|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 2 | Mould taper optimization for continuous casting steels by numerical simulation显示文摘A transient,two-dimensional,coupled finite element model was employed to simulate the solidification and shrinkage of continuous casting steels by means of ANSYSTM.In the model,a gap-dependent heat transfer condition was introduced to modify the heat flux function,and the variations of material thermal properties,mechanical properties as well as the yield function with temperature were considered.The solidification and shrinkage processes of four round billets and two square billets were simulated by indirect coupled method.Simulation results show that carbon content,pouring temperature,casting speed and shape of billets have distinct influence on the solidification shrinkage of billets.Ideal continuous parabolic tapers were designed and optimized according to the calculated shrinkage curves of billets. | Wang Tongmin Cai Shaowu Li Jun Xu Jingjing Chen Zongning Zhu Jing Cao Zhiqiang Li Tingju | 2010 | China Foundry2010，7，1： | 4 |
| 3 | Three dimensional microstructures and wear resistance of Al-Bi immiscible alloys with different grain refiners显示文摘The three dimensional(3D) microstructures of Al-Bi alloys with different grain refiners(Al-5Ti-B, Al-3B and Al-3Ti) have been studied using synchrotron X-ray microtomography. The relationships between the microstructures and the corresponding wear behavior are verified through the friction and wear tests. The worn surfaces of the samples with grain refiners tested under 15 and 60 N loads are analyzed using Scanning Electron Microscopy(SEM). The results indicate that the addition of grain refiners is beneficial to the size and distribution of the Bi-rich particles in Al-Bi alloys. Compared with Al-5Ti-B and Al-3B grain refiners, the Bi-rich particles are more uniformly distributed and spherical with finer size with the addition of Al-3Ti grain refiner. The refinement renders the Al-20wt%Bi alloy refined by Al-3Ti the superior wear resistance with respect to those refined by Al-5Ti-B and Al-3B grain refiners, corresponding to the microstructures with fine and uniformly distributed Bi-rich particles in the Al matrix. | WANG TongMin CAO Fei CHEN ZongNing KANG HuiJun ZHU Jing FU YaNan XIAO TiQiao LI TingJu | 2015 | Science China(Technological Sciences)2015，58，5： | 2 |
| 4 | Climate change and agriculture: Impacts and adaptation options in South Africa显示文摘 | Alvaro Calzadilla Tingju Zhu Katrin Rehdanz Richard S.J. Tol Claudia Ringler | 2014 | Water Resources and Economics2014，，： | 1 |
| 5 | A novel fading-resistant Al–3Ti–3B grain refiner for Al–Si alloys显示文摘 | Tongmin Wang Hongwang Fu Zongning Chen Jun Xu Jing Zhu Fei Cao Tingju Li | 2011 | Journal of Alloys and Compounds2011，，： | 1 |
| 6 | Climate Warming and Water Management Adaptation for California显示文摘 | Stacy K. Tanaka Tingju Zhu Jay R. Lund Richard E. Howitt Marion W. Jenkins Manuel A. Pulido Mélanie Tauber Randall S. Ritzema Inês C. Ferreira | 2006 | Climatic Change (-)2006，，3： | 1 |
| 7 | Water for Agriculture: Maintaining Food Security under Growing Scarcity显示文摘 | Mark W. Rosegrant Claudia Ringler Tingju Zhu | 2009 | Annual Review of Environment and Resources2009，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员