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| 1 | Porous γ-Fe_(2)O_(3) nanoparticle decorated with atomically dispersed platinum: Study on atomic site structural change and gas sensor activity evolution显示文摘Decorating semi-conducting metal oxide with noble metal has been recognized as a viable approach to improve the sensitivity of gas sensor. However, conventional method which relys on noble metal nanoparticles is confronted with drawback of significantly increased cost. To maximize the atom efficiency and reduce the cost for practical industrial application, designing sensor material with noble metal isolated single atom sites (ISAS) doping is a desired option. Here, we report an atomically dispersed platinum on one-dimensional arranged porous γ-Fe2O3 nanoparticle composites as highly efficient ethanol gas sensor. The optimized sample (Pt1-Fe2O3-ox) exhibited a high response (Ra/Rg = 102.4) and good selectivity to ethanol gas. It is demonstrated only the Pt single atom sites with high valance can effectively promote the adsorption capacity to ethanol and consequently enhance the sensitivity of sensing process by changing the electrical structure of Fe2O3 support. This work indicates the single atom sites could play a vital role in improving the performance of conventional metal oxides gas sensors and pave way for the exploration of ISAS-enhanced gas sensor for other volatile organic compounds (VOCs). | Qiheng Li Zhi Li Qinghua Zhang Lirong Zheng Wensheng Yan Xiao Liang Lin Gu Chen Chen Dingsheng Wang Qing Peng Yadong Li | 2021 | Nano Research2021，14，5： | 5 |
| 2 | Comparative FISH and molecular identification of new stripe rust resistant wheat-Thinopyrum intermedium ssp. trichophorum introgression lines显示文摘Thinopyrum intermedium(2 n = 6 x = 42, JJJ^sJ^sStSt) has been hybridized extensively with common wheat and has proven to be a valuable germplasm source for improving disease resistance, quality attributes, and yield potential in wheat. We characterized new disease resistant wheat-Th. intermedium derivatives A1082 and A5-5 using sequential multi-color fluorescence in situ hybridization(mc-FISH), genomic in situ hybridization(GISH), PCRbased landmark unique gene(PLUG) and intron targeting(IT) markers. A1082 was identified as a wheat-Th. intermedium 3J disomic addition line, and A5-5 was a T4BS·5J^sL homozygous Robertsonian translocation line. Seventy-one and 106 pairs of primers amplified Th.intermedium-specific bands allowing chromosomes 3J and 5J^s to be tracked, respectively. A new oligonucleotide probe, Oligo-6 H-2-100, was developed for FISH labeling of the subterminal region of the long arm of chromosome 5J^s. Both lines were highly resistant to stripe rust pathogen races prevalent in Chinese field screening nurseries. A5-5 also displayed a significant increase in tiller number compared to its wheat parent. The new lines can be exploited as useful germplasms for wheat improvement. | Jianbo Li Qiheng Chen Peng Zhang Tao Lang Sami Hoxha Guangrong Li Zujun Yang | 2019 | The Crop Journal2019，7，6： | 2 |
| 3 | Block-sparse recovery via redundant block OMP显示文摘 | Yuli Fu Haifeng Li Qiheng Zhang | 2014 | IEEE Trans on Signal Processing2014，97，： | 1 |
| 4 | KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway显示文摘Objective Somatic KRAS mutations have been identified in the majority of brain arteriovenous malformations(bAVMs),and subsequent in vivo experiments have confirmed that KRAS mutation in endothelial cells(ECs)causes AVMs in mouse and zebrafish models.Our previous study demonstrated that the KRASG12D mutant independently induced the endothelial-mesenchymal transition(EndMT),which was reversed by treatment with the lipid-lowering drug lovastatin.However,the underlying mechanisms of action were unclear.Methods We used human umbilical vein ECs(HUVECs)overexpressing the KRASG12D mutant for Western blotting,quantitative real-time PCR,and immunofluorescence and wound healing assays to evaluate the EndMT and determine the activation of downstream pathways.Knockdown of SMAD4 by RNA interference was performed to explore the role of SMAD4 in regulating the EndMT.BAVM ECs expressing the KRASG12D mutant were obtained to verify the SMAD4 function.Finally,we performed a coimmunoprecipitation assay to probe the mechanism by which lovastatin affects SMAD4.Results HUVECs infected with KRASG12D adenovirus underwent the EndMT.Transforming growth factor beta(TGF-β)and bone morphogenetic protein(BMP)signalling pathways were activated in the KRASG12D-mutant HUVECs and ECs in bAVM tissue.Knocking down SMAD4 expression in both KRASG12D-mutant HUVECs and ECs in bAVM tissues inhibited the EndMT.Lovastatin attenuated the EndMT by downregulating p-SMAD2/3,p-SMAD1/5 and acetylated SMAD4 expression in KRASG12D-mutant HUVECs.Conclusions Our findings suggest that the KRASG12D mutant induces the EndMT by activating the ERK-TGF-β/BMP-SMAD4 signalling pathway and that lovastatin inhibits the EndMT by suppressing TGF-β/BMP pathway activation and SMAD4 acetylation. | Hongyuan Xu Ran Huo Hao Li Yuming Jiao Jiancong Weng Jie Wang Zihan Yan Junze Zhang Shaozhi Zhao Qiheng He Yingfan Sun Shuo Wang Yong Cao | 2023 | Stroke & Vascular Neurology2023，8，3： | 1 |
| 5 | Characteristics of hydrogen production of an Enterobacter aerogenes mutant generated by a new atmospheric and room temperature plasma (ARTP)显示文摘 | Yuan Lu Liyan Wang Kun Ma Guo Li Chong Zhang Hongxin Zhao Qiheng Lai He-Ping Li Xin-Hui Xing | 2011 | Biochemical Engineering Journal2011，，1： | 1 |
| 6 | Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry显示文摘The outbreak of coronavirus disease 2019(COVID-19) caused by SARS-CoV-2 has created a global health crisis. SARS-CoV-2 infects varieties of tissues where the known receptor ACE2 is low or almost absent, suggesting the existence of alternative viral entry pathways. Here, we performed a genome-wide barcoded-CRISPRa screen to identify novel host factors that enable SARS-CoV-2 infection. Beyond known host proteins, i.e., ACE2, TMPRSS2, and NRP1, we identified multiple host components,among which LDLRAD3, TMEM30A, and CLEC4G were confirmed as functional receptors for SARS-CoV-2. All these membrane proteins bind directly to spike’s N-terminal domain(NTD). Their essential and physiological roles have been confirmed in either neuron or liver cells. In particular, LDLRAD3 and CLEC4G mediate SARS-CoV-2 entry and infection in an ACE2-independent fashion. The identification of the novel receptors and entry mechanisms could advance our understanding of the multiorgan tropism of SARS-CoV-2, and may shed light on the development of COVID-19 countermeasures. | Shiyou Zhu Ying Liu Zhuo Zhou Zhiying Zhang Xia Xiao Zhiheng Liu Ang Chen Xiaojing Dong Feng Tian Shihua Chen Yiyuan Xu Chunhui Wang Qiheng Li Xuran Niu Qian Pan Shuo Du Junyu Xiao Jianwei Wang Wensheng Wei | 2022 | Science China(Life Sciences)2022，65，4： | 1 |
| 7 | A generalized hard thresholding pursuit algorithm 显示文摘 | Li Haifeng Fu Yuli Zhang Qiheng | 2013 | Circuits Systemsand Signal Processing2013，33，4： | 1 |
| 8 | Effects of cytokines and chemokines on migration of mesenchymal stem cells following spinal cord injury显示文摘We investigated the effects of cytokines and chemokines and their associated signaling pathways on mesenchymal stem cell migration after spinal cord injury, to determine their roles in the curative effects of mesenchymal stem cells. This study reviewed the effects of tumor necrosis factor-α, vascular endothelial growth factor, hepatocyte growth factor, platelet-derived growth factor, basic fibroblast growth factor, insulin like growth factor-1, stromal cell-derived factor and monocyte chemoattractant protein-1, 3 during mesenchymal stem cell migration to damaged sites, and analyzed the signal transduction pathways involved in their effects on mesenchymal stem cell migration. The results confirmed that phosphatidylinositol 3-kinase/serine/threonine protein kinases and nuclear factor-κB play crucial roles in the migration of mesenchymal stem cells induced by cytokines and chemokines. | Longyun Li Maoguang Yang Chunxin Wang Qiheng Zhao Jian Liu Chuanguo Zhan Zhi Liu Xuepeng Li Weihua Wang Xiaoyu Yang | 2012 | Neural Regeneration Research2012，7，14： | 1 |
| 9 | Atomically dispersed Ni anchored on polymer-derived mesh-like Ndoped carbon nanofibers as an efficient CO_(2) electrocatalytic reduction catalyst显示文摘Efficient electroreduction of CO_(2) into CO and other chemicals turns greenhouse gases into fuels and value-added chemicals,holding great promise for a closed carbon cycle and the alleviation of climate changes.However,there are still challenges in the large-scale application of CO_(2) electroreduction due to the sluggish kinetics.Herein we develop a self-assembly strategy to synthesize a highly efficient CO_(2) reduction electrocatalyst with atomically dispersed Ni-N_(4) active centers anchored on polymerderived mesh-like N-doped carbon nanofibers(Ni-N_(4)/NC).The Ni-N_(4)/NC exhibits high selectivity for CO_(2) reduction reaction with CO Faradaic efficiency(CO FE)above 90% over a wide potential range from−0.6 to−1.0 V vs.RHE.The catalyst reaches a maximum CO FE up to 98.4% at−0.8 V with a TOF of 1.28×10^(5) h^(–1) and Tafel slope of 113 mV·dec^(–1).The catalyst also exhibits remarkable stability,with little change in current density and CO FE over a 10-hour durability test at–0.8 V vs.RHE.This method provides a new route for the synthesis of highly efficient CO_(2) reduction electrocatalyst. | Tai Cao Rui Lin Shoujie Liu Weng-Chon(Max)Cheong Zhi Li Konglin Wu Youqi Zhu Xiaolu Wang Jian Zhang Qiheng Li Xiao Liang Ninghua Fu Chen Chen Dingsheng Wang Qing Peng Yadong Li | 2022 | Nano Research2022，15，5： | 0 |
| 10 | Recoverability analysis of block-sparse representation显示文摘Recoverability of block-sparse signals by convex relaxation methods is considered for the underdetermined linear model. In previous works, some explicit but pessimistic recoverability results which were associated with the dictionary were presented. This paper shows the recoverability of block-sparse signals are associated with the block structure when a random dictionary is given. Several probability inequalities are obtained to show how the recoverability changes along with the block structure parameters, such as the number of nonzero blocks, the block length, the dimension of the measurements and the dimension of the blocksparse representation signal. Also, this paper concludes that if the block-sparse structure can be considered, the recoverability of the signals will be improved. Numerical examples are given to illustrate the availability of the presented theoretical results. | Yuli Fu Jian Zou Qiheng Zhang Haifeng Li | 2014 | Journal of Systems Engineering and Electronics2014，25，3： | 0 |
| 11 | Thermodynamically controllable synthesis of ZIF-8 exposing different facets and their applications in single atom catalytic oxygen reduction reactions显示文摘The development of thermodynamically controllable synthetic strategy to manipulate the morphology of ZIF-8 without capping agent is essential to help understanding their facet effect and the structure-activity relationship of single atom catalysts derived from ZIF-8.Here,we prepared ZIF-8 with different morphologies(cube,truncated rhombododecahedral and rhombododecahedral)and thus area ratio of exposed{100},{110}facets by a thermodynamically controllable synthetic strategy.When the reaction proceeds under room temperature(30℃),the assembling of ZIF-8 followed an area-reducing layered growth mode,while switched to an integral layered growth mode at lower temperature-40℃.Moreover,this strategy also works to obtain ZIF-8 encapsulated with metal precursors(Fe(acac)_(3),Cu(acac)_(2)and Co(acac)_(2)).Single Fe atom anchored on nitrogen doped carbon catalysts(SA-Fe/CN)derived from Fe-ZIF-8 retain their original morphologies and the unsaturated surface-active sites on{100}facet,which further displays different catalytic performance towards oxygen reduction reaction(ORR).This work not only reveals the different growth pattern of ZIF-8,but also points out a new direction for designing and synthesizing MOFs with different morphology rationally. | Runze Ma Qiheng Li Jun Yan Yu Tao Shouyao Hu Donghao Liu Jiaxin Gong Yu Xiong | 2023 | Nano Research2023，16，7： | 0 |
| 12 | Characteristics and exploration targets of Chang 7 shale oil in Triassic Yanchang Formation, Ordos Basin, NW China显示文摘The geological characteristics and enrichment laws of the shale oil in the third submember of the seventh member of Triassic Yanchang Formation(Chang 7_(3)) in the Ordos Basin were analyzed by using the information of core observations, experiments and logging, and then the exploration potential and orientation of the Chang 7_(3) shale oil were discussed. The research findings are obtained in three aspects. First, two types of shale oil, i.e. migratory-retained and retained, are recognized in Chang 7_(3). The former is slightly better than the latter in quality. The migratory-retained shale oil reservoir is featured with the frequent interbedding and overlapping of silty-sandy laminae caused by sandy debris flow and low-density turbidity current and semi-deep-deep lacustrine organic-rich shale laminae. The retained shale oil reservoir is composed of black shale with frequent occurrence of bedding and micro-laminae. Second, high-quality source rocks provide a large quantity of hydrocarbon-rich high-quality fluids with high potential energy. The source-reservoir pressure difference provides power for oil accumulation in thin interbeds of organic-poor sandstones with good seepage conditions and in felsic lamina, tuffaceous lamina and bedding fractures in shales. Hydrocarbon generation-induced fractures, bedding fractures and microfractures provide high-speed pathways for oil micro-migration. Frequent sandstone interlayers and felsic laminae provide a good space for large-scale hydrocarbon accumulation, and also effectively improve the hydrocarbon movability. Third, sand-rich areas around the depression are the main targets for exploring migratory-retained shale oil. Mature deep depression areas are the main targets for exploring retained oil with medium to high maturity. Theoretical research and field application of in-situ conversion in low-mature deep depression areas are the main technical orientations for exploring retained shale oil with low to medium maturity. | GUO Qiheng LI Shixiang JIN Zhenkui ZHOU Xinping LIU Chenglin | 2023 | Petroleum Exploration and Development2023，50，4： | 0 |
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