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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | N^6 -methyl-adenosine (m^6 A) in RNA: An Old Modification with A Novel Epigenetic Function显示文摘N6 -methyl-adenosine (m6A) is one of the most common and abundant modifications on RNA molecules present in eukaryotes. However, the biological significance of m6A methylation remains largely unknown. Several independent lines of evidence suggest that the dynamic regulation of m6A may have a profound impact on gene expression regulation. The m6A modification is catalyzed by an unidentified methyltransferase complex containing at least one subunit methyltransferase like 3 (METTL3). m6A modification on messenger RNAs (mRNAs) mainly occurs in the exonic regions and 3'-untranslated region (3'-UTR) as revealed by high-throughput m6A-seq. One significant advance in m6A research is the recent discovery of the first two m6A RNA demethylases fat mass and obesity-associated (FTO) gene and ALKBH5, which catalyze m6A demethylation in an a-ketoglutarate (a-KG)-and Fe2+-dependent manner. Recent studies in model organisms demonstrate that METTL3, FTO and ALKBH5 play important roles in many biological processes, ranging from development and metabolism to fertility. Moreover, perturbation of activities of these enzymes leads to the disturbed expression of thousands of genes at the cellular level, implicating a regulatory role of m6A in RNA metabolism. Given the vital roles of DNA and histone methylations in epigenetic regulation of basic life processes in mammals, the dynamic and reversible chemical m6A modification on RNA may also serve as a novel epigenetic marker of profound biological significances. | Yamei Niu Xu Zhao Yong-Sheng Wu Ming-Ming Li Xiu-Jie Wang Yun-Gui Yang | 2013 | Genomics, Proteomics & Bioinformatics2013，11，1： | 40 |
| 3 | Nitrification performance of nitrifying bacteria immobilized in waterborne polyurethane at low ammonia nitrogen concentrations显示文摘Suspended and waterborne polyurethane immobilized nitrifying bacteria have been adopted for evaluating the effects of environmental changes,such as temperature,dissolved oxygen (DO) concentration and pH,on nitrification characteristics under conditions of low ammonia concentrations.The results showed that nitrification was prone to complete with increasing pH,DO and temperature.Sensitivity analysis demonstrated the effects of temperature and pH on nitrification feature of suspended bacteria were slightly greater than those of immobilized nitrifying bacteria.Immobilized cells could achieve complete nitrification at low ammonia concentrations when DO was sufficient.Continuous experiments were carried out to discuss the removal of ammonia nitrogen from synthetic micropollute source water with the ammonia concentration of about 1 mg/L using immobilized nitrifying bacteria pellets in an up-flow inner circulation reactor under different hydraulic retention times (HRT).The continuous removal rate remains above 80% even under HRT 30 min.The results verified that the waterborne polyurethane immobilized nitrifying bacteria pellets had great potential applications for micro-pollution source water treatment. | Yamei Dong Zhenjia Zhang Yongwei Jin Zhirong Li Jian Lu | 2011 | Journal of Environmental Sciences2011，23，3： | 32 |
| 4 | Distribution of polycyclic aromatic hydrocarbons in sediments from Yellow River Estuary and Yangtze River Estuary,China显示文摘Surface sediment samples collected from twenty-one sites of Yellow River Estuary and Yangtze River Estuary were determined for sixteen priority polycyclic aromatic hydrocarbons (PAHs) by isotope dilution GC-MS method. The total PAH contents varied from 10.8 to 252 ng/g in Yellow River Estuary sediment, and from 84.6 to 620 ng/g in Yangtze River Estuary sediment. The mean total PAH content of Yangtze River Estuary was approximately twofold higher than that of Yellow River Estuary. The main reasons for the difference may be the rapid industrial development and high population along Yangtze River and high silt content of Yellow River Estuary. The evaluation of PAH sources suggested that PAHs in two estuaries sediments estuaries were derived primarily from combustion sources, but minor amounts of PAHs were derived from petroleum source in Yellow River Estuary. PAHs may be primary introduced to Yellow River Estuary via dry/wet deposition, wastewater effuents, and accidental oil spills, and Yangtze River Estuary is more prone to be affected by wastewater discharge. | HUI Yamei ZHENG Minghui LIU Zhengtao GAO Lirong | 2009 | Journal of Environmental Sciences2009，21，12： | 24 |
| 5 | Nitrification characteristics of nitrobacteria immobilized in waterborne polyurethane in wastewater of corn-based ethanol fuel production显示文摘A technology to achieve stable and high ammonia nitrogen removal rates for corn distillery wastewater (ethanol fuel production) treatment has been designed.The characteristics of nitrifying bacteria entrapped in a waterborne polyurethane (WPU) gel carrier were evaluated after acclimation.In the acclimation period,nitrification rates of WPU-immobilized nitrobacteria were monitored and polymerase chain reaction (PCR) was also carried out to investigate the change in ammonium-oxidizing bacteria.The results showed that the pellet nitrification rates increased from 21 to 228 mg-N/(L-pellet·hr) and the quantity of the ammonia oxidation bacteria increased substantially during the acclimation.A continuous ammonia removal experiment with the anaerobic pond effluent of a distillery wastewater system was conducted with immobilized nitrifying bacteria for 30 days using an 80 L airlift reactor with pellets at a fill ratio of 15% (V/V).Under the conditions of 75 mg/L influent ammonia,hydraulic retention time (HRT) of 3.7-5.6 hr,and dissolved oxygen (DO) of 4 mg/L,the effluent ammonia concentration was lower than 10 mg/L and the ammonia removal efficiency was 90%.While the highest ammonia removal rate,162 mg-N/(L-pellet·hr),was observed when the HRT was 1.3 hr. | Yamei Dong Zhenjia Zhang Yongwei Jin Jian Lut Xuehang Cheng Jun Li Yan-yan Deng Ya-nan Feng Dongning Chen | 2012 | Journal of Environmental Sciences2012，24，6： | 14 |
| 6 | Compound Zhebei granules combined with chemotherapy for the treatment of refractory acute leukemia: a randomized clinical trial显示文摘OBJECTIVE: To observe the effect of compound Zhebei granules(CZBG) with chemotherapy in the treatment of refractory acute leukemia.METHODS: In this multicenter, double-blind, placebo-controlled clinical trial, we used a central(online) randomization system to assign 235 patients to two treatment groups. A total of 118 patients received chemotherapy combined with CZBG(4 g,twice daily) and 117 patients received chemotherapy plus placebo. The clinical efficacy was evaluated at the end of one chemotherapeutic cycle.RESULTS: In the full analysis set, in which deaths due to disease progression were regarded as inefficacy, the rates of complete remission(CR) and partial remission(CR + PR) were 32.35% and 50.00%,respectively, for the chemotherapy combined with CZBG group, and 23.08% and 35.58%, respectively,for the chemotherapy plus placebo group. There was a statistically significant difference between the two groups according to a ysis set(PPχ2test(P < 0.05). In the per protocol analS), the CR(33.67%),CR+PR(52.04%) response rates for the chemotherapy plus CZBG group were significantly different from the response rates of the control group(CR:24.24% and CR+PR: 37.37%), respectively(P < 0.05).CONCLUSION: CZBG plus chemotherapy can improve the clinical remission rate of refractory acute leukemia after one just one therapeutic cycle. | Hou Li Yang Shulian Yang Wenhua Zhou Yuhong Liu Feng Yang Hongyong Sun Weizheng Li Dongyun Xu Yamei Chen Xinyi | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 13 |
| 7 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 8 | MiR156 regulates anthocyanin biosynthesis through SPL targets and other microRNAs in poplar显示文摘Anthocyanins biosynthesized from the flavonoid pathway are types of pigments that are involved in the protection of poplar from biotic and abiotic stresses.Previous researchers studying anthocyanin-related transcription factors and structural genes in poplar have made significant discoveries.However,little is known about the regulatory role of microRNAs in anthocyanin biosynthesis in poplar.Here,we overexpressed miR156 in poplar to study the comprehensive effects of the miR156-SPL module on the biosynthesis of anthocyanins.Small RNA sequencing analysis revealed 228 microRNAs differentially expressed in transgenic poplar plants with dramatically increased miR156 levels.Furthermore,integrated microRNAomic and transcriptomic analysis suggested that two microRNAs,miR160h,and miR858,have the potential to affect anthocyanin accumulation in poplar by regulating auxin response factors and MYB transcription factors,respectively.Additionally,the accumulation of miR160h and miR858 displayed a positive correlation with miR156 levels,suggesting a possible interaction between the miR156-SPL module and these microRNAs in poplar.Last,metabolomics analysis revealed that the levels of anthocyanins,flavones,and flavonols were substantially elevated in transgenic poplar plants overexpressing miR156 compared with the wild type,whereas the total lignin content was reduced in the transgenic plants.Taken together,our results indicate that miR156 can fine tune the anthocyanin biosynthetic pathway via multiple factors,including microRNAs,transcription factors,and the levels of structural genes,in poplar.This provides additional clues for understanding the complex regulatory network of anthocyanin biosynthesis in woody plants. | Yamei Wang Wenwen Liu Xinwei Wang Ruijuan Yang Zhenying Wu HanWang LeiWang Zhubing Hu Siyi Guo Hailing Zhang Jinxing Lin Chunxiang Fu | 2020 | Horticulture Research2020，7，1： | 9 |
| 9 | Preparation and arc erosion properties of Ag/Ti_2SnC composites under electric arc discharging显示文摘New Ag/Ti_2 SnC(Ag/TSC) composites with uniform microstructure were prepared by powder metallurgy. The superior wettability between Ag and Ti_2 SnC was confirmed with a contact angle of 14°. Arc erosion properties of Ag/10 wt%Ti_2 SnC(Ag/10 TSC) and Ag/20 wt%Ti_2 SnC(Ag/20 TSC) contacts were investigated under 400 V/100 A/AC-3 and compared with Ag/CdO contact.The Ag/10 TSC contact exhibited comparable arc erosion property to Ag/CdO contact. The fine arc erosion resistance was attributed to the good wettability between Ti_2 SnC and Ag,the good heat-conducting property of Ag/10 TSC, and the slight decomposition of Ti_2 SnC that absorbed part of electric arc energy. The excessive Ti_2 SnC significantly decreased the thermal conducting property of the Ag/20 TSC composite, resulting in the severe heat accumulation that decomposed Ti_2 SnC and deteriorated arc erosion property. The oxidation behavior of Ti_2 SnC under high electric arc temperature was also studied and then an arc erosion mechanism was proposed to get a comprehensive understanding on the arc erosion property of Ag/TSC composites. | Jianxiang DING Wubian TIAN Peigen ZHANG Min ZHANG Jian CHEN Yamei ZHANG Zhengming SUN | 2019 | Journal of Advanced Ceramics2019，8，1： | 9 |
| 10 | Experimental Investigation and Optimization Design of Multi-Support Pipeline System显示文摘The design of aircraft hydraulic pipeline system is limited by many factors,such as the integrity of aviation structure or narrow installation space,so the limited clamp support position should be considered.This paper studied the frequency adjustment and dynamic responses reduction of the multi-support pipeline system through experiment and numerical simulation.To avoid the resonance of pipeline system,we proposed two different optimization programs,one was to avoid aero-engine working range,and another was to avoid aircraft hydraulic pump pulsation range.An optimization method was introduced in this paper to obtain the optimal clamp position.The experiments were introduced to validate the optimization results,and the theoretical optimization results can agree well with the test.With regard to avoiding the aero-engine vibration frequency,the test results revealed that the first natural frequency was far from the aero-engine vibration frequency.And the dynamic frequency sweep results showed that no resonance occurred on the pipeline in the engine vibration frequency range after optimization.Additionally,with regard to avoiding the pump vibration frequency,the test results revealed that natural frequencies have been adjusted and far from the pump vibration frequency.And the dynamic frequency sweep results showed that pipeline under optimal clamp position cannot lead to resonance.The sensitivity analysis results revealed the changing relationships between different clamp position and natural frequency.This study can provide helpful guidance on the analysis and design of practical aircraft pipeline. | Xiantao Zhang Wei Liu Yamei Zhang Yujie Zhao | 2021 | Chinese Journal of Mechanical Engineering2021，34，2： | 9 |
| 11 | 华北克拉通西部陆块北缘新生代岩石圈地幔特征的初步研究显示文摘凉城、四子王旗、三义堂和大同的地幔包体的岩石学和矿物的主、微量元素成分显示华北克拉通中、西部北缘总体为过渡型岩石圈地幔,为原始地幔经过不同程度的熔体抽取和后期交代富集作用的残留。凉城岩石圈地幔经历的熔体抽取程度最低,后期交代富集作用比较强烈,这与其橄榄岩中尖晶石的Cr#较低,并且共存的单斜辉石的Mg#较低一致。三义堂岩石圈地幔经历的熔体抽取程度最高,后期交代富集作用最强烈,不同样品甚至同一样品中不同单斜辉石颗粒的La/Yb和LREE配分模式变化范围非常大,且矿物边部比核部更富集微量元素。大同、四子王旗岩石圈地幔经历的熔体抽取程度介于凉城和三义堂之间,但后期的交代富集作用明显不如凉城和三义堂强烈。研究区的岩石圈地幔主要受硅酸盐熔体交代作用的影响,只有三义堂岩石圈地幔还可能也受到了碳酸盐交代作用的影响。 | 王亚妹 William L GRIFFIN 韩宝福 WANG YaMei HAN BaoFu | 2011 | 岩石学报2011，27，10： | 9 |
| 12 | Early Pleistocene hominid teeth recovered in Mohui cave in Bubing Basin, Guangxi, South China显示文摘Two hominid teeth recovered in Mohui cave are morphologically distinguished from Australopithecus in Af-rica, but close to Homo erectus in China. These teeth are therefore provisionally assigned to Homo erectus. The associ-ated mammalian fauna include Gigantopithecus blacki, Nes-toritherium sp., Sus xiaozhu, Sus peii and Ailuropoda microta, which are typical early Pleistocene taxa in South China. The general characteristics of the Mohui faunal assemblage are similar to the Longgupo site, which is dated to 2 Ma, imply-ing a contemporaneity for the two sites. To date, compared with the discoveries in Africa, far fewer early Pleistocene hominid fossils have been recovered in Asia, and there are intensive controversies concerning their stratigraphic prove-nience and typological and temporal positions. The hominid fossils from Mohui cave, with their reliable biostratigraphic positions and distinct typological features, provide important evidence regarding the issue of early human origins and evo-lution. | WANG Wei Richard Potts HOU Yamei CHEN Yunfa WU Huaying YUAN Baoyin HUANG Weiwen | 2005 | Chinese Science Bulletin2005，50，23： | 8 |
| 13 | Slip casting and pressureless sintering of Ti3AlC2显示文摘Slip casting and subsequent pressureless sintering(PLS)allow the preparation of complex-shaped and large-sized Ti3AlC2 components for many potential applications.The behaviors of the suspensions,green compacts,and sintered samples of Ti3AlC2 were studied in this paper.The optimized condition of 1 wt%of arabic gum as dispersant at pH=10 results in a Ti3AlC2 suspension for slip casting Ti3AlC2 green compacts without macro defects or cracks.The sintering temperature and Al4C3 embedding powder are found to dominate the properties of the sintered Ti3AlC2 samples.The Ti3AlC2 sample sintered at 1450℃for 1.5 h with Al4C3 embedding powder reaches the best properties,namely 95.3%relative density,hardness of 4.18 GPa,thermal conductivity of 29.11W·m-1·K-1,and electrical resistivity of 0.39μΩ·m.The findings in this work may pave the way for the application of MAX phases with large size and complex shape. | Yimin GONG Wubian TIAN Peigen ZHANG Jian CHEN Yamei ZHANG Zhengming SUN | 2019 | Journal of Advanced Ceramics2019，8，3： | 6 |
| 14 | Mode of débitage and technical cognition of hominids at the Guanyindong site显示文摘Exploring and interpreting the mode of cognition and behavioral patterns of prehistoric hunter-gatherers is always one of the main goals of current Paleolithic research. In the 1940s, French prehistorians proposed the technological method for studying lithic assemblages which opened a brand-new perspective on the prehistoric domain. In the 1960s, French ethnographer and anthropologist André Leroi-Gourhan proposed the concept 'chane opératoire' and established the theory of lithic technological study. After the 1980s, the concept 'chane opératoire' was substituted for two different but complementary concepts: techno-cognition and techno-economy, which contributed not only to revealing the technical knowledge and know-how applied during lithic production but also to interpreting the technical behavior of prehistoric hunter-gatherers from social and economic viewpoints. The lithic technological study of the Guanyindong site, presented in this paper, was carried out for the first time by applying lithic technological method developed by French prehistorians to the Chinese materials. Our analytical results demonstrated that the débitage system of Guanyindong is quite distinct from the concept Levallois largely used in Europe, Near-East and Africa. The differentiation between these two débitage modes may contribute to exploring and interpreting the relationship in Middle Paleolithic between China and Europe, Near-East and Africa. | LI YingHua HOU YaMei BOEDA Eric | 2009 | Chinese Science Bulletin2009，54，21： | 6 |
| 15 | Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function显示文摘Radiation therapy is a standard treatment for head and neck tumors.However,patients often exhibit cognitive impairments following radiation therapy.Previous studies have revealed that hippocampal dysfunction,specifically abnormal hippocampal neurogenesis or neuroinflammation,plays a key role in radiation-induced cognitive impairment.However,the long-term effects of radiation with respect to the electrophysiological adaptation of hippocampal neurons remain poorly characterized.We found that mice exhibited cognitive impairment 3 months after undergoing 10 minutes of cranial irradiation at a dose rate of 3 Gy/min.Furthermore,we observed a remarkable reduction in spike firing and excitatory synaptic input,as well as greatly enhanced inhibitory inputs,in hippocampal CA1 pyramidal neurons.Corresponding to the electrophysiological adaptation,we found reduced expression of synaptic plasticity marker VGLUT1 and increased expression of VGAT.Furthermore,in irradiated mice,long-term potentiation in the hippocampus was weakened and GluR1 expression was inhibited.These findings suggest that radiation can impair intrinsic excitability and synaptic plasticity in hippocampal CA1 pyramidal neurons. | Min-Yi Wu Wen-Jun Zou Pei Yu Yuhua Yang Shao-Jian Li Qiang Liu Jiatian Xie Si-Qi Chen Wei-Jye Lin Yamei Tang | 2022 | Neural Regeneration Research2022，17，10： | 5 |
| 16 | Clinical characteristics and changes in living quality of patients with radiation encephalopathy induced by radiation therapy for treating nasopharyngeal carcinoma显示文摘BACKGROUND: Radiation encephalopathy (RE) caused by radiation therapy of nasopharyngeal carcinoma severely influences patients' quality of life (QOL). The factors, which influence such patients' QOL, have not been confirmed. OBJECTIVE: To observe the clinical and imageological characteristics of patients with radiation therapy of nasopharyngeal carcinoma-induced RE and the changes in QOL, and analyze QOL influencing factors. DESIGN: Retrospective case analysis. SETTING: Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University. PARTICIPANTS: Eighty-nine inpatients or outpatients with RE induced by radiation therapy of nasopharyngeal carcinoma admitted to Sun Yat-sen University Cancer Center and Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University from March 1994 to August 2004 were involved in this experiment. They all met the diagnosis criteria of RE from MERRITT'S neurology (10th edition). Thirty-three involved patients were randomly chosen as RE group. Another 34 concurrent inpatients or outpatients with nasopharyngeal carcinoma who received radiation therapy but without RE were chosen as control group. Informed consents of detected items were obtained from all the involved subjects. METHODS: ① Patients were evaluated when they were followed up. The World Health Organization Quality of Life Questionnaire abbreviated version (WHOQOL-BREF) was used for on-the-spot evaluation. High points of WHOQOL-BREF indicated better QOL. The Late Effects on Normal Tissues - Subjective, Objective, Management and Analytic (LENT-SOMA) scale for evaluating radiation injury was used to evaluate headache and neurologic disorder of patients with RE induced by radiation therapy of nasopharyngeal carcinoma. The evaluation was graded into 5 degrees. High degrees indicted severer clinical symptoms. ② Disease latency (i.e. time interval from symptoms and body signs appearing or radiation therapy ending to onset), initial symptoms, common symptoms, imageological characteristics, QOL and other related factors of patients were recorded. ③ Statistical management was carried out with SPSS 10.0 software. MAIN OUTCOME MEASURES: QOL and clinical characteristics of patients with RE induced by radiation therapy of nasopharyngeal carcinoma as well as QOL influencing factors. RESULTS: All the involved subjects participated in the final analysis. ① Disease latency of patients with RE ranged from 0 to 24 years, and 95% confidence interval was 0 to 15 years. There were significant differences in amount of invaded cases between 6 months after one radiation therapy and 6 months after two or more radiation therapies (χ2=36.76,P < 0.01). ② The common initial symptom of patients with RE was glossopharyngeal paralysis (33 cases, 37%). ③ The first 3 common symptoms of patients with RE were glossopharyngeal paralysis (52 cases, 58%), limb inertia and sensory disorder (25 cases, 28%) and headache (25 cases, 28%).④Imageology of patients with RE was characterized by long T1 and T2 signal shadow on magnetic resonance. ⑤Total scores of health, of daily life and of social relationship, measured with WHOQOL-BREF, of patients in RE group were significantly lower than those in the control group, respectively [(2.06±0.86)points vs. (2.59±0.66)points; (2.45±0.75)points vs. (2.91±0.75)points; (51.67±15.24) points vs. (59.22±13.03)points, P < 0.05]. Patients undergoing two or more radiation therapies were inferior to those undergoing one radiation therapy in total scores of health, and of daily life, scores of physiology, and of psychology (P < 0.05). ⑥Glossopharyngeal paralysis was negatively correlated with scores of psychology, total scores of daily life and of health in WHOQOL-BREF (P < 0.05); Head was negatively correlated with scores of psychology in WHOQOL-BREF (P < 0.05); Neurologic deficit wasnegatively correlated with scores of psychology, and total scores of health in WHOQOL-BREF (P < 0.05). CONCLUSION: ①The latency of RE of patients undergoing two or more radiation therapies is remarkably shortened, and QOL is decreased, but there is no difference in QOL between two genders. ② Brain edema is common in imageology of RE after radiation therapy. The first 3 ones of initial symptoms and common symptoms both are glossopharyngeal paralysis, neurologic deficit and headache, which greatly negatively influence QOL of patients. | Yamei Tang Yi Li Fusheng Zhang Yunlin Liu Haihong Zhou Jianhong Ye Yigang Xing | 2007 | Neural Regeneration Research2007，2，2： | 5 |
| 17 | A review for the breeding of orchids: Current achievements and prospects显示文摘Orchids are horticultural plants with significant ornamental and economic value.Increasing market circulation and rising trade in orchids is forcing breeders to develop varieties with unique characteristics,including flower color,morphology,and resistance using a range of approaches,including traditional and molecular breeding.Advances in high-throughput technologies have generated extensive data sets with greater sequencing depths and broader coverage,providing the potential for discovering new genes/pathways that give rise to key traits.Several attempts have been made to use emerging molecular and omics methods to accelerate the breeding process in certain of the commercially valuable orchids.This review consolidates current approaches and achievements in orchid breeding and discusses their future applications for improving the resistance,ornamental,and other valuable characteristics of these plants. | Chengru Li Na Dong Yamei Zhao Shasha Wu Zhongjian Liu Junwen Zhai | 2021 | Horticultural Plant Journal2021，7，5： | 5 |
| 18 | Spontaneous Growth of Metal Whiskers on Surfaces of Solids:A Review显示文摘Spontaneous metal whisker growth phenomenon has been studied for^70 years,but still resists interpretations,which has haunted the electronics-rich systems from the birth of the industry since whiskers may lead to short circuits and hence other disasters.In addition to reliability problems,threat of Pb whiskers to human health is also significant due to the toxicity of the element and its geometry as well as its nanometer size.This issue becomes more attention drawing and urgent due to the restrictions on Pb use in EU,Japan etc.,which phases out the Pb-addition practice to mitigate Sn whiskers.This paper reviews the origin of the whiskering phenomenon and whisker-induced problems,ranging from early in the World War Ⅱ to the present;details the development of this issue in the electronics-rich systems including the phenomenon,problems and remedies;pictures the long history of the developments of the growth mechanisms and models which are full of hardship and contradictions.New aspects on the spontaneous whisker growth in some different substrates,such as in brasses and MAX phase materials are reviewed in more details.The latter was found to be a promising system to understand the whisker growth phenomenon,with new growth models proposed that may shed new light to the intricate battle field of the metal whisker research in general. | Peigen Zhang Yamei Zhang Zhengming Sun | 2015 | Journal of Materials Science & Technology2015，31，7： | 5 |
| 19 | Crystal Structures, Thermal Analysis and Electrochemical Behaviors of Functionalized Pyridinium Ionic Liquids Comprising One 1-Ethyl Acetate Group显示文摘 | ZHAO Yamei CUI Hongmeng ZHENG Changzheng CHEN Xiaogang LI Chunyang | 2016 | Chemical Research in Chinese Universities2016，32，1： | 5 |
| 20 | Verification of Mutagen Function of Zeocin in Nannochloropsis oceanica Through Transcriptome Analysis显示文摘Zeocin can cause double strand breaks of DNA and thus is frequently used as a selective antibiotic of eukaryotic Sh ble transformants. In non-transformation system, Zeocin may function as a mutagen if not totally lethal. To verify such function of Zeocin, we mutated Nannochloropsis oceanica by increasing the concentration of Zeocin in medium gradually, and isolated a N. oceanica strain(single cell culture) which survived Zeocin up to 10.0μg mL^(-1). The Zeocin-tolerant strain entered the exponential growth phase later and grew slower than the wild strain. Transcriptome profiling showed that the Zeocin-tolerant N. oceanica strain survived Zeocin mainly by adapting(heritable), rather than acclimating(plastic) to Zeocin. Hence mutating N. oceanica with Zeocin was approved effective. Meanwhile, the physiological characteristics of this Zeocin-tolerant strain were demonstrated. As we proposed, N. oceanica tolerated Zeocin by strengthening its protein degradation and antioxidation. The genes controlling cell division and cellular response to stimuli may also have played important roles in the reduction of growth and the tolerance to Zeocin. Our findings evidenced that Zeocin can serve as an appropriate mutagen of microalgae. Creating variations through mutation with Zeocin may help to study the genetic basis of the traits of this monoploidy and asexual microalga, as well as improve its production. | LIN Genmei WANG Yamei GUO Li DING Haiyan HU Yongmei LIANG Sijie ZHANG Zhongyi YANG Guanpin | 2017 | Journal of Ocean University of China2017，16，3： | 5 |
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