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| 1 | New proofs of the recent climate warming over the Tibetan Plateau as a result of the increasing greenhouse gases emissions显示文摘A striking climate warming over the Ti- betan Plateau during the last decades has been re- vealed by many studies, but evidence linking it to human activity is insufficient. By using historical ob- servations, here we show that the in situ climate warming is accompanied by a distinct decreasing trend of the diurnal range of surface air temperature. The ERA40 reanalysis further indicates that there seems to be a coherent warming trend near the tro- popause but a cooling trend in the lower stratosphere. Moreover, all these features can be reproduced in two coupled climate models forced by observed CO2 concentration of the 20th century but cannot be pro- duced by the fixed external conditions before the industrial revolution. These suggest that the recent climate warming over the Tibetan Plateau primarily results from the increasing anthropogenic green- house gases emissions, and impacts of the increased greenhouse gases emissions upon the climate change in the plateau are probably more serious than the rest of the world. | DUAN Anmin WU Guoxiong ZHANG Qiong LIU Yimin | 2006 | Chinese Science Bulletin2006，51，11： | 51 |
| 2 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 3 | Effects of the tyrosine protein kinase inhibitor genistein on the proliferation,activation of cultured rat hepatic stellate cells显示文摘AIM: Hepatic stellate cell (HSC) plays a pivotal role inliver fibrosis and is considered as the therapeutic targetfor the treatment of hepatic fibrosis. Tyrosine proteinkinase plays an important role in the proliferation,activation of HSC. The purpose of the study is toinvestigate the effects of the tyrosine protein kinaseinhibitor genistein onthe proliferation and activationof cultured rat HscMETHODS: Rat HSC were isolated from Wistar rats by insitu perfusion of collagenase and pronase and single-stepdensity Nycodenz gradient. Culture-activated HSC wereserum-starved and incubated with 10-3 to 10-5 mol/Lconcentration of genistein for 24, 48 or 72 h. In PDGF-induced HSC proliferation, HSC were stimulatel with L0μg@L-1PDGF-BB for 15 min, and then treaeed with genisteinfor the same time. Cell proliferation was measured byMTr assay and based on flow cytometric analysis of cellcycle. The a-smooth muscle actin (α-SMA) expression inHSC was studied with confocal laser microscopy and flowcytometry. c-fos c-jun and cyclin D1 expression in HSCwas also detected by flow cytometry.RESULTS: Genistein inhibited basal and PDGF-inducedproliferation of HSC at the concentration of 10-8 to 10-5mol/L, and treatment with 10-7 mol/L concentration ofgenistein for 48 h inhibited the HSC proliferationsignificantly (the inhibition rate was 70.3 %, P<0.05).Immunofluorescence detected by confocal lasermicroscopy and flow cytometry showed that treatmentwith 10-7 mol/L genistein for 48 h suppressed theexpression of α-SMA significantly in HSC (the specificfluorescence intensity were 60.2±21.5 vs 35.3±11.6and 12.8± 10.4 vs9.54±6.39, respectively, both P<0.05).The intensity of c-fos, c-jun and cydin D1 expression ofHSCs treated with 10-7 mol/L genistein for 48 h wasalso significantly decreased compared with the controls.CONCLUSION: Genistein influences proliferation of HSC,suppresses the expression of α-SMA in HSC and tinhibits the intensity of c-fos, c-jun and cyclin D1expression of HSCs. Genistein has therapeutic potentialagainst liver fibrosis. | Xiao-Jing Liu Ming-Hui Huang Laboratory of Department of Internal Medicine,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Li Yang Qiong Wang Yi-Ping Wang Department of Gastroenterology of West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Yong-Qiu Mao Center for Cancer Biotherapy of West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Hong-Bin Wu Laboratory of Department of Surgery,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 38 |
| 4 | Metastatic human hepatocellular carcinoma models in nude mice and cell line with metastatic potential显示文摘Metastatic human HCC model is needed for the studies on mechanism and intervention of metastatic recurrence. By using orthotopic implantation of histologically intact tissues of 30 surgical specimens, a patient like metastatic model of human HCC in nude mice (LCI-D20)and a Iow metastatic model of human HCC in nude mice LCI-D35 ) have been established. All mice with transplanted LCI-D20 tumors exhibited extremely high metastatic ability including spontaneous metastasis to liver, lungs, lymph nodes and peritoneal seeding.Remarkable difference was also found in expression of some of the invasiveness related genes and growth factors between the LCI-D20 and LCI-D35 tumors. PAI-Iincreased gradually following tumor progression in LCID20 model, and correlated with tumor size and AFP level,Phasic expression of tissue intercellular adhesion molecule-I in this model was also observed. Using corneal micropocket model, it was demonstrated that the vascular response induced by LCI-D20 tumor was stronger than that induced by LCI-D35 tumor. Similar report on metastatic human HCC model in nude mice and human HCC cell line with metastatic potential was rarely found in the literature. This LCI-D20 model has been widely used for the studies on intervention of metastasis, including antiangiogenesis, antisense approach, metalloproteinase inhibitor, differentiation inducer, etc. It is concluded that the establishment of metastatic human HCC model in nude mice and human HCC cell line with metastatic potential will provide important models for the in vivo and in vitro study of HCC invasiveness, angiogenesis as well as intervention of HCC recurrence. | Zhao-You Tang Fan-Xian Sun Jian Tian Sheng-Long Ye Yin-Kun Liu Kang-Da Liu Qiong Xue Jie Chen Jing-Lin Xia Lun-Xiu Qin Hui-Chuan Sun Lu Wang Jian Zhou Yan Li Zeng-Chen Ma Xin-Da Zhou Zhi-Quan Wu Zhi-Ying Lin Bing-Hui Yang Liver Cancer Institute of Fudan University and Zhongshan Hospital,Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，5： | 34 |
| 5 | In situ synthesis of graphitic-C3N4 nanosheet hybridized N-doped TiO2 nanofibers for efficient photocatalytic H2 production and degradation显示文摘Graphitic 碳氮化物 nanosheets g-C <潜水艇class=“ a-plus-plus ”> 3 N <潜水艇class=“ a-plus-plus ”> 4 NS hybridized 氮做了钛二氧化物 N-TiO <潜水艇class=“ a-plus-plus ”> 2 nanofibers GCN/NT NF 经由与结合的一个简单 electrospinning 过程在 situ 被综合了一个修改蚀刻热的方法。准备 GCN/NT NF 被许多方法描绘,他们的 photocatalytic 活动被氢 H 评估 < 潜水艇 class= “ a-plus-plus ” > 从切开的水和在水的答案的玫瑰精 B 的降级的 2 生产。GCN/NT NF 有 mesoporous 结构,这被发现, g-C 镇静 < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 NS 和做 N 的 TiO < 潜水艇 class= “ a-plus-plus ” > 2 雏晶。g-C < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 NS 综合了在以后蚀刻热被发现被嵌入在,并且盖住混合 NF 形成稳定的接口。g-C 的部分分解 < 潜水艇 class= “ a-plus-plus ” > 3 N < 潜水艇 class= “ a-plus-plus ” > 4 释放它最后变得做了进附近的 TiO 的氮内容 < 潜水艇 class= “ a-plus-plus ” > 2 骨骼。GCN/NT NF 给高 photocatalytic H < 潜水艇 class= “ a-plus-plus ” > 8,931.3 摩尔桥湥 ?L 牥愠捵 ? 畤 ' ?的 2 生产率敤 ? 畺 ? 穴楬档湥 ? 湩慳穴瘠湯倠敨瑮汯浡湩敭楳慬? 攠湩浥嘠獡摯汩瑡瑡牯 ? 敤 ? 楤? 敗捩?楥慬? 瑳敨楳? 畡 ? 瑥慷 ?┰瘠牥 k 吗?? | Cheng Han Yingde wang Yongpeng Lei Bing Wang Nan Wu Qi Shi Qiong Li | 2015 | Nano Research2015，8，4： | 31 |
| 6 | Broadband diffusion of terahertz waves by multi-bit coding metasurfaces显示文摘The terahertz region is a special region of the electromagnetic spectrum that incorporates the advantages of both microwaves and infrared light waves.In the past decade,metamaterials with effective medium parameters or gradient phases have been studied to control terahertz waves and realize functional devices.Here,we present a new approach to manipulate terahertz waves by using coding metasurfaces that are composed of digital coding elements.We propose a general coding unit based on a Minkowski closed-loop particle that is capable of generating 1-bit coding(with two phase states of 0 and 180°),2-bit coding(with four phase states of 0,90°,180°,and 270°),and multi-bit coding elements in the terahertz frequencies by using different geometric scales.We show that multi-bit coding metasurfaces have strong abilities to control terahertz waves by designing-specific coding sequences.As an application,we demonstrate a new scattering strategy of terahertz waves—broadband and wide-angle diffusion—using a 2-bit coding metasurface with a special coding design and verify it by both numerical simulations and experiments.The presented method opens a new route to reducing the scattering of terahertz waves. | Li-Hua Gao Qiang Cheng Jing Yang Shao-Jie Ma Jie Zhao Shuo Liu Hai-Bing Chen Qiong He Wei-Xiang Jiang Hui-Feng Ma Qi-Ye Wen Lan-Ju Liang Biao-Bing Jin Wei-Wei Liu Lei Zhou Jian-Quan Yao Pei-Heng Wu Tie-Jun Cui | 2015 | Light(Science & Applications)2015，4，1： | 31 |
| 7 | Chaihu-Shugan-San exerts an antidepressive effect by downregulating miR-124 and releasing inhibition of the MAPK14 and Gria3 signaling pathways显示文摘Dysregulation of mi R-124 has been reported to be involved in the pathophysiology of depression. Chaihu-Shugan-San, a traditional Chinese medicine, has antidepressive activity; however, the underlying mechanisms remain unclear. In this study, to generate a rodent model of depression, rats were subjected to a combination of solitary confinement and chronic unpredictable mild stress for 28 days. Rats were intragastrically administered Chaihu-Shugan-San(2.835 m L/kg/d) for 4 weeks, once a day. Real-time reverse-transcription quantitative polymerase chain reaction, mi RNA microarray, western blot assay and transmission electron microscopy demonstrated that ChaihuShugan-San downregulated mi R-124 expression and upregulated the m RNA and protein levels of mitogen-activated protein kinase 14(MAPK14) and glutamate receptor subunit 3(Gria3). Chaihu-Shugan-San also promoted synapse formation in the hippocampus. The open field test, sucrose consumption test and forced swimming test were used to assess depression-like behavior. After intragastric administration of Chaihu-Shugan-San, sucrose consumption increased, while the depressive behaviors were substantially reduced. Together, these findings suggest that Chaihu-Shugan-San exerts an antidepressant-like effect by downregulating mi R-124 expression and by releasing the inhibition of the MAPK14 and Gria3 signaling pathways. | Qiong Liu Ning-Ning Sun Zheng-Zhi Wu Da-Hua Fan Mei-Qun Cao | 2018 | Neural Regeneration Research2018，13，5： | 26 |
| 8 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 9 | Chemical and optical properties of aerosols and their interrelationship in winter in the megacity Shanghai of China显示文摘A field campaign on air quality was carried out in Shanghai in winter of 2012. The concentrations of NO, NO2, NOx, SO2, CO, and PM2.5increased during haze formation. The average masses of SO42-, NO3-and NH4+were 10.3, 11.7 and 6.7 μg/m3 during the haze episodes, which exceeded the average(9.2, 7.9, and 3.4 μg/m3) of these components in the non-haze days. The mean values for the aerosol scattering coefficient(b sp), aerosol absorption coefficient(b ap) and single scattering albedo(SSA) were 288.7, 27.7 and0.91 Mm-1, respectively. A bi-peak distribution was observed for the mass concentrations of CO, NO, NO2, and NOx. More sulfate was produced during daytime than that in the evening due to photochemical reactions. The mass concentration of NH4+achieved a small peak at noontime. NO3-showed lower concentrations in the afternoon and higher concentrations in the early morning. There were obvious bi-peak diurnal patterns for b sp and b ap as well as SSA. b sp and b ap showed a positive correlation with PM2.5mass concentration.(NH4)2SO4, NH4NO3, organic mass, elemental carbon and coarse mass accounted for 21.7%, 19.3%, 31.0%, 9.3% and 12.3% of the total extinction coefficient during non-haze days, and 25.6%, 24.3%, 30.1%, 8.1% and 8.2% during hazy days. Organic matter was the largest contributor to light extinction. The contribution proportions of ammonium sulfate and ammonium nitrate to light extinction were significantly higher during the hazy time than during the non-haze days. | Tingting Han Liping Qiao Min Zhou Yu Qu Jianfei Du Xingang Liu Shengrong Lou Changhong Chen Hongli Wang Fang Zhang Qing Yu Qiong Wu | 2015 | Journal of Environmental Sciences2015，27，1： | 14 |
| 10 | Changes in the patterns of inorganic nitrogen and TN/TP ratio and the associated mechanism of biological regulation in the shallow lakes of the middle and lower reaches of the Yangtze River显示文摘The changes of NH3-N, NO3-N, NO2-N and TN/TP were studied during growth and non-growth season in 33 subtropical shallow lakes in the middle and lower reaches of the Yangtze River. There were significant positive correlations among all nutrient concentrations, and the correlations were better in growth season than in non-growth season. When TP>0.1 mgL-1, NH3-N increased sharply in non-growth season with increasing TP, and NO3-N increased in growth season but decreased in non-growth season with TP. These might be attributed to lower dissolved oxygen and low temperature in non-growth season of the hypereutrophic lakes, since nitrification is more sensitive to dissolved oxygen and temperature than antinitrification. When 0.1 mgL-1>TP>0.035 mgL-1, TN and all kinds of inorganic nitrogen were lower in growth season than in non-growth season, and phytoplankton might be the vital regulating factor. When TP<0.035 mgL-1, inorganic nitrogen concentrations were relatively low and NH3-N, NO2-N had significant correlations with phytoplankton, indicating that NH3-N and NO2-N might be limiting factors to phytoplankton. In addition, TN/TP went down with decline in TP concentration, and TN and inorganic nitrogen concentrations were obviously lower in growth season than in non-growth season, suggesting that decreasing nitrogen (especially NH3-N and NO3-N) was an important reason for the decreasing TN/TP in growth season. The ranges of TN/TP were closely related to trophic level in both growth and non-growth seasons, and it is apparent that in the eutrophic and hypertrophic state the TN/TP ratio was obviously lower in growth season than in non-growth season. The changes of the TN/TP ratio were closely correlated with trophic levels, and both declines of TN in the water column and TP release from the sediment were important factors for the decline of the TN/TP ratio in growth season. | WU Shikai XIE Ping WANG Songbo ZHOU Qiong | 2006 | Science China Earth Sciences2006，49，z1： | 14 |
| 11 | Beneficial effects of moderate to vigorous physical activity on cardiovascular disease among Chinese adults显示文摘Background In China,lack of evidence remains a significant challenge for the national initiative to promote physical activity(PA).We aimed to quantify the beneficial effects of meeting or maintaining the recommended PA level[150 minutes per week(min/wk)of moderate PA or 75 min/wk of vigorous PA or an equivalent combination]on incident cardiovascular disease(CVD)among Chinese population.Methods We included 100,560 participants without history of CVD from three cohorts in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project.Cox proportional hazards models were used to estimate hazard ratios(HRs)and 95%confidence intervals(CIs)for CVD events and its subtypes,including stroke,coronary heart disease,heart failure,and CVD death.Results During a median follow-up of 7.3 years(range:6–15 years),777,163 person-years and 4693 incident CVD events were observed.Compared with participants who were inactive at baseline,the multivariable adjusted HR(95%CI)of developing CVD was 0.74(0.69–0.79)for those who met recommended moderate to vigorous physical activity(MVPA)level at baseline.Furthermore,the risk of CVD incidence was reduced with increment of MVPA(Ptrend<0.001),and the HR(95%CI)of highly-active versus inactive category was 0.62(0.56–0.68).Compared with individuals who were inactive both at the baseline and follow-up,those keeping active over the period of follow-up had a substantial lower risk of incident CVD with the HR(95%CI)of 0.57(0.43–0.77).Conclusions The findings demonstrated that meeting and maintaining the recommended MVPA level could reduce the cardiovascular risk.Wider adoption of the PA recommendations would have considerable health impacts to the Chinese population. | Qiong LIU Fang-Chao LIU Ke-Yong HUANG Jian-Xin LI Xue-Li YANG Xin-Yan WANG Ji-Chun CHEN Xiao-Qing LIU Jie CAO Chong SHEN Ling YU Fang-Hong LU Xian-Ping WU Lian-Cheng ZHAO Ying LI Dong-Sheng HU Xiang-Feng LU Jian-Feng HUANG Dong-Feng GU | 2020 | Journal of Geriatric Cardiology2020，17，2： | 14 |
| 12 | Investigations on Nitrate Pollution of Soil, Groundwater and Vegetable from Three Typical Farmlands in Beijing Region, China显示文摘The aim of this study was to determine the nitrate pollution status of soil, groundwater, and vegetable from three typical farmlands (croplands, vegetable fields, and orchards) in Beijing region. During the investigation, hundreds of the soil, groundwater, and vegetable samples from three typical farmlands were collected and analyzed. In addition, attributes of all samples were recorded for data analysis. The results showed that nitrate was substantially accumulated in soil profiles, while the soil nitrate concentrations of vegetable fields and orchards were higher than those of croplands. Nitrate concentration in 0-30 cm soil of vegetable field and orchard were 3.8 and 1.2 times of that of cropland, respectively. Nitrate content of groundwater in vegetable field was 13.8 mg L-1 (with the over-standard ratio 44.8%), which was 2.8 folds of that in cropland. Nitrate concentration of groundwater under orchard was 9.3 mg L-1 (with the over-standard ratio 23.5%), which was 1.9 folds of that in cropland. High concentrations of the nitrate in vegetables were detected, particularly green leafy vegetables ranked first with 2 685.5 mg kg-1, followed by rhizome vegetables, cabbages, and fruit vegetables. The nitrate over-standard ratios of rhizome vegetables, green leafy vegetables, fruit vegetables, and cabbages were 80.9, 37.9, 29.7, and 2.2%, respectively. The results revealed that the high nitrate concentrations of soil, vegetable, and groundwater might result from the high fertilization dose. | DU Lian-feng ZHAO Tong-ke ZHANG Cheng-jun AN Zhi-zhuang WU Qiong LIU Bao-cun LI Peng MA Mao-ting | 2011 | Agricultural Sciences in China2011，10，3： | 13 |
| 13 | Corner-milling of Thin Walled Cavities on Aeronautical Components显示文摘通过铣削力系数实验确立了螺旋端面铣削力模型,并分析了不同条件下拐角加工的铣削力变化。针对拐角的加工过程,应用刀具轨迹的方程与加工几何动力学的结合,得到了加工参数与拐角的坐标的关系,从而在保证切削力恒定的条件下,通过改变刀具的中心坐标与铣削参数,实现了拐角加工过程的优化,同时将优化的参数应用到实际的铣削过程进行比较。结果显示,拐角处的加工质量得到了显著提高。基于优化的加工参数,采用有限元程序对拐角的变形进行计算,证明优化后的参数对工件的拐角变形影响较小。 | Wu Qiong Zhang Yidu Zhang Hongwei | 2009 | Chinese Journal of Aeronautics2009，22，6： | 12 |
| 14 | Resveratrol attenuates bone cancer pain through regulating the expression levels of ASIC3 and activating cell autophagy显示文摘骨头癌症疼痛(BCP ) 是在有恶意的癌症的病人的最普通的疼痛之一。位于 BCP 下面的机制大部分是未知的。我们的以前的研究和增加的证据两个都显示出那个酸察觉到的离子隧道(ASIC3 ) 3 是处于在一些疼痛模型的病理学的疼痛状态的重要蛋白质。我们假设了 ASIC3 的表示变化可能是与 BCP 有关的因素之一。在这研究,我们通过 intrathecally 把老鼠乳腺癌房间(MRMT-1 ) 注入 Sprague-Dawley 雌老鼠的左胫骨建立了 BCP 模型,并且发现 BCP 老鼠在 L4-L6 背面的根中心显示出骨头破坏,增加的机械疼痛敏感和起来调整的 ASIC3 蛋白质表示层次。然后, resveratrol, intraperitoneally 在手术后的白天 21 上被注入 BCP 老鼠, dose-dependently 增加了 BCP 老鼠的爪退却阀值,颠倒了疼痛行为,并且有 BCP 老鼠上的 antinociceptive 效果。在 ASIC3-transfected SH-SY5Y 房间, ASIC3 蛋白质表示层次被 resveratrol 在一个剂量依赖者和时间依赖者举止调整。同时, resveratrol 也在调停 ASIC3 的疼痛老鼠模型有 antinociceptive 效果。而且, resveratrol 也在 ASIC3-transfected SH-SY5Y 房间提高了 AMPK, SIRT1,和 LC3-II 层次的 phosphorylation,显示 resveratrol 能激活在 ASIC3-transfected SH-SY5Y 房间的 AMPK-SIRT1-autophagy 信号小径。在 BCP 老鼠, SIRT1 和 LC3-II 也是下面调整的。这些调查结果在 BCP 状态期间作为一个治疗学的处理为 resveratrol 的使用提供新证据(?作者 2017。代表生物化学和房间生物学的研究所由牛津大学出版社出版了,为生物科学的上海研究所,中国科学院。版权所有。为权限,请发邮件:journals.permissions@oup.com。) | Haili Zhu Jieqiong Ding Ji Wu Tingting Liu Jing Liang Qiong Tang Ming Jiao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，11： | 12 |
| 15 | Shenfu injection attenuates lipopolysaccharide-induced myocardial inflammation and apoptosis in rats显示文摘Shenfu injection(SFI), a Chinese medicinal product, shows potent efficacy in treating sepsis. The aim of the present study was to clarify the protective effects of SFI against lipopolysaccharide(LPS)-induced myocardial inflammation and apoptosis.Experiments were carried out in Sprague-Dawley(SD) rats treated with LPS or LPS + SFI, and in H9 C2 cardiomyocytes. The sepsisassociated myocardial inflammation and apoptosis was induced by the intraperitoneal injection of LPS(20 mg·kg–1). SFI attenuated the increased expression of tumor necrosis factor(TNF)-α and interleukin(IL)-1β induced by LPS both in serum and heart. In LPS group,cell viability was reduced, and reversed after SFI administration. LPS treatment increased the expression levels of cleaved-caspase 3 and Bax, and those of Bcl2 and Bcl2/Bax. These two trends were reversed by SFI administration. The expression levels of phosphorylated mitogen-activated protein kinase kinase(p-MEK) and phosphorylated extracellular regulated protein kinases(p-ERK) were increased by LPS, and reversed by SFI. MEK inhibitor U0126 attenuated the apoptosis induced by LPS. These results indicate that SFI could treat LPS-induced cardiac dysfunction. In conclusion, SFI attenuates the inflammation and apoptosis induced by LPS via downregulating the MEK and ERK signaling pathways. | CHEN Rui-Juan RUI Qing-Lin WANG Qiong TIAN Fang WU Jian KONG Xiang-Qing | 2020 | Chinese Journal of Natural Medicines2020，18，3： | 12 |
| 16 | Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on p H-monitoring and symptom-scale显示文摘AIM To compare the outcomes between laparoscopic Nissen fundoplication(LNF)and proton pump inhibitors(PPIs)therapy in patients with laryngopharyngeal reflux(LPR)and typeⅠhiatal hernia diagnosed by oropharyngeal p H-monitoring and symptom-scale assessment.METHODS From February 2014 to January 2015,70 patients who were diagnosed with LPR and type I hiatal hernia and referred for symptomatic assessment,oropharyngeal p H-monitoring,manometry,and gastrointestinal endoscopy were enrolled in this study.All of the patients met the inclusion criteria.All of the patients underwent LNF or PPIs administration,and completed a2-year follow-up.Patients’baseline characteristics and primary outcome measures,including comprehensive and single symptoms of LPR,PPIs independence,and satisfaction,and postoperative complications were assessed.The outcomes of LNF and PPIs therapy were analyzed and compared. RESULTS There were 31 patients in the LNF group and 39patients in the PPI group.Fifty-three patients(25 in the LNF group and 28 in the PPI group)completed reviews and follow-up.Oropharyngeal p H-monitoring parameters were all abnormal with high acid exposure,a large amount of reflux,and a high Ryan score,associated reflux symptom index(RSI)score.There was a significant improvement in the RSI and LPR symptom scores after the 2-year follow-up in both groups(P<0.05),as well as typical symptoms of gastroesophageal reflux disease.Improvement in the RSI(P<0.005)and symptom scores of cough(P=0.032),mucus(P=0.011),and throat clearing(P=0.022)was significantly superior in the LNF group to that in the PPI group.After LNF and PPIs therapy,13 and 53 patients achieved independence from PPIs therapy(LNF:44.0%vs PPI:7.14%,P<0.001)during follow-up,respectively.Patients in the LNF group were more satisfied with their quality of life than those in the PPI group(LNF:62.49±28.68 vs PPI:44.36±32.77,P=0.004).Body mass index was significantly lower in the LNF group than in the PPI group(LNF:22.2±3.1kg/m^2 vs PPI:25.1±2.9 kg/m^2,P=0.001).CONCLUSION Diagnosis of LPR should be assessed with oropharyngeal p H-monitoring,manometry,and the symptom-scale.LNF achieves better improvement than PPIs for LPR with type I hiatal hernia. | Chao Zhang Zhi-Wei Hu Chao Yan Qiong Wu Ji-Min Wu Xing Du Dian-Gang Liu Tao Luo Fei Li Zhong-Gao Wang | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 17 | Mapping regional cropping patterns by using GF-1 WFV sensor data显示文摘The successful launched Gaofen satellite no. 1 wide field-of-view(GF-1 WFV) camera is characterized by its high spatial resolution and may provide some potential for regional crop mapping. This study,taking the Bei'an City,Northeast China as the study area,aims to investigate the potential of GF-1 WFV images for crop identification and explore how to fully use its spectral,textural and temporal information to improve classification accuracy. In doing so,an object-based and Random Forest(RF) algorithm was used for crop mapping. The results showed that classification based on an optimized single temporal GF-1 image can achieve an overall accuracy of about 83%,and the addition of textural features can improve the accuracy by 8.14%. Moreover,the multi-temporal GF-1 data can produce a classification map of crops with an overall accuracy of 93.08% and the introduction of textural variables into multi-temporal GF-1 data can only increase the accuracy by about 1%,which suggests the importance of temporal information of GF-1 for crop mapping in comparison with single temporal data. By comparing classification results of GF-1 data with different feature inputs,it is concluded that GF-1 WFV data in general can meet the mapping efficiency and accuracy requirements of regional crop. But given the unique spectral characteristics of the GF-1 WFV imagery,the use of textual and temporal information is needed to yield a satisfactory accuracy. | SONG Qian ZHOU Qing-bo WU Wen-bin HU Qiong LU Miao LIU Shu-bin | 2017 | Journal of Integrative Agriculture2017，16，2： | 12 |
| 18 | The biological content of ballast water in China:A review显示文摘The introduction of species through the release of ballast water has become a major threats to marine biodiversity and ecosystem function worldwide.China is one of the top trading countries,yet little is known about exotic species in the ballast water of ships coming to its ports.Here,we review the biological surveys of ballast water from major Chinese ports.These surveys reveal that 40 species of nonindigenous phytoplankton that,belong to 25 genera and five phyla,have been observed in ballast water.The dominant species are diatoms and dinoflagellates.There were 17 red-tide causing species observed,five of which are noxious algae.Seventeen species of non-indigenous zooplankton have been reported,most of them(11)copepods.There were also 22 species of pathogenic bacteria recorded,including Vibrio alginolyticus,V.carchariae,V.parahaemolyticus,and V.vulnificus.These studies show that species introduction through ballast water potentially a serious threat to the ecology and human health in China.More research,including collaboration with the international community,is urgently needed to address this problem. | Huixian Wu Chen Chen Qiong Wang Junda Lin Junzeng Xue | 2017 | Aquaculture and Fisheries2017，2，6： | 11 |
| 19 | Effects of Machine Tool Configuration on Its Dynamics Based on Orthogonal Experiment Method显示文摘In order to analyze the influence of configuration parameters on dynamic characteristics of machine tools in the working space, the configuration parameters have been suggested based on the orthogonal experiment method. Dynamic analysis of a milling machine, which is newly designed for producing turbine blades, has been conducted by utilizing the modal synthesis method. The finite element model is verified and updated by experimental modal analysis (EMA) of the machine tool. The result gained by modal synthesis method is compared with whole-model finite element method (FEM) result as well. According to the orthogonal experiment method, four configuration parameters of machine tool are considered as four factors for dynamic characteristics. The influence of configuration parameters on the first three natural frequencies is obtained by range analysis. It is pointed out that configuration parameter is the most important factor affecting the fundamental frequency of machine tools, and configuration parameter has less effect on lower-order modes of the system than others. The combination of configuration parameters which makes the fundamental frequency reach the maximum value is provided. Through demonstration, the conclusion can be drawn that the influence of configuration parameters on the natural frequencies of machine tools can be analyzed explicitly by the orthogonal experiment method, which offers a new method for estimating the dynamic characteristics of machine tools. | GAO Xiangsheng ZHANG Yidu ZHANG Hongwei WU Qiong | 2012 | Chinese Journal of Aeronautics2012，25，2： | 11 |
| 20 | Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries显示文摘Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction,but morbidity and mortality of acute myocardial infarction are still high.Reperfusion injuries are inevitable due to the generation of reactive oxygen species(ROS)and apoptosis of cardiac muscle cells.However,many antioxidant and anti-inflammatory drugs are largely limited by pharmacokinetics and route of administration,such as short half-life,low stability,low bioavailability,and side effects for treatment myocardial ischemia reperfusion injury.Therefore,it is necessary to develop effective drugs and technologies to address this issue.Fortunately,nanotherapies have demonstrated great opportunities for treating myocardial ischemia reperfusion injury.Compared with traditional drugs,nanodrugs can effectively increase the therapeutic effect and reduces side effects by improving pharmacokinetic and pharmacodynamic properties due to nanodrugs’size,shape,and material characteristics.In this review,the biology of ROS and molecular mechanisms of myocardial ischemia reperfusion injury are discussed.Furthermore,we summarized the applications of ROS-based nanoparticles,highlighting the latest achievements of nanotechnology researches for the treatment of myocardial ischemia reperfusion injury. | Tianjiao Zhao Wei Wu Lihua Sui Qiong Huang Yayun Nan Jianhua Liu Kelong Ai | 2022 | Bioactive Materials2022，7，1： | 11 |
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