO2 也当面被决定或加 Basella 白长袍的余因子和芙蓉 macranthus 的缺席一( HMBA )摘录。结果:睾丸激素生产在在响应余因子(49%) 和水浸膏中等的 DME/Ham F12 孵化的睾丸片被增加(34%-60% 根据冲淡) 。在一样的大气的条件下面,没有到在 Krebs-Henseleit 的刺激缓冲包含 0.5% BSA 的余因子或 HMBA 摘录的睾丸片的积极反应。在与 HMBA 的效果有关的进一步的调查, DME/Ham F12 媒介被使用。从在试管内测试获得的结果证明这项活动在二氯甲烷和甲醇主要是在场的,自从这些摘录由睾丸片在睾丸激素生产导致了增加。结论:睾丸片系统是合适的被用于植物的生男性征的简历有功成分的隔离的进一步的在试管内调查。 | Paul E Moundipa Silvère Ngouela Pierre Kamtchouing Etienne Tsamo Félicité M.Tchouanguep Serge Carreau | 2006 | Asian Journal of Andrology2006，8，1： | 2 |
| 6 | Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation显示文摘 | Jean-Jacques Brie're 1 Judith Favier Anne Paule Gimenez Roqueplo | 2006 | Am J Physiol Cell Physiol2006，291，： | 1 |
| 7 | Interpleural block显示文摘 | Dravid RM Paul RE | 2007 | Anaesthesia2007，62，11： | 1 |
| 8 | Influence of Photoselective Vaporization of the Prostate on Sexual Function: Results of a Prospective Analysis of 149 Patients with Long-Term Follow-Up显示文摘 | Franck Bruyère Alexis Puichaud Helder Pereira Benjamin Faivre d’Arcier Antoine Rouanet Aurélie Paule Floc’h Thomas Bodin Nicolas Brichart | 2010 | European Urology2010，，： | 1 |
| 9 | Biodiversity gap analysis of the protected area system in poorly-documented Chad显示文摘 | David Brugière Paul Scholte | 2013 | Journal for Nature Conservation2013，，： | 1 |
| 10 | Design and function of novel superplasticizers for more durable high performance concrete (superplast project)显示文摘 | Yves F. Houst Paul Bowen Fran?ois Perche Annika Kauppi Pascal Borget Laurent Galmiche Jean-Fran?ois Le Meins Fran?oise Lafuma Robert J. Flatt Irene Schober Phil F.G. Banfill David S. Swift Bernt O. Myrvold Berit G. Petersen K?re Reknes | 2008 | Cement and Concrete Research2008，，10： | 1 |
| 11 | Selective bronchial arteriography and intra-arterial chemotherapy in carcinoma of the lung 显示文摘 | Kahn PC Paul RE Rheinlander HF | 1965 | J Thorac Cardiovasc Surg1965，50，5： | 1 |
| 12 | Mating patterns in malariaparasite populations of Papua New Guinea显示文摘 | Paul RE Packer MJ Walmsley M | 1995 | Science1995，269，5231： | 1 |
| 13 | lsomerization of lycopene in the gastri-c milieu显示文摘 | Robert Re Paul D F Marianne Long | 2001 | Biochemical and Biophysical Research Communications2001，，281： | 1 |
| 14 | Exercise capacity and idebenone intervention in children and adolescents with Friedreich ataxia显示文摘 | Drinkard BE Keyser RE Paul SM | 2010 | Arch phys Med Rehabil2010，91，： | 1 |
| 15 | Man-in-the-Barrel syndrome in a nncomatose patient:a case report显示文摘 | Paul GO maury RE Lawrence ME | 1991 | Arch Phy Med rehabll1991，72，： | 1 |
| 16 | Unique Characteristics of the Pyrrolysine System in the 7th Order of Methanogens: Implications for the Evolution of a Genetic Code Expansion Cassette显示文摘 | Guillaume Borrel Nadia Gaci Pierre Peyret Paul W. O’Toole Simonetta Gribaldo Jean-Fran?ois Brugère Kyung Mo Kim | 2014 | Archaea2014，，： | 1 |
| 17 | Endoscopic magnetic gastroenteric anastomosis for palliation of malignant gastric outlet obstruction: a prospective multicenter study显示文摘 | Jeanin E. van Hooft Frank P. Vleggaar Olivier Le Moine Alessandra Bizzotto Rogier P. Voermans Guido Costamagna Jacques Devière Peter D. Siersema Paul Fockens | 2010 | Gastrointestinal Endoscopy2010，，： | 1 |
| 18 | Isomerization of lycopene in the gastric milieu显示文摘 | Robert Re Paul D F Marianne Long | 2001 | Biochemical and Biophysical Research Communications2001，281，： | 1 |
| 19 | Influence of Photoselective Vaporization of the Prostate on Sexual Function: Results of a Prospective Analysis of 149 Patients with Long-Term Follow-Up显示文摘 | Franck Bruyère Alexis Puichaud Helder Pereira Benjamin Faivre d’Arcier Antoine Rouanet Aurélie Paule Floc’h Thomas Bodin Nicolas Brichart | 2010 | European Urology2010，，2： | 1 |
| 20 | Suppressor thymus-derived lymphocytes in fungal infection显示文摘 | Stobo JD Paul S Van Scoy RE | 1976 | J Clin Investm1976，57，2： | 1 |
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