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| 1 | Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers显示文摘 | Kaichao Feng Yang Liu Yelei Guo Jingdan Qiu Zhiqiang Wu Hanren Dai Qingming Yang Yao Wang Weidong Han1,3 | 2018 | Protein & Cell2018，9，10： | 37 |
| 2 | Experimental investigation on micro-dynamic behavior of gas explosion suppression with SiO_2 fine powders显示文摘To study the effect of inert dust on gas explosion suppression mechanism,SiO_2 fine powders were sprayed to suppress premixed CH_4-Air gas explosion in a 20 L spherical experimental system.In the experiment,high speed schlieren image system was adopted to record explosion flame propagation behaviors,meanwhile,pressure transducers and ion current probes were used to clearly record the explosion flame dynamic characteristics.The experimental results show that the SiO_2 fine powders suppressed evidently the... | Xianfeng Chen,~(1,2,a)) Yin Zhang,~1 Qingming Zhang,~2 Shaofeng Ren,~1 and Jianxing Wu~1 1)School of Natural Resources and Environmental Engineering,Wuhan University of Technology, Wuhan 430070,China 2)State Key Laboratory of Explosion Science and Technology,Beijing Institute of Technology, Beijing 100081,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，3： | 8 |
| 3 | Structure Analysis of Locking Mechanism of Gear-Rack Typed Ship-Lift显示文摘Contact nonlinear theory was researched. Contact problem was transformed into optimization problem containing Lagrange multiplier, and unsymmetrical stiffness matrix was transformed into symmetrical stiffness matrix. A finite element analysis (FEA) model defining more than 300 contact pairs for long nut-short screw locking mechanism of a large-scale vertical gear-rack typed ship-lift was built. Using augmented Lagrange method and symmetry algorithm of contact element stiffness, the FEA model was analyzed, and the contact stress of contact interfaces and the von Mises stress of key parts were obtained. The results show that the design of the locking mechanism meets the requirement of engineering, and this method is effective for solving large scale nonlinear contact pairs. | SHI Duanwei WU Qingming ZHANG Zhiqiang | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 6 |
| 4 | Computational neuroscience:a frontier of the 21^st century显示文摘THEORY IN NEUROSCIENCE The human brain is a biological organ,weighing about three pounds or 1.4 kg,that determines our behaviors,thoughts,emotions and consciousness.Although comprising only 2%of the total body weight,the brain consumes about 20%of the oxygen entering the body.With the expensive energy demand,the brain enables us to perceive and act upon the external world,as well as reflect on our internal thoughts and feelings. | Xiao-Jing Wang Hailan Hu Chengcheng Huang Henry Kennedy Chengyu Tony Li Nikos Logothetis Zhong-Lin Lu Qingming Luo Mu-ming Poo Doris Tsao Si Wu Zhaohui Wu Xu Zhang Douglas Zhou | 2020 | National Science Review2020，7，9： | 4 |
| 5 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 6 | Urban-rural disparities in mild cognitive impairment and its functional subtypes among community- dwelling older residents in central China显示文摘background Substantial variations in the prevalence of mild cognitive impairment(MCI)and its subtypes have been reported,although mostly in geographically defined developed countries and regions.Less is known about MCI and its subtypes in rural areas of less developed central China.Aims The study aimed to compare the prevalence of MCI and its subtypes in residents aged 65 years or older in urban and rural areas of Hubei Province,China.Methods Participants aged 65 years or older were recruited between 2018 and 2019.Inperson structured interviews and clinical and neuropsychological assessments were performed at city health community centres and township hospitals.results Among 2644 participants without dementia,735 had MCI,resulting in a prevalence of 27.8%for total MCI,20.9%for amnestic MCI(aMCI)and 6.9%for non-amnestic MCI(naMCI).The prevalence of MCI in urban and rural areas was 20.2%and 44.1%,respectively.After adjusting for demographic factors,the prevalence of total MCI,aMCI and naMCI differed significantly between rural and urban areas(adjusted odds ratio(OR)2.10,1.44 and 3.76,respectively).Subgroup analysis revealed an association between rural socioeconomic and lifestyle disadvantage and MCI and its subtypes.Conclusions Our findings suggest that the prevalence of MCI among urban residents in central China is consistent with that in other metropolis areas,such as Shanghai,but the prevalence in rural areas is twice that in urban areas.Prospective studies and dementia prevention in China should focus on rural areas. | Dan Liu Lin Li Lina An Guirong Cheng Cong Chen Mingjun Zou Bo Zhang Xuguang Gan Lang Xu Yangming Ou Qingming Wu Ru Wang Yan Zeng | 2021 | General Psychiatry2021，34，5： | 3 |
| 7 | Cold Model Study and Commercial Test on Novel Vapor-Liquid Distributor of Hydroprocessing Reactor显示文摘一个新奇蒸汽液体经销商在在处理反应堆的水疗院使用的存在经销商上根据足够的学习被开发。冷模型测试数据证明新奇蒸汽液体分发者的液体分发表演比传统的显然好。新分发者的商业测试在在西诺佩克·昌灵·布朗奇同伴对待反应堆的 300kt/a 气体油水疗院被执行,证明 newvapor 液体分发者能改进液体分发,支持对待效率的水疗院并且导致比传统的更好的性能。 | Wang Shaobing Zhang Zhanzhu Wu Defei Guo Qingming | 2007 | China Petroleum Processing & Petrochemical Technology2007，9，2： | 3 |
| 8 | Biomimetic polyetheretherketone microcarriers with specific surface topography and self-secreted extracellular matrix for large-scale cell expansion显示文摘Reusable microcarriers with appropriate surface topography,mechanical properties,as well as biological modification through decellularization facilitating repeated cell culture are crucial for tissue engineering applications.Herein,we report the preparation of topological polyetheretherketone(PEEK)microcarriers via gas-driven and solvent exchange method followed by hydrothermal treatment at high temperature and pressure.After hydrothermal treated for 8 h,the resulting topological PEEK microcarriers exhibit walnut-like surface topography and good sphericity as well as uniform size distribution of 350.24619.44 mm.And the average width between ravine-patterned surface of PEEK microcarriers is 7806290 nm.After repeated steam sterilization by autoclaving for three times,topological PEEK microcarriers show nearly identical results compared with previous ones indicating strong tolerance to high temperature and pressure.This is a unique advantage for large-scale cell expansion and clinical applications.Moreover,PEEK microcarriers with special topography possess higher protein adsorption efficiency.In addition,the reutilization and biofunctionalization with repeated decellularization of topological PEEK microcarriers show highly beneficial for cell adhesion and proliferation.Therefore,our study is of great importance for new generation microcarriers with micro-and nano-scale surface feature for a broad application prospect in tissue engineering. | Qingming Ji ZongliangWang Zixue Jiao Yu Wang Zhenxu Wu Peng Wang Yuhang Zhu Shuo Sun Yi Liu Peibiao Zhang | 2020 | Regenerative Biomaterials2020，7，1： | 3 |
| 9 | Human hepatopoietin augmenter of liver regeneration──A hepatotrophic factor for liver regeneration, and its potential antihepatitis effect in vivo显示文摘The effect of human hapatopoietin i.e. augmenter of liver regeneration (hALR) was determined on hepatocyte DNA synthesis, and on CCl 4-induced hepatitis in animal in vitro and in vivo. It is found that ALR could directly stimulate DNA synthesis of hepatocytes in primary culture in a dose-dependent manner. In 30% hepatectomied rats, significant DNA synthesis occurred in control rats ; even so, exogenous hALR gene encoding protein increased DNA synthesis of regeneration liver by 2.3 fold compared with control rats. A lower dose of CCl 4 was administrated in rats and the effect of ALR on DNA synthesis of regenerating liver 48 h after CCl 4 administration was analyzed. Few Budr-labeled hepatocytes were visible in control rats. However, exogenous hALR markedly increased the number of labeled cells in a dose-dependent manner. Statistical analysis showed that 10 or 40 μg·kg -1 ALR protein stimulated DNA synthesis by 1.7 and 4.8 fold respectively. In addition to enhancing cell growth, adiministration of hALR achieved a significant improvement in reversing the lethality of rat hepatic failure when compared with that of control group; the elevation of cytosolic enzymes was dramatically suppressed by exogenous hALR in CCl 4-treated mice in vivo and in vitro; histologically, hepatocytes around the central vein were necrotic, and the degree of hepatocyte necrosis in control mice was more prominent than that in the mice given 40 μg·kg-1 hALR 48 h after CCl 4 administration. We also noted that hALR had a strong antihepatitis effect in vitro which was determined with primary cultured rat hepatocytes. These findings suggest that hALR protects the integrity of hepatocytes against severe hepatitis, and indicate that ALR may be an important regulator of liver regeneration and play a major role in liver injury repair. It proves ALR adminstration to be a useful treatment to accelerate liver regeneration and to prevent the onset of hepatitis or intrahepatic cholestasis induced by toxin. | YANG Xiaoming 1, WANG Aimin 2, ZHOU Ping 3, XIE Ling 1, WANG Qingming 1, WU Zuze 1 and HE Fuchu 1 1. Institute of Radiation Medicine, Beijing 100850, China 2. No. 252 Hospital of PLA, Baoding 071000, China 3. General Hospital of the Air | 1998 | Chinese Science Bulletin1998，43，12： | 3 |
| 10 | ADAPTABLE DESIGN IN PRODUCT DEVELOPMENT显示文摘一个最新新兴的设计模式,命名同样能适应的设计(广告) 瞄准开发从设计是能适应的到生活以后的周期的产品,被讨论。广告由四个主要阶段组成:当模特儿的产品,设计站台,特定的设计和产品重新设计。一个基于 newprocess 的设计数据模型(PDDM ) 被介绍它根据方便知识抽取的原则被组织,数据表示,布局,分享并且复用。基于 thePDDM,为产品系列开发的一个通用设计平台被建立,它有模块化的字符,参数驱动,变体设计,等等。站台的框架也为产生产品的一个家庭作为概念的结构和全面逻辑组织被建议。广告方法论成功地被适用开发为不同工程的无聊的机器(TBM ) 投射的隧道的一个家庭,与我们的发展中的队的效率极大地被增加。 | WU Qingming MEI Huafeng | 2006 | Chinese Journal of Mechanical Engineering2006，19，3： | 2 |
| 11 | Porous polyetheretherketone microcarriers fabricated via hydroxylation together with cellderived mineralized extracellular matrix coatings promote cell expansion and bone regeneration显示文摘Porous microcarriers have aroused increasing attention recently by facilitating oxygen and nutrient transfer,supporting cell attachment and growth with sufficient cell seeding density.In this study,porous polyetheretherketone(PEEK)microcarriers coated with mineralized extracellular matrix(mECM),known for their chemical,mechanical and biological superiority,were developed for orthopedic applications.Porous PEEK microcarriers were derived from smooth microcarriers using a simple wet-chemistry strategy involving the reduction of carbonyl groups.This treatment simultaneously modified surface topology and chemical composition.Furthermore,the microstructure,protein absorption,cytotoxicity and bioactivity of the obtained porous microcarriers were investigated.The deposition of mECM through repeated recellularization and decellularization on the surface of porous MCs further promoted cell proliferation and osteogenic activity.Additionally,the mECM coated porous microcarriers exhibited excellent bone regeneration in a rat calvarial defect repair model in vivo,suggesting huge potential applications in bone tissue engineering. | Shuo Sun Zixue Jiao Yu Wang Zhenxu Wu Haowei Wang Qingming Ji Yi Liu Zongliang Wang Peibiao Zhang | 2021 | Regenerative Biomaterials2021，8，2： | 2 |
| 12 | Puerarin blocks the signaling transmission mediated by P2X 3 in SG and DRG to relieve myocardial ischemic damage显示文摘 | Shuangmei Liu Chunping Zhang Qingming Shi Guilin Li Miaomiao Song Yun Gao Changshui Xu Hong Xu Bo Fan Shicheng Yu Chaoran Zheng Qicheng Zhu Bing Wu Lichao Peng Huangui Xiong Qin Wu Shangdong Liang | 2014 | Brain Research Bulletin2014，，： | 1 |
| 13 | Human physiome based on the high-resolution dataset of human body structure显示文摘Physiome Project, as a new concept, is proceeding rapidly with the great advancement of genomics, physiological experiment, biologic modeling and computer simulation technique. The project seeks to provide a quantitative framework for modeling of the human physiological system using computational approaches, which is able to integrate the knowledge of molecular biology, biochemical, biophysical and anatomical information on different levels, including cell, tissue, organ, system and organism. This paper reviews the development of the Physiome Project in the past decade. The role of high-resolution datasets of human body structure in Physiome Project is discussed. The future plan and applications of the high-resolution datasets of human body structure to Physiome Project are discussed as well. | Qian Liu Bo Wu Shaoqun Zeng Qingming Luo | 2008 | Progress in Natural Science:Materials International2008，18，8： | 1 |
| 14 | Recovery of gold from hydrometallurgical leaching solution of electronic waste via spontaneous reduction by polyaniline显示文摘The present study is primarily designed to develop an environmentally-benign approach for the recovery of precious metals, especially gold, from the ever increasingly-discarded electronic wastes(e-waste). By coupling the metal reduction process with an increase in the intrinsic oxidation state of the aniline polymers, and the subsequent re-protonation and reduction of the intrinsically oxidized polymer to the protonated emeraldine(EM) salt, polyaniline(PANi) films and polyaniline coated cotton fibers are able to recover metallic gold from acid/halide leaching solutions of electronic wastes spontaneously and sustainably. The current technique, which does not require the use of extensive extracting reagents or external energy input, can recover as much as 90% of gold from the leaching acidic solutions. The regeneration of polyaniline after gold recovery, as confirmed by the X-ray photoelectron spectroscopy measurements, promises the continuous operation using the current approach. The as-recovered elemental gold can be further concentrated and purified by incineration in air. | Yuanzhao Wu Qingming Fang Xiaohui Yi Gang Liu Runwei Li | 2017 | Progress in Natural Science:Materials International2017，27，4： | 1 |
| 15 | Efficiency and side effects of anti-CD38 CAR T cells in an adult patient with relapsed B-ALL after failure of bi-specific CD19/CD22 CAR T cell treatment显示文摘(CAR)T cells and immune checkpoint blockade therapies has shown remarkable outcomes in the field of cancer treatment.1,2 In particular,great success has been achieved in B cell acute lymphocytic leukemia(B-ALL)treated with anti-CD19 CAR T cells.2 However,the loss,mutation,and reduced expression of CD19 are crucial causes for the failure of CAR T cell treatment in leukemia patients.3,4 CD38,a 45-kDa type II glycoprotein,is detectable in BALL,and several studies have indicated the efficacy and safety of CD38 monoclonal antibodies in clinical applications,suggesting that CD38 represents a suitable therapeutic target for the treatment of B-ALL.5,6 In addition,we developed a CAR against CD38,and our preclinical study indicated that anti-CD38 CAR T(CAR T-38)cells could specifically lyse CD38-positive tumor cells.7 Herein,we present the anti-leukemia ability of CAR T-38 cells in an adult relapsed B-ALL patient after failure of bi-specific CD19/CD22 CAR T cell treatment,and this administration of CAR T-38 cells was accompanied by the occurrence of target-mediated toxicities and severe and uncontrollable cytokine release syndrome(CRS). | Yelei Guo Kaichao Feng Chuan Tong Hejin Jia Yang Liu Yao Wang Dongdong Ti Qingming Yang Zhiqiang Wu Weidong Han | 2020 | Cellular & Molecular Immunology2020，17，4： | 1 |
| 16 | Vibration Control of Block Forming Machine Based on an Artificial Neural Network 显示文摘 | Qingming Wu Qiang Zhang Chi Zong and Gang Cheng | 2007 | ISNN 2007 PartI LNCS4491:231 - 2402007，2007，： | 1 |
| 17 | Characteristics of premanufacture CD8^(+) T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma显示文摘Although chimeric antigen receptor(CAR)T cells have become an important treatment option for patients with relapsed/refractory B-cell malignancies,more than 60%of patients with diffuse large B-cell lymphoma(DLBCL)treated with CAR-T cell therapies fail to achieve a durable response.To reveal changes in CAR-T cell therapy and identify response biomarkers,we conducted a retrospective analysis of pre-manufacture source T cells and CAR-T cell products and their association with outcome in 58 patients with r/rDLBCL who received tandem CD19/CD20 CAR-T cell therapy.We performed bulk RNA-Seq,single-cell RNA-Seq,and paired T cell receptor sequencing on CAR-T cell products and pre-manufacture T cells from DLBCL patients.We note that a CD8+stem cell-like memory T cell population with a higher proportion and enhanced activating capacity of the CAR-T cell products was key to achieving durable clinical response.By analysing autologously-derived,pre-manufacture T cells,our data suggest that heterogeneity in the cellular and molecular features of pre-manufacture T cells contribute to the variation in efficacy after CAR-T cell therapy in DLBCL.The differences in anti-tumour efficacy of CAR-T cells among patients with different clinical outcomes appear to be due to the loss of CCR7 gene expression,coupled with increased expression of activation-and inhibitor-related genes in the CD8+naïve-T cell populations among the apheresis T cells from patients with a poor molecular response.These findings significantly advance our understanding of the underlying molecular determinants of pre-manufacture T cell function. | Yao Wang Chuan Tong Yuting Lu Zhiqiang Wu Yelei Guo Yang Liu Jianshu Wei Chunmeng Wang Qingming Yang Weidong Han | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 18 | A Space State Forecast Model for Dam Construction Equipments Based on Analysis Prediction Theory显示文摘Anti-collision equipments system is developed to solve the collision problems of dam construction equipments, and in the system the determination of equipments' space state is important. A uniform moving equation of equipments is established based on the analysis prediction theory and the movements states of equipments. Method of least square was employed to deal with discrete data of equipments' space position. Fitting equation matched with the movement equation was presented to do data fitting, and a relevant algorithm was given. Applying the fitting equation, current and future space state of equipments can be accurately predicted. Finally, a case is given and results show that numerical values of data were steady and their precision was high. In LongTan dam construction of the equipments anti-collision system, applying this method to forecast the equipments' space states and practical running of the system indicate that this method can improve the precision of position, obtain the better forecasting effect and increase the robustness of the system. | WU Qingming CHEN Yongqiang ZHANG Zhiqiang | 2007 | Wuhan University Journal of Natural Sciences2007，12，2： | 0 |
| 19 | Effects of projectile parameters on the momentum transfer and projectile melting during hypervelocity impact显示文摘The effects of projectile/target impedance matching and projectile shape on energy,momentum transfer and projectile melting during collisions are investigated by numerical simulation.By comparing the computation results with the experimental results,the correctness of the calculation and the statistical method of momentum transfer coefficient is verified.Different shapes of aluminum,copper and heavy tungsten alloy projectiles striking aluminum,basalt,and pumice target for impacts up to 10 km/s are simulated.The influence mechanism of the shape of the projectile and projectile/target density on the momentum transfer was obtained.With an increase in projectile density and length-diameter ratio,the energy transfer time between the projectile and targets is prolonged.The projectile decelerates slowly,resulting in a larger cratering depth.The energy consumed by the projectile in the excavation stage increased,resulting in lower mass-velocity of ejecta and momentum transfer coefficient.The numerical simulation results demonstrated that for different projectile/target combinations,the higher the wave impedance of the projectile,the higher the initial phase transition velocity and the smaller the mass of phase transition.The results can provide theoretical guidance for kinetic impactor design and material selection. | Wenjin Liu Qingming Zhang Renrong Long Zizheng Gong Ren Jiankang Xin Hu Siyuan Ren Qiang Wu Guangming Song | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 20 | 3-Dimensional Bag of Visual Words Framework on Action Recognition显示文摘Human motion recognition plays a crucial role in the video analysis framework.However,a given video may contain a variety of noises,such as an unstable background and redundant actions,that are completely different from the key actions.These noises pose a great challenge to human motion recognition.To solve this problem,we propose a new method based on the 3-Dimensional(3D)Bag of Visual Words(BoVW)framework.Our method includes two parts:The first part is the video action feature extractor,which can identify key actions by analyzing action features.In the video action encoder,by analyzing the action characteristics of a given video,we use the deep 3D CNN pre-trained model to obtain expressive coding information.A classifier with subnetwork nodes is used for the final classification.The extensive experiments demonstrate that our method leads to an impressive effect on complex video analysis.Our approach achieves state-of-the-art performance on the datasets of UCF101(85.3%)and HMDB51(54.5%). | Shiqi Wang Yimin Yang Ruizhong Wei Qingming Jonathan Wu | 2020 | Computers, Materials & Continua2020，，6： | 0 |
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