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| 1 | Protective effect of propofol preconditioning and postconditioning against ischemic spinal cord injury显示文摘Propofol preconditioning has been shown to provide neuroprotection against spinal ischemia/reperfusion injury.In this study,spinal cord ischemia/reperfusion injury was induced by blocking the abdominal aorta in rabbits for 40minutes.Results showed that the co-application of propofol preconditioning and postconditioning regimen ameliorated pathological injury of the ischemic spinal cord and suppressed the elevation of malondialdehyde levels and increased superoxide dismutase activities in the spinal cord tissues.Co-application of propofol preconditioning and postconditioning resulted in potent protective effects against spinal cord ischemia/reperfusion injury and prolonged the spinal cord's tolerance to ischemia.This protection was associated with the anti-lipid peroxidation capacity of the spinal cord tissues. | Qijing Yu Ji Hu Jie Yang Shuzhou Yin | 2011 | Neural Regeneration Research2011，6，12： | 11 |
| 2 | Larix olgensis growth-climate response between lower and upper elevation limits:an intensive study along the eastern slope of the Changbai Mountains,northeastern China显示文摘Larix olgensis is a dominant tree species in the forest ecosystems of the Changbai Mountains of northeast China.To assess the growth response of this species to global climate change,we developed three tree-ring width and biomass chronologies across a range of elevations in the subalpine forests on the eastern slope of the Changbai Mountains.We used dendroclimatic analyses to study key factors limiting radial growth in L.olgensis and its variation with elevation.The statistical characteristics of chronologies suggested that elevation is a determinant of tree growth patterns in the study area.Response function analysis of chronologies with climate factors indicated that climate–growth relationships changed with increasing elevation:tree growth at high elevation was strongly limited by June temperatures of the previous year,and as elevation decreases,the importance of temperature decreased;tree radial growth at mid-elevation was mainly controlled by precipitation towards the end of the growing season of the current year.Biomass chronologies reflected a stronger climatic signal than tree-ring width chronologies.Spatial correlation with gridded climate data revealed that our chronologies contained a strong regional temperature signal for northeast China.Trees growing below timberline appeared to be more sensitive to climate,thus optimal sites for examining growth trends as a function of climate variation are considered to be just below timberline.Our study objective was to provide information for more accurate prediction of the growth response of L.olgensis to future climate change on the eastern slope of the Changbai Mountains,and to provide information for future climate reconstructions using this tree species in humid and semi humid regions. | Jian Yu Qijing Liu | 2020 | Journal of Forestry Research2020，31，1： | 4 |
| 3 | Systematic Full-Cycle Engineering Microbial Biofilms to Boost Electricity Production in Shewanella oneidensis显示文摘Electroactive biofilm plays a crucial rule in the electron transfer efficiency of microbial electrochemical systems(MES).However,the low ability to form biofilm and the low conductivity of the formed biofilm substantially limit the extracellular electron transfer rate of microbial cells to the electrode surfaces in MES. | Feng Li Rui Tang Baocai Zhang Chunxiao Qiao Huan Yu Qijing Liu Junqi Zhang Liang Shi Hao Song | 2023 | Research2023，，2： | 2 |
| 4 | Experimental Study on Improvement Effects of Completely Weathered Phyllite Using Red Clay and Cement for High-Speed Railway Embankments显示文摘Completely weathered phyllite(CWP)has the characteristics of difficult compaction,low shear strength after compaction and large settlement after construction.The traditional improvement method using a single agent of red clay or cement for CWP satisfies the subgrade requirements for ordinary railway,but cannot meet the requirements of immediate strength and long-term post-construction settlement of high-speed railway at the same time.A series of experimental investigations were undertaken for the blended CWP soils,with three additives used.The first additive was red clay,the second was cement and the third was a combination of both red clay and cement at various portions.Results of consolidation test and shear strength test carried out for the treated CWP soils show that:1)The effect of cement on improving the compression modulus of CWP is much better than that of red clay;2)The settlement of an embankment of 10 m high formed by blended soil of CWP with 3%cement can be controlled within 15 mm,while the settlement will be 25.15 mm for the same embankment of blended soil of CWP with 40%red clay;3)The shear strength and ultimate bearing capacity of CWP improved by red clay are much better than those of 5%cement;4)The ultimate bearing capacity of CWP improved by 40%red clay is 3.42 times of that by 3%cement and 2.95 times by 5%cement.Furthermore,the bearing capacity of CWP when improved by red clay can meet railway subgrade requirements immediately after compaction,while cement improved CWP needs a curing time of 1 day or longer.This is an impediment to rapid construction process.The improvement mechanism of red clay is mainly filling effect and grading improvement effect,while the improvement mechanism of cement is mainly hardening reaction,which produces high strength material to cement.It is found that 40%red clay and 3%cement treated CWP,which is considered to be optimum,can meet the subgrade requirements of both immediate bearing capacity and long-term post-construction settlement for the high-speed railway. | Xiushao Zhao Jianglong Rao Qijing Yang Yu Rong Zhitao Fu Zhiyao Wang Zixi Chen | 2022 | Journal of Renewable Materials2022，10，5： | 1 |
| 5 | Tree-ring response of Larix chinensis on regional climate and sea-surface temperature variations in alpine timberline in the Qinling Mountains显示文摘Tree-ring width chronologies of Larix chinensis were developed from the northern and southern slopes of the Qinling Mountains in Shaanxi Province,and climatic factors affecting the tree-ring widths of L.chinensis were examined.Correlation analysis showed that similar correlations between tree-ring width chronologies and climatic factors demonstrated that radial growth responded to climate change on both slopes.The radial growth of L.chinensis was mainly limited by temperature,especially the growing season.In contrast,both chronologies were negatively correlated with precipitation in May of the previous year and April of the current year.Spatial climate-correlation analyses with gridded land-surface climate data revealed that our tree-ring width chronologies contained a strong regional temperature signal over much of northcentral and eastern China.Spatial correlation with seasurface temperature fields highlights the influence of the Pacific Ocean,Indian Ocean,and North Atlantic Ocean.Wavelet coherence analysis indicated the existence of some decadal and interannual cycles in the two tree-ring width chronologies.This may suggest the influences of El Nin˜o-Southern Oscillation and solar activity on tree growth in the Qinling Mountains.These findings will help us understand the growth response of L.chinensis to climate change in the Qinling region,and they provide critical information for future climate reconstructions based on this species in semi-humid regions. | Boqian Yan Jian Yu Qijing Liu Lihua Wang Lile Hu | 2020 | Journal of Forestry Research2020，31，1： | 1 |
| 6 | Improved phase retrieval in holographic data storage based on a designed iterative embedded data显示文摘Embedded data are used to retrieve phases quicker with high accuracy in phase-modulated holographic data storage(HDS).We propose a method to design an embedded data distribution using iterations to enhance the intensity of the high-frequency signal in the Fourier spectrum.The proposed method increases the antinoise performance and signal-to-noise ratio(SNR)of the Fourier spectrum distribution,realizing a more efficient phase retrieval.Experiments indicate that the bit error rate(BER)of this method can be reduced by a factor of one after 10 iterations. | Changyu YU Suping WANG Ruixian CHEN Jianying HAO Qijing ZHENG Jinyu WANG Xianying QIU Kun WANG Dakui LIN Yi YANG Hui LI Xiao LIN Xiaodi TAN | 2021 | Frontiers of Optoelectronics2021，14，4： | 0 |
| 7 | Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review显示文摘Primordial germ cells(PGCs) are regarded as unipotent cells that can produce only either spermatogonia or oocytes. However, PGCs can be converted into the pluripotent state by ?rst dedifferentiation to embryonic germ cells and then by reprogramming to induce them to become pluripotent stem cells(iPSCs). These two stages can be completely implemented with mouse cells. However, authentic porcine iPSCs have not been established.Here, we discuss recent advances in the stem cell ?eld for obtaining iPSCs from PGCs. This knowledge will provide some clues which will contribute to the regulation of reprogramming to pluripotency in farm species. | Qijing LEI Qin PAN Shuai YU Na LI Shulin CHEN Kuldip SIDHU Jinlian HUA | 2019 | Frontiers of Agricultural Science and Engineering2019，6，1： | 0 |
| 8 | Glutamine metabolic microenvironment drives M2 macrophage polarization tomediate trastuzumab resistance in HER2-positive gastric cancer显示文摘Background:Trastuzumab is a first-line targeted therapy for human epidermal growth factor receptor-2(HER2)-positive gastric cancer.However,the inevitable occurrence of acquired trastuzumab resistance limits the drug benefit,and there is currently no effective reversal measure.Existing researches on the mechanism of trastuzumab resistance mainly focused on tumor cells themselves,while the understanding of the mechanisms of environment-mediated drug resistance is relatively lacking.This study aimed to further explore the mechanisms of trastuzumab resistance to identify strategies to promote survival in these patients.Methods:Trastuzumab-sensitive and trastuzumab-resistant HER2-positive tumor tissues and cells were collected for transcriptome sequencing.Bioinformatics were used to analyze cell subtypes,metabolic pathways,and molecular signaling pathways.Changes in microenvironmental indicators(such as macrophage,angiogenesis,and metabolism)were verified by immunofluorescence(IF)and immunohistochemical(IHC)analyses.Finally,a multi-scale agent-based model(ABM)was constructed.The effects of combination treatment were further validated in nude mice to verify these effects predicted by the ABM.Results:Based on transcriptome sequencing,molecular biology,and in vivo experiments,we found that the level of glutamine metabolism in trastuzumabresistant HER2-positive cells was increased,and glutaminase 1(GLS1)was significantly overexpressed.Meanwhile,tumor-derived GLS1 microvesicles drove M2macrophage polarization.Furthermore,angiogenesis promoted trastuzumab resistance.IHC showed high glutamine metabolism,M2 macrophage polarization,and angiogenesis in trastuzumab-resistant HER2-positive tumor tissues from patients and nudemice.Mechanistically,the cell division cycle 42(CDC42)promoted GLS1 expression in tumor cells by activating nuclear factor kappa-B(NF-κB)p65 and drove GLS1microvesicle secretion through IQmotif-containing GTPase-activating protein 1(IQGAP1).Based on the ABM and in vivo experiments,we confirmed that the combination of anti-glutamine metabolism,anti-angiogenesis,and pro-M1 polarization therapy had the best effect in reversing trastuzumab resistance in HER2-positive gastric cancer.Conclusions:This study revealed that tumor cells secrete GLS1 microvesicles via CDC42 to promote glutamine metabolism,M2 macrophage polarization,and pro-angiogenic function of macrophages,leading to acquired trastuzumab resistance in HER2-positive gastric cancer.A combination of anti-glutamine metabolism,anti-angiogenesis,and pro-M1 polarization therapy may provide a new insight into reversing trastuzumab resistance. | Xingbin Hu Zhenfeng Ma Beibei Xu Shulong Li Zhiqi Yao Bishan Liang Jiao Wang Wangjun Liao Li Lin Chunling Wang Siting Zheng Qijing Wu Qiong Huang Le Yu Fenghua Wang Min Shi | 2023 | Cancer Communications2023，43，8： | 0 |
| 9 | Three-Dimensional N-Doped Carbon Nanotube/Graphene Composite Aerogel Anode to Develop High-Power Microbial Fuel Cell显示文摘Optimizing the structure of electrode materials is one of the most effective strategies for designing high-power microbial fuel cells(MFCs).However,electrode materials currently suffer from a series of shortcomings that limit the output of MFCs,such as high intrinsic resistance,poor electrolyte wettability,and low microbial load capacity.Here,a three-dimensional(3D)nitrogen-doped multiwalled carbon nanotube/graphene(N-MWCNT/GA)composite aerogel is synthesized as the anode for MFCs.Comparing nitrogen-doped GA,MWCNT/GA,and N-MWCNT/GA,the macroporous hydrophilic N-MWCNT/GA electrode with an average pore size of 4.24μm enables high-density loading of the microbes and facilitates extracellular electron transfer with low intrinsic resistance.Consequently,the hydrophilic surface of N-MWCNT can generate high charge mobility,enabling a high-power output performance of the MFC.In consequence,the MFC system based on N-MWCNT/GA anode exhibits a peak power density and output voltage of 2977.8 mW m^(−2)and 0.654 V,which are 1.83 times and 16.3%higher than those obtained with MWCNT/GA,respectively.These results demonstrate that 3D N-MWCNT/GA anodes can be developed for high-power MFCs in different environments by optimizing their chemical and microstructures. | Shixuan Jin Yiyu Feng Jichao Jia Fulai Zhao Zijie Wu Peng Long Feng Li Huitao Yu Chi Yang Qijing Liu Baocai Zhang Hao Song Wei Feng | 2023 | Energy & Environmental Materials2023，6，3： | 0 |
| 10 | Propofol regulates Ca~(2+),Mg~(2+),Cu~(2+) and Zn~(2+) balance in the spinal cord after ischemia/reperfusion injury显示文摘This study assessed concentrations of Ca2+,Mg2+,Cu2+ and Zn2+ in blood serum and spinal cord tissues,as well as the possible mechanisms by which propofol may protect spinal cord tissues during ischemia/reperfusion injury.With prolonged duration of ischemia/reperfusion injury,serum Ca2+ and Cu2+ concentrations gradually increased,but Mg 2+ and Zn2+ concentrations gradually decreased.Seven days after spinal cord injury,changes in Ca2+,Mg2+,Cu2+ and Zn2+ concentrations were significant.After 7 days of reperfusion,changes in the concentrations of Ca2+,Mg2+,Cu2+ and Zn2+ in spinal cord homogenates were consistent with those in the serum.After propofol treatment,no significant changes in Ca2+,Mg2+,Cu2+ and Zn2+ concentrations in serum and spinal cord homogenates were noted during ischemia/reperfusion injury.These findings suggest that propofol exerts protective effects against spinal cord injury by stabilizing or recovering metal ion balance in ischemic regions. | Shuzhou Yin Qijing Yu Ji Hu Jie Yang Juan Chen | 2011 | Neural Regeneration Research2011，6，23： | 0 |
| 11 | Research on Computer Network Can and Performance Asalysis显示文摘ResearchonComputerNetworkCanandPerformanceAsalysisPanQijing;YangYonggao;WangYu(DepartmentofComputerScience,SouthwestJiaotongU... | Pan Qijing Yang Yonggao Wang Yu(Department of Computer Science,Southwest Jiaotong University, Chengdu 610031,China) | 1994 | Journal of Modern Transportation1994，11，1： | 0 |
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