|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 2 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 3 | Genetic diversity of Chinese summer soybean germplasm revealed by SSR markers显示文摘There are abundant soybean germplasm in China. In order to assess genetic diversity of Chinese sum- mer soybean germplasm, 158 Chinese summer soybean ac- cessions from the primary core collection of G. max were used to analyze genetic variation at 67 SSR loci. A total of 460 alleles were detected, in which 414 and 419 alleles oc- curred in the 80 Huanghuai and the 78 Southern summer accessions, respectively. The average number of alleles per locus was 6.9 for all the summer accessions, and 6.2 for both Huanghuai and Southern summer accessions. Marker diver- sity (D) per locus ranged from 0.414 to 0.905 with an average of 0.735 for all the summer accessions, from 0.387 to 0.886 with an average of 0.708 for the Huanghuai summer acces- sions, and from 0.189 to 0.884 with an average of 0.687 for the Southern summer accessions. The Huanghuai and Southern summer germplasm were different in the specific alleles, allelic-frequencies and pairwise genetic similarities. UPGMA cluster analysis based on the similarity data clearly separated the Huanghuai from Southern summer soybean accessions, suggesting that they were different gene pools. The results indicate that Chinese Huanghuai and Southern summer soybean germplasm can be used to enlarge genetic basis for developing elite summer soybean cultivars by ex- changing their germplasm. | XIE Hua1,2, GUAN Rongxia1, CHANG Ruzhen1 & QIU Lijuan1* 1. Institute of Crop Germplasm Resources, Chinese Academy of Agri- cultural Sciences/Key Laboratory of Crop Germplasm & Biotechnol- ogy, Ministry of Agriculture, Beijing 100081, China 2. Beijing Agro-biotechnology Research Center, Beijing 100089, China | 2005 | Chinese Science Bulletin2005，50，6： | 21 |
| 4 | BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders显示文摘Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey embryos. These monkeys showed higher nocturnal locomotion and reduced sleep, which was further exacerbated by a constant light regimen. Physiological circadian disruption was reflected by the markedly dampened and arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient monkeys exhibited anxiety and depression, consistent with their stably elevated blood cortisol, and defective sensory processing in auditory oddball tests found in schizophrenia patients. Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging. Thus, BMAL1 knockout monkeys are potentially useful for studying the physiological consequences of circadian disturbance, and for developing therapies for circadian and psychiatric disorders. | Peiyuan Qiu Jian Jiang Zhen Liu Yijun Cai Tao Huang Yan Wang Qiming Liu Yanhong Nie Fang Liu Jiumu Cheng Qing Li Yun-Chi Tang Mu-ming Poo Qiang Sun Hung-Chun Chang | 2019 | National Science Review2019，6，1： | 21 |
| 5 | Genetic Diversity of Soybean and the Establishment of a Core Collection Focused on Resistance to Soybean Cyst Nematode显示文摘大豆包囊线虫(SCN;Heterodera glycines ) 最重要的害虫之一正在影响大豆生产。SCN 的控制的最好的方法通过抵抗栽培变种的发展。然而,因为很现代的栽培变种没有抵抗到 SCN,有限进步在大豆在中国繁殖被取得了。432 免疫者或高度抵抗的中国就职的分发和显型被调查,一个主要核心集合是被选择是表象的为进一步的分析的样品。用均匀地分布式的简单顺序重复标记,五个选择方法被用于主要核心收集,最佳的方法被选择建立一个核心集合,它由 28 就职组成了。这些包含了在全面抵抗收集在场的 70.8% 突变而产生之遗传的变化。28 就职不同于在 genomic 的抵抗就职铺平的参考,显示中国抵抗就职从已知的抵抗就职是不同的。这个应用核心集合为承担差异调查提供一个合理框架,用为复杂特点的调查并且为新奇特点的发现的遗传变异。 | Yan-Song Ma Wen-Hui Wang Li-Xia Wang Feng-Ming Ma Pei-Wu Wang Ru-Zhen Chang Li-Juan Qiu | 2006 | Journal of Integrative Plant Biology2006，48，6： | 16 |
| 6 | Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenstr(o)m macroglobulinemia显示文摘 | Yi Shuhua Cui Rui Li Zengjun An Gang Qi Junyuan Zou Dehui Zhang Peihong Chen Huishu Wang Jianxiang Chang Hong Qiu Lugui | 2014 | Chinese Medical Journal2014，，12： | 12 |
| 7 | Chloroplast phylogeography of a temperate tree Pteroceltis tatarinowii (Ulmaceae) in China显示文摘提炼 Pteroceltis tatarinowii 格言。(Ulmaceae ) ,在大陆中国的最普遍的适度的华盖树之一,是类 Pteroceltis 的唯一的代表。照亮 biogeographic 和这适度的树种的人口统计的历史,我们执行了叶绿体 DNA 顺序变化(trnS-trnG 和 psbA-trnH ) 的调查在以内并且在代表大多数种类的分布范围的 28 张人口(总共的 284 个个人) 之中。基于识别的 13 haplotypes 的一个总数, P。tatarinowii 被发现到 haplotype 和核苷酸差异令人惊讶地高级的港口(hT= 0.71;T= 2. | Xiao-Hong LI Jian-Wen SHAO Chang LU Xiao-Ping ZHANG Ying-Xiong QIU | 2012 | Journal of Systematics and Evolution2012，50，4： | 11 |
| 8 | Facile synthesis of ultrathin metal-organic framework nanosheets for Lewis acid catalysis显示文摘Ultrathin metalorganic framework (MOF) nanosheets are attracting great interest in catalysis due to their unique and intriguing two-dime nsional (2D) features. Although many progresses have been achieved, it is still highly desirable to develop novel strategies for controllable synthesis of the well-defined ultrathin MOF nanosheets. Herein we report a polyvinylpyrrolidone (PVP)-assisted route to synthesize the ultrathin Ni-MOF nanosheets characteristic of 1.5 nm in thickness, in which PVP is reacted with 2-aminoterephthalic acid (H2BDC-NH2) via formation of C=N bon d, followed by coord inatio n with Ni2+ io ns to form the ultrathi n MOF n anosheets. Impressively, when used in the Kno eve nagel condensation reactions of propane dinitrile with different aldehydes, ultrathin Ni-MOF nanosheets display the significantly enhanced catalytic activity and good stability in respect with the bulk Ni-MOF, mainly owing to the exposed active sites as well as facile mass transfer and diffusion of substrates and products. | Xiaofei Zhang Lin Chang Zhongjie Yang Yanan Shi Chang Long Jianyu Han Binhao Zhang Xueying Qiu Guodong Li Zhiyong Tang | 2019 | Nano Research2019，12，2： | 11 |
| 9 | Assessing the numbers of SNPs needed to establish molecular IDs and characterize the genetic diversityof soybean cultivars derived from Tokachi nagaha显示文摘The development of a core set of SNP molecular markers that could be widely used in soybean genetic research would greatly facilitate research into the genetic diversity of soybean.We conducted an analysis of Tokachi nagaha and 137 of its descendant soybean cultivars using 4044 SNP markers with the goal of determining the appropriate number of single-nucleotide polymorphisms(SNPs)needed to construct unambiguous molecular IDs and characterize genetic diversity based on a genetic distance matrix correlation method.When the number of SNPs was held constant,the number of accession pairs that could be distinguished increased as the polymorphism informative content(PIC)value of the SNPs increased.A core panel of 20 selected SNPs from 11 linkage groups with a mean PIC value of 0.3703 and a range of 0.3640–0.3749 was able to identify almost all of the accession pairs in our study[9445 pairs(99.92%)].The eight accession pairs that could not be identified with this core SNP set all originated from the same province and some of them had the same parental cultivars.The molecular IDs of the 138 accessions were constructed using the core 20 SNPs.It is known that both the number of SNPs and PIC values should be considered when SNPs are selected for use in the analysis of genetic diversity.In this study,when the PIC value was 0.3460,the correlation coefficient between the genetic distance matrices associated with a panel of 200 SNPs and the total population was>0.800,indicating satisfactory correlation.Our high-accuracy,high-resolution core SNP panel for germplasm fingerprinting and our findings about assessing genetic diversity will likely markedly improve the management and utilization efficiency of soybean germplasm resources. | Zhangxiong Liu Jun Li Xuhong Fan Nang Myint Phyu Sin Htwe Shuming Wang Wen Huang Jiyu Yang Lili Xing Lijun Chen Yinghui Li Rongxia Guan Ruzhen Chang Dechun Wang Lijuan Qiu | 2017 | The Crop Journal2017，5，4： | 10 |
| 10 | Study on the Characteristics of the Gas Switch Electrode Erosion显示文摘Gas spark switch is one of the key parts in pulsed power technology.Electrode erosion has great influence on the switch performance and lifetime.In this paper,a field distortion gas switch is selected for the experiment and a great deal of discharging experiments have been conducted in different test conditions.The forming process of etch pit as well as its influencing factors is discussed briefly and surface roughness coefficient(SRC) of the electrode is put forward to evaluate the state of electrode erosion.Experimental results show that current peak plays an important role in electrode erosion when waveforms of discharge current are the same,and electric charge and oscillation frequency of discharge current also have great effect on the electrode erosion when waveforms of discharge current are different.With the increase of discharge times,SRC decreases slowly at first and then decreases quickly after three thousand of discharge times. | WANG Hu CHANG Jia-sen TONG Xin ZHANG Qiao-gen QIU Ai-ci | 2011 | 高压电器2011，47，9： | 10 |
| 11 | An Innovative Process for Direct Reduction of Cold bound Pellets from Iron Concentrate with a Coal-based Rotary Kiln显示文摘Successfully developed an innovative process of direct reduction of cold bound pellets from iron ore concentrate with a coal based rotary kiln, in comparison with the traditional direct reduction of fired oxide pellets in coal based rotary kilns , possesses such advantages as: shorter flowsheet, lower capital investment, greater economic profit, good quality of direct reduced iron. The key technologies , such as the composite binder and corresponding feasible techniques were employed in practice. A mill utilizing this process and with an annual capacity of 50 thousand ton DRI has been put into operation. | ZHU De qing QIU Guan zhou JIANG Tao XU Jin chang | 2000 | Journal of Central South University2000，12，2： | 10 |
| 12 | Metal oxide and hydroxide nanoarrays: Hydrothermal synthesis and applications as supercapacitors and nanocatalysts显示文摘The development of nanotechnology in recent decades has brought new opportunities in the exploration of new materials for solving the issues of fossil fuel consumption and environment pollution.Materials with nano-array architecture are emerging as the key due to their structure advantages,which offer the possibility to fabricate high-performance electrochemical electrodes and catalysts for both energy storage and effcient use of energy.The main challenges in this feld remain as rational structure design and corresponding controllable synthesis.This article reviews recent progress in our laboratory related to the hydrothermal synthesis of metal oxide and hydroxide nanoarrays,whose structures are designed aiming to the application on supercapacitors and catalysts.The strategies for developing advanced materials of metal oxide and hydroxide nanoarrays,including NiO,Ni(OH)2,Co3O4,Co3O4@Ni–Co–O,cobalt carbonate hydroxide array,and mixed metal oxide arrays like Co3 xFex O4and Znx Co3 xO4,are discussed.The different kinds of structure designs such as 1D nanorod,2D nanowall and hierarchical arrays were involved to meet the needs of the high performance materials.Finally,the future trends and perspectives in the development of advanced nanoarrays materials are highlighted. | Qiu Yang Zhiyi Lu Junfeng Liu Xiaodong Lei Zheng Chang Liang Luo Xiaoming Sun | 2013 | Progress in Natural Science:Materials International2013，23，4： | 9 |
| 13 | 阀芯形状对套筒式调节阀内空化流动的影响研究(英文)显示文摘目的:套筒式调节阀内空化的发生不仅会增加整个管路系统的能量损耗,而且会造成阀体及管路的失效破坏。本文旨在探讨四种不同形状的阀芯对套筒式调节阀内不同阀芯位移工况下的空化流动及空化强度的影响,为套筒式调节阀的优化设计及空化控制提出建议。创新点:1.根据四种不同形状的阀芯,研究套筒式调节阀内阀芯形状对流动及空化特性的影响;2.建立数值模型,对套筒式调节阀在不同阀芯形状和不同阀芯位移条件下进行流动及空化分析。方法:1.建立带有不同形状阀芯的套筒式调节阀数值计算模型,并比较分析阀芯形状对阀内速度、压力及空化情况的影响(图4,8和11);2.建立不同阀芯位移条件下的阀门数值模型,比较分析阀芯位移对阀内速度、压力及空化情况的影响(图6和10);3.建立不同形状阀芯及不同阀芯位移下的阀门模型,分析阀芯形状和位移对阀内流动及空化特性的综合影响(图7和13)。结论:1.在四种不同形状阀芯的条件下,高速流动区域和空化发生区主要位于套筒与阀芯之间的间隙;2.在直筒形和椭球形阀芯条件下的阀内空化强度明显强于平底形和圆台形阀芯条件下的空化强度,因此平底形和圆台形阀芯在空化控制方面具有更好的效果;3.在四种不同形状阀芯的条件下,随着阀芯位移的增加,阀内由空化产生的蒸汽总体积先增加后减少。 | Zhi-jiang JIN Chang QIU Cheng-hang JIANG Jia-yi WU Jin-yuan QIAN | 2020 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2020，21，1： | 9 |
| 14 | Synthesis and Degradation of the Major Allergens in Developing and Germinating Soybean Seed显示文摘Gly m Bd 28K,Gly m Bd 30K and Gly m Bd 60K are the major soybean(Glycine max(L.)Merr.)allergens limiting the consumption of a good protein source for sensitive individuals.However,little is known about their temporal-spatial expression during seed development and upon germination.The present data shows that soy allergens accumulated in both the embryonic axes and cotyledon,but expression patterns differed depending on the specific allergen.Allergens accumulated sooner and to a greater level in cotyledons than in embryonic axes.Gly m Bd 28 began at 14 d after flowering,7 to 14 d earlier than Gly m Bd 30K and Gly m Bd 60K.Comparatively,their degradation was faster and more profound in embryonic axes than in cotyledons.Gly m Bd 60K began to decline at 36 h after imbibition and remained detectable up to 108 h in cotyledons.In contrast,the Glym Bd 60K protein was reduced at 24 h,and eventually disappeared at 96 h.In cotyledons Gly m Bd 28K first declined at 24 h,then increased from 36 h to 48 h,followed by its large reduction at 72 h after seed germination.These findings provide useful information on soy allergen biosynthesis and will help move forward towards developing a hypoallergenic soybean for safer food. | Yong-Mei Wu Rong-Xia Guan Zhang-Xiong Liu Run-Zhi Li Ru-Zhen Chang Li-Juan Qiu | 2012 | Journal of Integrative Plant Biology2012，54，1： | 9 |
| 15 | β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation显示文摘AIM:To explore the potential of β-elemene as a radiosensitizer for gastric cancer cells and the underlying mechanisms.METHODS:SGC7901,MKN45,MKN28,N87,and AGS human gastric cancer cell lines were used to screen for radioresistant gastric cancer cell lines. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium(MTT) assay was used to determine the effects of β-elemene and IPA-3 on cell viability in MKN45 and SGC7901 gastric cancer cell lines. A clonogenic survival assay and annexin V-FITC/PI apoptosis detection assay were used to evaluate cellular radiosensitivity and radiation-induced cell death,respectively. A proteomic method,isobaric tags for relative and absolute quantitation(i TRAQ),was employed to screen the proteins regulated by β-elemene pretreatment prior to ionizing radiation(IR) in SGC7901 gastric cancer cell line. IPA-3 was used as a specific small molecule inhibitor of p21-activated protein kinase 1(Pak1) to target Pak1 signaling. Protein levels of PAK1IP1(p21-activated protein kinase-interacting protein 1),total Pak1(t-Pak1),phospho-Pak1(T423),phospho-ERK1/2( Thr202/Tyr204),and cleaved caspase-3(17 k Da) were assessed by western blotting.RESULTS:MKN45 and SGC7901 gastric cancer cell lines were relatively more resistant to IR. β-elemene pretreatment decreased clonogenic survival following IR in MKN45 and SGC7901 gastric cancer cell lines. Additionally,β-elemene pretreatment prior to IR increased radiation-induced cell death compared with IR alone in MKN45(10.4% ± 0.9% vs 34.8% ± 2.8%,P < 0.05) and SGC7901(11.6% ± 0.9% vs 46.7% ± 5.2%,P < 0.05) human gastric cancer cell lines,respectively,consistent with the level of cleaved caspase-3(17 k Da). Through i TRAQ analysis and western blot validation,we found that β-elemene upregulated PAK1IP1 and downregulated phospho-Pak1(T423) and phosphoERK1/2 in SGC7901 gastric cancer cells. IR increased the level of phospho-Pak1(T423). Pretreatment with β-elemene decreased radiation-induced Pak1 and ERK1/2 phosphorylation. Inhibition of Pak1 using IPA-3 decreased clonogenic survival following IR. In addition,IPA-3 increased radiation-induced cell death in MKN45(13.4% ± 0.3% vs 26.6% ± 1.0%,P < 0.05) and SGC7901(16.0% ± 0.6% vs 37.3% ± 1.7%,P < 0.05) gastric cancer cell lines,respectively,consistent with the level of cleaved caspase-3(17 k Da). Western blotting showed that IPA-3 decreased radiation-induced Pak1 and ERK1/2 phosphorylation.CONCLUSION:This is the first demonstration that β-elemene enhances radiosensitivity of gastric cancer cells,and that the mechanism involves inhibition of Pak1 signaling. | Jun-Song Liu Xiang-Ming Che Shuai Chang Guang-Lin Qiu Shi-Cai He Lin Fan Wei Zhao Zheng-Liang Zhang Shu-Feng Wang | 2015 | World Journal of Gastroenterology2015，21，34： | 9 |
| 16 | Closure temperature of(U-Th)/He system in apatite obtained from natural drillhole samples in the Tarim basin and its geological significance显示文摘The apatite(U-Th)/He thermochronometry has been used to study the tectono-thermal evolution of mountains and sedimentary basins for over ten years.The closure temperature of helium is important for the apatite(U-Th)/He thermochronometry and has been widely studied by thermal simulation experiments.In this paper,the apatite He closure temperature was studied by establishing the evolutionary pattern between apatite He ages and apatite burial depth based on examined apatite He ages of natural samples obtained from drillholes in the Tarim basin,China.The study showed that the apatite He closure temperature of natural samples in the Tarim basin is approximately 88±5℃,higher than the result(~75℃) obtained from the thermal simulation experiments.The high He closure temperature resulted from high effective uranium concentration,long-term radiation damage accumulation,and sufficient particle radii.This study is a reevaluation of the conventional apatite He closure temperature and has a great significance in studying the uplifting events in the late period of the basin-mountain tectonic evolution,of which the uplifting time and rates can be determined accurately. | CHANG Jian QIU NanSheng | 2012 | Chinese Science Bulletin2012，57，26： | 8 |
| 17 | Development and utilization of a new chemically-induced soybean library with a high mutation density显示文摘Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate(EMS)-induced soybean(Glycine max) population,consisting of 21,600 independent M_2 lines, was developed.Over 1,000 M_(4(5))families, with diverse abnormal phenotypes for seed composition, seed shape, plant morphology and maturity that are stably expressed across different environments and generations were identified. Phenotypic analysis of the population led to the identification of a yellow pigmentation mutant, gyl, that displayed significantly decreased chlorophyll(Chl) content and abnormal chloroplast development. Sequence analysis showed that gyl is allelic to Minn Gold, where a different single nucleotide polymorphism variation in the Mg-chelatase subunit gene(ChlI1a) results in golden yellow leaves. A cleaved amplified polymorphic sequence marker was developed and may be applied to marker-assisted selection for the golden yellow phenotype in soybean breeding. We show that the newly developed soybean EMS mutant population has potential for functional genomics research and genetic improvement in soybean. | Zhongfeng Li Lingxue Jiang Yansong Ma Zhongyan Wei Huilong Hong Zhangxiong Liu Jinhui Lei Ying Liu Rongxia Guan Yong Guo Longguo Jin Lijuan Zhang Yinghui Li Yulong Ren Wei He Ming Liu Nang Myint Phyu Sin Htwe Lin Liu Bingfu Guo Jian Song Bing Tan Guifeng Liu Maiquan Li Xianli Zhang Bo Liu Xuehui Shi Sining Han Sunan Hua Fulai Zhou Lili Yu Yanfei Li Shuang Wang Jun Wang Ruzhen Chang Lijuan Qiu | 2017 | Journal of Integrative Plant Biology2017，59，1： | 6 |
| 18 | Drainage does not Promote Post-operative Rehabilitation After Bilateral Total Knee Arthroplasties Compared With Nondrainage显示文摘Objective To assess the effects of suction drainage versus nondrainage on the post-operative rehabilitation of patients receiving primary bilateral total knee arthroplasties(TKA).Methods A prospective study including 40 patients was conducted.These patients were diagnosed with osteoarthritis and underwent primary bilateral TKA between October 2007 and September 2009 with the same operation team.A suction drainage was placed by randomization in only one knee for each patient,while the other knee as self-control.Pain visual analogue scale score,extremity swelling,wound healing,range of motion and incidence of early post-operative complications between the drained and nondrained group were compared statistically.Results Each patient was followed up for 12 months.Placing drainage did not relieve the pain,extremity swelling,ecchymosis,or reduce the incidence of early complications(all P>0.05).Conclusions Suction drainage in TKA does not exhibit substantial advantages in promoting post-operative rehabilitation after unsophisticated TKA,compared with nondrainage.On the other hand,it might complicate the surgical operation,and increase the incidence of post-operative hemorrhage and retrograde infection.Thus we do not recommend suction drainage in unsophisticated TKA. | Yu Fan Yong Liu Jin Lin Xiao Chang Wei Wang Xi-sheng Weng Gui-xing Qiu | 2013 | Chinese Medical Sciences Journal2013，28，4： | 6 |
| 19 | Development of Soybean EST-SSR Markers and Their Use to Assess Genetic Diversity in the Subgenus Soja显示文摘Developing expressed sequence tag-derived SSR(EST-SSR)markers is imperative in genetic research.In this paper,we reported 37 EST-SSR markers which were developed from 286 unigenes obtained from soybean cDNA library.Among the 286 markers designed for the 4 accessions of Glycine max and 6 of its wild progenitor(G.soja)within the subgenus Soja,209 markers amplified DNA fragments,taking 73.1% and 37 markers appeared to be polymorphic,which was 12.9% of the total.The 37 loci detected a total of 142 alleles,while the PIC values varied from 0.194 to 0.794.Both the number of alleles per locus and PIC value were significantly related to the SSR motif.Six EST-SSR loci may be fixed for different alleles between G.max and G.soja since they were particularly polymorphic among the 6 G.soja accessions.A neighbor-joining tree placed the G.max accessions together as a group within the G.soja,though the average genetic distance among G.soja accessions was much higher.These new EST-SSRs markers will be useful for genetic diversity analysis,genetic mapping construction and gene discovery in Soja subgenus. | LIU Yu-lin LI Ying-hui ZHOU Guo-an Uzokwe N CHANG Ru-zhen CHEN Shou-yi QIU Li-juan | 2010 | Agricultural Sciences in China2010，9，10： | 6 |
| 20 | Recent research advances of self-discharge in supercapacitors:Mechanisms and suppressing strategies显示文摘Supercapacitors are one of the most promising energy storage devices in the fields of vehicle transportation,flexible electronic devices,aerospace,etc.However,the existed self-discharge that is the spontaneous voltage decay after supercapacitors are fully charged,brings about the wide gap between experimental studies and practical utilization of supercapacitors.Although eliminating the selfdischarge completely is not reachable,suppressing the self-discharge rate to the lowest point is possible and feasible.So far,the significant endeavors have been devoted to achieve this goal.Herein,we summary and discuss the possible mechanisms for the self-discharge and the underlying influence factors.Moreover,the strategies to suppress the self-discharge are systemically summed up by three independent but unified aspects:modifying the electrode,modulating the electrolyte and tuning the separator.Finally,the major challenges to suppress the self-discharge of supercapacitors are concluded and the promising strategies are also pointed out and discussed.This review is presented with the view of serving as a guideline to suppress the self-discharge of supercapacitors and to across-the-board facilitate their widespread application. | Kunlun Liu Chang Yu Wei Guo Lin Ni Jinhe Yu Yuanyang Xie Zhao Wang Yongwen Ren Jieshan Qiu | 2021 | Journal of Energy Chemistry2021，30，7： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员