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| 1 | A risk-prediction score for colorectal lesions on 12,628 participants at high risk of colorectal cancer显示文摘Background The uptake of colonoscopy is low in individuals at risk of colorectal cancer(CRC).We constructed a riskprediction score(RPS)in a large community-based sample at high risk of CRC to enable more accurate risk stratification and to motivate and increase the uptake rate of colonoscopy.Methods A total of 12,628 participants classified as high-risk according to positivity of immunochemical fecal occult blood tests or High-Risk Factor Questionnaire underwent colonoscopy.Logistic regression was used to derive a RPS and analysed the associations of the RPS with colorectal lesions,giving odds ratios(ORs)and 95%confidence intervals(CIs).Results Of the participants,men(OR=1.73,95%CI=1.58–1.90),older age(≥65 years;1.41,1.31–1.53),higher body mass index(≥28 kg/m^(2);1.22,1.07–1.39),ever smoking(1.47,1.31–1.65),and weekly alcohol use(1.28,1.09–1.52)were associated with a higher risk of colorectal lesions.We assigned 1 point to each of the above five risk factors and derived a RPS ranging from 0 to 5,with a higher score indicating a higher risk.Compared with a RPS of 0,a RPS of 1,2,3,and 4–5 showed a higher risk of colorectal lesions,with the OR(95%CI)being 1.50(1.37–1.63),2.34(2.12–2.59),3.58(3.13–4.10),and 3.91(3.00–5.10),respectively.The area under the receiver-operating characteristic curve of RPS in predicting colorectal lesions was 0.62.Conclusions Participants with an increase in the RPS of≥1 point had a significantly higher risk of colorectal lesions,suggesting the urgency for measuring colonoscopy in this very high-risk group.High-risk strategies incorporating RPS may be employed to achieve a higher colonoscopy-uptake rate. | Lixin Liang Yingru Liang Ke Li Pengzhe Qin Guozhen Lin Yan Li Huan Xu Suixiang Wang Qinlong Jing Boheng Liang Lin Xu | 2022 | Gastroenterology Report2022，10，1： | 2 |
| 2 | Generation and Analysis of Expressed Sequence Tags from Chimonanthus praecox (Wintersweet) Flowers for Discovering Stress-Responsive and Floral Development-Related Genes显示文摘 | Shunzhao Sui Jianghui Luo Jing Ma Qinlong Zhu Xinghua Lei Mingyang Li Jinfa Zhang | 2012 | Comparative and Functional Genomics2012，，： | 1 |
| 3 | A unified global genotyping framework of dengue virus serotype-1 for a stratified coordinated surveillance strategy of dengue epidemics显示文摘Background: Dengue is the fastest spreading arboviral disease, posing great challenges on global public health. A reproduceable and comparable global genotyping framework for contextualizing spatiotemporal epidemiological data of dengue virus (DENV) is essential for research studies and collaborative surveillance.Methods: Targeting DENV-1 spreading prominently in recent decades, by reconciling all qualified complete E gene sequences of 5003 DENV-1 strains with epidemiological information from 78 epidemic countries/areas ranging from 1944 to 2018, we established and characterized a unified global high-resolution genotyping framework using phylogenetics, population genetics, phylogeography, and phylodynamics.Results: The defined framework was discriminated with three hierarchical layers of genotype, subgenotype and clade with respective mean pairwise distances 2-6%, 0.8-2%, and ≤ 0.8%. The global epidemic patterns of DENV-1 showed strong geographic constraints representing stratified spatial-genetic epidemic pairs of Continent-Genotype, Region-Subgenotype and Nation-Clade, thereby identifying 12 epidemic regions which prospectively facilitates the region-based coordination. The increasing cross-transmission trends were also demonstrated. The traditional endemic countries such as Thailand, Vietnam and Indonesia displayed as persisting dominant source centers, while the emerging epidemic countries such as China, Australia, and the USA, where dengue outbreaks were frequently triggered by importation, showed a growing trend of DENV-1 diffusion. The probably hidden epidemics were found especially in Africa and India. Then, our framework can be utilized in an accurate stratified coordinated surveillance based on the defined viral population compositions. Thereby it is prospectively valuable for further hampering the ongoing transition process of epidemic to endemic, addressing the issue of inadequate monitoring, and warning us to be concerned about the cross-national, cross-regional, and cross-continental diffusions of dengue, which can potentially trigger large epidemics.Conclusions: The framework and its utilization in quantitatively assessing DENV-1 epidemics has laid a foundation and re-unveiled the urgency for establishing a stratified coordinated surveillance platform for blocking global spreading of dengue. This framework is also expected to bridge classical DENV-1 genotyping with genomic epidemiology and risk modeling. We will promote it to the public and update it periodically. | Liqiang Li Xiang Guo Xiaoqing Zhang Lingzhai Zhao Li Li Yuji Wang Tian Xie Qingqing Yin Qinlong Jing Tian Hu Ziyao Li Rangke Wu Wei Zhao Sherman Xuegang Xin Benyun Shi Jiming Liu Shang Xia Zhiqiang Peng Zhicong Yang Fuchun Zhang Xiao‑Guang Chen Xiaohong Zhou | 2022 | Infectious Diseases of Poverty2022，11，5： | 0 |
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