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| 1 | Development and utilization of a new chemically-induced soybean library with a high mutation density显示文摘Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate(EMS)-induced soybean(Glycine max) population,consisting of 21,600 independent M_2 lines, was developed.Over 1,000 M_(4(5))families, with diverse abnormal phenotypes for seed composition, seed shape, plant morphology and maturity that are stably expressed across different environments and generations were identified. Phenotypic analysis of the population led to the identification of a yellow pigmentation mutant, gyl, that displayed significantly decreased chlorophyll(Chl) content and abnormal chloroplast development. Sequence analysis showed that gyl is allelic to Minn Gold, where a different single nucleotide polymorphism variation in the Mg-chelatase subunit gene(ChlI1a) results in golden yellow leaves. A cleaved amplified polymorphic sequence marker was developed and may be applied to marker-assisted selection for the golden yellow phenotype in soybean breeding. We show that the newly developed soybean EMS mutant population has potential for functional genomics research and genetic improvement in soybean. | Zhongfeng Li Lingxue Jiang Yansong Ma Zhongyan Wei Huilong Hong Zhangxiong Liu Jinhui Lei Ying Liu Rongxia Guan Yong Guo Longguo Jin Lijuan Zhang Yinghui Li Yulong Ren Wei He Ming Liu Nang Myint Phyu Sin Htwe Lin Liu Bingfu Guo Jian Song Bing Tan Guifeng Liu Maiquan Li Xianli Zhang Bo Liu Xuehui Shi Sining Han Sunan Hua Fulai Zhou Lili Yu Yanfei Li Shuang Wang Jun Wang Ruzhen Chang Lijuan Qiu | 2017 | Journal of Integrative Plant Biology2017，59，1： | 6 |
| 2 | Ultrahigh-pressure and Retrograde Metamorphic Ages for Paleozoic Protolith of Paragneiss in the Main Drill Hole of the Chinese Continental Scientific Drilling Project(CCSD-MH),SW Sulu UHP Terrane显示文摘激光拉曼光谱学和阴极射线发光(CL ) 想象大多数锆石晶体在在 Maobei 钻工程(CCSD-MH ) 的中国 ContinentalScientific 的主要钻孔与帕拉片麻岩分开了的表演,西南的 Sulu 岩层,包含 low-pressuremineral-bearing 由岩屑形成的核心,忍受 coesite 披风并且忍受石英或矿物质 inclusion-freerims。在锆石产出的这些 zoned 上标明日期三个分离、有意义的年龄组的虾 U-Pb。Thedetrital 核心从 659 ~ 313 妈产出大年龄跨度,显示为分析帕拉片麻岩的 protolith 年龄是古生代的而非原生地。忍受 coesite 披风产出 228 ±的加权平均值年龄为 UHP 事件的 5 妈。忍受石英的最外面的边界产出 213 ±的加权平均值年龄为与在 Sulu UHP 岩层的地区性的闪石外形变态有关的倒退的事件的 6 妈。与在 CCSD-MH 标明日期结果 fromorthogneiss 的以前的虾 U-Pb 结合了, Neoproterozoic 花岗石的 protolith 和 Paleozoicsedimentary 岩石是到披风深度在的潜水艇 ducted,这被建议晚三叠纪。大约 1500 万年以后, Sulu UHP 变质岩被掘出到中间外壳的层次并且由 anamphibole 外形退化变质酌套印了。从 SHRIMP 数据和变形的磅条件推出的发掘率是大约 6.7 km/Ma。如此的快发掘建议 Sulu UHPparagneiss 和正片麻岩作为一个快活的裂片的主导的部分向表面回来了,开作为平板裂缝的后果引起了。 | LIU Fulai XU Zhiqin XUE Huaimin ZHOU Kaifu | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 5 |
| 3 | A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor显示文摘Glucagon-like peptides(GLP-1 and GLP-2)are two proglucagon-derived intestinal hormones that mediate distinct physiological functions through two related receptors(GLP-1R and GLP-2R)which are important drug targets for metabolic disorders and Crohn's disease,respectively.Despite great progress in GLP-1 R structure determination,our understanding on the differences of peptide binding and signal transduction between these two receptors remains elusive.Here we report the electron microscopy structure of the human GLP-2R in complex with GLP-2 and a Gs heterotrimer.To accommodate GLP-2 rather than GLP-1,GLP-2R fine-tunes the conformations of the extracellular parts of transmembrane helices(TMs)1,5,7 and extracellular loop 1(ECL1).In contrast to GLP-1,the N-terminal histidine of GLP-2 penetrates into the receptor core with a unique orientation.The middle region of GLP-2 engages with TM1 and TM7 more extensively than with ECL2,and the GLP-2 C-terminus closely attaches to ECL1,which is the most protruded among 9 class B G protein-coupled receptors(GPCRs).Functional studies revealed that the above three segments of GLP-2 are essential for GLP-2 recognition and receptor activation,especially the middle region.These results provide new insights into the molecular basis of ligand specificity in class B GPCRs and may facilitate the development of more specific therapeutics. | Wen Sun Li-Nan Chen Qingtong Zhou Li-Hua Zhao Dehua Yang Huibing Zhang Zhaotong Cong Dan-Dan Shen Fenghui Zhao Fulai Zhou Xiaoqing Cai Yan Chen Yan Zhou Sarina Gadgaard Wijnand JCvan der Velden Suwen Zhao Yi Jiang Mette MRosenkilde HEric Xu Yan Zhang Ming-Wei Wang | 2020 | Cell Research2020，30，12： | 4 |
| 4 | The Study of The Tight Sandstone Reservoir’s Characteristics and The Fluid Inclusions in Fuyu Oil Layer,Daqing Placanticline显示文摘1 Introduction The exploration and development of unconventional oil and gas is gradually becoming the new hot topic,which is promoted by the increasing demand of oil and gas,as well as the decline in conventional oil and gas production(Jia et al.,2012;Zou et al.,2012).The researches of unconventional oil and gas resources started late in China,while the resources are widely distributed。 | SONG Tushun LIU Li LI Fulai LIU Na ZHOU Bing | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 2 |
| 5 | Molecular basis of ligand recognition and activation of human V2 vasopressin receptor显示文摘Dear Editor,Vasopressin type 2 receptor(V2R)belongs to the vasopressin(VP)/oxytocin(OT)receptor subfamily of G protein-coupled receptors(GPCRs),which comprises at least four closely related receptor subtypes:V1aR,V1bR,V2R,and OTR. | Fulai Zhou Chenyu Ye Xiaomin Ma Wanchao Yin Tristan I.Croll Qingtong Zhou Xinheng He Xiaokang Zhang Dehua Yang Peiyi Wang H.Eric Xu Ming-Wei Wang Yi Jiang | 2021 | Cell Research2021，31，8： | 1 |
| 6 | Discriminating hydrocarbon generation potential of coaly source rocks and their contribution:a case study from the Upper Paleozoic of Bohai Bay Basin,China显示文摘Although various coaly source rocks widely developed in the Carboniferous-Permian(C-P)of the Bohai Bay Basin,their geochemical characteristics and hydrocarbon generation potential are poorly understood.This study aims to discriminate the contribution of hydrocarbon generation from different C-P coaly source rocks and clarify the differences within generated oils using organic geochemistry,organic petrology,and thermal simulation experiments.The coaly source rocks containt coal clarain and durain,carbonaceous shale,and shale deposited in deltaic and lagoonal environment.The results indicated that clarain,durain,and carbonaceous shale exhibited higher hydrogen index and liquid-gas hydrocarbon yields than lagoonal and deltaic shales,which was mainly associated with the concentrations of sporinite,cutinite,and hydrogen-rich collodetrinite.Aliphatic hydro-carbons originated firom coal and carbonaceous shale presented lower Ts/(Ts+Tm),Ga/17α(H)21β(H)-C_(30)hopane,18α(H)-oleanane/17α(H)21β(H)-C_(30)hopane ratios,and higher 17β3(H)21α(H)-C_(30)Morane/17α(H)21β(H)-C_(30)hopane than deltaic lagoonal shales.Parameters of aromatic hydrocarbons generated from five lithologies of coaly source rocks trended as clear group distribution,e.g.,clarain and durain showing lower MNR,DBT/Fluorene(F)ratios and higher DBF/F ratio than coaly shales.The distinct descending trend of hydrocarbon potential is obtained from clarain,durain,carbonaceous shale to lagoonal and deltaic shales,implying dominated the petroleum and natural gas supplement from coal and carbonaceous shale.The difference between aliphatic and aromatic hydrocarbons provides a significant contribution to analyze the generic relationship between coaly source rock and lacustrine shale.Our results illustrate the importance of coaly source rocks for the in-depth oil-gas exploration of the Bohai Bay Basin and understanding hydrocarbon generation potential of source rocks in coal bearing strata. | Jinjun XU Da LOU Qiang JIN Lixin FU Fuqi CHENG Shuhui ZHOU Xiuhong WANG Chao LIANG Fulai LI | 2021 | Frontiers of Earth Science2021，15，4： | 1 |
| 7 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 8 | Metal-Free Synthesis of β-Bromoalkenyl Sulfides via Deoxygenative Bromination/Olefination/Sulfenylation of Ketones with SulfonylHydrazides and Pyridinium Tribromide显示文摘A novel metal-free method for synthesis of β-bromoalkenyl sulfides via deoxygenative bromination/olefination/sulfenylation process usingcommercially available ketones, sulfonyl hydrazides and pyridinium tribromide as starting materials has been developed. In this reaction, pyridiniumtribromide plays the role of oxidant and substrate, wherein water and molecular nitrogen are generated as environmentally benign by-products. Prelimi-nary investigation revealed that vinyl bromides were critical intermediate. Importantly, this protocol not only obviates the use of alkynes and traditionalsulfenylating agents, but also reveals that ketones can be used as precursors of vinyl bromides. | Yishu Bao Lingyu Zhong Qiaodan Hou Qingfa Zhou Fulai Yang | 2018 | Chinese Journal of Chemistry2018，36，11： | 0 |
| 9 | Structural mechanism of calcium-mediated hormone recognition and Gβinteraction by the human melanocortin-1 receptor显示文摘Melanocortins are peptide hormones critical for the regulation of stress response,energy homeostasis,inflammation,and skin pigmentation.Their functions are mediated by five G protein-coupled receptors(MC1R–MC5R),predominately through the stimulatory G protein(Gs).MC1R,the founding member of melanocortin receptors,is mainly expressed in melanocytes and is involved in melanogenesis.Dysfunction of MC1R is associated with the development of melanoma and skin cancer.Here we present three cryo-electron microscopy structures of the MC1R–Gs complexes bound to endogenous hormoneα-MSH,a marketed drug afamelanotide,and a synthetic agonist SHU9119.These structures reveal the orthosteric binding pocket for the conserved HFRW motif among melanocortins and the crucial role of calcium ion in ligand binding.They also demonstrate the basis of differential activities among different ligands.In addition,unexpected interactions between MC1R and the Gβsubunit were discovered from these structures.Together,our results elucidate a conserved mechanism of calcium-mediated ligand recognition,a specific mode of G protein coupling,and a universal activation pathway of melanocortin receptors. | Shanshan Ma Yan Chen Antao Dai Wanchao Yin Jia Guo Dehua Yang Fulai Zhou Yi Jiang Ming-Wei Wang H.Eric Xu | 2021 | Cell Research2021，31，10： | 0 |
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