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| 1 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 2 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 3 | Clinical significance of main pancreatic duct dilation on computed tomography: Single and double duct dilation显示文摘AIM: To study the patients with main pancreatic duct dilation on computed tomography (CT) and thereby to provide the predictive criteria to identify patients at high risk of significant diseases, such as pancreatic cancer, and to avoid unnecessary work up for patients at low risk of such diseases. METHODS: Patients with dilation of the main pancreatic duct on CT at Emory University Hospital in 2002 were identified by computer search. Clinical course and ultimate diagnosis were obtained in all the identified patients by abstraction of their computer database records. RESULTS: Seventy-seven patients were identified in this study. Chronic pancreatitis and pancreatic cancer were the most common causes of the main pancreatic duct dilation on CT. Although the majority of patients with isolated dilation of the main pancreatic duct (single duct dilation) had chronic pancreatitis, one-third of patients with single duct dilation but without chronic pancreatitis had pancreatic malignancies, whereas most of patients with concomitant biliary duct dilation (double duct dilation) had pancreatic cancer. CONCLUSION: Patients with pancreatic double duct dilation need extensive work up and careful followup since a majority of these patients are ultimately diagnosed with pancreatic cancer. Patients with single duct dilation, especially such patients without any evidence of chronic pancreatitis, also need careful follow-up since the possibility of pancreatic malignancy, including adenocarcinoma and intraductal papillary mucinous tumors, is still high. | Mark D Edge Maarouf Hoteit Amil P Patel Xiaoping Wang Deborah A Baumgarten Qiang Cai | 2007 | World Journal of Gastroenterology2007，13，11： | 9 |
| 4 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 5 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 6 | Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice显示文摘 | Ma Q Qiang J Gu P | 2011 | Exp Gerontol2011，46，7： | 1 |
| 7 | Vector theory of four- wave mixing: polarization effects in fiber- optic parametric amplifiers 显示文摘 | Lin Qiang P Agrawal Govind | 2004 | Journal of the Optical Society of America B2004，21，6： | 1 |
| 8 | CHAMP Orbit Determination and Gravity Field Recovery 显示文摘 | MOORE P TURNER J F QIANG Z | 2003 | Adv Space Res2003，31，8： | 1 |
| 9 | Electrochemical generation of hydrogen peroxide from dissolved oxygen in acidic solutions显示文摘 | Qiang Z Chang J H Huang C P | 2002 | Water Res2002，36，： | 1 |
| 10 | Copula - based evaluations of drought variations in Guangdong, South China显示文摘 | Liu C I Qiang Z Vijay P S | 2011 | Nat Hazards2011，59，： | 1 |
| 11 | On two - sided bounds related to weakly diagonally dominant M - matrices with application to digital circuit dynamics显示文摘 | Shivakumar P N Williams Joseph J Ye Qiang | 1996 | SIAM J Matrix Anal Appl1996，17，2： | 1 |
| 12 | Prognostics of lithium-ion batteries based on relevance vectors and a conditional three-parameter capacity degradation model显示文摘 | Wang Dong Miao Qiang Michael P | 2013 | Journal of Power Sources2013，239，1： | 1 |
| 13 | Antibody and cytokine responses to hydatid in experimentally infected Kazakh sheep with hydatidosis resistance haplotype显示文摘 | Li R Y Qiang P Jia B | 2011 | Parasitol Res2011，108，5： | 1 |
| 14 | Characteristics of the Precursors and Their Thermal Decomposition During the Preparation of LiNbO3 Thin Films by the Pechini Method显示文摘 | Zhao J P Liu X R Qiang L S | 2006 | Thin Solid Films2006，515，4： | 1 |
| 15 | Error Analyses of CHAMP Data for Recovery of the Earth's Gravity Field 显示文摘 | MOORE P TURNER J F QIANG Z | 2003 | Journal of Geodesy2003，77，： | 1 |
| 16 | Wavelet-Based Pavement Distress Image Edge Detection with ' a Trous' Algorithm 显示文摘 | WANG K C P LI Qiang GONG Wei-guo | 2007 | Transportation Research Record2007，2024，： | 1 |
| 17 | Thermal performance of dimpled surfaces in laminar flows显示文摘 | XIAO Nian ZHANG Qiang Ligrani P M Mongia R | 2009 | Internntional Journal of Heat and Mass Transfer2009，52，78： | 1 |
| 18 | Preparation and antitumor study of camptothecin nanocrystals 显示文摘 | Zhang Hua Christin P Hollis Zhang Qiang | 2011 | International Journal of Pharmaceutics2011，415，： | 1 |
| 19 | Pavement smoothness prediction based on fuzzy and gray theories显示文摘 | Wang Kelvin C P Li Qiang | 2011 | ComputerAided Civil and Infrastructure Engineering2011，26，1： | 1 |
| 20 | Simultaneous determination of sulfonamides,tetracy-clines and tiamulin in swine waste water by solid-phase extraction and liquid chromatography-mass spectrometry显示文摘 | BEN W W QIANG Z M ADAMS C ZHANG H Q CHEN L P | 2008 | J Chromatogr:A2008，1202，2： | 1 |
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