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| 1 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 2 | A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein显示文摘Baicalein(BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate and bioavailability of BE. Baicalein-nicotinamide(BE-NCT) nanococrystals were prepared by high pressure homogenization and evaluated both in vitro and in vivo. Physical characterization results including scanning electron microscopy, dynamic light scattering, powder X-ray diffraction and differential scanning calorimetry demonstrated that BE-NCT nano-cocrystals were changed into amorphous state with mean particle size of 251.53 nm. In the dissolution test, the BE-NCT nano-cocrystals performed 2.17-fold and 2.54-fold enhancement than BE coarse powder in FaSSIF-V2 and FaSSGF. Upon oral administration, the integrated AUC0-t of BE-NCT nano-cocrystals(6.02-fold) was significantly higher than BE coarse powder(1-fold), BE-NCT cocrystals(2.87-fold) and BE nanocrystals(3.32-fold). Compared with BE coarse powder, BE-NCT cocrystals and BE nanocrystals, BENCT nano-cocrystals possessed excellent performance both in vitro and in vivo evaluations.Thus, it can be seen that nano-cocrystal is an appropriate novel strategy for improving dissolution rate and bioavailability of poor soluble natural products such as BE. | Jiaxin Pi Shuya Wang Wen Li Dereje Kebebe Ying Zhang Bing Zhang Dongli Qi Pan Guo Nan Li Zhidong Liu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 12 |
| 3 | Improved quantum bacterial foraging algorithm for tuning parameters of fractional-order PID controller显示文摘The quantum bacterial foraging optimization(QBFO)algorithm has the characteristics of strong robustness and global searching ability. In the classical QBFO algorithm, the rotation angle updated by the rotation gate is discrete and constant,which cannot affect the situation of the solution space and limit the diversity of bacterial population. In this paper, an improved QBFO(IQBFO) algorithm is proposed, which can adaptively make the quantum rotation angle continuously updated and enhance the global search ability. In the initialization process, the modified probability of the optimal rotation angle is introduced to avoid the existence of invariant solutions. The modified operator of probability amplitude is adopted to further increase the population diversity.The tests based on benchmark functions verify the effectiveness of the proposed algorithm. Moreover, compared with the integerorder PID controller, the fractional-order proportion integration differentiation(PID) controller increases the complexity of the system with better flexibility and robustness. Thus the fractional-order PID controller is applied to the servo system. The tuning results of PID parameters of the fractional-order servo system show that the proposed algorithm has a good performance in tuning the PID parameters of the fractional-order servo system. | LIU Lu SHAN Liang DAI Yuewei LIU Chenglin QI Zhidong | 2018 | Journal of Systems Engineering and Electronics2018，29，1： | 6 |
| 4 | Room temperature ferromagnetism in ultra-thin van der Waals crystals of 1T-CrTe2显示文摘Although many emerging new phenomena have been unraveled in two dimensional(2D)materials with long-range spin orderings,the usually low critical temperature in van der Waals(vdW)magnetic material has thus far hindered the related practical applications.Here,we show that ferromagnetism can hold above 300 K in a metallic phase of 1T-CrTe2 down to the ultra-thin limit.It thus makes CrTe2 so far the only known exfoliated ultra-thin vdW magnets with intrinsic long-range magnetic ordering above room temperature.An in-plane room-temperature negative anisotropic magnetoresistance(AMR)was obtained in ultra-thin CrTe2 devices,with a sign change in the AMR at lower temperature,with−0.6%and+5%at 300 and 10 K,respectively.Our findings provide insights into magnetism in ultra-thin CrTe2,expanding the vdW crystals toolbox for future room-temperature spintronic applications. | Xingdan Sun Wanying Li Xiao Wang Qi Sui Tongyao Zhang Zhi Wang Long Liu Da Li Shun Feng Siyu Zhong Hanwen Wang Vincent Bouchiat Manuel Nunez Regueiro Nicolas Rougemaille Johann Coraux Anike Purbawati Abdellali Hadj-Azzem Zhenhua Wang Baojuan Dong Xing Wu Teng Yang Guoqiang Yu Bingwu Wang Zheng Han Xiufeng Han Zhidong Zhang | 2020 | Nano Research2020，13，12： | 6 |
| 5 | Experimental investigation on impact performances of GLARE laminates显示文摘An experimental investigation was carried out on the damage resistance to a concentrated quasi-static indentation force and low-velocity impact of four kinds of glass-reinforced aluminum laminates(GLARE for short). Compared with the experimental results of the CFRP(Carbon Fiber Reinforced Plastics) laminates, the performance of GLARE was determined. By means of concentrated quasi-static indentation force test, typical force–displacement response,the maximum contact force and dent depth were received. Through drop-weight low-velocity impact tests, impact force histories, indentation depths(through a new method) and dissipated energy were obtained. The test results show that the force–displacement response of GLARE 4laminates under the concentrated quasi-static indentation force has an obvious flat roof and the failure is instantaneous, which are different from CFRP laminates. The indention will be visible once the impact happens. C-scan results find that there is no delamination besides the impact area after both the concentrated quasi-static indentation and low-velocity impact. The dissipated energy approximately equals the impact energy. | Chen Qi Guan Zhidong Li Zengshan Ji Zhaojie Zhuo Yue | 2015 | Chinese Journal of Aeronautics2015，28，6： | 3 |
| 6 | An Improved Grid Security Infrastructure by Trusted Computing显示文摘Current delegation mechanism of grid security infrastructure (GSI) can’t satisfy the requirement of dynamic, distributed and practical security in grid virtual organization. To improve this situation, a TC-enabled GSI is discussed in this paper. With TC-enabled GSI, a practical delegation solution is proposed in this paper through enforcing fine granularity policy over distributed platforms with the emerging trusted computing technologies. Here trusted platform module is treated as a tamper-resistance module to improve grid security infrastructure. With the implement of Project Daonity, it is demonstrated that the solution could gain dynamic and distributed security in grid environment. | YAN Fei ZHANG Huanguo SUN Qi SHEN Zhidong ZHANG Liqiang QIANG Weizhong | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 3 |
| 7 | PEMFC Fractional-order Subspace Identification Model显示文摘A proton exchange membrane fuel cell(PEMFC)is a new type of hydrogen fuel cell that plays an indispensable role in an energy network.However,the multivariable and fractional-order characteristics of PEMFC make it difficult to establish a practical model.Herein,a fractional-order subspace identification model based on the adaptive monarch butterfly optimization algorithm with opposition-based learning(ALMBO)algorithm is proposed for PEMFC.Introducing the fractional-order theory into the subspace identification method by adopting a Poisson filter for with input and output data,a weight matrix is proposed to improve the identification accuracy.Additionally,the ALMBO algorithm is employed to optimize the parameters of the Poisson filter and fractional order,which introduces an opposition-based learning strategy into the migration operator and incorporates adaptive weights to improve the optimization accuracy and prevent falling into a locally optimal solution.Finally,the PEMFC fractional-order subspace identification model is established,which can accurately describe the dynamic process of PEMFC. | Sun Chengshuo Qi Zhidong Qin Hao Shan Liang | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，3： | 2 |
| 8 | Study of penetration mechanism of labrasol on rabbit cornea by Ussing chamber, RT-PCR assay, Western blot and immunohistochemistry显示文摘Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, and is extensively used in topical, transdermal, and oral pharmaceutical preparations as an emulsifier and absorption enhancer. Recent studies in our laboratory have indicated that labrasol has a strong absorption enhancing effect on different types of drugs in vitro and in vivo. This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Western blot, and immunohistochemical staining. The results indicated that labrasol obviously enhance the transcorneal permeability of fluorescein sodium, and the enhancement was realized by interacting with and down-regulating the associated proteins, such as Factin, claudin-1 and β-catenin, which were contributed to cell-cell connections, respectively. | Pan Guo Nan Li Lili Fan Jun Lu Boying Liu Bing Zhang Yumei Wu Zhidong Liu Jiawei Li Jiaxin Pi Dongli Qi | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 2 |
| 9 | Change of Cytokines in Chronic Hepatitis B Patients and HBeAg are Positively Correlated with HBV RNA, Based on Real-world Study显示文摘Background and Aims:The natural course of chronic hepatitis B virus(HBV)infection is widely studied;however,follow-up studies of the same patients are scanty.Here,we studied the dynamic changes of serum HBV RNA and cytokines in hepatitis B virus e antigen(HBeAg)-positive patients treated with entecavir(ETV)to explore the relationship between the HBV serum viral nucleic acids and host immunity.Methods:Thirty-three chronic hepatitis B patients who are HBeAg-positive,with high virus load(HBV DNA>20,000 IU/mL),and received standard nucleos(t)ide analogue(NA)antiviral therapy(ETV)for more than 48 weeks were included.The serum levels of HBV nucleic acids and selected cytokines were measured at 0,12,24,and 48 weeks respectively.Results:Serum HBV RNA could still be detected while serum HBV DNA had fallen below the detection limit in patients treated with ETV.There was a strong positive correlation between HBV RNA and HBeAg,with a concomitant decrease in the secretion of cytokines from type 1 helper T(Th1)/type 2 helper T(Th2)/interleukin(IL)-17 producing T(Th17)cells.IL-4 and IL-10 were the main cytokines negatively associated with serum HBV RNA.Conclusions:HBeAg can be used to reflect the load of HBV RNA indirectly,because serum HBV RNA has not been widely used in clinical practice.Meanwhile,serum IL-4 and IL-10 might be explored in combination with HBV RNA in guiding future clinical antiviral therapy. | Qiqi Zhang Hui Huang Aijun Sun Chunyan Liu Zhidong Wang Feifan Shi Wei Duan Xueying Sun Qi Wang Ping Sun Chunwen Pu Yong Zhang | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 1 |
| 10 | Absorption and metabolism of formaldehyde in solutions by detached banana leaves显示文摘 | Zhidong Zeng Chuanjiao Qi Qi Chen Kunzhi Li Limei Chen | 2013 | Journal of Bioscience and Bioengineering2013，，： | 1 |
| 11 | Phase Transformation and Magnetic Properties of Mechanically Alloyed PrCo5-based Magnets显示文摘基于 PrCo_5 的 nanograin Pr_xCo_(100x )(x=14~22 ) 有高 coercivitywere 的合金由机械 alloying 并且随后的退火综合了。结晶化,阶段部件和合金的磁性系统地被调查。为 x=14 的合金的主要阶段与菱形的 Th_2Zn_(17 ) 类型是 Pr_2Co_(17 ) 。Pr_2Co_(17 ) 的数量与增加 Pr 内容分阶段执行减少,并且有 hexagonalCaCu_5 类型的将近单个的阶段 PrCo_5 在 Pr_(19 )Co_(81 ) 合金被形成。 Pr 内容的另外的增加与它大约 350 deg C.Remanences 减少单调地与增加 Pr 满足的居里温度导致另一个有磁力地难的 Pr_2Co_7 阶段的形成,而 coercivities 增加,为更高的 Pr 内容为 2 min ,然后减少为 5 h 和退火的 at973 K 在Pri_( 19 )Co_( 81 )粉末 milled 到达 2040 kA/m ( 25.6 kOe )的最大值。高 coercivity 被归因于 PrCo_5 阶段和它的 nanoscale 谷物尺寸的高 anisotropy 地。 | Xinguo ZHAO Zhidong ZHANG Qi YAO Jinjun LIU Weijun REN Wei LIU Dianyu GENG | 2006 | Journal of Materials Science & Technology2006，22，6： | 1 |
| 12 | Enhancing cathode performance for CO2 electrolysis with Ce0.9M0.1O2-δ(M=Fe, Co, Ni) catalysts in solid oxide electrolysis cell显示文摘Electrochemical conversion with solid oxide electrolysis cells is a promising technology for CO2 utilization and simultaneously store renewable energy.In this work,Ce0.9M0.1O2-δ(CeM,M=Fe,Co,Ni)catalysts are infiltrated into La0.6Sr0.4Cr0.5Fe0.5O3-δ-Gd0.2Ce0.8O2-δ(LSCr Fe-GDC)cathode to enhance the electrochemical performance for CO2 electrolysis.CeCo-LSCrFe-GDC cell obtains the best performance with a current density of 0.652 A cm^-2,followed by CeFe-LSCrFe-GDC and CeNi-LSCrFe-GDC cells with the value of 0.603 and 0.535 A cm^-2,respectively,about 2.44,2.26 and 2.01 times higher than that of the LSCrFe-GDC cell at1.5 V and 800℃.Electrochemical impedance spectra combined with distributions of relaxed times analysis shows that both CO2 adsorption process and the dissociation of CO2 at triple phase boundaries are accelerated by Ce M catalysts,while the latter is the key rate-determining step. | Zhidong Huang Zhe Zhao Huiying Qi Xiuling Wang Baofeng Tu Mojie Cheng | 2020 | Journal of Energy Chemistry2020，29，1： | 0 |
| 13 | Flow regime changes in three catchments with different landforms following ecological restoration in the Chinese Loess Plateau显示文摘The Chinese Loess Plateau is known as one of the most severe soil erosion regions in the world.Two ecological restoration projects,i.e.,the integrated soil conservation project since the 1970s and the''Grain for Green''project since 1999,have been progressively implemented to control the soil erosion in this area.Ecological restoration has greatly changed flow regime over the past five decades.However,the mechanism of how flow regime responds to ecological restoration among landforms remains poorly understood.In this study,we investigated the temporal dynamics of flow regime in three catchments,i.e.,Wuqi,Honghe and Huangling hydrological stations,respectively representing the loess hilly-gully,loess table-gully and rocky mountain(covered by secondary forest)areas in the Chinese Loess Plateau,using daily hydrological data during the 1960s–2010s.The nonparametric Mann-Kendall test,Pettitt's test and daily flow series were used to investigate the changes of flow regime.Significantly negative trends of annual streamflow were detected at the Wuqi and Honghe stations,except for the Huangling station.The annual baseflow at the Wuqi station showed a significantly positive trend whereas a significantly negative trend was observed at the Honghe station,and there was no significant trend at the Huangling station.It was interesting that baseflow index significantly increased during the whole period in all catchments.However,the trends and change points of daily flow series derived by different percentages of exceedance and extreme series in different consecutive days varied among individuals.Based on the change points analysis of annual streamflow,we divided data series into three periods,i.e.,the baseline period(from 1959 and 1963 to 1979,PI),the integrated soil conservation period(1980–1999,PII)and the''Grain for Green''period(2000–2011,PIII).We found that streamflow decreased due to the reduction of high streamflow(exceeding 5%of time within a year)and median streamflow(50%)in PII and PIII at the Wuqi and Honghe stations.However,low flow(95%)increased in PII and PIII at the Wuqi station while decreased at the Honghe station.Streamflow change at the Huangling station was more stable,thus potentially resulting in much less soil erosion in the forestry area than in the other areas.The great improvement in ecological environment on the Chinese Loess Plateau revealed the advantages of ecological restoration in reducing flood amount and compensating streamflow at a regional scale. | LUO Zhidong LIU Erjia QI Shi ZHAO Nan SUN Yun | 2020 | Journal of Arid Land2020，12，1： | 0 |
| 14 | Advances in Research of TCM Antimicrobial Resistance显示文摘This paper analyzed and summarized the mechanism of antimicrobial resistance,the characteristics and advantages of traditional Chinese medicine(TCM)antimicrobial resistance,and ingredients of antimicrobial resistance,in the hope of providing a theoretical basis and research idea for tackling the problem of antimicrobial resistance and developing new TCM green antibiotics. | Fei HAN Ye LIU Wei XIONG Yi HUANG Lai CHEN Zhidong ZHAO Qi CHEN | 2019 | Medicinal Plant2019，10，5： | 0 |
| 15 | PEMFC Identification Based on a Fractional-Order Hammerstein State-Space Model with ADE-BH Optimization显示文摘Considering the fractional-order and nonlinear characteristics of proton exchange membrane fuel cells(PEMFC),a fractional-order subspace identification method based on the ADE-BH optimization algorithm is proposed to establish a fractional-order Hammerstein state-space model of PEMFCs.Herein,a Hammerstein model is constructed by connecting a linear module and a nonlinear module in series to precisely depict the nonlinear property of the PEMFC.During the modeling process,fractional-order theory is combined with subspace identification,and a Poisson filter is adopted to enable multi-order derivability of the data.A variable memory method is introduced to reduce computation time without losing precision.Additionally,to improve the optimization accuracy and avoid obtaining locally optimum solutions,a novel ADEBH algorithm is employed to optimize the unknown parameters in the identification method.In this algorithm,the Euclidean distance serves as the theoretical basis for updating the target vector in the absorption-generation operation of the black hole(BH)algorithm.Finally,simulations demonstrate that the proposed model has small output error and high accuracy,indicating that the model can accurately describe the electrical characteristics of the PEMFC process. | Qin Hao Qi Zhidong Ye Weiqin Sun Chengshuo | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，2： | 0 |
| 16 | News Recommendation System Based on Topic Embedding and Knowledge Embedding显示文摘News recommendation system is designed to deal with massive news and provide personalized recommendations for users.Accurately capturing user preferences and modeling news and users is the key to news recommendation.In this paper,we propose a new framework,news recommendation system based on topic embedding and knowledge embedding(NRTK).NRTK handle news titles that users have clicked on from two perspectives to obtain news and user representation embedding:1)extracting explicit and latent topic features from news and mining users’preferences for them in historical behaviors;2)extracting entities and propagating users’potential preferences in the knowledge graph.Experiments in a real-world dataset validate the effectiveness and efficiency of our approach. | ZHANG Haojie SUN Hui QI Baiwen SHEN Zhidong | 2023 | Wuhan University Journal of Natural Sciences2023，28，1： | 0 |
| 17 | Adversarial Example Generation Method Based on Sensitive Features显示文摘As deep learning models have made remarkable strides in numerous fields,a variety of adversarial attack methods have emerged to interfere with deep learning models.Adversarial examples apply a minute perturbation to the original image,which is inconceivable to the human but produces a massive error in the deep learning model.Existing attack methods have achieved good results when the network structure is known.However,in the case of unknown network structures,the effectiveness of the attacks still needs to be improved.Therefore,transfer-based attacks are now very popular because of their convenience and practicality,allowing adversarial samples generated on known models to be used in attacks on unknown models.In this paper,we extract sensitive features by Grad-CAM and propose two single-step attacks methods and a multi-step attack method to corrupt sensitive features.In two single-step attacks,one corrupts the features extracted from a single model and the other corrupts the features extracted from multiple models.In multi-step attack,our method improves the existing attack method,thus enhancing the adversarial sample transferability to achieve better results on unknown models.Our method is also validated on CIFAR-10 and MINST,and achieves a 1%-3%improvement in transferability. | WEN Zerui SHEN Zhidong SUN Hui QI Baiwen | 2023 | Wuhan University Journal of Natural Sciences2023，28，1： | 0 |
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