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| 1 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 2 | Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats显示文摘AIM To investigate the effects of herb-partitioned moxibustion(HPM) on phosphorylation of mitogen-activated extracellular signal-regulated kinase(MEK)1, extracellular signal-regulated kinase(ERK)1/2 and c AMP response element binding protein(CREB) in spinal cord of rats with chronic inflammatory visceral pain(CIVP), and to explore the central mechanism of HPM in treating CIVP.METHODS Male Sprague-Dawley rats were randomized into normal, model, HPM, sham-HPM, MEK-inhibitor and dimethyl sulfoxide(DMSO) groups. The CIVP model was established using an enema mixture of trinitrobenzene sulfonic acid and ethanol. HPM was applied at bilateral Tianshu(ST25) and Qihai(CV6) acupoints in the HPM group, while in the sham-HPM group, moxa cones and herb cakes were only placed on the same points but not ignited. The MEK-inhibitor and DMSO groups received L5-L6 intrathecal injection of U0126 and 30% DMSO, respectively. Abdominal withdrawal reflex(AWR), mechanical withdrawal threshold(MWT) and thermal withdrawal latency(TWL) were applied for the assessment of pain behavior. The colonic tissue was observed under an optical microscope after hematoxylin-eosin staining. Expression of phosphor(p)MEK1, p ERK1/2 and p CREB in rat spinal cord was detected using Western blotting. The levels of MEK, ERK and CREB m RNA in rat spinal cord were detected using real-time polymerase chain reaction. RESULTS Compared with the normal group, the AWR scores were increased significantly(P < 0.01) and the MWT and TWL scores were decreased significantly(P < 0.05) in the model, sham-HPM and DMSO groups. Compared with the model group, the AWR scores were decreased significantly(P < 0.01) and the MWT and TWL scores were increased significantly in the HPM and MEK-inhibitor groups(P < 0.05). Compared with the sham-HPM and DMSO groups, the AWR scores were decreased significantly(P < 0.01) and the MWT and TWL scores were increased significantly(P < 0.05) in the HPM and MEK-inhibitor groups. Compared with the normal group, the expression of p MEK1, p ERK1/2 and p CREB proteins and the levels of MEK, ERK and CREB m RNA in rat spinal cord were increased significantly in the model, sham-HPM and DMSO groups(P < 0.01 or < 0.05). Compared with the model group, the expression of p MEK1, p ERK1/2 and p CREB proteins and the levels of MEK, ERK and CREB m RNA in rat spinal cord were reduced significantly in the HPM and MEK-inhibitor groups(P < 0.01 or < 0.05). Compared with the sham-HPM and DMSO groups, expression of p MEK1, p ERK1/2 and p CREB proteins and the levels of MEK, ERK and CREB m RNA in rat spinal cord were reduced significantly in the HPM and MEK-inhibitor groups(P < 0.01 or < 0.05). CONCLUSION HPM down-regulates protein phosphorylation of MEK1, ERK1/2 and CREB, and m RNA expression of MEK, ERK and CREB, inhibiting activation of the MEK/ERK/CREB signaling pathway in the spinal cord of CIVP rats, which is possibly a critical central mechanism of the analgesic effect of HPM. | Zhi-Yuan Li Yan Huang Yan-Ting Yang Dan Zhang Yan Zhao Jue Hong Jie Liu Li-Jie Wu Cui-Hong Zhang Huan-Gan Wu Ji Zhang Xiao-Peng Ma | 2017 | World Journal of Gastroenterology2017，23，34： | 12 |
| 3 | Herb-partitioned moxibustion alleviates colon injuries in ulcerative colitis rats显示文摘AIM To observe the effect of herb-partitioned moxibustion(HPM) on expression of colonic cytokines in ulcerative colitis(UC) rats.METHODS A UC rat model was established by protein immunization in combination with topical chemical stimulation.Rats in the HPM group(n = 8) received HPM at bilateral Tianshu(ST25) points.The gross injury and pathological scores of the colon were recorded.The expression profile of colonic cytokines was assayed using the protein microarray technique.Specific differential cytokines were selected and verified by ELISA.The corresponding Uni Prot Accessions of the differentially expressed cytokines were retrieved in the Uni Prot database.The pathways involved were analyzed with the help of the KEGG PATHWAY database.The DAVID database was used for functional cluster and pathway analysis.RESULTS HPM improved colon injuries in UC rats,manifested by accelerated repair of ulcers and alleviation of inflammation,and the gross injury and pathological scores both significantly decreased(P < 0.01).Fold change > 1.3 or < 0.77 was taken as the screening standard.There were 77 down-regulated and 9 up-regulated differentially expressed colonic cytokines in the HPM group compared with the model group,and expression of 20 differed significantly(P < 0.05).Twelve of the 20 significantly differentially expressed cytokines [β-catenin,interleukin-1 receptor 6(IL-1 R6),IL-1β,B7-1,nerve growth factor receptor,AMP-activated protein kinase-α1,neuropilin-2,orexin A,adipocyte differentiation-related protein,IL-2,Fas and Fas L] were up-regulated in the model group(n = 3,compared with the normal group) but downregulated in the HPM group(n = 3,compared with the model group).Functional cluster analysis showed that the differentially expressed colonic cytokines in the HPM group regulated apoptosis and protein phosphorylation.KEGG pathway analysis showed that 52 down-regulated and 7 up-regulated differentially expressed colonic cytokines in the HPM group had pathways.The pathways that interacted between the cytokines and their receptors accounted for the largest proportion(28 of the downregulated and 5 of the up-regulated cytokines).CONCLUSION HPM promotes the repair of colon injuries in UC rats,which is related to the regulation of several abnormally expressed cytokines. | Dan Zhang Yan-Bo Ren Kai Wei Jue Hong Yan-Ting Yang Li-Jie Wu Ji Zhang Zheng Shi Huan-Gan Wu Xiao-Peng Ma | 2018 | World Journal of Gastroenterology2018，24，30： | 11 |
| 4 | ERK1/2 Activities Are Dispensable for Oocyte Growth but Are Required for Meiotic Maturation and Pronuclear Formation in Mouse显示文摘Previous studies revealed that extracellular regulated kinase-1 and-2(ERK1/2) cascade plays pivotal roles in regulating oocyte meiotic cell cycle progression. However, most knowledge about the in vivo function of ERK1/2 in mammalian oocytes was indirectly obtained from analyzing the phenotypes of Mos knockout mice. In this study, we knocked out Erk1 and Erk2 in mouse oocytes as early as the primordial follicle stage using the well-characterized Gdf9-Cre mouse model, and for the first time directly investigated the in vivo function of ERK1/2 in mouse oocytes. In this novel mouse model, we observed that ERK1/2 activities in oocyte are dispensable for primordial follicle maintenance,activation and follicle growth. Different from the Mos null oocytes, the ERK1/2-deleted oocytes had well-assembled spindles at metaphase Ⅰ(MⅠ), extruded polar body-1(PB1) with normal sizes, and did not undergo a full parthenogenetic activation characterized for pronuclear formation. However, the ovulated ERK1/2-deleted oocytes had poorly-assembled metaphase Ⅱ(MⅡ) spindles, spontaneously released polar body-2(PB2), and were arrested at another metaphase called metaphase Ⅲ(MⅢ). In addition, ERK1/2 deletion prevented male pronuclear formation after fertilization, and caused female infertility. In conclusion, these results indicate that ERK1/2 activities are required for not only MⅡ-arrest maintenance, but also efficient pronuclear formation in mouse oocytes. | Yin-Li Zhang Xiao-Man Liu Shu-Yan Ji Qian-Qian Sha Jue Zhang Heng-Yu Fan | 2015 | Journal of Genetics and Genomics2015，42，9： | 4 |
| 5 | Modulation Recognition in Maritime Multipath Channels:A Blind Equalization-Aided Deep Learning Approach显示文摘Modulation recognition has been long investigated in the literature,however,the performance could be severely degraded in multipath fading channels especially for high-order Quadrature Amplitude Modulation(QAM)signals.This could be a critical problem in the broadband maritime wireless communications,where various propagation paths with large differences in the time of arrival are very likely to exist.Specifically,multiple paths may stem from the direct path,the reflection paths from the rough sea surface,and the refraction paths from the atmospheric duct,respectively.To address this issue,we propose a novel blind equalization-aided deep learning(DL)approach to recognize QAM signals in the presence of multipath propagation.The proposed approach consists of two modules:A blind equalization module and a subsequent DL network which employs the structure of ResNet.With predefined searching step-sizes for the blind equalization algorithm,which are designed according to the set of modulation formats of interest,the DL network is trained and tested over various multipath channel parameter settings.It is shown that as compared to the conventional DL approaches without equalization,the proposed method can achieve an improvement in the recognition accuracy up to 30%in severe multipath scenarios,especially in the high SNR regime.Moreover,it efficiently reduces the number of training data that is required. | Xuefei Ji Jue Wang Ye Li Qiang Sun Chen Xu | 2020 | China Communications2020，17，3： | 4 |
| 6 | The Essential Spectrum and Banach Reducibility of Operator Weighted Shifts | Jue Xian LI Department of Mathematics,Jilin University,Changchun 130023,P.R.China Department of Mathematics.Liaoning University.Shenyang 110036.P.R.China E-mail:Lixli@263.netYou Qing JI Shan Li SUN Departmerit of Mathematics.Jilin University,Changchun 130023.P.R.China | 2001 | Acta Mathematica Sinica,English Series2001，17，3： | 3 |
| 7 | Cytokinesis and cancer:Polo loves ROCK'n' Rho(A)显示文摘Cytokinesis is the last step of the M (mitosis) phase, yet it is crucial for the faithful division of one cell into two. Cytokinesis failure is often associated with cancer. Cytokinesis can be morphologically divided into four steps: cleavage furrow initiation, cleavage furrow ingression, midbody formation and abscission. Molecular studies have revealed that RhoA as well as its regulators and effectors are important players to ensure a successful cytokinesis. At the same time, Polo-like kinase 1 (Plk1) is an important kinase that can target many substrates and carry out different functions during mitosis, including cytokinesis. Recent studies are beginning to unveil a closer tie between Plk1 and RhoA networks. More specifically, Plk1 phosphorylates the centralspindlin complex Cyk4 and MKLP1/CHO1, thus recruiting RhoA guanine nucleotide-exchange factor (GEF) Ect2 through its phosphopeptide-binding BRCT domains. Ect2 itself can be phosphorylated by Plk1 in vitro. Plk1 can also phosphorylate another GEF MyoGEF to regulate RhoA activity. Once activated, RhoA-GTP will activate downstream effectors, including ROCK1 and ROCK2. ROCK2 is among the proteins that associate with Plk1 Polo-binding domain (PBD) in a large proteomic screen, and Plk1 can phosphorylate ROCK2 in vitro. We review current understandings of the interplay between Plk1, RhoA proteins and other proteins (e.g., NudC, MKLP2, PRC1, CEP55) involved in cytokinesis, with particular emphasis of its clinical implications in cancer. | Jing Li Jue Wang Hong Jiao Ji Liao Xingzhi Xu | 2010 | Journal of Genetics and Genomics2010，37，3： | 3 |
| 8 | Altered relationship between thickness and intrinsic activity amplitude in generalized tonic–clonic seizures显示文摘A thinner cortex has higher potential for binding GABA receptor A which is associated with larger amplitudes of intrinsic brain activity(i BA). However, the relationship between cortical thickness and i BA is unknown in intact and epileptic brains. To this end, we investigated the relationship between cortical thickness measured by highresolution MRI and surface-based i BA derived from resting-state functional MRI in normal controls(n = 82) andpatients with generalized tonic–clonic seizures(GTCS)only(n = 82). We demonstrated that the spatial distribution of cortical thickness negatively correlated with surface-based i BA amplitude at both whole-brain and within independent brain functional networks. In GTCS patients,spatial coupling between thickness and i BA amplitude decreased in the default mode, dorsal attention, and somatomotor networks. In addition, the vertex-wise acrosssubject thickness–i BA amplitude correspondence altered in the frontal and temporal lobes as well as in the precuneus in GTCS patients. The relationship between these two modalities can serve as a brain-based marker for detecting epileptogenic changes. | Wei Liao Jue Wang Ting Xu Zhiqiang Zhang Gong-Jun Ji Qiang Xu Zhengge Wang Fang Yang Xi-Nian Zuo Anqi Qiu Yu-Feng Zang Guangming Lu Huafu Chen | 2016 | Science Bulletin2016，61，24： | 3 |
| 9 | Estimation of rural housing structure and its vulnerability in China显示文摘住所房子的损坏在发生在中国农村区域的地震灾难组成伤亡和财产损失的主要原因。房子的结构为估计农村房子的危险是关键的。然而,目前农村住房结构上的可得到的数据是不完全的,他们的空间规模是不一致的。这份报纸在五结构估计了农村房子的数量和比率,也就是木头,砖,混合、增强的水泥,和其它,为越过中国的 2380 个县。与在 2005 的百分比采样普查数据,四个精确性层次被指定。然后,在农村住房上的文化因素组织的气候,经济发展水平和种族少数的影响,以及附近的空间单位的空间自相关被考虑的地方,一套 down-scaling 模型被建立。基于评价结果,县级的农村住房结构的一个数据库被建立,基于哪个在不同区域的农村房子的危险被澄清。 | GAO Xiaolu JI Jue | 2013 | Journal of Geographical Sciences2013，23，1： | 2 |
| 10 | Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia显示文摘Patients with chronic kidney disease are at high risk of hyperkalemia that is associated with various lifethreatening complications.Treatments primarily rely on orally administered potassium binding agents,along with low curative effects and various side effects.Herein,direct serum potassium uptake was realized via zeolite–heparin-mimicking-polymer hybrid microbeads.The preparation process involved the synthesis of the heparin-mimicking polymer via the in situ cross-linking polymerization of acrylic acid and N-vinylpyrrolidone in polyethersulfone solution,the fabrication of microbeads via zeolite-mixing,electro-spraying and phase-inversion,and the subsequent aqueous-phase modifications based on ion-exchange and metal-leaching.An ultra-high(about 88%)amount of zeolite could be incorporated and well locked inside the polymer matrix.Potassium uptake capability was verified in water,normal saline and human serum,showing high selectivity and fast adsorption.The microbeads exhibited satisfying blood compatibility,negligible hemolysis ratio,prolonged clotting time,inhibited contact activation,and enhanced antifouling property toward serum proteins and cells.The proposed approach toward zeolite–heparin-mimicking-polymer hybrid microbeads provided a cheap,efficient and safe treatment protocol of hyperkalemia for the high-risk patients. | Zhoujun Wang Wei Sun Zhiwei Wei Jianxu Bao Xin Song Yupei Li Haifeng Ji Jue Zhang Chao He Baihai Su Weifeng Zhao Changsheng Zhao | 2021 | Bioactive Materials2021，6，2： | 2 |
| 11 | Clinical Research Progress of Acupuncture-moxibustion for Chronic Urticaria显示文摘To learn the current research status of acupuncture-moxibustion in treating chronic urticaria,the relevant clinical reports indexed by CNKI and VIP databases during 2000 and 2012 were retrieved,and then summarized and analyzed from the aspects of treatment method,acupoint selection,medicine,treatment frequency,and criteria of therapeutic efficacy,for guiding the treatment of chronic urticaria with acupuncture-moxibustion.The results show that acupuncture-moxibustion therapy has stable therapeutic efficacy in treating chronic urticaria with low adverse reaction rate,but the current evaluation criteria are too subjective to quantify. | Ji Jun Zhang Cui-hong Zhang Fu-qing Hong Jue | 2013 | Journal of Acupuncture and Tuina Science2013，11，5： | 2 |
| 12 | The Gut Microbiome and Ferroptosis in MAFLD显示文摘Metabolic-associated fatty liver disease(MAFLD)is a new disease definition,and is proposed to replace the previous name,nonalcoholic fatty liver disease(NAFLD).Globally,MAFLD/NAFLD is the most common liver disease,with an incidence rate ranging from 6%to 35%in adult populations.The pathogenesis of MAFLD/NAFLD is closely related to insulin resistance(IR),and the genetic susceptibility to acquired metabolic stress-associated liver injury.Similarly,the gut microbiota in MAFLD/NAFLD is being revaluated by scientists,as the gut and liver influence each other via the gut-liver axis.Ferroptosis is a novel form of programmed cell death caused by iron-dependent lipid peroxidation.Emerging evidence suggests that ferroptosis has a key role in the pathological progression of MAFLD/NAFLD,and inhibition of ferroptosis may become a novel therapeutic strategy for the treatment of NAFLD.This review focuses on the main mechanisms behind the promotion of MAFLD/NAFLD occurrence and development by the intestinal microbiota and ferroptosis.It outlines new strategies to target the intestinal microbiota and ferroptosis to facilitate future MAFLD/NAFLD therapies. | Jie Ji Liwei Wu Jue Wei Jianye Wu Chuanyong Guo | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 2 |
| 13 | Long‐term outcomes of complete versus incomplete revascularization after drug‐eluting stent implantation in patients with multivessel coronary disease显示文摘 | Zhan Gao Bo Xu Yue‐jin Yang Jin‐qing Yuan Jue Chen Ji‐lin Chen Shu‐bin Qiao Yong‐jian Wu Hong‐bin Yan Run‐lin Gao | 2013 | Intervent2013，，3： | 1 |
| 14 | Transient and long-term effects of bicarbonate on the ANAMMOX process显示文摘 | Ren-Cun Jin Jin-Jin Yu Chun Ma Guang-Feng Yang Jue Zhang Hui Chen Qian-Qian Zhang Yu-Xin Ji Bao-Lan Hu | 2014 | Applied Microbiology and Biotechnology2014，，3： | 1 |
| 15 | A region and data hiding based error concealment scheme for images显示文摘 | Liang Ji | 2001 | IEEE Transactions on Consumer Electronics2001，47，： | 1 |
| 16 | Retrograde Type A Aortic Dissection After Endovascular Stent Graft Placement for Treatment of Type B Dissection显示文摘 | Zhi Hui Dong Wei Guo Fu Yu Qi Wang Da Qiao Guo Xin Xu Yuan Ji Bin Chen Jun Hao Jiang Jue Yang Zhen Yu Shi Ting Zhu Yun Shi | 2009 | Circulation2009，，5： | 1 |
| 17 | Retrograde Type A Aortic Dissection After Endovascular Stent Graft Placement for Treatment of Type B Dissection显示文摘 | Zhi Hui Dong Wei Guo Fu Yu Qi Wang Da Qiao Guo Xin Xu Yuan Ji Bin Chen Jun Hao Jiang Jue Yang Zhen Yu Shi Ting Zhu Yun Shi | 2009 | Circulation2009，，5： | 1 |
| 18 | Association between a COMT polymorphism and clinical response to risperidone treatment: a pharmacogenetic study显示文摘 | Qing-Zhu Zhao Bao-Cheng Liu Jing Zhang Lei Wang Xing-Wang Li Yang Wang Jue Ji Feng-Ping Yang Chun-Ling Wan Yi-Feng Xu Guo-Yin Feng Lin He Guang He | 2012 | Psychiatric Genetics2012，，6： | 1 |
| 19 | BARMR1-mediated sorafenib resistance is derived through stem-like property acquisition by activating integrin-FAK signaling pathways显示文摘Dear Editor,BARMR1(alternatively named FAM92A1 or FAM92A)gene was first identified in 2002 and is a highly conserved gene and widely expressed in most tissues in mammals.1 We first cloned the complete CDS sequence of BARMR1 in 2007,2 which encodes a protein with a Bin-Amphiphysin-Rvs(BAR)domain.BARcontaining proteins are known to bind onto lipid membrane surface and generate membrane curvature and have been demonstrated to play diverse roles in cell growth,inflammation and cell migration. | Xing Rong Guo Meng Ye Shan Yu Huang Zong Li Zhang Yue Yuan Long Jun Dai Jue Wang Xue Peng Zhou Fu Yun Ji Jun Ming Tang Zhong Ji Meng Xu Zhi Ruan | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 20 | Transport of a volatile contaminant in a free-surface wetland flow显示文摘在这介绍了纸是进免费表面的沼泽地流动的搏动的不稳定的沾染物排出物的分析研究。一个简化模型在免费的水表面在移流,集体分散,明显的反应,和挥发的联合行动下面为沾染物运输被给。沾染物运输上的周期的明显的反应的效果经由扩大转变与水力的效果被分开,与盖住为经常的明显的反应率的已知的转变的一个限制盒子。zeroth 和第一顺序集中时刻的分析答案严厉地被导出并且说明。沾染物的数量从底部床减少到,这被发现在挥发,和有时间的沾染物腐烂的全部的数量下面免费表面。整个沾染物的集体中心的动人的速度遮蔽增加,这也被发现,作为到垂直有效集体 dispersivity 增加的挥发系数的比率[出版摘要] | Jue YUAN Li ZENG Yijun ZHAO Yihong WU Ping JI Bin CHEN | 2014 | Frontiers of Earth Science2014，8，1： | 0 |
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