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| 1 | Platelet-to-lymphocyte ratio in the setting of liver transplantation for hepatocellular cancer: A systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on platelet-to-lymphocyte ratio(PLR) as a risk factor for post-transplant hepatocellular cancer(HCC) recurrence. METHODS A systematic literature search was performed using PubM ed. Participants of any age and sex, who underwent liver transplantation for HCC were considered following these criteria:(1) studies comparing pre-transplant low vs high PLR values;(2) studies reporting post-transplant recurrence rates; and(3) if more than one study was reported by the same institute, only the most recent was included. The primary outcome measure was set for HCC recurrence after transplantation. RESULTS A total of 5 articles, published between 2014 and 2017, fulfilled the selection criteria. As for the quality of the reported studies, all the investigated articles presented an overall high quality. A total of 899 cases were investigated: 718 cases(80.0%) were males. Three studies coming from European countries and one from Japan presented HCV as the main cause of cirrhosis. On the opposite, one Chinese study presented a greater incidence of HBV-related cirrhotic cases. In all the studies apart one, the PLR cut-off value of 150 was reported. At meta-analysis, high PLR value was associated with a significant increase in recurrence after transplantation(OR = 3.33; 95%CI: 1.78-6.25; P < 0.001). A moderate heterogeneity was observed among the identified studies according to the Higgins I^2 statistic value.CONCLUSION Pre-transplant high PLR values are connected with an increased risk of post-operative recurrence of hepatocellular cancer. More studies are needed for better clarify the biological mechanisms of this results. | Quirino Lai Fabio Melandro Zoe Larghi Laureiro Francesco Giovanardi Stefano Ginanni Corradini Flaminia Ferri Redan Hassan Massimo Rossi Gianluca Mennini | 2018 | World Journal of Gastroenterology2018，24，15： | 19 |
| 2 | Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control显示文摘AIM:To investigate the effect of drinking sulphate-bicarbonate-calcium thermal water (TW) on risk factors for atherosclerosis and cholesterol gallstone disease.METHODS:Postmenopausal women with functional dy-spepsia and/or constipation underwent a 12 d cycle of thermal (n=20) or tap (n=20) water controlled drinking.Gallbladder fasting volume at ultrasound,blood vitamin E,oxysterols (7-β-hydroxycholesterol and 7-ketocholesterol),bile acid (BA),triglycerides,total/low density lipoprotein and high density lipoprotein cholesterol were measured at baseline and at the end of the study.Food consumption,stool frequency and body weight were recorded daily.RESULTS:Blood lipids,oxysterols and vitamin E were not affected by either thermal or tap water consumption.Fasting gallbladder volume was significantly (P<0.005) smaller at the end of the study than at baseline in the TW (15.7±1.1 mL vs 20.1±1.7 mL) but not in the tap water group (19.0±1.4 mL vs 19.4±1.5 mL).Total serum BA concentration was significantly (P<0.05) higher at the end of the study than at baseline in the TW (5.83±1.24μmol vs 4.25±1.00μmol) but not in the tap water group (3.41±0.46μmol vs 2.91±0.56μmol).The increased BA concentration after TW consumption was mainly accounted for by glycochenodeoxycholic acid.The number of pasta (P<0.001),meat (P<0.001) and vegetable (P<0.005) portions consumed during the study and of bowel movements per day (P<0.05) were significantly higher in the TW than in the tap water group.Body weight did not change at the end of the study as compared to baseline in both groups.CONCLUSION:Sulphate-bicarbonate-calcium water consumption has a positive effect on lithogenic risk and intestinal transit and allows maintenance of a stable body weight despite a high food intake. | Stefano Ginanni Corradini Flaminia Ferri Michela Mordenti Luigi Iuliano Maria Siciliano Maria Antonella Burza Bruno Sordi Barbara Caciotti Maria Pacini Edoardo Poli Adriano De Santis Aldo Roda Carolina Colliva Patrizia Simoni Adolfo Francesco Attili | 2012 | World Journal of Gastroenterology2012，18，9： | 3 |
| 3 | Transarterial chemoembolization in very early and early-stage hepatocellular carcinoma patients excluded from curative treatment: A prospective cohort study显示文摘 | Irene Bargellini Rodolfo Sacco Elena Bozzi Marco Bertini Barbara Ginanni Antonio Romano Antonio Cicorelli Emanuele Tumino Graziana Federici Roberto Cioni Salvatore Metrangolo Michele Bertoni Giampaolo Bresci Giuseppe Parisi Emanuele Altomare Alfonso Capri | 2011 | European Journal of Radiology2011，，6： | 2 |
| 4 | Recipient Interleukin-28B Rs12979860 C/T Polymorphism and Acute Cellular Rejection After Liver Transplantation: Role of the Calcineurin Inhibitor Used显示文摘 | Davide Bitetto Carlo Fabris Edmondo Falleti Ezio Fornasiere Claudio Avellini Sara Cmet Annarosa Cussigh Elisabetta Fontanini Mario Pirisi Stefano Ginanni Corradini Manuela Merli Antonio Molinaro Pierluigi Toniutto | 2012 | Transplantation Journal2012，，10： | 2 |
| 5 | PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals显示文摘 | Maria Antonella Burza Carlo Pirazzi Cristina Maglio Kajsa Sj?holm Rosellina Margherita Mancina Per-Arne Svensson Peter Jacobson Martin Adiels Marco Giorgio Baroni Jan Borén Stefano Ginanni Corradini Tiziana Montalcini Lars Sj?str?m Lena Mariana Susann Car | 2012 | Digestive and Liver Disease2012，，12： | 2 |
| 6 | Al-pha-SMA exprossionin hepatic stellate cells and quan-titative analysis of hepatic'fibrosis incirrhosis and inrecurrent chronic hepatifis after liver transplantation显示文摘 | Carpino G Morini S Ginanni Corradini S | 2005 | Dig Liver Dis2005，37，5： | 1 |
| 7 | Low-dose intramuscular hepatitis B immune globulin and lamivudine for long-term prophylaxis of hepatitis B recurrence after liver transplantation 显示文摘 | Ferretti G Merli M Ginanni Corradini S | 2004 | Transplant Proe2004，36，3： | 1 |
| 8 | The human gallbladder increases cholesterol solubility in lille by differential lipid absorption: a study using a new in vitro model of isolated intra- arlerially perfused gallbladder显示文摘 | Ginanni Corradini S Ripani C Della Guardia P el al | 1998 | Hepatology1998，28，2： | 1 |
| 9 | Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation显示文摘 | Carpino G Morini S Ginanni Corradini S | 2005 | Dig Liver Dis2005，37，5： | 1 |
| 10 | Triple-negative breast cancer: an unmet medical need 显示文摘 | Hadis C A Ginanni L | 2011 | Oncologist2011，1，： | 1 |
| 11 | Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation显示文摘 | CARPINO G MORINI S GINANNI CORRADINI S | 2005 | Dig Liver Dis2005，37，5： | 1 |
| 12 | Alpha-SMA expression in hepatic stellate cells and quantitative analaysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation显示文摘 | Carpino G Morini S Ginanni Corradini S | 2005 | Dig Liver Dis2005，37，5： | 1 |
| 13 | Purification and characterization of a novel human 15 kd cholesterol crystallization inhibitor protein in bile显示文摘 | Secknus R Yamashita G Ginanni CS | 1996 | J Lab Clin Med1996，127，2： | 1 |
| 14 | Biomarker discovery in urine by proteomics显示文摘 | Pang JX Ginanni N Dongre AR | 2002 | J Proteome Res2002，1，2： | 1 |
| 15 | Alpha-SMA expression in hepatic stellate ceils and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation显示文摘 | Carpino G Morini S Ginanni Corradini S | 2005 | Dig Liver Dis2005，37，5： | 1 |
| 16 | Conventional versus Doxorubicin-eluting Bead Transarterial Chemoembolization for Hepatocellular Carcinoma显示文摘 | Rodolfo Sacco Irene Bargellini Marco Bertini Elena Bozzi Antonio Romano Pasquale Petruzzi Emanuele Tumino Barbara Ginanni Graziana Federici Roberto Cioni Salvatore Metrangolo Michele Bertoni Giampaolo Bresci Giuseppe Parisi Emanuele Altomare Alfonso Capri | 2011 | Journal of Vascular and Interventional Radiology2011，，11： | 1 |
| 17 | Liver transplantation in adults:Choosing the appropriate timing显示文摘Liver transplantation is indicated in patients with acute liver failure,decompensated cirrhosis,hepatocellular carcinoma and rare liver-based genetic defects that trigger damage of other organs.Early referral to a transplant center is crucial in acute liver failure due to the high mortality with medical therapy and its unpredictable evolution.Referral to a transplant center should be considered when at least one complication of cirrhosis occurs during its natural history.However,because of the shortage of organ donors and the short-term mortality after liver transplantation on one hand and the possibility of managing the complications of cirrhosis with other treatments on the other,patients are carefully selected by the transplant center to ensure that transplantation is indicated and that there are no medical,surgical and psychological contraindications.Patients approved for transplantation are placed on the transplant waiting list and prioritized according to disease severity.Thus,the appropriate timing of transplantation depends on recipient disease severity and,although this is still a matter of debate,also on donor quality.These two variables are known to determine the 'transplant benefit'(i.e.,when the expected patient survival is better with,than without,transplantation) and should guide donor allocation. | Maria Siciliano Lucia Parlati Federica Maldarelli Massimo Rossi Stefano Ginanni Corradini | 2012 | World Journal of Gastrointestinal Pharmacology and Therapeutics2012，3，4： | 1 |
| 18 | Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells显示文摘 | Zhan Y Ginanni N Tota MR | 2008 | C/in Cancer Res2008，14，18： | 1 |
| 19 | Preoperative Donor Scores and Postoperative Early Measures of Graft Function: Relevance to the Outcome of Liver Transplantation显示文摘 | Q. Lai A. Molinaro G. Mennini F. Nudo V. Morabito S. Ginanni Corradini G. Novelli P.B. Berloco M. Rossi | 2010 | Transplantation Proceedings2010，，4： | 1 |
| 20 | Alpha-SMA expression in hepatic stellate cells and quantitative analysis of hepatic fibrosis in cirrhosis and in recurrent chronic hepatitis after liver transplantation显示文摘 | G. Carpino S. Morini S. Ginanni Corradini A. Franchitto M. Merli M. Siciliano F. Gentili A. Onetti Muda P. Berloco M. Rossi A.F Attili E. Gaudio | 2005 | Digestive and Liver Disease2005，，5： | 1 |
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