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| 1 | Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-a-treated human vascular endothelial cells by blocking NF-KB activation显示文摘 | Yu-ping ZHU Tao SHEN Ya-jun LIN Bei-dong CHEN Yang RUAN Yuan CAO Yue QIAO Yong MAN Shu WANG Jian LI | 2013 | Acta Pharmacologica Sinica2013，34，8： | 20 |
| 2 | Efficacy and Safety of Tripterygium wilfordii Hook F Versus Acitretin in Moderate to Severe Psoriasis Vulgaris:A Randomized Clinical Trial显示文摘 | Chao Wu Hong-Zhong Jin Dan Shu Feng Li Chun-Xia He Ju Qiao Xiao-Ling Yu | 2015 | Chinese Medical Journal2015，，4： | 14 |
| 3 | Associations of big endothelin-1 and C-reactive protein in atrial fibrillation显示文摘 | Li-Hui ZHENG Wei SUN Yan YAO Bing-Bo HOU Yu QIAO Shu ZHANG | 2016 | Journal of Geriatric Cardiology2016，13，5： | 13 |
| 4 | Four new constituents from Taraxacum mongolicum显示文摘二新黄酮 glycosides ,isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- l-arabinopyranoside ( 1 )和isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- d-glucopyranoside ( 2 ),新 lignan , mongolicumin A ( 3 ),和新 guaianolide , mongolicumin B ( 4 )从薄公英属 mongolicum 的天线部分被孤立。他们的结构被主要阐明光谱分析。 | Shu Yun Shi Qi Zhou Hua Peng Chang Xin Zhou Ming Hui Hu Qiao Feng Tao Xiao Jiang Hao Joachim Stoeckigt Yu Zhao | 2007 | Chinese Chemical Letters2007，18，11： | 11 |
| 5 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 6 | Evaluation on data assimilation of a global high resolution wave-tide-circulation coupled model using the tropical Pacific TAO buoy observations显示文摘In order to evaluate the assimilation results from a global high resolution ocean model, the buoy observations from tropical atmosphere ocean(TAO) during August 2014 to July 2015 are employed. The horizontal resolution of wave-tide-circulation coupled ocean model developed by The First Institute of Oceanography(FIOCOM model) is 0.1°×0.1°, and ensemble adjustment Kalman filter is used to assimilate the sea surface temperature(SST), sea level anomaly(SLA) and Argo temperature/salinity profiles. The simulation results with and without data assimilation are examined. First, the overall statistic errors of model results are analyzed. The scatter diagrams of model simulations versus observations and corresponding error probability density distribution show that the errors of all the observed variables, including the temperature, isotherm depth of 20°C(D20), salinity and two horizontal component of velocity are reduced to some extent with a maximum improvement of 54% after assimilation. Second, time-averaged variables are used to investigate the horizontal and vertical structures of the model results. Owing to the data assimilation, the biases of the time-averaged distribution are reduced more than70% for the temperature and D20 especially in the eastern Pacific. The obvious improvement of D20 which represents the upper mixed layer depth indicates that the structure of the temperature after the data assimilation becomes more close to the reality and the vertical structure of the upper ocean becomes more reasonable. At last,the physical processes of time series are compared with observations. The time evolution processes of all variables after the data assimilation are more consistent with the observations. The temperature bias and RMSE of D20 are reduced by 76% and 56% respectively with the data assimilation. More events during this period are also reproduced after the data assimilation. Under the condition of strong 2014/2016 El Ni?o, the Equatorial Undercurrent(EUC) from the TAO is gradually increased during August to November in 2014, and followed by a decreasing process. Since the improvement of the structure in the upper ocean, these events of the EUC can be clearly found in the assimilation results. In conclusion, the data assimilation in this global high resolution model has successfully reduced the model biases and improved the structures of the upper ocean, and the physical processes in reality can be well produced. | SHI Junqiang YIN Xunqiang SHU Qi XIAO Bin QIAO Fangli | 2018 | Acta Oceanologica Sinica2018，37，3： | 7 |
| 7 | The prediction on the 2015/16 El Nino event from the perspective of FIO-ESM显示文摘Recently atmospheric and oceanic observations indicate the tropical Pacific is at the El Ni?o condition. However,it's not clear whether this El Ni?o event of this year is comparable to the very strong one of 1997/98 which brought huge influence on the whole world. In this study, based on the Ensemble Adjusted Kalman Filter(EAKF)assimilation scheme and First Institute of Oceanography-Earth System Model(FIO-ESM), the assimilation system is setup, which can provide reasonable initial conditions for prediction. And the hindcast results suggest the skill of El Ni?o-Southern Oscillation(ENSO) prediction is comparable to other dynamical coupled models. Then the prediction for 2015/16 El Ni?o by using FIO-ESM is started from 1 November 2015. The ensemble results indicate that the 2015/16 El Ni?o will continue to be strong. By the end of 2015, the strongest strength is very like more than 2.0°C and the ensemble mean strength is 2.34°C, which indicates 2015/16 El Ni?o event will be very strong but slightly less than that of 1997/98 El Ni?o event(2.40°C) calculated relative a climatology based on the years1992–2014. The prediction results also suggest 2015/16 El Ni?o event will be a transition to ENSO-neutral level in the early spring(FMA) 2016, and then may transfer to La Ni?a in summer 2016. | SONG Zhenya SHU Qi BAO Ying YIN Xunqiang QIAO Fangli | 2015 | Acta Oceanologica Sinica2015，34，12： | 6 |
| 8 | Prognostic Value of NT-proBNP in Stable Coronary Artery Disease in Chinese Patients after Percutaneous Coronary Intervention in the Drug-eluting Stent Era显示文摘Objective The predictive value of N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with stable coronary artery disease(SCAD) in the drug-eluting stent era is not yet clear. We aimed to evaluate the prognostic value of NT-proBNP in SCAD patients after percutaneous coronary intervention(PCI). Methods We examined 4,293 consecutive SCAD patients who underwent PCI between January 2013 and December 2013 in Fuwai Hospital, China. The primary endpoint was all-cause death. NT-proBNP levels were measured before PCI using Elisa kits(Biomedica, Austria). The indication for PCI was based on the degree of coronary stenosis and evidence of ischemia. Results Among 3,187 SCAD patients with NT-proBNP data, after a 2-year follow-up, NT-proBNP levels were predictive for all-cause death in the SCAD population [area under the receiver operating characteristic curve, 0.768; 95% confidence interval(CI), 0.687-0.849; P < 0.001]. At the optimum cutoff point of 732 pg/mL, the sensitivity and specificity of death was 75.0% and 72.3%, respectively. In a multivariable Cox regression model, the death hazard ratio was 6.43(95% CI, 2.99-13.82; P < 0.001) for patients with NT-proBNP levels ≥ 732 pg/mL, compared with < 732 pg/mL. Conclusion NT-proBNP is a strong predictor of 2-year death with SCAD after PCI in the drug-eluting stent era. | ZHAO Xue Yan LI Jian Xin TANG Xiao Fang XU Jing Jing SONG Ying JIANG Lin CHEN Jue SONG Lei GAO Li Jian GAO Zhan QIAO Shu Bin YANG Yue Jin GAO Run Lin XU Bo YUAN Jin Qing | 2018 | Biomedical and Environmental Sciences2018，31，12： | 5 |
| 9 | Could CMIP6 climate models reproduce the early-2000s global warming slowdown?显示文摘The unexpected global warming slowdown during 1998–2013 challenges the existing scientific understanding of global temperature change mechanisms,and thus the simulation and prediction ability of state-of-the-art climate models since most models participating in phase 5 of the Coupled Model Intercomparison Project(CMIP5)cannot simulate it.Here,we examine whether the new-generation climate models in CMIP6 can reproduce the recent global warming slowdown,and further evaluate their capacities for simulating key-scale natural variabilities which are the most likely causes of the slowdown.The results show that although the CMIP6 models present some encouraging improvements when compared with CMIP5,most of them still fail to reproduce the warming slowdown.They considerably overestimate the warming rate observed in 1998–2013,exhibiting an obvious warming acceleration rather than the observed deceleration.This is probably associated with their deficiencies in simulating the distinct temperature change signals from the human-induced long-term warming trend and/or the three crucial natural variabilities at interannual,interdecadal,and multidecadal scales.In contrast,the 4 models that can successfully reproduce the slowdown show relatively high skills in simulating the long-term warming trend and the three keyscale natural variabilities.Our work may provide important insight for the simulation and prediction of near-term climate changes. | Meng WEI Qi SHU Zhenya SONG Yajuan SONG Xiaodan YANG Yongqing GUO Xinfang LI Fangli QIAO | 2021 | Science China Earth Sciences2021，64，6： | 5 |
| 10 | Causes for different spatial distributions of minimum Arctic sea-ice extent in 2007 and 2012显示文摘Satellite records show the minimum Arctic sea ice extents(SIEs) were observed in the Septembers of 2007 and2012, but the spatial distributions of sea ice concentration reduction in these two years were quite different.Atmospheric circulation pattern and the upper-ocean state in summer were investigated to explain the difference.By employing the ice-temperature and ice-specific humidity(SH) positive feedbacks in the Arctic Ocean, this paper shows that in 2007 and 2012 the higher surface air temperature(SAT) and sea level pressure(SLP)accompanied by more surface SH and higher sea surface temperature(SST), as a consequence, the strengthened poleward wind was favorable for melting summer Arctic sea ice in different regions in these two years. SAT was the dominant factor influencing the distribution of Arctic sea ice melting. The correlation coefficient is –0.84 between SAT anomalies in summer and the Arctic SIE anomalies in autumn. The increase SAT in different regions in the summers of 2007 and 2012 corresponded to a quicker melting of sea ice in the Arctic. The SLP and related wind were promoting factors connected with SAT. Strengthening poleward winds brought warm moist air to the Arctic and accelerated the melting of sea ice in different regions in the summers of 2007 and 2012. Associated with the rising air temperature, the higher surface SH and SST also played a positive role in reducing summer Arctic sea ice in different regions in these two years, which form two positive feedbacks mechanism. | CUI Hongyan QIAO Fangli SHU Qi SONG Yajuan JIANG Chunfei | 2015 | Acta Oceanologica Sinica2015，34，9： | 5 |
| 11 | Improvement of P-wave dispersion is associated with a lower incidence of atrial fibrillation after cardiac resynchronization therapy显示文摘 | DING Li-gang HUA Wei CHU Jian-min QIAO Qing CHEN Ke-ping WANG Fang-zheng ZHANG Shu | 2012 | Chinese Medical Journal2012，，6： | 4 |
| 12 | Two new compounds from Zingiber officinale显示文摘新周期的 diarylheptanoid, 1,5-epoxy-3-hydroxy-1-(3-methoxy-4,5-dihydroxyphenyl )-7-(4-hydroxyphenyl)-heptane (1 ) ,以及新单音的萜烯, 10-O- β - d-glucopyranosyl-hydroxy cineole (2 ) 从姜 officinale 的根茎被孤立。混合物的结构 1 和 2 被建立基于他们的光谱数据。另外,这些混合物的抗氧化剂活动也被测量。 | Yu Zhao Qiao Feng Tao Rong Ping Zhang Chang Xin Zhou Hui Dou Shu Yun Shi Ye Cheng Xiao Lian Li Sun Su Zeng Ke Xin Huang Xiao Dong Zhang Xiao Kun Li | 2007 | Chinese Chemical Letters2007，18，10： | 4 |
| 13 | A new anti-diabetic sesquiterpenoid from Acorus calamus显示文摘新 sesquiterpenoid, 1,5-guaiane-4,10-diol-6-one (1 ) ,从 Acorus 省藤属的植物的根茎的 70% EtOH 摘录被孤立。结构在分光镜的方法上被决定,特别 2D NMR 技术。1 的绝对配置被它的 ECD 光谱的 TDDFT 量化学药品计算证实。在 HepG2 房间的一个调停胰岛素的葡萄糖消费模型上加重 1 项显示出的有希望的反糖尿病的活动。 | Chang Xin Zhou Di Qiao You You Yan Hao Shu Wu Jian Xia Mo Li She Gan | 2012 | Chinese Chemical Letters2012，23，10： | 3 |
| 14 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 15 | Potential predictors of non-response and super-response to cardiac resynchronization therapy显示文摘背景尽管心脏的再同步治疗(CRT ) 已经是确定的治疗,有优秀回答到不得到利益遗体到的 CRT 和那些的病人的特征被决定。这研究的目的是寻找非反应的潜在的预言者并且对 CRT.Methods 超级反应接受了 CRT 治疗的 76 个连续病人被划分成组 A (非应答者) ,组 C (超级应答者) 并且组 B (独占的应答者超级应答者) 。学生的 t 测试, Mann-Whitney 测试,操作典型曲线的逻辑回归和接收装置被采用在病人的人口统计的特征之中识别潜在的预言者,临床的特征,在 CRT 培植前后的几个 electrocardiographic 参数,并且他们的预先植入 echocardiographic parameters.Results 组 A 有最低3月的左室的喷射部分( LVEF )。有的组 C 最小预先植入左室的结束心脏舒张的尺寸(LVEDD ) ,最短的 implant 以后 QRS 持续时间,最小的 3 月的 LVEDD 和最高 3 月的 LVEF。另外,有在左捆分支块的百分比的渐渐的变化的一个趋势,严厉预先植入僧帽形的流回,预先植入从组织 B 的组 A 并且从组织 C 的组 B 的 QRS 分散, implant 以后 QRS 持续时间以及 implant 以后 QRS 分散。Multivariable 逻辑分析表明那仅仅预先植入 LVEDD 能预言 CRT 超级反应。A 预先植入 68.5 公里的 LVEDD 是识别的截止价值与 87.5% 敏感和 79.7% 特性超级应答者。A 预先植入与 50.0% 敏感和一个 CRT 非反应遗体的 89.8% specificity.Conclusions 预言者超级应答者的识别的 62.5mm 的 LVEDD 不清楚目前。但是有一个更小的左室的病人将有一个更好的机会对 CRT 变得超级应答者,是可信的。 | QIAO Qing DING Li-gang HUA Wei CHEN Ke-ping WANG Fang-zheng ZHANG Shu | 2011 | Chinese Medical Journal2011，，9： | 3 |
| 16 | A comparison of two global ocean-ice coupled models with different horizontal resolutions显示文摘A global eddy-permitting ocean-ice coupled model with a horizontal resolution of 0.25 by 0.25 is established on the basis of Modular Ocean Model version 4 (MOM4) and Sea Ice Simulator (SIS). Simulation results are compared with those of an intermediate resolution ocean-ice coupled model with a horizontal resolution of about 1 by 1 . The results show that the simulated ocean temperature, ocean current and sea ice concentration from the eddy-permitting model are better than those from the intermediate resolution model. However, both the two models have the common problem of ocean general circulation models (OGCMs) that the majority of the simulated summer sea surface temperature (SST) is too warm while the majority of the simulated subsurface summer temperature is too cold. Further numerical experiments show that this problem can be alleviated by incorporating the non-breaking surface wave-induced vertical mixing into the vertical mixing scheme for both eddy-permitting and intermediate resolution models. | SHU Qi QIAO Fangli SONG Zhenya YIN Xunqiang | 2013 | Acta Oceanologica Sinica2013，32，8： | 2 |
| 17 | Risk or Beneficial Factors Associated with Unplanned Revascularization Risk Following Percutaneous Coronary Intervention: A Large Single-Center Data显示文摘Objective To analyze factors associated with unplanned revascularization(UR) risk in patients with coronary artery disease(CAD) who underwent percutaneous coronary intervention(PCI).Methods A total of 10,640 cases with CAD who underwent PCI were analyzed. Multivariate COX regressions and competing risk regressions were applied.Results The patients who underwent UR following PCI in 30 days, 1, and 2 years accounted for 0.3%,6.5%, and 8.7%, respectively. After multivariate adjustment, the number of target lesions [hazard ratio(HR) = 2.320;95% confidence interval(CI): 1.643–3.277;P < 0.001], time of procedure(HR = 1.006;95%CI: 1.001–1.010;P = 0.014), body mass index(HR = 1.104;95% CI: 1.006–1.210;P = 0.036), incomplete revascularization(ICR)(HR = 2.476;95% CI: 1.030–5.952;P = 0.043), and age(HR = 1.037;95% CI:1.000–1.075;P = 0.048) were determined as independent risk factors of 30-day UR. Factors, including low-molecular-weight heparin or fondaparinux(HR = 0.618;95% CI: 0.531–0.719;P < 0.001), secondgeneration durable polymer drug-eluting stent(HR = 0.713;95% CI: 0.624–0.814;P < 0.001), left anterior descending artery involvement(HR = 0.654;95% CI: 0.530–0.807;P < 0.001), and age(HR = 0.992;95%CI: 0.985–0.998;P = 0.014), were independently associated with decreased two-year UR risk. While,Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery score(HR =1.024;95% CI: 1.014–1.033;P < 0.001) and ICR(HR = 1.549;95% CI: 1.290–1.860;P < 0.001) were negatively associated with two-year UR risk.Conclusion Specific factors were positively or negatively associated with short-and medium-long-term UR following PCI. | LIU Ru GAO Zhan GAO Li Jian ZHAO Xue Yan CHEN Jue QIAO Shu Bin YANG Yue Jin GAO Run Lin XU Bo YUAN Jin Qing | 2020 | Biomedical and Environmental Sciences2020，33，6： | 2 |
| 18 | The performance of a z-level ocean model in modeling the global tide显示文摘The performance of a z-level ocean model, the Modular Ocean Model Version 4(MOM4), is evaluated in terms of simulating the global tide with different horizontal resolutions commonly used by climate models. The performance using various sets of model topography is evaluated. The results show that the optimum filter radius can improve the simulated co-tidal phase and that better topography quality can lead to smaller rootmean square(RMS) error in simulated tides. Sensitivity experiments are conducted to test the impact of spatial resolutions. It is shown that the model results are sensitive to horizontal resolutions. The calculated absolute mean errors of the co-tidal phase show that simulations with horizontal resolutions of 0.5° and 0.25° have about 35.5% higher performance compared that with 1° model resolution. An internal tide drag parameterization is adopted to reduce large system errors in the tidal amplitude. The RMS error of the best tuned 0.25° model compared with the satellite-altimetry-constrained model TPXO7.2 is 8.5 cm for M_2. The tidal energy fluxes of M_2 and K_1 are calculated and their patterns are in good agreement with those from the TPXO7.2. The correlation coefficients of the tidal energy fluxes can be used as an important index to evaluate a model skill. | XIAO Bin QIAO Fangli SHU Qi | 2016 | Acta Oceanologica Sinica2016，35，11： | 2 |
| 19 | Toxicity of Sodium Fluoride to Caenorhabditis elegans显示文摘Objective To investigate the toxic effect of sodium fluoride(NaF) on the nematode Caenorhabditis elegans(C.elegans).Methods Adult C.elegans were exposed to different concentrations of NaF(0.038 mmol/L,0.38 mmol/L,and 3.8 mmol/L) for 24 h.To assess the physiological effects of NaF,the brood size,life span,head thrashes,and body bend frequency were examined.Reactive oxygen species(ROS) and cell apoptosis were detected as parameters of biochemical response.The gene expressions were determined by real‐time polymerase chain reaction(PCR) to assess the molecular‐level response.Results At the physiological level,the brood size of C.elegans exposed to 0.038 mmol/L,0.38 mmol/L,and 3.8 mmol/L concentrations of NaF were reduced by 6%,26%,and 28% respectively in comparison with the control group.The maximum life spans of C.elegans exposed to 0.038 mmol/L,0.38 mmol/L,and 3.8 mmol/L concentrations of NaF were reduced by 3 days and 5 days,respectively.Head thrashes and body bend frequency both decreased with increasing concentrations of NaF.At the biochemical level,the production of ROS and the incidence of cell apoptosis increased with increasing concentrations of NaF(P<0.05).At the molecular level,different concentrations of NaF exposure raised the expression of stress‐related genes,such as hsp16.1,sod‐3,ctl‐2,dhs‐28,gst‐1,and cep‐1.Conclusion NaF exposure could induce multiple biological toxicities to C.elegans in a concentration‐dependent manner.These toxicities may be relevant to the oxidative stress induced by increased ROS production and accumulation in C.elegans. | LI Qiao ZHANG Shu Hua YU Yuan Hua WANG Li Ping GUAN Shu Wen LI Peng Fei | 2012 | Biomedical and Environmental Sciences2012，25，2： | 2 |
| 20 | Single-cell RNA sequencing reveals Nestin+active neural stem cells outside the central canal after spinal cord injury显示文摘Neural stem cells(NSCs)in the spinal cord hold great potential for repair after spinal cord injury(SCI).The ependyma in the central canal(CC)region has been considered as the NSCs source in the spinal cord.However,the ependyma function as NSCs after SCI is still under debate.We used Nestin as a marker to isolate potential NSCs and their immediate progeny,and characterized the cells before and after SCI by single-cell RNA-sequencing(scRNA-seq).We identified two subgroups of NSCs:the subgroup located within the CC cannot prime to active NSCs after SCI,while the subgroup located outside the CC were activated and exhibited the active NSCs properties after SCI.We demonstrated the comprehensive dynamic transcriptome of NSCs from quiescent to active NSCs after SCI.This study reveals that Nestin+cells outside CC were NSCs that activated upon SCI and may thus serve as endogenous NSCs for regenerative treatment of SCI in the future. | Muya Shu Xiaoyu Xue Hu Nie Xianming Wu Minghan Sun Lianyong Qiao Xing Li Bai Xu Zhifeng Xiao Yannan Zhao Yongheng Fan Bing Chen Jixiang Zhang Ya Shi Yaming Yang Falong Lu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
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