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| 1 | High-quality Arabidopsis thaliana Genome Assembly with Nanopore and HiFi Long Reads显示文摘Arabidopsis thaliana is an important and long-established model species for plant molecular biology,genetics,epigenetics,and genomics.However,the latest version of reference genome still contains a significant number of missing segments.Here,we reported a high-quality and almost complete Col-0 genome assembly with two gaps(named Col-XJTU)by combining the Oxford Nanopore Technologies ultra-long reads,Pacific Biosciences high-fidelity long reads,and Hi-C data.The total genome assembly size is 133,725,193 bp,introducing 14.6 Mb of novel sequences compared to the TAIR10.1 reference genome.All five chromosomes of the Col-XJTU assembly are highly accurate with consensus quality(QV)scores>60(ranging from 62 to 68),which are higher than those of the TAIR10.1 reference(ranging from 45 to 52).We completely resolved chromosome(Chr)3 and Chr5 in a telomere-to-telomere manner.Chr4 was completely resolved except the nucleolar organizing regions,which comprise long repetitive DNA fragments.The Chrl centromere(CEN1),reportedly around 9 Mb in length,is particularly challenging to assemble due to the presence of tens of thousands of CEN180 satellite repeats.Using the cutting-edge sequencing data and novel computational approaches,we assembled a 3.8-Mb-long CEN1 and a 3.5-Mb-long CEN2.We also investigated the structure and epigenetics of centromeres.Four clusters of CEN180 monomers were detected,and the centromere-specific histone H3-like protein(CENH3)exhibited a strong preference for CEN180 Cluster 3.Moreover,we observed hypomethylation patterns in CENH3-enriched regions.We believe that this high-quality genome assembly,Col-XJTU,would serve as a valuable reference to better understand the global pattern of centromeric polymorphisms,as well as the genetic and epigenetic features in plants. | Bo Wang Xiaofei Yang Yanyan Jia Yu Xu Peng Jia Ningxin Dang Songbo Wang Tun Xu Xixi Zhao Shenghan Gao Quanbin Dong Kai Ye | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 6 |
| 2 | Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages显示文摘发炎是到损害和感染的身体纸巾的回答。能禁止发炎的混合物被显示了有潜在的治疗学的临床的申请。Gambogenic 酸(GEA ) 有有势力 antitumor 和反煽动性的活动。此处, GEA 反煽动性的效果的分子的机制在刺激的 lipopolysaccharide (LPS ) 被调查巨噬细胞房间。结果证明有 GEA 的那个预告的处理能显著地禁止 interleukin (IL )-1, IL-1,肿瘤坏死因素 -- ,以在导致 LPS 的模型的一种剂量依赖者方式的 IFN- , IL-12b,和 IL-23a 生产。而且,这药显著地减少了氮的氧化物的版本(没有) ,并且损害了蛋白质水平可诱导没有 synthase 和 cyclooxygenase 2。发现也证明 GEA 的效果可能与原子 factor-B (NF-B ) 和表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 GEA 能由 attenuating 部分压制模仿 LPS 的煽动性的反应没有合成和 NF-B 和 MAPK 激活,建议它可以成为一个有势力为煽动性的疾病的处理的治疗学的代理人。 | Xianjun Yu Qun Zhao Haiwei Zhang Cunxian Fan Xixi Zhang Qun Xie Chengxian Xu Yongbo Liu Xiaoxia Wu Quanbin Han Haibing Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 3 | Suppression of Vortex-Induced Vibration by Fairings on Marine Risers显示文摘Vortex-induced vibration is quite common during the operation of offshore risers or umbilical cables,commonly leading to serious damage to risers and reduced service life.Vortex-induced vibration of the offshore risers could be effectively suppressed by fairing devices.In this paper,a newly developed vortex-induced vibration fairing and large eddy simulation model of the FLUENT software were used for numerical analysis,experimental research and stimulating vortex-induced vibration at 0.1–2 ms^-1.The data of the numerical model with fairing was compared and analyzed to study the vortex shedding frequency at different Reynolds numbers and changes in drag and lift coefficients.The displacement state of 12 in risers with and without fairing was experimentally tested using a five degree-of-freedom balance.The vortex-induced vibration effect of the fairing was tested at different velocities.The result shows the drag reduction effect of the fairing is more obvious when the flow velocity is 0.4–1.2 ms^-1 and the maximum drag reduction reaches 55.6%when the flow velocity is 0.6 ms^-1.Additionally,the drag reduction effect was obvious when the flow velocity was greater than 1.3 ms^-1 and less than 0.3.The result indicates that the developed 12 in fairing,with good potential in engineering applications,has good vortex-induced vibration-suppression effects. | KANG Yongtian XIAO Wensheng WANG Quanbin ZHANG Dagang ZHAO Jun | 2020 | Journal of Ocean University of China2020，19，2： | 4 |
| 4 | Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis显示文摘环境暗示和细胞内部的 bioenergetic 状态深刻地影响细胞内部的 pH (pHi ) 。一个房间怎么对 pHi 变化作出回应维持 bioenergetic 动态平衡,留下逃犯。这里,我们显示出那 Smad5,发信号的形态基因的蛋白质(BMP ) 回答到 pHi 的骨头的一个描绘得好的下游的部件变化。冷、基本或张力亢进的条件增加 pHi,它接着在 Smad5 的 MH1 域以内声言不赞成控告的氨基酸簇,推动它到细胞质的从原子核的重定位。在另一方面,加热,酸或张力减退的条件减少 pHi,堵住 Smad5 的原子出口,并且因此引起它的原子累积。环境变化和 pHi 变化导致的 Smad5 的活跃 nucleocytoplasmic shuttling 独立于 BMP 发信号, carboxyl 终点 phosphorylation 和 Smad4。另外, Smad5 的脱离引起在区别识别了的神经发展过程人的 pluripotent 干细胞建模的细胞的 bioenergetic 动态平衡和破坏正常的长期、不可逆的 dysregulation。重要地,在 Smad5 缺乏的房间的这些新陈代谢、发展的赤字能仅仅由细胞质的 Smad5 被救。细胞质的 Smad5 身体上与 hexokinase 交往 1 并且加速 glycolysis。一起,我们的调查结果显示 Smad5 充当一个 pHi 送信人并且由调整细胞质的新陈代谢的机械维持房间的 bioenergetic 动态平衡。 | Yujiang Fang Zhongliang Liu Zhenyu Chen Xiangjie Xu Mengtao Xiao Yanyan Yu Yuanyuan Zhang Xiaobai Zhang Yanhua Du Cizhong Jiang Yuzheng Zhao Yiran Wang Beibei Fan Daniel Terheyden-Keighley Yang Liu Lei Shi Yi Hui Xin Zhang Bowen Zhang Hexi Feng Lin Ma Quanbin Zhang Guohua Jin Yi Yang Bin Xiang Ling Liu Xiaoqing Zhang | 2017 | Cell Research2017，27，9： | 2 |
| 5 | Antioxidant activity of different molecular weight sulfated polysaccharides from Ulva pertusa Kjellm(Chlorophyta)显示文摘 | Huimin Qi Tingting Zhao Quanbin Zhang | 2005 | Journal of Applied Phycology2005，17，6： | 1 |
| 6 | Transcriptional expression of glioma chemotherapy drugs associatedmarker molecules in gliomas and normal brain tissues显示文摘 | Yaodong Zhao Yajun Xue Quanbin Zhang Ke Wang Jia Yin Meiqing Lou | 2013 | Cancer Biomarkers2013，，1： | 1 |
| 7 | Effect of All-Trans Retinoic Acid on the Differentiation of U87 Glioma Stem/Progenitor Cells显示文摘 | Zhe Shi Meiqing Lou Yaodong Zhao Quanbin Zhang Daming Cui Ke Wang | 2013 | Cellular and Molecular Neurobiology2013，，7： | 1 |
| 8 | Preliminary design of an SCO_(2) conversion system applied to the sodium cooled fast reactor显示文摘The supercritical carbon dioxide(SCO_(2))Brayton cycle has become an ideal power conversion system for sodium-cooled fast reactors(SFR)due to its high efficiency,compactness,and avoidance of sodiumwater reaction.In this paper,the 1200 MWe large pool SFR(CFR1200)is used as the heat source of the system,and the sodium circuit temperature and the heat load are the operating boundaries of the cycle system.The performance of different SCO_(2) Brayton cycle systems and changes in key equipment performance are compared.The study indicates that the inter-stage cooling and recompression cycle has the best match with the heat source characteristics of the SFR,and the cycle efficiency is the highest(40.7%).Then,based on the developed system transient analysis program(FR-Sdaso),a pool-type SFR power plant system analysis model based on the inter-stage cooling and recompression cycle is established.In addition,the matching between the inter-stage cooling recompression cycle and the SFR during the load cycle of the power plant is studied.The analysis shows that when the nuclear island adopts the flow-advanced operation strategy and the carbon dioxide flowrate in the SCO_(2) power conversion system is adjusted with the goal of maintaining the sodium-carbon dioxide heat exchanger sodium side outlet temperature unchanged,the inter-stage cooling recompression cycle can match the operation of the SFR very well. | Hongyi YANG Xiaoyan YANG Jun YANG Quanbin ZHAO Xiaokun WANG Daotong CHONG Chanjuan TANG Chengyuan JIANG | 2021 | Frontiers in Energy2021，15，4： | 1 |
| 9 | Antioxidant activity of different sulfate content derivatives of lysaccharide extracted from Ulva pertusa ( Chlorophyta ) in vitro 显示文摘 | Huimin Qi Quanbin Zhang Tingting Zhao | 2005 | International Journal of Biological Macromolecules2005，37，4： | 1 |
| 10 | In vitro antioxidant activity of acetylated and benzoylated derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta)显示文摘 | Huimin Qi Quanbin Zhang Tingting Zhao Rugui Hu Kun Zhang Zhien Li | 2006 | Bioorganic & Medicinal Chemistry Letters2006，，9： | 1 |
| 11 | Antioxidant activity of different molecular weight sulfated polysaccharides from Ulva pertusa Kjellm (Chlorophyta)显示文摘 | Huimin Qi Tingting Zhao Quanbin Zhang Zhien Li Zengqin Zhao Ronge Xing | 2005 | Journal of Applied Phycology2005，，6： | 1 |
| 12 | Antioxidant activity of different sulfate content derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta) in vitro显示文摘 | QI Huimin ZHANG Quanbin ZHAO Tingting | 2005 | International Journal of Biological Macrornolecules2005，37，4： | 1 |
| 13 | Fucoidan inhibits the development of proteinuria in active Heymann nephritis显示文摘 | Zhang Quanbin LiNing Zhao Tingting | | 0，，01： | 1 |
| 14 | Antioxidant activity of different sulfate content derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta) in vitro显示文摘 | Huimin Qi Quanbin Zhang Tingting Zhao | 2005 | International Journal of Biological Macromolecnles2005，37，： | 1 |
| 15 | Antioxidant activity of different sulfate content derivatives ofpolysaccharide extracted from Ulvapertusa (Chlorophyta) in vitro显示文摘 | Qi Huimin Zhang Quanbin Zhao Tingting | 2005 | Internationa Journal of Biological Macromolecules2005，，37： | 1 |
| 16 | In vitro antioxidant activity of acetylated and benzoylated derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta) 显示文摘 | Huimin Qi Quanbin Zhang Tingting Zhao | 2006 | Bioorganic & Medicinal Chemistry Letters2006，16，： | 1 |
| 17 | Antioxidant activity of different molecular weight sulfated polysaccharides from Ulva pertusa Kjellm(Chlorophyta)显示文摘 | Huimin Qi Tingting Zhao Quanbin Zhang | 2005 | Journal of Applied Phycology2005，17，： | 1 |
| 18 | Antioxidant activity of different molecular weight sulfated polysaccharides from Ulva pertusa Kjellm (Chlorephyta) 显示文摘 | Humin Qi Tingting Zhao Quanbin Zhang | 2005 | Journal of applied phycology2005，17，6： | 1 |
| 19 | Fucoidan inhibits the development of proteinuria in active Heymann nephritis显示文摘 | ZHANG Quanbin LI Ning ZHAO Tingting | 2005 | Phytother Res2005，19，1： | 1 |
| 20 | Degradation of porphyran from Porphyra haitanensis and the antioxidant activities of the degraded porphyrans with different molecular weight 显示文摘 | ZHAO Tingting ZHANG Quanbin QI Huimin | 2006 | Int J Biol Macromol2006，38，1： | 1 |
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