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| 1 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 2 | The Application of a Grey Markov Model to Forecasting Annual Maximum Water Levels at Hydrological Stations显示文摘Compared with traditional real-time forecasting,this paper proposes a Grey Markov Model(GMM) to forecast the maximum water levels at hydrological stations in the estuary area.The GMM combines the Grey System and Markov theory into a higher precision model.The GMM takes advantage of the Grey System to predict the trend values and uses the Markov theory to forecast fluctuation values,and thus gives forecast results involving two aspects of information.The procedure for forecasting annul maximum water levels with the GMM contains five main steps:1) establish the GM(1,1) model based on the data series;2) estimate the trend values;3) establish a Markov Model based on relative error series;4) modify the relative errors caused in step 2,and then obtain the relative errors of the second order estimation;5) compare the results with measured data and estimate the accuracy.The historical water level records(from 1960 to 1992) at Yuqiao Hydrological Station in the estuary area of the Haihe River near Tianjin,China are utilized to calibrate and verify the proposed model according to the above steps.Every 25 years' data are regarded as a hydro-sequence.Eight groups of simulated results show reasonable agreement between the predicted values and the measured data.The GMM is also applied to the 10 other hydrological stations in the same estuary.The forecast results for all of the hydrological stations are good or acceptable.The feasibility and effectiveness of this new forecasting model have been proved in this paper. | DONG Sheng CHI Kun ZHANG Qiyi ZHANG Xiangdong | 2012 | Journal of Ocean University of China2012，11，1： | 12 |
| 3 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 4 | Nuclear domain 10 of the viral aspect显示文摘Nuclear domain 10(ND10) are spherical bodies distributed throughout the nucleoplasm and measuring around 0.2-1.0 μm. First observed under an electron microscope, they were originally described as dense bodies found in the nucleus. They are known by a number of other names, including Promyelocytic Leukemia bodies(PML bodies), Kremer bodies, and PML oncogenic domains. ND10 are frequently associated with Cajal bodies and cleavage bodies. It has been suggested that they play a role in regulating gene transcription. ND10 were originally characterized using human autoantisera, which recognizes Speckled Protein of 100 kD a, from patients with primary biliary cirrhosis. At the immunohistochemical level, ND10 appear as nuclear punctate structures, with 10 indicating the approximate number of dots per nucleus observed. ND10 do not colocalize with kinetochores, centromeres, sites of mR NA processing, or chromosomes. Resistance of ND10 antigens to nuclease digestion and salt extraction suggest that ND10 are associated with the nuclear matrix.They are often identified by immunofluorescent assay using specific antibodies against PML, Death domainassociated protein, nuclear dot protein(NDP55), and so on. The role of ND10 has long been the subject of investigation, with the specific connection of ND10 and viral infection having been a particular focus for almost 20 years. This review summarizes the relationship of ND10 and viral infection. Some future study directions are also discussed. | Yisel A Rivera-Molina Francisco Puerta Martínez Qiyi Tang | 2013 | World Journal of Virology2013，2，3： | 7 |
| 5 | Application of chemical vapor-deposited monolayer ReSe2 in the electrocatalytic hydrogen evolution reaction显示文摘 | Shaolong Jiang Zhepeng Zhang Na Zhang Yahuan Huan Yue Gong Mengxing Sun Jianping Shi Chunyu Xie Pengfei Yang Qiyi Fang He Li Lianming Tong Dan Xie Lin Gu Porun Liu Yanfeng Zhang | 2018 | Nano Research2018，11，4： | 6 |
| 6 | Synthesis and characterization of tungsten and barium co-doped La2Mo2O9 by sol-gel process for solid oxide fuel cells显示文摘Herein,we demonstrate the synthesis of W and Ba co-doped La2Mo2O9(LBMWO)nanocrystalline powder by a sol-gel process.In all the compositions have general formulae La1.9Ba0.1Mo2-xWxO8.95(x=0-0.40).The crystal structure,microstructure and conductivity of LBMWO were characterized by X-ray diffraction,scanning electron microscopy and electrical impedance spectroscopy.In addition,the thermal and decomposition properties of the LBMWO gel were analyzed by differential scanning calorimetry-thermogravimetric.The results reveal that all LBMWO powders calcined at 700℃have a cubic structure;the average crystallite size is about 48 nm.The unit cell parameter of LBMWO powders increases with increase in W content.The as-synthesized nanocrystalline LBMWO samples exhibit excellent sinterability and a relatively lower sintering temperature of 900℃.A high relative density of-96%is achieved after sintering at 900℃which is in good agreeme nt with the re sults of the SEM.Moreover,W and Ba codoping suppresses the phase transition and effectively stabilizes theβ-phase at low temperature.At the same time,La1.9Ba0.1Mo1.85W0.15O8.95 exhibits high ionic conductivity,3.07 x 10^-2 S/cm at 800℃.It is therefore concluded that co-doping can improve the properties of La2MO2O9 electrolytes. | Chang′an Tian Lingbo Shao Dongdong Ji Jie Yang Jinsong Xie Qiyi Yin Huirong Le | 2019 | Journal of Rare Earths2019，37，9： | 5 |
| 7 | Heterostructured graphene quantum dot/WSe2/Si photo-detector with suppressed dark current and improved detectivity显示文摘 | Mengxing Sun Qiyi Fang Dan Xie Yilin Sun Liu Qian Jianlong Xu Peng Xiao Changjiu Teng Weiwei Li Tianling Ren Yanfeng Zhang | 2018 | Nano Research2018，11，6： | 5 |
| 8 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 9 | Dual functional transparent film for proximity and pressure sensing显示文摘在过去几年,触觉的察觉到的技术的快速的开发显著地作出贡献到直觉的触摸控制和聪明的人机器的相互作用的实现。除了察觉到的物理触觉或压力,最近作为互补功能察觉到能扩大普通单个功能的触觉的传感器的察觉模式。在这个工作,我们在场一透明,矩阵结构集成在一台设备察觉到的最近和压力的能力的双功能的电容的传感器,并且电容的象素的孤立的反应提供的优秀空间分辨率使我们能认识到与快反应,高稳定性和高可逆性接近对象和装载压力的精确地点鉴定。 | Bo Zhang Zemin Xiang Siwei Zhu Qiyi Hu Yuanzhi Cao Junwen Zhong Qize Zhong Bo Wang Yunsheng Fang Bin Hu Jun Zhou Zhonglin wang | 2014 | Nano Research2014，7，10： | 4 |
| 10 | Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters显示文摘The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 230 million cases and over four million deaths worldwide.Furthermore,multiple emerging SARS-CoV-2 variants have shown enhanced infectivity,transmissibility,pathogenicity and ability to escape neutralization by vaccine-induced humoral immunity[1].The antibody resistance of SARS-CoV-2 variants constitutes a challenge for current vaccines and therapeutic antibodies.No specific antiviral is currently available for coronavirus in humans[2].Although remdesivir was approved by the FDA for the treatment of SARS-CoV-2 infection,the therapeutic effect is limited,particularly for critical cases with severe pneumonia. | Lunzhi Yuan Ming Zhou Jian Ma Xuan Liu Peiwen Chen Huachen Zhu Qiyi Tang Tong Cheng Yi Guan Ningshao Xia | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 11 | Saturable and reverse saturable absorption in molybdenum disulfide dispersion and film by defect engineering显示文摘Understanding and controlling defect in two-dimensional materials is important for both linear and nonlinear optoelectronic devices,especially in terms of tuning nonlinear optical absorption.Taking advantage of an atomic defect formed easily by smaller size,molybdenum disulfide nanosheet is prepared successfully with a different size by gradient centrifugation.Interestingly,size-dependent sulfur vacancies are observed by high-resolution X-ray photoelectron spectroscopy,atomic force microscopy,and transmission electron microscopy.The defect effect on nonlinear absorption is investigated by Z-scan measurement at the wavelength of 800 nm.The results suggest the transition from saturable absorption to reverse saturable absorption can be observed in both dispersions and films.First principle calculations suggest that sulfur vacancies act as the trap state to capture the excited electrons.Moreover,an energy-level model with the trap state is put forward to explain the role of the sulfur vacancy defect in nonlinear optical absorption.The results suggest that saturable absorption and reverse saturable absorption originate from the competition between the excited,defect state and ground state absorption.Our finding provides a way to tune the nonlinear optical performance of optoelectronic devices by defect engineering. | CHUNHUI LU HONGWEN XUAN YIXUAN ZHOU XINLONG XU QIYI ZHAO AND JINTAO BAI | 2020 | Photonics Research2020，8，9： | 3 |
| 12 | Study of deformation and aging behaviors of a hot rolled–quenched Cu–Cr–Zr–Mg–Si alloy during thermomechanical treatments显示文摘 | Chengdong Xia Yanlin Jia Wan Zhang Ke Zhang Qiyi Dong Genying Xu Mingpu Wang | 2012 | Materials and Design2012，，： | 3 |
| 13 | Mitochondrial biogenesis of astrocytes is increased under experimental septic conditions显示文摘 | Wang Yang Chen Zhijiang Zhang Yu Fang Suzhen Zeng Qiyi | 2014 | Chinese Medical Journal2014，，10： | 3 |
| 14 | 3D-printed dermis-specific extracellular matrix mitigates scar contraction via inducing early angiogenesis and macrophage M2 polarization显示文摘Scar contraction frequently happens in patients with deep burn injuries.Hitherto,porcine dermal extracellular matrix(dECM)has supplied microenvironments that assist in wound healing but fail to inhibit scar contraction.To overcome this drawback,we integrate dECM into three-dimensional(3D)-printed dermal analogues(PDA)to prevent scar contraction.We have developed thermally gelled,non-rheologically modified dECM powder(dECMp)inks and successfully transformed them into PDA that was endowed with a micron-scale spatial structure.The optimal crosslinked PDA exhibited desired structure,good mechanical properties as well as excellent biocompatibility.Moreover,in vivo experiments demonstrated that PDA could significantly reduced scar contraction and improved cosmetic upshots of split thickness skin grafts(STSG)than the commercially available dermal templates and STSG along.The PDA has also induced an early,intense neovascularization,and evoked a type-2-like immune response.PDA’s superior beneficial effects may attribute to their desired porous structure,the well-balanced physicochemical properties,and the preserved dermis-specific ECM cues,which collectively modulated the expression of genes such as Wnt11,ATF3,and IL1β,and influenced the crucial endogenous signalling pathways.The findings of this study suggest that PDA is a clinical translatable material that possess high potential in reducing scar contraction. | Lei Chen Zhiyong Li Yongtai Zheng Fei Zhou Jingling Zhao Qiyi Zhai Zhaoqiang Zhang Tianrun Liu Yongming Chen Shaohai Qi | 2022 | Bioactive Materials2022，7，4： | 3 |
| 15 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 16 | Immediate–Early(IE) gene regulation of cytomegalovirus:IE1-and pp71-mediated viral strategies against cellular defenses显示文摘Three crucial hurdles hinder studies on human cytomegalovirus(HCMV): strict species specificity, differences between in vivo and in vitro infection, and the complexity of gene regulation. Ever since the sequencing of the whole genome was first accomplished, functional studies on individual genes have been the mainstream in the CMV field. Gene regulation has therefore been elucidated in a more detailed fashion. However, viral gene regulation is largely controlled by both cellular and viral components. In other words, viral gene expression is determined by the virus–host interaction. Generally, cells respond to viral infection in a defensive pattern; at the same time, viruses try to counteract the cellular defense or else hide in the host(latency). Viruses evolve effective strategies against cellular defense in order to achieve replicative success. Whether or not they are successful, cellular defenses remain in the whole viral replication cycle: entry, immediate–early(IE) gene expression, early gene expression, DNA replication, late gene expression, and viral egress. Many viral strategies against cellular defense, and which occur in the immediate–early time of viral infection, have been documented. In this review, we will summarize the documented biological functions of IE1 and pp71 proteins, especially with regard to how they counteract cellular intrinsic defenses. | Lilith Torres Qiyi Tang | 2014 | Virologica Sinica2014，29，6： | 2 |
| 17 | A new type of Shipboard Meteorological Satellite Receiving-processing System显示文摘The Shipboard Meteorological Satellite Receiving-processing System (SMSRPS) is specially developed for the navigation meteorological safeguard of the Antarctic exploration ship over the sea ice area of the forth Ocean. This system can suit to the climate environment of very high temperature high moisture and very low temperature - supersaturation; it has a self-protection ability to against the hurricane - force wind over force 12 and the strong vibration during icebreaking, as well as strong magnetic disturbance. It has two sets of receiving-imagery processing systems for polar orbit low-resolution and quasi-stationary high-solution satellites. The key creation Points of this system are as follows: 1. the active gyro-control stabilization platform and a mixed mounting system of three rotating a - B and x -- y axes are used. It solved the tracing difficulties both in the low elevation angle and very high elevation angle of polar-orbit satellite, even in the status of ship moving with continuously changing its poition, direction and ship roll and pitch. 2. Imagery processing subsystem. The newest BORLAND-- DELPHI language and PASCAL language pro gramming software are used under WINDOWS 95 environment. It has a dynamic positioning nested-grid system and electric mapping grid data system. It can show the latitude-longitude of any point on the map, and marks any object such as ship, station or island, and draws the route. It can monitor cloud and temperature, forest fire, anomalous change of ocean and land. It can output satellite cloud maps of 24 bit with very high clarity. This system is very advanced in technique for the whole structure with the features of small volume, light weight and very low cost. It suits to very bad climate and ocean environment. Its imagery process ing system has complete functions with high resolution and being very easy to operate. It is not only suit to land use, but also and specially to all kinds of ship over the sea. It can be extended to domestic and international use. This system played a very important role in the 14th Chinese Antarctic Exploration Navigation, and was introduced a broad attention paid by Chinese newspapers and TV Stations. | Xie Simei Hao Chunjiang Zou Bin Jing Qiyi Liao Xiaohong Sheng Xiaowen Zhang Canrong (1. National Research Center for Marine Environment Forecasts, Beijing 100081, China 2, Second Institute of China Aerospace Corporation 3. Beijing Chuanyi Electric Compan | 2000 | Acta Oceanologica Sinica2000，19，1： | 2 |
| 18 | Preparation of micro-patterned surfaces of Si-N-O films and their influence on adhesion behavior of endothelial cells显示文摘Microgrooves were prepared on Si(100) surface by photolithography and wet etching.Subsequently,Si-N-O films were deposited on the microgrooves by unbalanced magnetron sputtering(UBMS) and micro-patterned surfaces of Si-N-O films were obtained.The size of the micropatterns was measured by surface profilometer.The chemical composition of Si-N-O films were characterized by X-ray photoelectron spectrometry(XPS) and the wettability of the micropatterned surfaces was evaluated by contact angle measurement.The behavior of endothelial cells adhered on the micro-patterned surfaces,including cells adhesion,proliferation and orientation,was evaluated by cell culture test and Alamar blue assay.The results showed that the amount and activity of endothelial cells on micro-patterned samples were higher than those on flat samples.After one day's incubation,the cells were well guided along the microgrooves.Three days later,most of the cells grew across the grooves and contacted each other.Their activity was also much higher than that on flat samples.It was suggested that the adhesion and proliferation of endothelial cells could be effectively enhanced by micropattern method. | ZHENG Nan,YANG Ping,WANG QiYi,YANG ZhongHai & HUANG Nan Key Laboratory of Advanced Technology for Materials of Education Ministry,Key Laboratory of Artificial Organ Surface Engineering of Sichuan,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China | 2010 | Science China(Technological Sciences)2010，53，1： | 2 |
| 19 | Functional cure of chronic hepatitis B: Efforts and prospects显示文摘Worldwide,more than 240 million people are chronically infected with hepatitis B virus(HBV),1 and more than 887,000 deaths in 2015 are due to HBV-related end-stage liver disease or hepatocellular carcinoma.China has the largest burden of HBV in the world,with approximately 70 million HBV carriers,of which 20e30 million are chronic hepatitis B(CHB)patients.2,3 As the development of medicine,the treatment goal of CHB is getting higher and higher. | Zhishuo Mo Weiqiang Gan Qiyi Zhao Yalin Yin Zhiliang Gao | 2020 | Liver Research2020，4，1： | 2 |
| 20 | Biological and historical overview of Zika virus显示文摘The recent outbreak of the Zika virus attracts worldwide attention probably because the most recently affected country(Brazil) will host the 2016 Olympic Game. Zika virus infected cases are now spreading to many other countries and its infection might be linked to some severe medical sequelae. Since its first isolation from the infected monkey in 1947 in Uganda, only a few studies had been taken until recent outbreak. According to the history of referenced publications, there is a 19-year gap from 1989 to 2007. This might be because only mild diseases were diagnosed from Zika virus infected populations. Obviously, the recent reports that Zika virus infection is probably associated with microcephaly of the neonates makes us reevaluate the medical significance of the viral pathogen. It can be transmitted sexually or by mosquito biting. Sexual transmission of the Zika virus distinguishes it from other members of the Genus Flavivirus. Detailed information of the Zika virus is needed through a thorough investigation covering basic, epidemical, subclinical and clinical studies. Here, we reviewed the published information of Zika virus. | Najealicka Armstrong Wangheng Hou Qiyi Tang | 2017 | World Journal of Virology2017，6，1： | 2 |
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