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| 1 | H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet显示文摘 | Qianyi Zhang Jianzhong Shi Guohua Deng Jing Guo Xianying Zeng Xijun He Huihui Kong Chunyang Gu Xuyong Li Jinxiong Liu Guojun Wang Yan Chen Liling Liu Libin Liang Yuanyuan Li Jun Fan Jinliang Wang Wenhui Li Lizheng Guan Qimeng Li Huanliang Yang Pucheng Che | 2013 | Science2013，，6144： | 1 |
| 2 | H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet显示文摘 | Qianyi Zhang Jianzhong Shi Guohua Deng Jing Guo Xianying Zeng Xijun He Huihui Kong Chunyang Gu Xuyong Li Jinxiong Liu Guojun Wang Yan Chen Liling Liu Libin Liang Yuanyuan Li Jun Fan Jinliang Wang Wenhui Li Lizheng Guan Qimeng Li Huanliang Yang Pucheng Che | 2013 | Science2013，，6144： | 1 |
| 3 | Immunosenescence:molecular mechanisms and diseases显示文摘Infection susceptibility,poor vaccination efficacy,age-related disease onset,and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging(known as immunosenescence).During aging,organisms tend to develop a characteristic inflammatory state that expresses high levels of pro-inflammatory markers,termed inflammaging.This chronic inflammation is a typical phenomenon linked to immunosenescence and it is considered the major risk factor for age-related diseases.Thymic involution,naïve/memory cell ratio imbalance,dysregulated metabolism,and epigenetic alterations are striking features of immunosenescence.Disturbed T-cell pools and chronic antigen stimulation mediate premature senescence of immune cells,and senescent immune cells develop a proinflammatory senescence-associated secretory phenotype that exacerbates inflammaging.Although the underlying molecular mechanisms remain to be addressed,it is well documented that senescent T cells and inflammaging might be major driving forces in immunosenescence.Potential counteractive measures will be discussed,including intervention of cellular senescence and metabolic-epigenetic axes to mitigate immunosenescence.In recent years,immunosenescence has attracted increasing attention for its role in tumor development.As a result of the limited participation of elderly patients,the impact of immunosenescence on cancer immunotherapy is unclear.Despite some surprising results from clinical trials and drugs,it is necessary to investigate the role of immunosenescence in cancer and other age-related diseases. | Zaoqu Liu Qimeng Liang Yuqing Ren Chunguang Guo Xiaoyong Ge Libo Wang Quan Cheng Peng Luo Yi Zhang Xinwei Han | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 1 |
| 4 | Nonlinear instability suppression of closed-loop pilot-vehicle system with rate-limiting actuator based on anti-windup compensation显示文摘To solve the flight safety problem caused by nonlinear instabilities(category II pilot induced oscillations, PIOs) of the closed-loop pilot-vehicle system with rate-limiting actuator, the antiwindup(AW) compensation method to avoid category II PIOs is investigated. Firstly, the AW compensation method originally used for controlling input magnitude limited system is introduced, then this method is extended for controlling input rate-limiting system through a circle criterion theorem. Secondly, the establishment of the AW compensator is transformed into the solving of linear matrix inequalities. Finally, an AW compensator establishment algorithm for the closed-loop pilot-vehicle system with the rate-limiting actuator is obtained. The effectiveness of the AW compensation method to avoid category II PIOs is validated by time-domain simulations,and compared with rate-limited feedback(RLF) command rate compensation method. The results show that the AW compensation method can effectively suppress category II PIOs and maintain the nominal performance when the closed-loop pilot-vehicle system is normal. Unlike the command rate compensator which works upon system uninterruptedly, the AW compensation method affects the closed-loop pilot-vehicle system only when the rate-limiting of actuator is activated, so it is a novel PIO avoidance method. | Liang Qu Yinghui Li Haojun Xu Qimeng Cao | 2016 | Journal of Systems Engineering and Electronics2016，27，4： | 0 |
| 5 | Spin-related electronic pathway through single molecule on Au(111)显示文摘Spin properties of organic molecules have attracted great interest for their potential applications in spintronic devices and quantum computing.Fe-tetraphenyl porphyrin(Fe TPP)is of particular interest for its robust magnetic properties on metallic substrates.Fe TPP is prepared in vacuum via on-surface synthesis.Molecular structure and spin-related transport properties are characterized by low-temperature scanning tunneling microscope and spectroscopy at 0.5 K.Density functional theory calculations are performed to understand molecular adsorption and spin distribution on Au(111).The molecular structure of Fe TPP is distorted upon adsorption on the substrate.Spin excitations of Fe TPP are observed on the Fe atom and high pyrrole groups in differential conductance spectra.The calculated spin density distribution indicates that the electron spin of Fe TPP is mainly distributed on the Fe atom.The atomic transmission calculation indicates that electrons transport to substrate is mediated through Fe atom,when the tip is above the high pyrrole group. | Mingjun Zhong Qimeng Wu Liang Ma Jie Li Yifan Wang Yansong Wang Xin Li Yajie Zhang Jingtao Lü Yongfeng Wang | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
| 6 | J-shaped association between dietary zinc intake and new-onset hypertension:a nationwide cohort study in China显示文摘We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults.A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included.Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory.Participants with systolic blood pressure≥140 mmHg or diastolic blood pressure≥90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up were defined as having new-onset hypertension.During a median follow-up duration of 6.1 years,4269 participants developed new-onset hypertension.Overall,the association between dietary zinc intake and new-onset hypertension followed a J-shape(P for non-linearity<0.001).The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake(per mg/day:hazard ratio(HR)0.93;95%confidence interval(CI)0.88–0.98)in participants with zinc intake<10.9 mg/day,and increased with the increment of zinc intake(per mg/day:HR 1.14;95%CI 1.11–1.16)in participants with zinc intake≥10.9 mg/day.In conclusion,there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults,with an inflection point at about 10.9 mg/day. | Panpan He Huan Li Mengyi Liu Zhuxian Zhang Yuanyuan Zhang Chun Zhou Ziliang Ye Qimeng Wu Min Liang Jianping Jiang Guobao Wang Jing Nie Fan Fan Hou Chengzhang Liu Xianhui Qin | 2023 | Frontiers of Medicine2023，17，1： | 0 |
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