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| 1 | G2/M inhibitors as pharmacotherapeutic opportunities for glioblastoma:the old,the new,and the future显示文摘Glioblastoma(GBM) is one of the deadliest tumors and has a median survival of 3 months if left untreated. Despite advances in rationally targeted pharmacological approaches, the clinical care of GBM remains palliative in intent. Since the majority of altered signaling cascades involved in cancer establishment and progression eventually affect cell cycle progression, an alternative approach for cancer therapy is to develop innovative compounds that block the activity of crucial molecules needed by tumor cells to complete cell division. In this context, we review promising ongoing and future strategies for GBM therapeutics aimed towards G2/M inhibition such as anti-microtubule agents and targeted therapy against G2/M regulators like cyclin-dependent kinases,Aurora inhibitors, PLK1, BUB, 1, and BUBR1, and survivin. Moreover, we also include investigational agents in the preclinical and early clinical settings. Although several drugs were shown to be gliotoxic, most of them have not yet entered therapeutic trials. The use of either single exposure or a combination with novel compounds may lead to treatment alternatives for GBM patients in the near future. | Angel Mauricio Castro-Gamero Julia Alejandra Pezuk Maria Sol Brassesco Luiz Gonzaga Tone | 2018 | Cancer Biology & Medicine2018，15，4： | 3 |
| 2 | In vitro PLK1 inhibition by BI 2536 decreases proliferation and induces cell-cycle arrest in melanoma cetls显示文摘 | DE OLIVEIRA J C BRASSESCO M S PEZUK J A | 2012 | J Drugs Derrnatol2012，11，5： | 1 |
| 3 | Timing of the ovarian circadian clock is regulated by gonadotropins显示文摘 | Yoshikawa T Sellix M Pezuk P | 2009 | Endocrinology2009，150，9： | 1 |
| 4 | Glucocorticoids as entraining signals for peripheral circadian oscillators显示文摘 | PEZUK P MOHAWK J A WANG L A | 2012 | Endocrinology2012，153，10： | 1 |
| 5 | Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features显示文摘 | Jaqueline Carvalho de Oliveira Carlos Alberto Scrideli María Sol Brassesco Andressa Gois Morales Julia Alejandra Pezuk Rosane de Paula Queiroz José Andres Yunes Silvia Regina Brandalise Luiz Gonzaga Tone | 2011 | Leukemia Research2011，，3： | 1 |
| 6 | Polo-like kinase 1 in- hibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma 显示文摘 | Pezuk J A Brassesco M S Morales A G | 2013 | Cancer Gene Ther2013，20，9： | 1 |
| 7 | In vitro PLKI inhibition by BI 2536 decreases proliferation and induces cell-cycle arrest in melanoma cells 显示文摘 | de Oliveira JC Brassesco MS Pezuk JA | 2012 | J Drugs Dermatol2012，11，5： | 1 |
| 8 | In vitro Plkl inhibition by BI 2536 decrease proliferation and induces cell-cycle arrest in melanoma cells 显示文摘 | DE OLIVEIRA J C BRASSESCO M S PEZUK J A | 2012 | J Drugs Dermato12012，11，5： | 1 |
| 9 | Antiproliferative in vitro effects of BI 2536-mediated Plkl inhibition on cervical adenocarcinoma cells显示文摘 | Pezuk J A Brassesco M S Oliveira J C | 2013 | Clin Exp Med2013，13，1： | 1 |
| 10 | Antiproliferative in vitro effects of BI 2536-mediated PLK1 inhibition on cervical adenocarcinoma cells显示文摘 | Julia A. Pezuk María Sol Brassesco Jaqueline C. Oliveira Andressa G. Morales Ana P. Montaldi Elza T. Sakamoto-Hojo Carlos A. Scrideli Luiz G. Tone | 2013 | Clinical and Experimental Medicine2013，，1： | 1 |
| 11 | Antiproliferative in vitro effects of BI 2536-mediated PLK1 inhibition on cervical adenocarcinoma cells显示文摘 | Pezuk JA Brassesco MS Oliveira JC | 2013 | Clin Exp Med2013，13，1： | 1 |
| 12 | PLK1 expression and BI2536 effects in childhood acute lymphoblastic leukemia显示文摘 | Oliveira JC Pezuk JA Brassesco MS | 2014 | Pediatr Blood Cancer2014，61，7： | 1 |
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