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| 1 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 2 | Passive-source ocean bottom seismograph(OBS) array experiment in South China Sea and data quality analyses显示文摘Long-term passive source ocean bottom seismograph(OBS) observatory is challenging due to various technical difficulties. In order to gain experience in this field, and to reveal the lithospheric structure beneath the extinct ridge in the central South China Sea(SCS), we carried out a passive source OBS array experiment, which includes 18 OBSs, in the deep portion of SCS. Here we present the instrumentation, the OBS deployment and recovery of this experiment, and more importantly, the data quality evaluated by a number of approaches. Through processing and inspecting waveforms from global, regional and local earthquakes, we find that most of recovered OBSs have good data quality with discernible main phases. The ambient noise analyses of OBS recordings show that their noise is higher than the global average, and the horizontal component is noisier than the vertical, indicating current impacts on horizontal components are more severe. In the period range of 5–10 s, there is a noise notch for the SCS OBSs, and noise levels of horizontal components are comparable to the vertical. This feature, which is not seen at OBS stations in open ocean, suggests the distant sources for double frequency microseism in this marginal sea are not significant. In addition, we successfully determined the orientations for 7 OBSs by investigating their Rayleigh wave polarizations; and we demonstrated the dispersion feature of Rayleigh waves through the frequency-time analysis. Finally, we summarized lessons learned from this experiment regarding the passive source OBS investigations in SCS. | Chenguang Liu Qingfeng Hua Yanliang Pei Ting Yang Shaohong Xia Mei Xue Ba Manh Le Da Huo Fang Liu Haibo Huang | 2014 | Chinese Science Bulletin2014，59，33： | 11 |
| 3 | Can ultrasound predict the severity of acute pancreatitis early by observing acute fluid collection?显示文摘INTRODUCTIONThe spectrum of acute pancreatitis (AP) ranges from a mild spontaneously resolved disorder to severe disease with mortality up to 20%-48.4%[1-3]. sAP is defined as the AP with organ failure and /or local complications which developed form acute fluid collection (AFC) including necrosis ,abscess , pseudocyst formation into or around the pancreas [4]. | Yan Luo1 Chao Xin Yuan1 Yu Lan Peng1 Pei Lin Wei1 Zhao Da Zhang2 Jun Ming Jiang3 Lin Dai1 Yun Kai Hu1 1Ultrasound Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China2Surgery Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China3Tranditional Chinese Medicine, Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China | 2001 | World Journal of Gastroenterology2001，7，2： | 8 |
| 4 | The Survey of Cronobacter spp.(formerly Enterbacter sakazakii) in Infant and Follow-up Powdered Formula in China in 2012显示文摘Objective To determine Cronobacter spp.contamination in infant and follow-up powdered formula in China.Methods All of 2282 samples were collected from the retail markets in China from January 2012 to December 2012,and analyzed for Cronobacter spp.by the Chinese National Food Safety Standard.Characterization of the isolates was analyzed by pulsed-field gel electrophoresis(PFGE)with XbaI and Spe I restriction enzymes.Results Cronobacter spp.strains were isolated from 25 samples,and the positive rates in infant powdered formulas and follow-up powdered formulas were 0.90%(10/1011)and 1.18%(15/1271),respectively.Analysis of variable data regarding different purchasing store formats,seasonality,and production locations as well as comparison of infant versus follow-up formulas did not reveal statistically significant factors.During the sampling period,one of six surveillance zones did exhibit a statistically significant trend towards higher positive rate.PFGE characterization of Cronobacter spp.to elucidate genetic diversity revealed only three pairs of Cronobacter spp.out of 25 having the same PFGE patterns.Conclusion The current investigation indicated a lower positive rate of Cronobacter spp.in the powdered formula in China.This evidence suggested contamination originating from multiple different sources during the manufacturing process. | PEI Xiao Yan YAN Lin ZHU Jiang Hui LI Ning GUO Yun Chang FU Ping JIA Hua Yun ZHANG Xiu Li YANG Xiao Rong YANG Da Jin | 2016 | Biomedical and Environmental Sciences2016，29，2： | 4 |
| 5 | A novel linear microprobe array for the fabrication of neural microelectrodes显示文摘A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from silicon.The LMPA leverages the properties of conventional microwire with additional features of naturally formed regular spacing.With the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’rear ends,the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the LMPA.The fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy(EIS)and in vivo test.The SNR of the spikes recorded was 6. | ZHAO Shan Shan PEI Wei Hua ZHAO Hui WANG Yi Jun CHEN San Yuan CHEN Yuan Fang ZHANG He GUO Dong Mei GUI Qiang CHEN Hong Da | 2015 | Science China(Technological Sciences)2015，58，2： | 3 |
| 6 | Cotransplantation of haploidentical hematopoietic and umbilical cord mesenchymal stem cells for severe aplastic anemia: Successful engraftment and mild GVHD显示文摘 | Yamei Wu Yongbin Cao Xiaohong Li Lixin Xu Zhihong Wang Pei Liu Pei Yan Zhouyang Liu Jing Wang Shuang Jiang Xiaoxiong Wu Chunji Gao Wanming Da Zhongchao Han | 2014 | Stem Cell Research2014，，1： | 3 |
| 7 | Full-Length Genome Sequencing of SARS-CoV-2 Directly from Clinical and Environmental Samples Based on the Multiplex Polymerase Chain Reaction Method显示文摘The new coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is spreading worldwide with the number of confirmed cases increasing dramatically[1,2].Coronaviruses have the largest genome among RNA viruses and have caused two major outbreaks[3,4]. | NIU Pei Hua ZHAO Xiang LU Rou Jian ZHAO Li HUANG Bao Ying YE Fei WANG Da Yan TAN Wen Jie | 2021 | Biomedical and Environmental Sciences2021，34，9： | 3 |
| 8 | The granites of South China andtheir metallogeny显示文摘 | PEI RONGFU HONG DA WEI | 1995 | Episodes1995，18，： | 1 |
| 9 | A Study of the Key Techniques of High-Speed Optical Time Division Multiplexing Systems显示文摘 | LIU Xian bing directed by YE Pei da, ZHAO Zi sen | 2001 | The Journal of China Universities of Posts and Telecommunications2001，8，4： | 1 |
| 10 | Effects of acupuncture at acupoint neiguan( PC6 ) and intravenous Injection of Larginine on the Improvement of Acute Myocardia ischemia 显示文摘 | ZHOU Pei hua LV Juan xiu ZHU Da nian | 2006 | Joural of Acupuncture and Tuina Science2006，4，3： | 1 |
| 11 | Solution Properties of Chlorinated Polypropylene and Maleic Anhydride Grafted Chlorinated Plypropylene 显示文摘 | Da - Zhuang Liu Zhong - Lei Fan Pei - Qin Sun Xue - Ru Dung | 2004 | Physics and Chemistry of Liquids2004，42，6： | 1 |
| 12 | Activated TNF-α/NF-κB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice显示文摘 | Altomare DA Menges CW Pei J | 2009 | Proc Natl Acad Sci USA2009，106，9： | 1 |
| 13 | Lepida Acid A from Basidiomycetes Russula lepida显示文摘A new compound, lepida acid A l, has been isolated from the fruiting bodies of Basidiomycetes Russula lepida. Its structure was elucidated by spectral methods. | Jian Wen TAN Ji Kai LIU Ze Jun DONG Pei Gui LIU Da Gan JI(Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204)(Department of Chemistry, Zhongshan University, Guangzhou 510275) | 1999 | Chinese Chemical Letters1999，10，4： | 1 |
| 14 | Functiongal regu- lation of thymic stromal lymphopoietin on proliferation and invasion of trophoblasts in human first -trimester pregnency 显示文摘 | Hai - Xia Wu Pei - Fen Guo Da - Jin Li | 2010 | Humen Re- production2010，25，5： | 1 |
| 15 | Study on the miscibility of chlorinated polypropylene with alkyd resin by dilute solution viscometry显示文摘 | DA - ZHUANG LIU ZHONG - LEI FAN PEI - QIN SUN | 2004 | Physics and Chemistry of Liquids2004，42，6： | 1 |
| 16 | A heterogeneous-aware cooperative MIMO transmission scheme in WSN 显示文摘 | Pei Tingrui Xie Da Li Zhetao | 2013 | Journal of Software2013，8，3： | 1 |
| 17 | Mineralocortieoid receptor, CYP11B2 mRNA expression, and atrial matrix remodelling in patients with atrial fibrillation显示文摘 | Pei DA Yan YY Li L | 2010 | Aeta Cardiol2010，65，： | 1 |
| 18 | Onconase responsive gene in human mesothelioma cells: implications for an RNA damaging therapeutic agent显示文摘 | Altomare DA Rybak SM Pei J | 2010 | BMC Cancer2010，10，： | 1 |
| 19 | Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice 显示文摘 | Altomare DA Menges CW Pei 1 | 2009 | Proc Natl Acad Sci USA2009，106，9： | 1 |
| 20 | Effect of Lanthanum on Mechanical Properties of ZL702 Alloy at Room and High Temperature Condition显示文摘Effects of lanthanum on microstructure and mechanical properties of ZL702 alloy at room and high temperature conditions are studied. The experiment shows that high temperature intermetallics reticularly distributing at grain boundary are formed with La and Al, Si, Fe etc. elements of alloy, which enhances the thermal stability of the alloy. With appropriate content of La (0.10%~ 0.15%), the mechanical properties of the alloy, such as strength, at room temperature and high temperature can be improved. | LI Pei jie 1,2 , ZENG Da ben 1, JIA Jun 2, LI Qing chun 2( 1. Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China 2. School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China | 2000 | Journal of Rare Earths2000，18，2： | 1 |
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