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| 1 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 2 | Coding metamaterials, digital metamaterials and programmable metamaterials显示文摘Metamaterials are artificial structures that are usually described by effective medium parameters on the macroscopic scale,and these metamaterials are referred to as‘analog metamaterials’.Here,we propose‘digital metamaterials’through two steps.First,we present‘coding metamaterials’that are composed of only two types of unit cells,with 0 and p phase responses,which we name‘0’and‘1’elements,respectively.By coding‘0’and‘1’elements with controlled sequences(i.e.,1-bit coding),we can manipulate electromagnetic(EM)waves and realize different functionalities.The concept of coding metamaterials can be extended from 1-bit coding to 2-bit coding or higher.In 2-bit coding,four types of unit cells,with phase responses of 0,p/2,p,and 3p/2,are required to mimic the‘00’,‘01’,‘10’and‘11’elements,respectively.The 2-bit coding has greater freedom than 1-bit coding for controlling EM waves.Second,we propose a unique metamaterial particle that has either a‘0’or‘1’response controlled by a biased diode.Based on this particle,we present‘digital metamaterials’with unit cells that possess either a‘0’or‘1’state.Using a field-programmable gate array,we realize digital control over the digital metamaterial.By programming different coding sequences,a single digital metamaterial has the ability to manipulate EM waves in different manners,thereby realizing‘programmable metamaterials’.The above concepts and physical phenomena are confirmed through numerical simulations and experiments using metasurfaces. | Tie Jun Cui Mei Qing Qi Xiang Wan Jie Zhao Qiang Cheng | 2014 | Light(Science & Applications)2014，3，1： | 130 |
| 3 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 4 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 5 | Cap-assisted endoscopic sclerotherapy for hemorrhoids: Methods, feasibility and efficacy显示文摘AIM: To evaluate the methodology, feasibility, safety and efficacy of a novel method called cap-assisted endoscopic sclerotherapy(CAES) for internal hemorrhoids.METHODS: A pilot study on CAES for grade Ⅰ to Ⅲ internal hemorrhoids was performed. Colon and terminal ileum examination by colonoscopy was performed for all patients before starting CAES. Polypectomy and excision of anal papilla fibroma were performed if polyps or anal papilla fibroma were found and assessed to be suitable for resection under endoscopy. CAES was performed based on the requirement of the cap, endoscope, disposable endoscopic long injection needle, enough insufflated air and sclerosing agent.RESULTS: A total of 30 patients with grade Ⅰ to Ⅲ internal hemorrhoids was included. The follow-up was more than four weeks. No bleeding was observed after CAES. One(3.33%) patient claimed mild tenesmus within four days after CAES in that an endoscopist performed this procedure for the first time. One hundred percent of patients were satisfied with this novel procedure, especially for those patients who underwent CAES in conjunction with polypectomy or excision of anal papilla fibroma.CONCLUSION: CAES as a novel endoscopic sclerotherapy should be a convenient, safe and effective flexible endoscopic therapy for internal hemorrhoids. | Ting Zhang Li-Juan Xu Jie Xiang Zhi He Zhao-Yuan Peng Guang-Ming Huang Guo-Zhong Ji Fa-Ming Zhang | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 22 |
| 6 | MADS-Box Transcription Factor AGL21 Regulates Lateral Root Development and Responds to Multiple External and Physiological Signals显示文摘植物根系统形态学被各种各样的环境暗示戏剧性地影响。到环境限制的根系统建筑学的改编,主要取决于侧面的根的形成和生长,是一个重要农学的特点。侧面的根开发被与内在的发信号的小径仔细协调的外部信号调整。疯盒子的抄写因素是到 flowering 和花开发的转变的已知的关键管理者。然而,他们在根开发的功能仍然糟糕被理解。这里,我们报导那 AGL21, AGL17-clade 疯盒子的基因,在侧面的根开发起一个关键作用。AGL21 高度在根被表示,特别地在根中央柱体和侧面的根 primordia。当 agl21 异种显示出损害的侧面的根开发时, AGL21 overexpression 植物生产了更多和更长侧面的根,特别在氮缺乏的条件下面。AGL21 被许多植物荷尔蒙和环境压力导致,建议在响应各种各样的信号的根系统粘性的这基因的一个函数。而且, AGL21 断然被发现由提高本地植物生长素生合成,因此刺激的侧面的根开始和生长在侧面的根 primordia 和侧面的根调整植物生长素累积。我们建议 AGL21 可以涉及各种各样的环境、生理的调停信号的侧面的根开发和生长。 | Lin-Hui Yu Zi-Qing Miao Guo-Feng Qi Jie Wu Xiao-Teng Cai Jie-Li Mao Cheng-Bin Xiang | 2014 | Molecular Plant2014，7，11： | 21 |
| 7 | Analysis of the Fungal Community in Apple Replanted Soil Around Bohai Gulf显示文摘Apple replant disease(ARD) is a frequently occurring plant disease in replanted orchards around Bohai Gulf, which causes growth inhibition and even death of plants. The aim of this study was to investigate the etiology of ARD around Bohai Gulf. In this study, the primary growth inhibition of apple seedlings was evaluated in ten replanted soils, sampled around Bohai Gulf. A fungal clone library was used to identify changes in the structure and composition of the soil fungal community. The results revealed that the Simpson diversity indices of Laizhou and Pulandian orchards were higher than others, presenting severe ARD. Ascomycota dominated around Bohai Gulf at the phyla level. Fusarium and Saccharomyces were abundant in all replanted soils. In addition, correlations between the relative abundance of fungal genera in soils and the severity of ARD were analyzed. The results showed that Fusarium was correlated positively with the severity of ARD, but Mortierella was negatively correlated. Furthermore, the quantitative PCR of Fusarium oxysporum, which was regarded as a factor of ARD, was performed. Overall, this study demonstrated that ARD was strongly associated with an unbalanced microbial ecosystem with more pathogenic fungi, while Fusarium in the apple replanted soil was the key factor for ARD around Bohai Gulf. | WANG Gongshuai YIN Chengmiao PAN Fengbing WANG Xiaobao XIANG Li WANG Yanfang WANG Jinzheng TIAN Changping CHEN Jie MAO Zhiquan | 2018 | Horticultural Plant Journal2018，4，5： | 21 |
| 8 | U and Th Contents and Th/U Ratios of Zircon in Felsic and Mafic Magmatic Rocks:Improved Zircon-Melt Distribution Coefficients显示文摘U 和 Th 内容和锆石的 Th/U 比率上的高精确的数据获得了使用第二等的离子团 spectrometry 分析从文学被收集了。在花岗石的岩石中的锆石有 350 ppm U, 140 ppm Th,和 Th/U=0.52 的中部的价值;推荐锆石融化分区系数为杜是 81 并且 8.2 为 DTh。在从 mafic 和中间的岩石的锆石,中部的价值是 270 ppm U , 170 ppm Th ,和 Th/U=0.81 ,并且推荐 zirconmelt 分区系数为杜是 169 并且 59 当锆石与melt 在平衡结晶时,为 DTh , magmatic 锆石的 U 和 Th 内容和 Th/U 比率是低的。增加的岩浆温度应该相对 U 内容支持更高的 Th 内容,导致为在到比在花岗石的岩石中的中间的岩石的 mafic 的锆石的更高的 Th/U 比率。然而,当锆石与 melt 在不平衡结晶时, U 和 Th 更容易能进入锆石格子,并且他们的内容和 Th/U 比率主要取决于不平衡的度。在 magmatic 锆石的 U 和 Th 的行为能被用作 geochemical 指示物决定起源和 magmatic 锆石的结晶化环境。 | WANG Xiang Williams L. GRIFFIN CHEN Jie HUANG Pinyun LI Xiang | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 18 |
| 9 | Combination of serum inhibin B and follicle-stimulating hormone levels can not improve the diagnostic accuracy on testicular sperm extraction outcomes in Chinese non-obstructive azoospermic men显示文摘 | HUANG Xiang BAI Quan YAN Li-ying ZHANG Qiu-fang GENG Li QIAO Jie | 2012 | Chinese Medical Journal2012，，16： | 17 |
| 10 | Efficacy and safety of sunitinib in the treatment of metastatic renal cell carcinoma显示文摘背景酷氨酸 kinase 禁止者(TKI ) sunitinib,为变形肾的房间癌(RCC ) 的第一线治疗的首先指向的代理人,指向脉管的 endothelial 生长因素(VEGF ) 小径。如果高血压是有效预兆的 factor.Methods,这研究的目的是在对待变形清楚房间的 RCC 调查 sunitinib 的功效和安全并且证实有变形 RCC 的 36 个病人的一个总数在 2008 年 6 月和 2010 年 12 月之间被注册。在他们之中, 29 个案例是第一线治疗, 7 个案例在首要的 cytokine 或 sorafinib 治疗上的前进。所有病人的病理被证实在清楚的房间类型占优势。Sunitinib 单音治疗在每日的口头的治疗的重复 6 星期的周期被管理 4 个星期,到 2 个星期列在后面离开在 34 个病人;并且 3 个病人连续地与 37.5 mg/d 被管理直到疾病前进或不能接受的毒性发生了。全面反应率和安全被评估。我们根据中部的后续是的血压 level.Results 把病人划分了成组 A 和组 B 15 个月(10 个周期,范围 1.5-30.0 月(1-20 周期)) 。十个病人(29.4 ) 完成了部分回答(PR ) ;23 个病人(67.6 ) 表明了持续 2 个周期的稳定的疾病(SD ) 。十七个病人(50 ) 在后续期间得了进步疾病(PD ) 。中部的没有前进的幸存(PFS ) 是 15 个月(范围 3.0-28.5 ) 月。9 个病人的一个总数死了;全面幸存没被到达;死亡病人的中部的幸存时间是 13 个月(范围 7-24 ) 月。最普通的不利事件是手脚症候群(77.8 ) , thrombocytopenia (75.0 ) ,高血压(61.1 ) 和腹泻(46.0 ) 。最不利的事件由治疗打断是可逆的。22 个病人(61.1 ) 得了高血压;并且高血压与很长时间被联系到疾病前进和长全面的幸存(P=0.004, 0.000,分别地) 这研究的结果表明的 .Conclusions 功效和可管理的不利事件与变形清楚的房间 RCC 为病人在首要或第二线的治疗作为一个单个代理人 sunitinib 介绍。进一步,联系 sunitinib 的高血压可以是为在变形 RCC 的治疗功效的一个强壮的预兆的标记。 | LI Xue-song WU Xiang ZHAO Peng-ju HUANG Li-hua SONG Yi GONG Kan SHEN Cheng YU Wei SONG Gang ZHAO Zheng ZHANG Zheng ZHANG Qian WANG Gang HE Zhi-song ZHOU Li-qun JIN Jie | 2011 | Chinese Medical Journal2011，，18： | 17 |
| 11 | High porosity and low thermal conductivity high entropy(Zr0.2Hf0.2Ti0.2Nb0.2Ta0.2C显示文摘Porous ultra-high temperature ceramics(UHTCs)are promising for ultrahigh-temperature thermal insulation applications.However,the main limitations for their applications are the high thermal conductivity and densification of porous structure at high temperatures.In order to overcome these obstacles,herein,porous high entropy(Zr(0.2)Hf(0.2)Ti(0.2)Nb(0.2)Ta(0.2))C was prepared by a simple method combing in-situ reaction and partial sintering.Porous high entropy(Zr(0.2)Hf(0.2)Ti(0.2)Nb(0.2)Ta(0.2))C possesses homogeneous microstructure with grain size in the range of 100–500 nm and pore size in the range of 0.2–1μm,which exhibits high porosity of 80.99%,high compressive strength of 3.45 MPa,low room temperature thermal conductivity of 0.39 W·m^-1K^-1,low thermal diffusivity of 0.74 mm^2·s^-1and good high temperature stability.The combination of these properties renders porous high entropy(Zr(0.2)Hf(0.2)Ti(0.2)Nb(0.2)Ta(0.2))Cpromising as light-weight ultrahigh temperature thermal insulation materials. | Heng Chen Huimin Xiang Fu-Zhi Dai Jiachen Liu Yiming Lei Jie Zhang Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，8： | 16 |
| 12 | A long-term Global LAnd Surface Satellite(GLASS)data-set for environmental studies显示文摘Recently,five Global LAnd Surface Satellite(GLASS)products have been released:leaf area index(LAI),shortwave broadband albedo,longwave broadband emissivity,incident short radiation,and photosynthetically active radiation(PAR).The first three products cover the years 19822012(LAI)and 19812010(albedo and emissivity)at 15 km and 8-day resolutions,and the last two radiation products span the period 20082010 at 5 km and 3-h resolutions.These products have been evaluated and validated,and the preliminary results indicate that they are of higher quality and accuracy than the existing products.In particular,the first three products have much longer time series,and are therefore highly suitable for various environmental studies.This paper outlines the algorithms,product characteristics,preliminary validation results,potential applications and some examples of initial analysis of these products. | Shunlin Liang Xiang Zhao Suhong Liu Wenping Yuan Xiao Cheng Zhiqiang Xiao Xiaotong Zhang Qiang Liu Jie Cheng Hairong Tang Yonghua Qu Yancheng Bo Ying Qu Huazhong Ren Kai Yu John Townshend | 2013 | International Journal of Digital Earth2013，6，S01： | 16 |
| 13 | Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients显示文摘BACKGROUND The methylated septin 9(mSEPT9) assay was the first blood-based test approved by the United States Food and Drug Administration as a colorectal screening test.However, the diagnostic and prognostic role of preoperative mSEPT9 for colorectal cancer(CRC) in Chinese patients is still unknown.AIM To improve the understanding of diagnostic and prognostic factors, serum m SEPT9 was detected in Chinese CRC patients.METHODS A retrospective analysis of 354 cases, of which 300 had CRC and 54 were normal,was performed in China. Patients' characteristics, treatments, and laboratory data, including age, the date of surgery, Union for International Cancer Control(UICC) stages, distant metastasis(M), and so on, were collected. Methylation levels of SEPT9 were quantified by quantitative, methylation-specific polymerase chain reaction before surgery. In addition, the effects of mSEPT9 on the occurrence and prognosis of 330 CRC cases from The Cancer Genome Atlas(TCGA) database were evaluated using bioinformatics analyses. Potential prognostic factors for overall survival(OS) and progression-free survival(PFS)were evaluated by Kaplan-Meier univariate analysis.RESULTSIn Chinese CRC patients, positive mSEPT9 was strongly associated with advanced UICC stages, deeper invasion by the primary tumor, and more distant metastasis. Methylation levels of SEPT9 were stage-dependent and showed a stepwise increase in UICC stages(I–IV), primary tumor categories(T1–T4),regional node categories(N0–N2), and distant metastasis categories(M0–M1).The patients with positive mSEPT9 showed a tendency toward lower PFS. After analyzing TCGA clinical data, the high mSEPT9 group was found to be obviously correlated only with more distant metastasis. The patients with high mSEPT9 levels showed a tendency toward lower OS. Besides, nine meaningful mSEPT9 sites were found to provide guidance for the follow-up studies.CONCLUSION MSEPT9 analysis may add valuable information to current tumor staging. Serum m SEPT9 in Chinese CRC patients appears to offer promising novel prognostic markers and might be considered for monitoring CRC recurrence. | Xue Yang Zhi-Jie Xu Xi Chen Shuang-Shuang Zeng Long Qian Jie Wei Mei Peng Xiang Wang Wan-Li Liu Hong-Ying Ma Zhi-Cheng Gong Yuan-Liang Yan | 2019 | World Journal of Gastroenterology2019，25，17： | 16 |
| 14 | Comprehensive treatments for hepatocellular carcinoma with tumor thrombus in major portal vein显示文摘AIM: To evaluate the efficacy of transcatheter arterial chemoembolisation(TACE) compared with surgical intervention and sorafenib for treatment of hepatocellular carcinoma(HCC) in patients with tumor thrombus extending to the main portal vein.METHODS: From 2009 to 2013, a total of 418 HCC patients with tumor thrombus extending to the main portal vein were enrolled in this study and divided into four groups. These groups underwent different treatments as follows: TACE(n = 307), surgical intervention(n = 54), sorafenib(n = 15) and palliativetreatment(n = 42). Overall survival rates were determined by Kaplan-Meier method, and differences between the groups were identified through log-rank analysis. Cox's proportional hazard model was used to identify the risk factors for survival.RESULTS: The mean survival periods for patients in the TACE, surgical intervention, sorafenib and palliative treatment groups were 10.39, 4.13, 5.54 and 2.82 mo, respectively. For the TACE group, the 3-, 6-, 12-and 24-mo survival rates were 94.1%, 85.9%, 51.5% and 0.0%, respectively. The corresponding rates were 60.3%, 22.2%, 0.0% and 0.0% for the surgical intervention group and 50.9%, 29.5%, 0.0% and 0.0% for the sorafenib group. Evidently, the results in the TACE group were significantly higher than those in the other groups(P < 0.0001). Furthermore, no significant difference among survival rates was observed between TACE with/without sorafenib(10.22 mo vs 10.52 mo, P = 0.615). No significant difference in survival rates was also found among the surgical intervention, sorafenib and palliative treatment groups(P > 0.05). These values significantly increased after TACE with/without sorafenib compared with other treatments(P < 0.05).CONCLUSION: For HCC patients with tumor thrombus extending to the main portal vein, TACE can yield a higher survival rate than surgical intervention or sorafenib treatment. | Hai-Hong Ye Jia-Zhou Ye Zhi-Bo Xie Yu-Chong Peng Jie Chen Liang Ma Tao Bai Jun-Ze Chen Zhan Lu Hong-Gui Qin Bang-De Xiang Le-Qun Li | 2016 | World Journal of Gastroenterology2016，22，13： | 14 |
| 15 | Health-related quality of life in gastroesophageal reflux patients with noncardiac chest pain: Emphasis on the role of psychological distress显示文摘AIM To investigate the effects of depression and anxiety on health-related quality of life(QoL)in gastroesophageal reflux disease(GERD)patients and those suffering from cardiac(CCP)and noncardiac(NCCP)chest pain in Wuhan,China.METHODS In this cross-sectional study,a total of 358 consecutive patients with GERD were enrolled in Wuhan,China,of which 176 subjects had complaints of chest pain.Those with chest pain underwent coronary angiography and were divided into a CCP group(52 cases)and NCCP group(124 cases).Validated GERD questionnaires were completed,and the 36-item Short-Form Health Survey and Hospital Anxiety/Depression Scale were used for evaluation of Qo L and psychological symptoms,respectively.RESULTS There were similar ratios and levels of depression and anxiety in GERD with NCCP and CCP.However,the QoL was obviously lower in GERD with CCP than NCCP(48.34±17.68 vs 60.21±20.27,P<0.01).In the GERD-NCCP group,rather than the GERD-CCP group,the physical and mental QoL were much poorer in subjects with depression and/or anxiety than those without anxiety or depression.Anxiety and depression had strong negative correlations with both physical and mental health in GERD-NCCP(all P<0.01),but only a weak relationship with mental components of QoL in GERD-CCP.CONCLUSION High levels of anxiety and depression may be more related to the poorer QoL in GERD patients with NCCP than those with CCP.This highlights the importance of evaluation and management of psychological impact for improving QoL in GERD-NCCP patients. | Lei Zhang Lei Tu Jie Chen Jun Song Tao Bai Xue-Lian Xiang Rui-Yun Wang Xiao-Hua Hou | 2017 | World Journal of Gastroenterology2017，23，1： | 14 |
| 16 | A Mitochondria-Targeted PPR Protein Restores pol Cytoplasmic Male Sterility by Reducing orF224 Transcript Levels in Oilseed Rape显示文摘 | Liu, Zhi Yang, Zonghui Wang, Xiang Li, Kaidi An, Hong Liu, Jie Yang, Guangsheng Fu, Tingdong Yi, Bin Hong, Dengfeng | 2016 | Molecular Plant2016，9，7： | 14 |
| 17 | Fabrication of homogeneously dispersed graphene/Al composites by solution mixing and powder metallurgy显示文摘Graphene-reinforced aluminum(Al) matrix composites were successfully prepared via solution mixing and powder metallurgy in this study. The mechanical properties of the composites were studied using microhardness and tensile tests. Compared to the pure Al alloy, the graphene/Al composites showed increased strength and hardness. A tensile strength of 255 MPa was achieved for the graphene/Al composite with only 0.3 wt% graphene, which has a 25% increase over the tensile strength of the pure Al matrix. Raman spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy were used to investigate the morphologies, chemical compositions, and microstructures of the graphene and the graphene/Al composites. On the basis of fractographic evidence, a relevant fracture mechanism is proposed. | Xiang Zeng Jie Teng Jin-gang Yu Ao-shuang Tan Ding-fa Fu Hui Zhang | 2018 | International Journal of Minerals,Metallurgy and Materials2018，25，1： | 13 |
| 18 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 19 | Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis显示文摘The role of Fas/Fas ligand (FasL) in mediating alveolar macrophage (AM)-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied.It showed that the serum levels of IL-1β,TNF-α,IL-8,MIP-1α,MCP-1,and TGF-β1were higher in silicosis patients than in controls,and increased with the progression of silicosis except TGF-β1 and IL-8.TGF-β1,IL-8,MCP-1,MIP-1αwere efficiently down-regulated by anti-FasL antibody or caspase-8 inhibitor,indicating that Fas/FasL signaling promotes the | YAO San Qiao HE Qin Cheng YUAN Ju Xiang CHEN Jie CHEN Gang LU Yao BAI Yu Ping ZHANG Chun Min YUAN Yang XU Ying Jun | 2013 | Biomedical and Environmental Sciences2013，26，11： | 13 |
| 20 | Impact of Cardiovascular Disease Deaths on Life Expectancy in Chinese Population显示文摘Objective We aimed to analyze the impact of cardiovascular disease(CVD) deaths on life expectancy(LE) in Chinese population and estimate the percentage reduction in CVD mortality needed to increase LE by 1 year from the current level, a national target of health improvement. Methods We used life tables, cause-elimination life tables, and age decomposition of LE with corrected mortality data from the National Disease Surveillance System in 2010. Results LE at birth of Chinese people was 73.24 years in 2010. Women had a longer LE than men, and urban population had a longer LE than rural population. CVD deaths resulted in a 4.79-year LE loss and premature deaths in people aged 25 to 64 years were responsible for a substantial part of LE loss from CVD. Death from ischemic heart disease and cerebrovascular diseases accounted for 69.2% of LE loss from CVD deaths and death from cerebrovascular diseases was the largest contributor. In rural men, 51.1% LE loss from CVD deaths was caused by cerebrovascular diseases. If there were no changes in mortality rates for all other diseases, a 27.4% reduction in CVD mortality would increase LE by 1 year in Chinese population. Conclusion There is a considerable impact of CVD deaths on LE. A 1-year LE increase in the future requires at least a 27.4% reduction in CVD mortality from the current level. Targeting the rural population and tackling cerebrovascular diseases are important for reaching the national goal of health improvement. | FAN Jie LI Guo Qi LIU Jing WANG Wei WANG Miao QI Yue XIE Wu Xiang LIU Jun ZHAO Fan LI Yan ZHAO Dong | 2014 | Biomedical and Environmental Sciences2014，27，3： | 13 |
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