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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Genetic Analysis of Gynogenetic and Common Populations of Verasper moseri Using SSR Markers显示文摘The genetic structure and variation of the artificial meio- gy- nogenetic population and common population of barfin flounder (Verasper moseri) were analyzed using eight microsatellite markers. A total of 29 alleles were detected, of which 23 alleles were in the artificial gynogenetic population while 29 alleles were in the control group. The average ob- served heterozygosity (HO) of eight loci in the control group (0.526 8) was several times higher than that (0.185 8) in the gynogenetic population. The results indicate that the genetic diversity of the control group was much higher than that of the gynogenetic population of barfin flounder (Verasper moseri). Most loci significantly deviated from Hardy-Weinberg equilib- rium (HWE) after Bonferroni correction (p <0.005 56) in the gynoge- netic population, while four loci deviated from HWE in the control group. The coefficient of gene differentiation (GST) was 0.131 0, and the genetic distance was 0.171 8 between the two populations, suggesting a signifi- cant genetic differentiation between the two populations. | MA Hongyu YANG Jingfeng SU Pengzhi CHEN Songlin | 2009 | Wuhan University Journal of Natural Sciences2009，14，3： | 5 |
| 3 | Optimizing write operation on replica in data grid显示文摘Replication technique can improve access performance and data availability of data grid systems. So far,most related work on data replication in data grid systems focuses on read-only dataset.Though write operations have been widely used in practice,its optimization problem has not been suciently studied.In this paper,we show that write requests from users can be processed by a nearest site,regardless of the location of latest written replicas.The policy of write nearby instead of write to the latest replica can improve the performance of write operations,while inconsistency is caused between multiple replicas.Therefore,we propose two metadata management algorithms to make sure that users can retrieve up-to-date datasets at any time.We extend OptorSim to support the implementation and evaluation of our scheme.The results of simulation show that our scheme achieves performance gains up to 3.3 compared with WriteMaster scheme. | XU PengZhi WU YongWei HUANG XiaoMeng YANG GuangWen ZHENG WeiMin | 2011 | Science China(Information Sciences)2011，54，1： | 2 |
| 4 | Optimization of process parameters for supercritical carbon dioxide extraction of Passiflora seed oil by response surface methodology显示文摘 | Shucheng Liu Feng Yang Chaohua Zhang Hongwu Ji Pengzhi Hong Chujin Deng | 2008 | The Journal of Supercritical Fluids2008，，1： | 1 |
| 5 | Steroidal saponins with anti-inflammatory activity from Tribulus terrestris L.显示文摘Objective:Tribulus terrestris L.(T.terrestris)is a highly valuable traditional Chinese medicine used to treat stroke,inflammation,pulmonary fibrosis,liver cancer,and urolithiasis.To identify the basic substance responsible for the anti-inflammatory effect of TST(total saponins of Tribulus),its chemical composition was systematically studied,and its effect of inhibiting nitric oxide generation and the expression of related inflammatory factors were determined.Methods:To separate chemical constituents from T.terrestris by column chromatography.Spectroscopic methods,including 1D and 2D nuclear magnetic resonance spectroscopy(NMR)and mass spectrometry(MS)techniques,were used to elucidate the isolated compounds.The anti-inflammatory activities of TST and several compounds were evaluated in vitro.Results:Fifteen steroidal saponins,including 9 furostanol steroidal saponins(1,2,3,4,5,6,7,8,and 15)and 6 isospirostanol steroidal saponins(9,10,11,12,13,and 14),were isolated from T.terrestris.TST significantly decreased the expression of tumor necrosis factor-a(TNF-a)and interleukin-6(IL-6)in RAW 264.7 cells stimulated by lipopolysaccharides.Compounds 13 and 15 evidently reduced TNF-a expression.Compounds 6,10,12,13,and 15 markedly reduced IL-6 expression.Conclusions:Compounds 1 was a novel furostanol steroidal saponin,named 26-O-b-D-glucopyranosyl-(25R)-5afurostan-12-carbonyl-20(22)-en-3b,26-diol-3-O-{b-D-xylopyranosyl-(1→2)-[b-D-xylopyranosyl-(1→3)]-b-D-glucopyranosyl-(1→4)-[a-L-rhamnopyranosyl-(1→2)]-b-D-galactopyranoside}.Compounds 2 was isolated from the family Zygophyllaceae for the first time,and 5 and 6 were isolated from the Tribulus genus.TST and compounds 6,10,12,13,and 15 exerts antiinflammatory activity. | Miaojie Yang Mahmood Brobbey Oppong Jingrui Di Qing Yuan Yanxu Chang Miaomiao Jiang Shijie Cao Pengzhi Dong Lin Li Yan Xie Xiaoying Luan Limin Hu Lijuan Chai Peng Zhang | 2022 | Acupuncture and Herbal Medicine2022，2，1： | 1 |
| 6 | Two-phase smooth particle hydrodynamics modeling of air-water interface in aerated flows显示文摘Abstracted/indexed in:Science Citation Index,Science Citation Index Expanded(SciSearch),Journal Citation Reports/Science Edition,SCOPUS,INSPEC,Zentralblatt Math,Chemical Abstracts Service(CAS),Google Scholar,CSA,Academic OneFile,Current Contents/Engineering,Computing and Technology,Earthquake Engineering Abstracts,EI-Compendex,Gale,OCLC,SCImago,Summon by ProQuest Supervised by Chinese Academy of | YANG HuiXia LI Ran LIN PengZhi WAN Hang FENG JingJie | 2017 | Science China(Technological Sciences)2017，60，3： | 0 |
| 7 | A compartment model and numerical analysis of circulatory economy显示文摘This paper describes an industrial structure and its equation system of a circular economy for material circulation and builds a system dynamic model for resources recycling utilization based on Compartment Model Theory.A circulation multiplier and its computational formula are defined for measuring the efficiency of resources recycling utilization.The simulated results indicate that the resources recycling utilization can not only realize the amount accumulation of natural resources and improve the resources recycling efficiency but can minimize discharges into natural environment by means of adjustment to each compartment parameter in the circular economy. | Zhongzhi Yang Pengzhi Kong Boying Li Bo Chao | 2019 | Journal of Management Analytics2019，6，1： | 0 |
| 8 | Research on the hydrogen terminated single crystal diamond MOSFET with MoO_3 dielectric and gold gate metal显示文摘The single crystal diamond with maximum width about 10 mm has been grown by using microwave plasma chemical vapor deposition equipment. The quality of the grown diamond was characterized using an X-ray diffractometer. The FWHM of the(004) rocking curve is 37.91 arcsec, which is comparable to the result of the electronic grade single crystal diamond commercially obtained from Element Six Ltd. The hydrogen terminated diamond field effect transistors with Au/Mo03 gates were fabricated based on our CVD diamond and the characteristics of the device were compared with the prototype Al/MoO_3 gate. The device with the Au/MoO_3 gate shows lower on-resistance and higher gate leakage current. The detailed analysis indicates the presence of aluminum oxide at the Al/MoO_3 interface, which has been directly demonstrated by characterizing the interface between A1 and MoO_3 by X-ray photoelectron spectroscopy. In addition, there should be a surface transfer doping effect of the MoO_3 layer on H-diamond even with the atmospheric-adsorbate induced 2 DHG preserved after MoO_3 deposition. | Zeyang Ren Jinfeng Zhang Jincheng Zhang Chunfu Zhang Pengzhi Yang Dazheng Chen Yao Li Yue Hao | 2018 | Journal of Semiconductors2018，39，7： | 0 |
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