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| 1 | Effect of hepatocyte apoptosis induced by TNF-α on acute severe hepatitis in mouse models显示文摘AIM To study the effect of hepatocyteapoptosis and necrosis induced by TNF-α on thepathogenesis of acute severe hepatitis(ASH).METHODS The model of ASH was prepared inD-galactosamine(GAIN)sensitized BALB/c miceby injection of either endotoxin(ET)or tumornecrosis factor-α(TNF-α).Morphologicalchanges of apoptotic hepatocytes were studiedby both light and electron microscope and in siteend labeling method(ISEL).Molecular biologicalchanges of DNA ladder were observed byelectrophoresis of extract from liver tissues.Biochemical changes were measured by alanineaminotransferase(ALT),asparticaminotransferase(AST)and TNF-α.The relationbetween apoptosis and necrosis was evaluatedsimultaneously.RESULTS The sequence of hepatocyteapoptosis,necrosis,and final death from ASHwas observed both in GAIN/ET and GAIN/TNF-agroup.Apoptosis was prominent at 3.5 h and 5 hafter injection of inducer,while necrosis becamedominant at 9 h after challenge.The appearanceof apoptosis was earlier in GAIN/TNF-α groupthan that in GAIN/ ET group.Pretreatment ofmice with antiTNF IgG1 may completely preventthe liver injury induced by GalN/ET.CONCLUSION TNF-α can cause liver damageby inducing hepatic apoptosis and necrosis inmice with endotoxemia. | Guo Qing Zang Xia Qiu Zhou Hong Yu Qing Xie Guo Ming Zhao Bin Wang Qing Guo Yue Qin Xiang Dan Liao Department of Infectious Diseases,Rujin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2000 | World Journal of Gastroenterology2000，6，5： | 30 |
| 2 | Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs显示文摘INTRODUCTIONChemotherapyisoneofthemajormethodsintumortreatment,butitoftendoesnotworkduetomultidrugresistance(MDR).Recentstudi... | XIAO Bing, SHI Yong Quan, ZHAO Yan Qiu, YOU Han, WANG Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming | 1998 | World Journal of Gastroenterology1998，4，5： | 24 |
| 3 | NIR-induced highly sensitive detection of latent finger- marks by NaYF4:Yb,Er upconversion nanoparticles in a dry powder state显示文摘通常在犯罪场面发现 fingermarks 的大多数是潜伏的并且,这样为检测潜伏的 fingermarks 的一个有效方法是很重要的。然而,传统的发展中技术有象低察觉敏感,高背景干扰,复杂操作,和高毒性那样的缺点。处理这挑战,我们采用了荧光灯 NaYF 4:Yb,Er upconversion nanoparticles (UCNP ) 它能发荧光可见的光什么时候由 980 nm 使对人安全的在红外线附近的光激动,到污点,各种各样的底层上的潜伏的 fingermarks 出现。 UCNP 成功地被用作一篇小说荧光灯为有包括非渗入的材料(玻璃,大理石,铝合金表,不锈钢表,铝陪衬,和塑料卡片)的各种各样的底层上的高敏感,低背景,高效率,和低毒性的潜伏的 fingermarks 的察觉的标签,渗入半的材料(地板皮革,陶器的瓦,木头地板,和油漆木头),和象报纸的各种各样的类型那样的渗透的材料。这个工作证明 UCNP 是一万用荧光灯为几乎任何东西上的 fingermarks 的灵巧的察觉的标签材料,在法庭的科学启用他们的实际应用。 | Meng Wang Ming Li Mingying Yang Xiaomei Zhang Aoyang Yu Ye Zhu Penghe Qiu Chuanbin Mao | 2015 | Nano Research2015，8，6： | 20 |
| 4 | Epidemiological Survey of the Prevalence of Non-fatal Injury among Children Aged 5-14 Years in China显示文摘Objective To determine the prevalence of non-fatal injuries among children aged 5-14 years in China.Methods Data of 21 973 children aged 5-14 years were extracted from the Fourth National Health Service Survey of China carried out between June 15 and July 10,2008.Injury-related indicators included:history of ever having had an injury,and injury frequency,cause,location and severity.Results The overall prevalence of non-fatal injuries among the children in the previous 12 months was 17.0 per 1000 subjects.The leading causes of non-fatal injuries were falls,animal bites,traffic accidents,falling objects and burns.The majority of children sustained only one injury.The main place of injury was at home in 40% and 54% of urban boys and girls,respectively,at school in 48% of rural boys,and at home and at school each in 33% of rural girls.Medical treatment for one day was the main option for 80% of urban boys and girls,84% of rural boys,and 72% of rural girls.Conclusion Nonfatal injuries among children aged 5-14 years are a serious public health concern in China. | HU Ming HU Guo Qing SUN Zhen Qiu HE Xiang | 2012 | Biomedical and Environmental Sciences2012，25，4： | 18 |
| 5 | Transplantation of endothelial progenitor cells transfected with VEGF165 to restore erectile function in diabetic rats显示文摘现在的学习调查了移植 endothelial 祖先细胞(EPC ) 的效果有进有糖尿病的可勃起的机能障碍(编辑) 的老鼠的阴茎海绵体的脉管的 endothelial 生长因素基因(VEGF165 ) 的 transfected。糖尿病的编辑的一个老鼠模型经由 streptozotocin 的 intraperitoneal 注射被构造。在 streptozotocin 治疗以后,预先对待从每三组老鼠的 EPC 被移植进他们的阴茎海绵体。我们的结果,监视的后面的 intracavernosal 压力(ICP ) ,看了在试用组在老鼠之中显著地增加的那 ICP 什么时候在基础条件和电的刺激期间与从在 blank-plasmid 和控制的老鼠的结果相比组织(P < 0.01 为两比较) 。组织学的检查在试用组在老鼠的阴茎海绵体揭示了广泛的 neovascularisation。荧光显微镜学在熬过的试用组移植 EPC 显示了那许多,区分了房间进 endothelial 并且集成于 neovascularisation 的地点。基于这研究的结果,我们断定进有糖尿病的编辑的老鼠的阴茎海绵体的 VEGF165-transfected EPC 的移植恢复可勃起的功能。 | Xin Gou Wei-Yang He Ming-Zhao Xiao Ming Qiu Ming Wang Yuan-Zhong Deng Chao-Dong Liu Zao-Bing Tang lie Li Yong Chen | 2011 | Asian Journal of Andrology2011，13，2： | 17 |
| 6 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 7 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 8 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
| 9 | Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone显示文摘当与口头的 antidiabetic 药(OAD ) 结合了时,很少研究在适当开始胰岛素剂量上给了建议的背景。这研究是与在这是的胰岛素剂量和相关 factors.Methods 之间的不同联合和关系为胰岛素天真的类型 2diabetes 病人调查适当开始胰岛素剂量一使随机化,开标签,指向学习的对待。目标是两 fasting 血浆葡萄糖(FPG ) 和 2 个小时的 20% 减少早餐以后的血葡萄糖(P2hBG ) 。招募的 147 个胰岛素天真的中国病人是分到 3 个组的 randomiy:组 A,病人们收到了胰岛素 monotherapy;组 B,加 metformin 的收到的胰岛素(0.5 g, tid ) 并且组 C,加 metformin 的收到的胰岛素(0.5 g, tid ) 并且 pioglitazone (15 mg, qd ).Results 两个都,得到 FPG 和 P2hBG 的 20% 减小的时间在三个组之中显示出重要差别。时间在组 C 是最短的。胰岛素剂量需要在三个治疗组完成 20% 的葡萄糖减小(0.40 吗? | LIAO Lin YANG Ming QIU Lu-lu MOU Ya-ru ZHAO Jia-jun DONG Jian-jun | 2010 | Chinese Medical Journal2010，，24： | 11 |
| 10 | Studies on the evolution process of rockbursts in deep tunnels显示文摘This paper focuses on the evolution processes of different types of rockbursts occurring in deep tunnels. A series of laboratory tests and in-situ monitoring in deep tunnels excavated by tunnel boring machine (TBM) and drill-and-blast (D&B) method have been conducted to understand the mechanisms and processes of the evolution of different types of rockbursts, including strain rockburst, strain-structure slip rockburst, immediate rockburst and time-delayed rockburst. Three different risk assessment methods are proposed to evaluate the intensity and potential failure depth of rockbursts. These methods can be applied before excavation and the results can be updated according to the real-time information during excavation. Two micro-seismicity based real-time warning systems have been established for predicting various intensities of rockbursts, such as slight, moderate, intensive and extremely intensive rockbursts. Meanwhile, the probability and intensity of the rockburst are also given. The strategy for excavation and support design has been suggested for various intensities of rockbursts before excavation. The strategy for dynamic control of the rockburst evolution process is also proposed according to the monitoring results. The methodology has been successfully applied to rockburst risk reduction for deep tunnels at Jinping II hydropower project. The results have illustrated the applicability of the proposed methodology and techniques concerning rockbursts. | Xiating Feng Bingrui Chen Shaojun Li Chuanqing Zhang Yaxun Xiao Guangliang Feng Hui Zhou Shili Qiu Zhouneng Zhao Yang Yu Dongfang Chen Huajun Ming | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，4： | 11 |
| 11 | A Facile Synthetic Route to L-Phosphinothricin显示文摘A convenient and effective method for synthesis of L-phosphinothricin was described.The highlight was involved in a simple access to the key intermediate L-2-amino-4-chlorobutyricacid derivative from the inexpensive L-methionine. | Xue Song XU Han Bing TENG Guo Fu QIU Shu Cai LIANG Xian Ming HU | 2006 | Chinese Chemical Letters2006，17，2： | 9 |
| 12 | Characteristics of the lower layer of sandstorms in the Minqin desert-oasis zone显示文摘By measuring the sand-dust flux,vertical deposition,and the wind velocity throughout 19 sandstorms in the Minqin region,we quantitatively analyzed the horizontal distribution and vertical variation in sandstorm characteristics under different land cover conditions.The effect of different land cover on mitigating sandstorms was also investigated.The results indicated that,in the surface layer ranging from 0-50 m,the intensity of sand-dust horizontal flux and concentration of sand-dust decreased with the increase of the height in the desert and the edge of oasis,whereas the two physical quantities increased slightly with the increase of the height in the oasis.The two physical quantities obey power function well under all three cover conditions.Moreover,in the desert and at the edge of oasis,the sand-dust vertical deposition decreased with the increase of the height.But a partial unimodal distribution at the oasis site and the maximum deposition occurred at the height of 9 m,which corresponds to the middle height of farmland protection forest.The annual flux that passed through a section of 1 m in width and 50 m in height was 9169 kg in the desert,5318 kg at the edge of oasis,and 2345 kg in the oasis.And the annual fluxes at the edge of oasis and in the oasis are 42% and 74% less,respectively,than that in the desert.This implies that the wind break forest significantly reduced the intensity of sandstorms. | ZHAO Ming ZHAN KeJie YANG ZiHui FANG ErTian QIU GuoYu WANG QiangQiang ZHANG YinChang GUO ShuJiang LI AiDe ZHANG JingChun | 2011 | Science China Earth Sciences2011，54，5： | 8 |
| 13 | Investigation on MoS_2 and Graphite Coatings and Their Effects on the Tribological Properties of the Radial Spherical Plain Bearings显示文摘With constant enlargement of the application areas of the spherical plain bearings,higher quality lubrication of the bearings is required.To solve the lubricating problems of spherical plain bearings under high temperature,high vacuum,high speed,heavy loads and strong oxidation conditions,it is urgent for us to develop more excellent self-lubricating technologies.In this paper,the bonded solid lubricant coatings,which use inorganic phosphate as the binder,the mixture of MoS_2 and graphite with two different weight proportions as the solid lubricant,are prepared by spraying under three different spray gun pressures.The bonding strength tests on the coatings show that the best spraying pressure is 0.2 MPa and the better mixing proportion of MoS_2 to Graphite is 3:1.Then for the radial spherical plain bearings with steel/steel friction pair,after the coatings are made on the inner ring outer surfaces,the friction coefficient,the wear loss and the friction temperature of the bearings under four oscillating frequencies are investigated by a self-made tribo-tester.The test results,SEM of the worn morphologies and EDS of worn areas show that tribological properties of the bearing are obviously improved by the bonded solid lubricant coatings.When sprayed under the spray gun pressure of 0.2 MPa,the bearings have better anti-friction and anti-wear properties than those sprayed under 0.1 MPa and 0.3 MPa.Further as proved from the XPS analysis,between the coating with 3:1 mixing ratio of MoS_2 to Graphite and the coating with 1:1 ratio,the former has less oxidation occurred on the surface and therefore has better tribological characteristics than the latter.This paper provides a reference to developing a new product of the radial spherical plain bearings with high bonding strength,oxidation resistance and abrasion resistance. | QIU Ming LU Jianjun LI Yingchun LV Guisen | 2016 | Chinese Journal of Mechanical Engineering2016，29，4： | 8 |
| 14 | Effect of Topography and Accessibility on Vegetation Dynamic Pattern in Mountain-hill Region显示文摘Knowledge of both vegetation distribution pattern and phenology changes is very important.Their complicated relationship with elevation and accessibility were explored through a geographically weighted regression(GWR) framework in Fujian province,China.The 16-day time series of 250 m Moderate Resolution Imaging Spectroradiometer(MODIS) Enhanced Vegetation Index(EVI) dataset from 2000 to 2010 was applied.Wavelet transform method was adopted to decompose the original time series and construct the annual maximum EVI and amplitude of the annual phenological cycle(EVI).Candidate explaining factors included topographic conditions,accessibility variables and proportions of primary vegetation types.Results revealed very strong positive influence from parameters of elevation and accessibility to big rivers and negative effect from accessibility to resident on both maximum EVI and phenological magnitude through ordinary linear least square(OLS) regression analysis.GWR analysis revealed that spatially,the parameters of topography and accessibility had a very complex relationship with both maximum EVI and phenology magnitude,as a result of the various combinations of environmental factors,vegetation composition and also intensive anthropogenic impact.Apart from the continuously increasing trend of phenology magnitude with increasing altitude,the influence of topography and accessibility on maximum EVI and phenological magnitude generally decreased,even from strongly positive to negative,with increasing altitude or distance.Specially,the most rapid change of correlation coefficient between them was observed within a low elevation or close distance;less variation was discovered within a certain range of medium altitude or distance and their relationship might change above this range.Non-stationary approaches are needed to better characterize the complex vegetation dynamic pattern in Mountain-hill Region. | QIU Bingwen ZHONG Ming ZENG Canying TANG Zhenghong CHEN Chongcheng | 2012 | Journal of Mountain Science2012，9，6： | 8 |
| 15 | Evidence-based appraisal in laparoscopic Nissen and Toupet fundoplications for gastroesophageal reflux disease显示文摘AIM: To demonstrate the optimal surgical procedure for gastroesophageal reflux disease. METHODS: The electronic databases of Medline, Elsevier, Springerlink and Embase over the last 16 years were searched. All clinical trials involved in the outcomes of laparoscopic Nissen fundoplication (LNF) and laparoscopic Toupet fundoplication (LTF) were identified. The data of assessment in benefits and adverse results of LNF and LTF were extracted and compared using metaanalysis. RESULTS: We ultimately identified a total of 32 references reporting nine randomized controlled trials, eight prospective cohort trials and 15 retrospective trials. These studies reported a total of 6236 patients, of whom 4252 (68.18%) underwent LNF and 1984 (31.82%) underwent LTF. There were no differences between LNF and LTF in patients' satisfaction, perioperative complications, postoperative heartburn, refluxrecurrence and reoperation. Both LNF and LTF enhanced the function of lower esophageal sphincter and improved esophagitis. The postoperative dysphagia, gasbloating syndrome, inability to belch and the need for dilatation after LNF were more common than after LTF. Subgroup analyses showed that dysphagia after LNF and LTF was similar in patients with normal esophageal peristalsis (EP), but occurred more frequently in patients with weak EP after LNF than after LTF. Furthermore, patients with normal EP after LNF still had a higher risk of developing dysphagia than did patients with abnormal EP after LTF.CONCLUSION: Compared with LNF, LTF offers equivalent symptom relief and reduces adverse results. | Shan, Cheng-Xiang Zhang, Wei Zheng, Xiang-Min Jiang, Dao-Zhen Liu, Sheng Qiu, Ming | 2010 | World Journal of Gastroenterology2010，16，24： | 8 |
| 16 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 17 | Enhanced tolerance to drought in transgenic rice plants overexpressing C_4 photosynthesis enzymes显示文摘Maize-specific pyruvate orthophosphate dikinase(PPDK) was overexpressed in rice independently or in combination with the maize C4-specific phosphoenolpyruvate carboxylase(PCK). The wild-type(WT) cultivar Kitaake and transgenic plants were evaluated in independent field and tank experiments. Three soil moisture treatments,well-watered(WW), moderate drought(MD) and severe drought(SD), were imposed from 9d post-anthesis till maturity. Leaf physiological and biochemical traits, root activities,biomass, grain yield, and yield components in the untransformed WT and two transgenic rice lines(PPDK and PCK) were systematically studied. Compared with the WT, both transgenic rice lines showed increased leaf photosynthetic rate: by 20%–40% under WW, by45%–60% under MD, and by 80%–120% under SD. The transgenic plants produced 16.1%,20.2% and 20.0% higher grain yields than WT under the WW, MD and SD treatments,respectively. Under the same soil moisture treatments, activities of phosphoenolpyruvate carboxylase(PEPC) and carbonic anhydrase(CA) in transgenic plants were 3–5-fold higher than those in WT plants. Compared with ribulose-1,5-bisphosphate carboxylase, activities of PEPC and CA were less reduced under both MD and SD treatments. The transgenic plants also showed higher leaf water content, stomatal conductance, transpiration efficiency, and root oxidation activity and a stronger active oxygen scavenging system than the WT under all soil moisture treatments, especially MD and SD. The results suggest that drought tolerance is greatly enhanced in transgenic rice plants overexpressing C4photosynthesis enzymes. This study was performed under natural conditions and normal planting density to evaluate yield advantages on a field basis. It may open a new avenue to droughttolerance breeding via overexpression of C4enzymes in rice. | Jun-Fei Gu Ming Qiu Jian-Chang Yang | 2013 | The Crop Journal2013，1，2： | 7 |
| 18 | Comparative study of on-pump and off-pump coronary bypass surgery for patients with triple coronary artery disease显示文摘Objective To compare the clinical results of on-pump and off-pump coronary bypass surgery in patients with triple-vessel disease. Methods A total of 300 consecutive isolated multiple CABG patients entered into off-pump coronary artery bypass (OPCAB group, n=150) or CABG with cardiopulmonary bypass (CPB) (CCABG group, n=150). There were no significant difference regarding the degree of angina, history of myocardial infarction, diabetes and left main disease between two groups. The ejection fraction in OPCAB before surgery was lower than CCABG (P<0.01). More patients had a history of stroke, and abnormal renal function in OPCAB pre-operatively( P< 0.01 ). Single deep pericardial stay suture with a sling snared down was used to expose the target vessels in OPCAB, along with a stabilizer and a coronary shunt. Medi-Stim Butterfly Flowmeter was used to measure the flow of grafts in both groups. Results No one in OPCAB needed to convert to CCABG. The number of the distal anastomosis and the index of completeness of revisualization (ICR) were similar in both groups. The respiratory support time, the volume of chest tube drainage and blood transfusion were less in OPCAB than in CCABG post-operatively (both P<0.01). The incidence of pulmonary dysfunction and renal insufficiency were less in OPCAB than in CCABG post-operatively ( both P<0.05 ) . There was no significant difference in the mortality and other morbidities (peri-opetative MI, stroke, atrial fibrillation). Conclusion OPCAB can be applied to patients with triple vessels disease and achieved similar completeness of revascularization, similar early surgical results with shorter respiratory support, reduced transfusion requirement, less pulmonary dysfunction and abnormal renal function. | CHEN Xin, XU Ming, SHI Hong-wei, MU Xin-wei, CHEN Zhen-qiang, QIU Zhi-bing Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing Heart Institute, Nanjing, 210006 P.R.China | 2004 | 介入放射学杂志2004，13，S2： | 7 |
| 19 | Alcohol Drinking, Dyslipidemia, and Diabetes: A Population-based Prospective Cohort Study among Inner Mongolians in China显示文摘Objective No previous studies have evaluated the association between dyslipidemia,alcohol drinking,and diabetes in an Inner Mongolian population.We aimed to evaluate the co-effects of drinking and dyslipidemia on diabetes incidence in this population.Methods The present study was based on 1880 participants from a population-based prospective cohort study among Inner Mongolians living in China.Participants were classified into four subgroups according to their drinking status and dyslipidemia.Multivariate logistic regression analysis and receiver operating characteristic(ROC) curves were used to evaluate the association between alcohol drinking,dyslipidemia,and diabetes.Results During the follow-up period,203 participants were found to have developed diabetes.The multivariable-adjusted odds ratios(95% confidence interval) for the incidence of non-dyslipidemia/drinkers,dyslipidemia/non-drinkers,and dyslipidemia/drinkers in diabetic patients were 1.40(0.82-2.37),1.73(1.17-2.55),and 2.31(1.38-3.87),respectively,when compared with non-dyslipidemia/non-drinkers.The area under the ROC curve for a model containing dyslipidemia and drinking status along with conventional factors(AUC=0.746) was significantly(P=0.003) larger than the one containing only conventional factors(AUC=0.711).Conclusion The present study showed that dyslipidemia was an independent risk factor for diabetes,and that drinkers with dyslipidemia had the highest risk of diabetes in the Mongolian population.These findings suggest that dyslipidemia and drinking status may be valuable in predicting diabetes incidence. | LIANG Zhu QIU Qiao Yan WU Jia Hui ZHOU Jing Wen XU Tian ZHANG Ming Zhi ZHANG Yong Hong ZHANG Shao Yan | 2016 | Biomedical and Environmental Sciences2016，29，8： | 7 |
| 20 | The gas sensing properties of TiO_2 nanotubes synthesized by hydrothermal method显示文摘在这份报纸, TiO2 nanotubes 被热水的方法在 150 点用 10 mol/L NaOH | Yan Li Wang Shun Tan Jia Wang Zhi Jin Tan Qiu Xia Wu Zheng Jiao Ming Hong Wu | 2011 | Chinese Chemical Letters2011，22，5： | 7 |
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