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| 1 | Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis显示文摘Diabetic osteoporosis(DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1(HO-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that HO-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or HO-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and HO-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment. | Yiqi Yang Yixuan Lin Minqi Wang Kai Yuan Qishan Wang Pei Mu Jingke Du Zhifeng Yu Shengbing Yang Kai Huang Yugang Wang Hanjun Li Tingting Tang | 2022 | Bone Research2022，10，3： | 19 |
| 2 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 3 | Extraction and back-extraction behaviors of 14 rare earth elements from sulfuric acid medium by TODGA显示文摘The unique physical and chemical properties of rare earth elements lay the foundation for their extensive application. N,N,N',N' Tetra-octyl-3-oxopentanediamide(TODGA) is excellent in its ability of extracting rare earth elements and it is favored for green initiative. In this paper, the extraction and back-extraction of14 rare earth elements by TODGA were studied. Experiments show that in conditions of 6 mol/L sulfuric acid, the extraction temperature of 25 ℃,the phase ratio of 1:1 and 0.04 mol/LTODGA(aviation kerosene as the diluent), the extraction rates of 14 rare earth elements including lanthanum, cerium, praseodymium,neodymium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, and yttrium were 99.00%-99.73%. Mixed with hydrochloric acid and nitric acid(HCl 3.5 mol/L, HNO_30.5 mol/L), the recoveries of the 14 rare earth elements are 91.52%-99.91% when the extraction temperature is 25 ℃ and the ratio is 1:1. The following application is based on the optimum conditions above with practical samples(from the roasting production line of China North Rare Earth High-tech Company Limited) for extraction and back-extraction experiments. Experiments show that TODGA has excellent enrichment effect on 14 rare earth elements, the extraction rates are 91.36%-99.80%, the back-extraction rates are 87.29%-99.64% and the total recoveries are 81.19%-99.44%. | Huiting Yuan Weixiang Hong Yushan Zhou Baisong Pu Aijun Gong Tao Xu Qishan Yang Fukai Li Lina Qiu Weiwei Zhang Yuning Liu | 2018 | Journal of Rare Earths2018，36，6： | 4 |
| 4 | EVOLUTION OF STATISTICAL DISTRIBUTION OF PIT GEOMETRIC PARAMETERS UNDER FATIGUE LOADING显示文摘The pits and pit-associated fatigue crack initiation of the offshore structure steel A537cLlhave been investigated under salt water spray condition.The tests were interrupted on sched-ule to make plastic replica of corroded specimen surface on which many randomly distributedpits can be found.The development of the geometric parameters of pits was obtained and thestatistical distributions of these parameters were determined.Instead of depth,the ratio ofdepth to width is the most dominant parameter in relation to crack initiation.Also,the pittingwas enhanced when low frequency or high stress range was applied and although stress rangehas no effect on the nucleation of pits,it can accelerate the initiation of cracks from pits. | ZHO U Xiangyang KE Wei Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang,ChinaZANG Qishan Institute of Metal Research,Academia Sinica,Shenyang,China ZHOU Xiangyang,Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang 110015,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，11： | 2 |
| 5 | Decomposition reaction kinetics of Baotou RE concentrate with concentrated sulfuric acid at low temperature显示文摘Baotou RE concentrate was decomposed with concentrated sulfuric acid by controlling the roasting temperature below 500°C.Thermogravimetry-differential thermal analysis(TG-DTA) and chemical analytical methods were used to study the thermal decomposition process and the thermal decomposition effect.The Freeman-Carroll method was applied to analyze the TG-DTA curves.The activation energy, reaction order, and reaction frequency factor at different stages were calculated.The Satava method was used to deduce the reaction mechanism and the relative reaction rate during the thermal decomposition process. | WANG Xiuyan LIU Jiemin LI Mei FAN Huili YANG Qishan | 2010 | Rare Metals2010，29，2： | 2 |
| 6 | The estimation method of GPS instrumental biases显示文摘A model of estimating the global positioning system (GPS) instrumental biases and the methods to calculate the relative instrumental biases of satellite and receiver are presented. The calculated results of GPS instrumental biases, the relative instrumental biases of satellite and receiver, and total electron content (TEC) are also shown. Finally, the stability of GPS instrumental biases as well as that of satellite and receiver instrumental biases are evaluated, indicating that they are very stable during a period of two months and a half. | CHANG Qing ZHANG Donghe XIAO Zuo ZHANG Qishan | 2001 | Chinese Science Bulletin2001，46，3： | 2 |
| 7 | Stability on Finite Time interval andTime-Dependent Bifurcation Analysis ofDuffing's Equations显示文摘IntroductionInPhysics,MechanicsandEngineering,ChemistryandLifeScienceetc.,thereealstbfforcationproblemsmodeledbyordinarydials^ialeqttationswithtake-dependentpa-ramoters.IthasbeenshownthatasthebifUrcationparametervariesslowlywiththetimepassingthrought... | Cuncai HUA Qishan LU(School of Science, Beijing University of Aeronautics and Astronautics, Beijing 100083,China) | 1999 | Communications in Nonlinear Science and Numerical Simulation1999，4，4： | 2 |
| 8 | Causes and control of filamentous growth in aerobic granular sludge sequencing batch reactors 显示文摘 | Liu Yu Liu Qishan | 2006 | Biotechnology Advances2006，24，1： | 1 |
| 9 | Multi-objective particle swarm optimization algorithm based on grey relational analysis with entropy weight显示文摘 | Liu H Zhang Qishan Yao Ligang | 2010 | The J of Grey System2010，22，3： | 1 |
| 10 | A NEW KEY MANAGEMENT METHOD FOR AD HOC NETWORKS显示文摘Some security-sensitive fields like military scenarios are the main application areas of ad hoc networks.In those areas,security issues have to be considered seriously for the network.In this paper, a key management method based on the combined public key is proposed for ad hoc networks. Through this method,private and public key pairs can be distributed to nodes of ad hoc networks efficiently.No certificate or other authentic channel is needed while two nodes perform authentication and key agreement protocol.The key management method is especially suitable for ad hoc networks,which has no fixed infrastructure and has constrained resources. | Liu, Chun Liu, Jianwel Zhang, Qishan | 2007 | China Communications2007，4，1： | 1 |
| 11 | Technology research on waterworks sludge for ceramsite显示文摘 | Hi Jun Wang Qishan | 2012 | Advanced Materials Research Vols2012，，383390： | 1 |
| 12 | Removal of organic carbon from wastepaper pulp effluent by lab-scale solar photo-Fenten process 显示文摘 | Xu Meijuan Wang Qishan Hao Yueli | 2007 | Journal of Hazardous Materials2007，148，12： | 1 |
| 13 | Failure analysis of the 304 stainless steel tube in a gas analyzer显示文摘 | Yongde Li Na Xu Xiaofeng Wu Junbo Shi Lili Zhang Mei Zhao Qishan Zang | 2011 | Engineering Failure Analysis2011，，： | 1 |
| 14 | Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma显示文摘 | Qishan Tang Guanwu Li Xiaoning Wei Jun Zhang Jen-Fu Chiu Don Hasenmayer Dianzheng Zhang Hao Zhang | 2013 | Cancer Letters2013，，2： | 1 |
| 15 | Degradation of microcystin-RR by UV radiation in the presence of hydrogen peroxide 显示文摘 | Qiao RuiPing Li Nan Wang QiShan et ol | 2005 | Toxieon2005，45，6： | 1 |
| 16 | Air gap field for PM electric machines显示文摘 | Gu Qishan Gao Hongzhan | 1985 | Electric Machines and Power System1985，，10： | 1 |
| 17 | Coordinated grain boundary deformation governed nanograin annihilation in shear cycling显示文摘Grain growth and shrinkage are essential to the thermal and mechanical stability of nanocrystalline metals,which are assumed to be governed by the coordinated deformation between neighboring grain boundaries(GBs)in the nanosized grains.However,the dynamics of such coordination has rarely been reported,especially in experiments.In this work,we systematically investigate the atomistic mechanism of coordinated GB deformation during grain shrinkage in an Au nanocrystal film through combined stateof-the-art in situ shear testing and atomistic simulations.We demonstrate that an embedded nanograin experiences shrinkage and eventually annihilation during a typical shear loading cycle.The continuous grain shrinkage is accommodated by the coordinated evolution of the surrounding GB network via dislocation-mediated migration,while the final grain annihilation proceeds through the sequential dislocation-annihilation-induced grain rotation and merging of opposite GBs.Both experiments and simulations show that stress distribution and GB structure play important roles in the coordinated deformation of different GBs and control the grain shrinkage/annihilation under shear loading.Our findings establish a mechanistic relation between coordinated GB deformation and grain shrinkage,which reveals a general deformation phenomenon in nanocrystalline metals and enriches our understanding on the atomistic origin of structural stability in nanocrystalline metals under mechanical loading. | Yingbin Chen Qishan Huang Qi Zhu Kexing Song Yanjun Zhou Haofei Zhou Jiangwei Wang | 2021 | Journal of Materials Science & Technology2021，，27： | 1 |
| 18 | G20 Must Look Beyond the Needs Of the Top 20显示文摘After the financial crisis broke out,China was quick to put in place a decisive plan to boost domestic demand,advance eco-nomic restructuring and improve people’s well being.These mea-sures have started to produce results.At present,the Chinese economy still faces severe challenges. | Wang Qishan,Vice Premier of the People’s Republic of China | 2009 | Beijing Review2009，52，14： | 1 |
| 19 | Multi-objective location-routing problem of reverse logistics based on GRA with entropy weight显示文摘 | Hong Liu Wenping Wang Qishan Zhang | 2012 | Grey Systems: Theory and Application2012，，2： | 1 |
| 20 | The fringing effectin PM electrical machines显示文摘 | Gu Qishan Gao Hongzhan | 1986 | Electric Machines and Power Systems1986，，： | 1 |
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