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| 1 | Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress显示文摘AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP, distinct compartmentalized pools of AMPK are activated, phosphorylating different sets of targets. Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting early anti-anabolic and pro-catabolic roles. Moderate increases in AMP expand this to activate cytosolic AMPK also in an AXIN-dependent manner. In contrast, high concentrations of AMP, arising from severe nutrient stress, activate all pools of AMPK independently of AXIN. Surprisingly, mitochondrion-localized AMPK is activated to phosphorylate ACC2 and mitochondrial fission factor (MFF) only during severe nutrient stress. Our findings reveal a spatiotemporal basis for hierarchical activation of different pools of AMPK during differing degrees of stress severity. | Yue Zong Chen-Song Zhang Mengqi Li Wen Wang Zhichao Wang Simon A. Hawley Teng Ma Jin-Wei Feng Xiao Tian Qu Qi Yu-Qing Wu Cixiong Zhang Zhiyun Ye Shu-Yong Lin Hai-Long Piao D. Grahame Hardie Sheng-Cai Lin | 2019 | Cell Research2019，29，6： | 8 |
| 2 | Additive manufacturing of thin electrolyte layers via inkjet printing of highly-stable ceramic inks显示文摘Inkjet printing is a promising alternative for the fabrication of thin film components for solid oxide fuel cells(SOFCs) due to its contactless, mask free, and controllable printing process. In order to obtain satisfying electrolyte thin layer structures in anode-supported SOFCs, the preparation of suitable electrolyte ceramic inks is a key. At present, such a kind of 8 mol% Y_(2)O_(3)-stabilized ZrO_(2)(8 YSZ) electrolyte ceramic ink with long-term stability and high solid loading(> 15 wt%) seems rare for precise inkjet printing, and a number of characterization and performance aspects of the inks, such as homogeneity, viscosity, and printability, should be studied. In this study, 8 YSZ ceramic inks of varied compositions were developed for inkjet printing of SOFC ceramic electrolyte layers. The dispersing effect of two types of dispersants, i.e., polyacrylic acid ammonium(PAANH4) and polyacrylic acid(PAA), were compared. The results show that ultrasonic dispersion treatment can help effectively disperse the ceramic particles in the inks. PAANH4 has a better dispersion effect for the inks developed in this study. The inks show excellent printable performance in the actual printing process. The stability of the ink can be maintained for a storage period of over 30 days with the help of initial ultrasonic dispersion. Finally, micron-size thin 8 YSZ electrolyte films were successfully fabricated through inkjet printing and sintering, based on the as-developed high solid loading 8 YSZ inks(20 wt%). The films show fully dense and intact structural morphology and smooth interfacial bonding, offering an improved structural quality of electrolyte for enhanced SOFC performance. | Zhongqi Zhu Zhiyuan Gong Piao Qu Ziyong Li Sefiu Abolaji Rasaki Zhiyuan Liu Pei Wang Changyong Liu Changshi Lao Zhangwei Chen | 2021 | Journal of Advanced Ceramics2021，10，2： | 7 |
| 3 | Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer显示文摘Lacking a precise targeting strategy,castration-resistant prostate cancer(CRPC)is still hard to be treat effectively.Exploring treatment options that can accurately target CPRC is an important issue with urgent need.In this study,a novel nanotechnologybased strategy had been developed for the precise target treatment of CRPC.By combining microwaves and photothermal therapy(PTT),this nanoplatform,cmHSP70-PL-AuNC-DOX,targets tumor tissues with outstanding precision and achieves better anti-tumor activity by simultaneously eliciting photothermal and chemotherapeutic effects.From nanotechnology,cmHSP70-modified and thermo-sensitive liposome-coated AuNC-DOX were prepared and used for CRPC-targeted photothermal ablation and chemotherapy.Doxorubicin(DOX)was selected as the chemotherapeutic agent for cytotoxicity.In terms of the curative scheme,prostate tissues were firstly pre-treated with microwaves to induce the expression of heat shock protein 70(HSP70)and its migration to the cell membrane,which was then targeted by HSP70 antibody(cmHSP70)coated on the nanoparticles to achieve accurate drug delivery.The nanoplatform then achieved precise ablation and controlled release of DOX under external near-infrared(NIR)irradiation.Through the implementation,the targeting,cell killing,and safety of this therapeutical strategy had been verified in vivo and in vitro.This work establishes an accurate,controllable,efficient,non-invasive,and safe treatment platform for targeting CRPC,provides a rational design for CRPC’s PTT,and offers new prospects for nanomedicines with great precision. | Pengyuan Liu Yajun Wu Xiaogang Xu Xudong Fan Chuan Sun Xiaojie Chen Jindan Xia Shiting Bai Li Qu Huasong Lu Jing Wu Jun Chen Ji-Gang Piao Zhibing Wu | 2023 | Nano Research2023，16，7： | 2 |
| 4 | Studies on the Effectiveness of NaFeEDTA-Forti ]ed Soy Sauce in Controlling Iron Deciency: A Population-Based Intervention Trial 显示文摘 | Chen J Zhao X Zhang X Yin S Piao J Huo J Yu B Qu N Lu Q Wang S Chen C | 2005 | Food and NutritionBulletin2005，26，2： | 1 |
| 5 | Effect of solvent type on the formation of tubular fullerene nanofibers 显示文摘 | Qu Y T Liang S C Piao G Z | 2011 | Mater Lett2011，65，： | 1 |
| 6 | Structure and Morphology Characteristics of Fullerene C<sub>60</sub> Nanotubes Fabricated with N -Methyl-2-pyrrolidone as a Good Solvent显示文摘 | Yongtao Qu Wenwen Yu Shaocen Liang Shaoxiang Li Jian Zhao Guangzhe Piao Theodorian Borca-Tasciuc | 2011 | Journal of Nanomaterials2011，，： | 1 |
| 7 | 肥胖乳腺癌患者的临床特征及预后的回顾性研究(英文)显示文摘Objective:The aim of our study was to investigate the prognosis of obese breast cancer patients.Methods:This study was conducted on a total of 317 breast cancer patients who were histopathologically and clinically diagnosed at the General Hospital of Shenyang Military Region(China)from 2004 to 2006.Clinical data including height,weight,age at diagnosis,tumor size,lymph node status,menopausal status,family history of cancer and hormone receptor status were collected.Log-rank test was performed to compare the disease free survival(DFS)and overall survival(OS).Cox proportional hazards regression analysis was conducted to make multivariate analysis.The Chi square test was used to compare the clinical features among normal weight group,overweight group,and obese group.Results:Obesity was an independent prognostic factor for DFS(P=0.022)and OS(P=0.032)in breast cancer patients.In the stratified analysis based on the hormone receptor status,obesity was independently associated with OS in patients with negative ER/PR(P=0.002),but such association was not observed in patients with positive hormone receptors.Obesity was also associated with lymph node status(P=0.001)and smoking(P=0.009).Conclusion:Obesity is associated with poor DFS and OS in patients with breast cancer.Therefore,maintaining normal weight may benefit breast cancer patients. | Zhendong Zheng Heng Cao Shuxian Qu Yongye Liu Ying Piao Xiaodong Xie | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，9： | 1 |
| 8 | Contrasting effects of N addition on the N and P status of understory vegetation in plantations of sapling and mature Larix principis-rupprechtii显示文摘Aims The productivity of forest plantations in temperate areas is often lim-ited by nitrogen(N),but may shift towards phosphorus(P)limitation with increasing atmospheric N deposition.Nutrient resorption is a nutrient conservation strategy in plants.Although data on nutrient resorption are available for overstory trees,there are few data for understory vegetation.Methods We examined leaf N and P concentrations and N and P resorption efficiencies(NRE and PRE,respectively)in eight understory species in 11-and 45-year-old Larix principis-rupprechtii stands subjected to N supplementation over a 3-year period.Important findings Leaf N concentrations and N:P ratios increased and P concentrations decreased,with N input in species within the 45-year-old stand,but not in the 11-year-old stand.NRE and PRE were not altered by N input in any of the species in either stand,but N resorption pro-ficiency decreased and P resorption proficiency increased,in the species in the 45-year-old stand.Thus,the growth of understory species may be more P-limited in the 45-versus 11-year-old stand,and nutrient resorption proficiency was more sensitive to N add-ition than nutrient resorption efficiency.These results will improve the understanding of nutrient use strategies and their responses to N addition in understory vegetation.The contrasting effects of N addition on nutrient status between stand ages cannot be ignored when modeling ecosystem nutrient cycling under global N depos-ition conditions. | Tao Yan Tiantian Qu Huanhuan Song Philippe Ciais Shilong Piao Zhenzhong Sun Hui Zeng | 2018 | Journal of Plant Ecology2018，11，6： | 1 |
| 9 | MINE:A Method of Multi-Interaction Heterogeneous Information Network Embedding显示文摘Interactivity is the most significant feature of network data,especially in social networks.Existing network embedding methods have achieved remarkable results in learning network structure and node attributes,but do not pay attention to the multi-interaction between nodes,which limits the extraction and mining of potential deep interactions between nodes.To tackle the problem,we propose a method called Multi-Interaction heterogeneous information Network Embedding(MINE).Firstly,we introduced the multi-interactions heterogeneous information network and extracted complex heterogeneous relation sequences by the multi-interaction extraction algorithm.Secondly,we use a well-designed multi-relationship network fusion model based on the attention mechanism to fuse multiple interactional relationships.Finally,applying a multitasking model makes the learned vector contain richer semantic relationships.A large number of practical experiments prove that our proposed method outperforms existing methods on multiple data sets. | Dongjie Zhu Yundong Sun Xiaofang Li Haiwen Du Rongning Qu Pingping Yu Xuefeng Piao Russell Higgs Ning Cao | 2020 | Computers, Materials & Continua2020，，6： | 0 |
| 10 | The current and future of terrestrial carbon balance over the Tibetan Plateau显示文摘The contemporary carbon balance over the Tibetan Plateau is highly uncertain with a ten-fold difference between various estimates.In a warming world,the potential exists for a large carbon release from its permafrost which could compromise China’s 2060 carbon-neutral goal.Here,we used a satellite-and inventory-based approach,ecosystem models,and atmospheric inversions to estimate that the carbon sink was 33.12–37.84 TgC yr^(–1)during 2000–2015.The carbon sink induced by climate change and increasing CO_(2) levels largely overcompensated for a livestock grazing-induced carbon source of 0.38TgC yr^(-1).By 2060,the carbon sink is projected to increase by 38.3–74.5% under moderate to high emissions scenarios,with the enhanced vegetation carbon uptake outweighing the warming-induced permafrost carbon release.The restoration of degraded grassland could sequestrate an additional 9.06 TgC yr^(-1),leading to a total carbon sink of 57.78–70.52 TgC yr^(-1).We conclude that the Tibetan Plateau’s ecosystems absorbed two-and-a-half times the amount of its cumulative fossil CO_(2) emissions during 2000–2015 and that their carbon sinks will almost double in strength in the future,helping to achieve China’s pledge to become carbon neutral by 2060. | Tao WANG Xiaoyi WANG Dan LIU Guanting LV Shuai REN Jinzhi DING Baozhang CHEN Jiansheng QU Yafeng WANG Shilong PIAO Fahu CHEN | 2023 | Science China Earth Sciences2023，66，7： | 0 |
| 11 | 长春瑞滨联合顺铂或卡培他滨治疗蒽环类及紫杉耐药晚期乳腺癌的对照研究(英文)显示文摘Objective: The aim of our study was to compare the efficacy and toxicities of vinorelbine plus cisplatin(NP) regimen with that of vinorelbine plus capecitabine(NX) regimen in the treatment of anthracycline- and taxane-refractory advanced breast cancer. Methods: Forty-six patients with anthracycline- and taxane-refractory advanced breast cancer were equally randomized into a NP group(n = 23) and a NX group(n = 23). Response rates and toxicities were evaluated after 2 cycles of chemotherapy. Results: The overall response rate were 48.0% in both groups. There were no significant differences in disease control rates(78.0% vs. 83%) or 1-year survival rates(54.6% vs. 55.9%). The main adverse events were bone marrow depression and gastrointestinal reaction, and no significant difference was found in toxicities between the groups. Conclusion: For anthracycline- and taxane-refractory advanced breast cancer, NP and NX regimens exerted similar curative effects with acceptable toxicity. | Zhendong Zheng Shuxian Qu Xiaoxia Chen Yongye Liu Ying Piao Yaling Han Xiaodong Xie | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，4： | 0 |
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