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| 1 | Association of TNF-α promoter polymorphisms with the outcome of persistent HBV infection in a northeast Chinese Han population显示文摘肿瘤坏死因素 --(TNF-) 在致病和长期的肝炎 B 的临床的结果起一个重要作用病毒(HBV ) 感染。这研究的目的是在一张东北汉语汉人口评估在 TNF- 的功能的多型性和坚持的 HBV 感染的不同结果之间的关系。这里, 189 HBV 自发地恢复了题目(SR ) ,包括 180 长期的肝炎 B (CHB ) 的 571 个感染 HBV 的病人, 196 肝肝硬化(LC ) ,和 195 hepatocellular 癌(HCC ) 个人在这研究被注册。所有样品用聚合酶链反应限制碎片长度多型性方法是为 TNF- 857C/T 和 863C/A 的 genotyped。857CC 遗传型的频率与 SR 题目的相比在 CHB 和 LC 个人是显著地更高的(P= 0.03,或 = 1.57, 95% CI 1.042.39 和 P= 0.03,或 = 1.57, 95% CI 1.042.35,分别地) 。在等位基因 857C 的分发的重要差别为 CHB 对 SR 被观察(P= 0.01,或 = 1.52, 95% CI 1.082.13 ) 并且 LC 对 SR (P= 0.02,或 = 1.47, 95% CI 1.062.04 ) 队。另外, 863AA 遗传型的频率比 SR 题目的在 CHB 和 LC 病人是显著地更高的( P= 0.01 ,或= 3.90 ,95% CI 1.3511.23 和 P= 0.01 ,或= 3.83 ,95% CI 1.3410.96 ,分别地),并且等位基因 863A 频率是显著地在比 SR 控制的 CHB , LC ,和 HCC 队更普通( P= 0.004 ,或= 1.72 ,95% CI 1.192.50 ;P= 0.001,或 = 1.81, 95% CI 1.262.61 和 P= 0.001,或 = 1.90, 95% CI 1.332.73,分别地) 。我们的数据也表明 haplotype CA 强烈与坚持的 HBV 感染被联系。这些结果在学习人口建议在 TNF- 倡导者变体和坚持的 HBV 感染的不同结果之间的一个协会。 | Bing Qiui Xi Wang Peiyi Zhang Chunlin Shi Jiye Zhang Wenliang Qiu Wenduo Wang Dongfu Li | 2012 | Acta Biochimica et Biophysica Sinica2012，44，8： | 4 |
| 2 | Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures显示文摘抗菌素编码 anti-CRISPR suppressors 抵抗他们的细菌的主人的 CRISPR/Cas 免疫,因此便于他们的幸存和复制。以前的研究显示出那二编码噬菌体的 anti-CRISPR 蛋白质, AcrF1 和 AcrF2,如果由由 Csy 监视建筑群阻止目标 DNA 识别的 Pseudomonas aeruginosa 的 CRISPR/Cas 系统,而是精确位于下面机制是未知的,压制类型。这里我们在场 Csy 建筑群一定的 AcrF1/2 的结构由 cryo 他们决定了单个粒子的重建。由结构的分析,我们发现 AcrF1 由防碍在 DNA 目标海滨和 crRNA 分隔符之间的基础配对禁止 Csy 建筑群的目标 DNA 识别。另外,当个别地工作或与 AcrF2 合作时, AcrF1 的多重拷贝与不同模式绑在 Csy 建筑群,它可能排除通过不同机制有约束力的目标 DNA。和以前的报告,我们为二 anti-CRISPR suppressors, AcrF1 和 AcrF2 提供一种全面工作情形,它由指向 Csy 监视建筑群的沉默 CRISPR/Cas 免疫。 | Ruchao Peng Ying Xu Tengfei Zhu Ningning Li Jianxun Qi Yan Chai Min Wu Xinzheng Zhang Yi Shi Peiyi Wang Jiawei Wang Ning Gao George Fu Gao | 2017 | Cell Research2017，27，7： | 3 |
| 3 | Regulating solid electrolyte interphases on phosphorus/carbon anodes via localized high-concentration electrolytes for potassium-ion batteries显示文摘The resourceful and inexpensive red phosphorus has emerged as a promising anode material of potassium-ion batteries(PIBs) for its large theoretical capacities and low redox potentials in the multielectron alloying/dealloying reactions,yet chronically suffering from the huge volume expansion/shrinkage with a sluggish reaction kinetics and an unsatisfactory interfacial stability against volatile electrolytes.Herein,we systematically developed a series of localized high-concentration electrolytes(LHCE) through diluting high-concentration ether electrolytes with a non-solvating fluorinated ether to regulate the formation/evolution of solid electrolyte interphases(SEI) on phosphorus/carbon(P/C) anodes for PIBs.Benefitting from the improved mechanical strength and structural stability of a robust/uniform SEI thin layer derived from a composition-optimized LHCE featured with a unique solvation structure and a superior K+migration capability,the P/C anode with noticeable pseudocapacitive behaviors could achieve a large reversible capacity of 760 mA h g^(-1)at 100 mA g^(-1),a remarkable capacity retention rate of 92.6% over 200 cycles at 800 mA g^(-1),and an exceptional rate capability of 334 mA h g^(-1)at8000 mA g^(-1).Critically,a suppressed reduction of ether solvents with a preferential decomposition of potassium salts in anion-derived interfacial reactions on P/C anode for LHCE could enable a rational construction of an outer organic-rich and inner inorganic-dominant SEI thin film with remarkable mechanical strength/flexibility to buffer huge volume variations and abundant K+diffusion channels to accelerate reaction kinetics.Additionally,the highly reversible/durable full PIBs coupling P/C anodes with annealed organic cathodes further verified an excellent practical applicability of LHCE.This encouraging work on electrolytes regulating SEI formation/evolution would advance the development of P/C anodes for high-performance PIBs. | Wei Xiao Peiyi Shi Zhengkui Li Chong Xie Jian Qin Huijuan Yang Jingjing Wang Wenbin Li Jiujun Zhang Xifei Li | 2023 | Journal of Energy Chemistry2023，，3： | 1 |
| 4 | NPC1蛋白介导胆固醇转运和埃博拉病毒入侵的结构基础显示文摘尼曼一匹克C型疾病是由NPC1或者NPC2基因突变造成的一类脂类代谢异常疾病。NPC1和NPC2蛋白在胆固醇的细胞内转运过程中发挥了重要功能,同时NPCI还作为埃博拉病毒位于细胞内的受体参与了病毒的入侵过程。 | Xin Gong Hongwu Qian Xinhui Zhou Jianping Wu Tao Wan Pingping Cao Weiyun Huang Xin Zhao Xudong Wang Peiyi Wang Yi Shi George F.Gao 周强 颜宁 | 2017 | 科学新闻2017，19，4： | 0 |
| 5 | In vitro assembly of Ebola virus nucleocapsidlike complex expressed in E. coil显示文摘 | Ruchao Peng Tengfei Zhu Babayemi Olawale Oladejo Abednego Moki Musyoki Yingzi Cui Yi Shi Peiyi Wang George Fu Gao | 2016 | Protein & Cell2016，7，12： | 0 |
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