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| 1 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 2 | Ameliorating effects of Inonotus obliquus on high fat diet-induced obese rats显示文摘根据从的数据,将在在一年 2030 的世界上有 21.6 亿过重和 11.2 亿个肥胖的个人[1 ] ,它提起多重疾病的风险例如高血压,癌症的糖尿病,心血管的疾病,和几种类型[2,3 ] 。肥胖被看作新陈代谢的混乱,它被高精力吸入主要导致。在哺乳动物,过量精力首先在脂肪质的织物作为 triglyceride (TG ) 被存储。在过去的十年,调整 adipogenesis 的过程的众多的分子很好被记录了。Peroxisome 激活 proliferator 的受体(PPAR-) 为脂肪质的织物的累积被要求并且贡献肥胖[4 ] 。甾醇规章的元素绑定蛋白质(SREBP ) 作为激活胆固醇和丰满的酸合成的全部节目的抄写因素的一个家庭被识别了[5 ] 。Glyceraldehydes 3 磷酸盐 acyltransferase (GPAT ) 和 diacylglycerol acyltransferase (DGAT ) 广泛地在哺乳动物的纸巾被表示并且催化第一并且在 TG 合成的最后的步,分别地[6 ] 。因此,这些分子可以是为肥胖和类脂化合物新陈代谢的评估的大目标。最近,阳光等。[7 ] 证明了在糖尿病的老鼠的类脂化合物的浆液层次显著地与 Inonotus obliquus 的文化肉汤的干燥的事在 3 星期的治疗以后被减少。李和 Hyun [8 ] 证明水摘录从我。obliquus 减少了高脂肪的饮食的胖重量喂的肥胖的老鼠。因此,我们对什么进一步感兴趣,是怎么能我。obliquus 摘录影响类脂化合物新陈代谢并且什么是位于这反肥胖效果下面的可能的机制。在现在的学习,我们造了一个高脂肪的导致食谱的老鼠模型。 | Tao Wu Qingyu Shu Kai Yang Xiaoxian Xie Xia Wang Yangling Wang Anqi Guo Nate Y-uan Binggong Zhao Binbin Chi QiaobeiWu Zhengwei Fu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 3 | Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19显示文摘Multi-organ injuries are a major complication of severe Coronavirus Disease 2019(COVID-19).However,its pathogenesis is barely understood.Herein;we profile host responses to fatal SARS-CoV-2 infection by performing quantitative proteomics of 19 post-mortem samples of 8 different organs or tissues,including lungs,liver,intestine,kidney;spleen,brain,heart and muscle,from 3 deceased COVID-19 victims during the first wave of the pandemic(Supplementary Fig.S1A and B,Tables SI-S3). | Yang Qiu Di Wu Wanshan Ning Jiqian Xu Ting Shu Muhan Huang Rong Chen Jiancheng Zhang Yang Han Qingyu Yang Ruiting Li Xiaobo Yang Yaxin Wang Xiaojing Zou Shangwen Pan Chaolin Huang Yu Xue You Shang Xi Zhou | 2021 | National Science Review2021，8，11： | 1 |
| 4 | Longitudinal Characteristics of T Cell Responses in Asymptomatic SARS-CoV-2 Infection显示文摘Dear Editor,SARS-Co V-2 causes a spectrum of illness,ranging from an asymptomatic state to life-threatening multi-organ failure,and imposes a high socioeconomic burden on its sufferers and on society(Chen et al.2020;Pan et al.2020). | Jingyi Yang Ejuan Zhang Maohua Zhong Qingyu Yang Ke Hong Ting Shu Dihan Zhou Jie Xiang Jianbo Xia Xi Zhou Dingyu Zhang Chaolin Huang You Shang Huimin Yan | 2020 | Virologica Sinica2020，35，6： | 1 |
| 5 | The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP显示文摘Dear Editor,Chemoresistance is a major problem in the treatment of ovarian cancer patients and leads to poor prognosis,but its underlying mechanism remains elusive.Accumulating evidences have found that the aberrant regulation of the protein ubiquitination pathway plays an essential role in ovarian cancer chemoresistance.13 However,it is unclear whether and how deubiquitinase-USP11 involves in ovarian cancer chemoresistance. | Xiaolin Zhu Yiping Zhang Qingyu Luo Xiaowei Wu Furong Huang Tong Shu Yong Wan Hongyan Chen Zhihua Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 6 | Laser spectroscopy imaging technique coupled withnanomaterials for cancer diagnosis: A review显示文摘Laser spectroscopic imaging techniques have received tremendous attention in the-eld of cancer diagnosis due to their high sensitivity,high temporal resolution,and short acquisition time.However,the limited tissue penetration of the laser is still a challenge for the in vivo diagnosis of deep-seated lesions.Nanomaterials have been universally integrated with spectroscopic imaging techniques for deeper cancer diagnosis in vivo.The components,morphology,and sizes of nanomaterials are delicately designed,which could realize cancer diagnosis in vivo or in situ.Considering the enhanced signal emitting from the nanomaterials,we emphasized their combination with spectroscopic imaging techniques for cancer diagnosis,like the surface-enhanced Raman scattering(SERS),photoacoustic,fluorescence,and laser-induced breakdown spectroscopy(LIBS).Applications ofthe above spectroscopic techniques offer new prospectsfor cancer diagnosis. | Zhengying Peng Pengkun Yin Dan Li Youyuan Chen Kaiqiang Shu Qingwen Fan Yixiang Duan Qingyu Lin | 2024 | Journal of Innovative Optical Health Sciences2024，17，1： | 0 |
| 7 | Feasibility Study of Mixing Throat Swab Samples for Severe Acute Respiratory Syndrome Coronavirus-2 Screening显示文摘Dear Editor,The outbreak of coronavirus disease 2019(COVID-19)has been declared a pandemic by the World Health Organization(WHO)and has resulted in the worst public health crisis since World War II(Wang et al.2020). | Yang Han Qingyu Yang Ying Liu Ting Shu Li Yue Ting Xiao Qin Zeng Ying Wu Xi Zhou Dingyu Zhang | 2020 | Virologica Sinica2020，35，6： | 0 |
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