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| 1 | Analysis of in vivo patterns of caspase 3 gene expression in primary hepatocellular carcinoma and its relationship to p21^(WAF1) expression and hepatic apoptosis显示文摘AIM To detect the expression of caspase 3gene in primary human hepatocellular carcinoma(HCC)and investigate its relationship to p21WAF1gene expression and HCC apoptosis.METHODS In situ hybridization was employedto determine caspase 3 and p21WAF1expression inHCC.In situ end-labeling was used to detecthepatocytic apoptosis in HCC.RESULTS Twenty-one of 39(53.8%)cases ofHCC were found to express caspase 3transcripts,while 45.2% of HCC failed toexpress caspase 3.Non-cancerous adjacent livertissues showed more positive caspase 3(87.5%,7/8)as compared with HCC(P<0.05).The expression of caspase 3 is correlated withHCC differentiation,72.2%(13/18)ofmoderately to highly differentiated HCC showedcaspase 3 transcripts positive,while only 38.1%of poorly differentiated HCC harbored caspase 3transcripts(P<0.05).No relationship wasfound between caspase 3 expression and tumorsize or grade or metastasis,although 52.5%(5/8)of HCC with metastasis were caspase 3positive and a little higher than that with nometastasis(51.6%,P>0.05).Expression of caspase 3 alone did not affect the apoptosisindex(AI)of HCC.The AI was 7.12%o in caspase3-positive tumors(n=21),while in caspase 3-negative cases(n=18)6.59%0(P>0.05).Expression of caspase 3 clearly segregated withp21WAF1positive tumors as compared withp21WAF1-negative cases(16 of 23,69.6% versus5 of 16,31.3%)with statistical significance(P=0.017).In the cases with positive caspase 3and negative p21WAF1,the Al was found slightlyhigher,but with no statistical significance,thanthat with expression of p21WAF1and caspase 3(7.21‰ vs 6.98‰,P>0.05).CONCLUSION Loss of caspase 3 expressionmay contribute to HCC carcinogenesis,althoughthe expression of caspase 3 does not correlatewell with cell apoptosis in HCC.p21WAF1may bemerely one of the inhibitors which can reducecaspase 3 mediated cell apoptosis in HCCs. | Bao Hua Sun Jun Zhang Bao JǜWang Xi Ping Zhao You Kun Wang Zhi Qun Yu Dong Liang Yang Lian Jie Hao Department of Clinical Immunology,Tongji Hospital,Tongji Medical University,Wuhan 430030,Hubei Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 65 |
| 2 | Chemical characteristics and source apportionment of PM_(2.5) between heavily polluted days and other days in Zhengzhou, China显示文摘PM_(2.5) samples were collected in Zhengzhou during 3 years of observation, and chemical characteristics and source contribution were analyzed. Approximately 96% of the daily PM_(2.5) concentrations and annual average values exceeded the Chinese National Ambient Air Quality Daily and Annual Standards, indicating serious PM_(2.5) pollution. The average concentration of water-soluble inorganic ions was 2.4 times higher in heavily polluted days(daily PM32.5 concentrations > 250 μg/mand visibility < 3 km) than that in other days, with sulfate, nitrate, and ammonium as major ions. According to the ratio of NO-3/SO2-4,stationary sources are still the dominant source of PM_(2.5) and vehicle emission could not be ignored. The ratio of secondary organic carbon to organic carbon indicated that photochemical reactivity in heavily polluted days was more intense than in other days.Crustal elements were the most abundant elements, accounting for more than 60% of 23 elements. Chemical Mass Balance results indicated that the contributions of major sources(i.e., nitrate, sulfate, biomass, carbon and refractory material, coal combustion, soil dust,vehicle, and industry) of PM_(2.5) were 13%, 16%, 12%, 2%, 14%, 8%, 7%, and 8% in heavily polluted days and 20%, 18%, 9%, 2%, 27%, 14%, 15%, and 9% in other days, respectively.Extensive combustion activities were the main sources of polycyclic aromatic hydrocarbons during the episode(Jan 1-9, 2015) and the total benzo[a]pyrene equivalency concentrations in heavily polluted days present significant health threat. Because of the effect of regional transport, the pollution level of PM_(2.5) in the study area was aggravated. | Nan Jiang Qiang Li Fangcheng Su Qun Wang Xue Yu Panru Kang Ruiqin Zhang Xiaoyan Tang | 2018 | Journal of Environmental Sciences2018，30，4： | 22 |
| 3 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 4 | Temporal changes in SSR allelic diversity of major rice cultivars in China显示文摘Forty simple sequence repeats (SSRs) were used to assess the changes of diversity in 310 major Chinese rice cultivars grown during the 1950s-1990s. Of the 40 SSR loci, 39 were polymorphic. A total of 221 alleles were detected with an average of 5.7 alleles per locus (Na). The Nei’s genetic diversity index (He) varied drastically among the loci (0.207 to 0.874, mean 0.625). Comparing the temporal changes in Na and He, the cultivars from the 1950s had more alleles and higher He scores than the cultivars from the other four decades Analysis of molecular variance (AMOVA) indicated that the genetic differentiation among the five decades was not significant in the whole set, but significant within indica and japonica. More changes among the decades were revealed in indica cultivars than in japonica cultivars. Some alleles had been lost in current rice cultivars in the 1990s, occurring more frequently in indica. These results suggest that more elite alien genetic resources should be explored to widen the genetic backgrounds of rice cultivars currently grown in China. | Xinghua Wei Xiaoping Yuan Hanyong Yu Yiping Wang Qun Xu Shengxiang Tang | 2009 | Journal of Genetics and Genomics2009，36，6： | 16 |
| 5 | An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice显示文摘Cerebral ischemia activates an endogenous repair program that induces plastic changes in neurons. In this study, we investigated the effects of environmental enrichment on spatial learning and memory as well as on synaptic remodeling in a mouse model of chronic cerebral ischemia, produced by subjecting adult male C57 BL/6 mice to permanent left middle cerebral artery occlusion. Three days postoperatively, mice were randomly assigned to the environmental enrichment and standard housing groups. Mice in the standard housing group were housed and fed a standard diet. Mice in the environmental enrichment group were housed in a cage with various toys and fed a standard diet. Then, 28 days postoperatively, spatial learning and memory were tested using the Morris water maze. The expression levels of growth-associated protein 43, synaptophysin and postsynaptic density protein 95 in the hippocampus were analyzed by western blot assay. The number of synapses was evaluated by electron microscopy. In the water maze test, mice in the environmental enrichment group had a shorter escape latency, traveled markedly longer distances, spent more time in the correct quadrant(northeast zone), and had a higher frequency of crossings compared with the standard housing group. The expression levels of growth-associated protein 43, synaptophysin and postsynaptic density protein 95 were substantially upregulated in the hippocampus in the environmental enrichment group compared with the standard housing group. Furthermore, electron microscopy revealed that environmental enrichment increased the number of synapses in the hippocampal CA1 region. Collectively, these findings suggest that environmental enrichment ameliorates the spatial learning and memory impairment induced by permanent middle cerebral artery occlusion. Environmental enrichment in mice with cerebral ischemia likely promotes cognitive recovery by inducing plastic changes in synapses. | Chuan-Jie Wang Yi Wu Qun Zhang Ke-Wei Yu Yu-Yang Wang | 2019 | Neural Regeneration Research2019，14，3： | 14 |
| 6 | Gibberellin homeostasis and plant height control by EUI and a role for gibberellin in root gravity responses in rice显示文摘米饭 Eui (伸长最高节间) 基因编码撤销的细胞色素 P450 monooxygenase 简历活跃赤霉素(气体) 。在这研究,我们在植物开发调查了 Eui 基因和它的角色的控制表示。我们发现 Eui 是外长的气体导致的差别并且 Eui 倡导者在维管束举办了最高的活动。eui 异种在在根冠的淀粉小粒开发是有缺点的,在表达式上的 Eui 提高了淀粉小粒产生和严肃回答,揭示为在根淀粉小粒开发和严肃回答的 GA 的一个角色。使用胚胎更少一半种子的实验揭示了那 RAmy1A, GAmyb 是高度起来当外长的 GA 不在时在 eui 糊粉房间调整了。另外, GA 生合成基因 GA3ox1 和 GA20ox2 是调整的 down, GA2ox1 起来在 eui 调整了幼苗。这些结果显示 EUI 涉及 GA 动态平衡,不是在仅仅内部在出发阶段的节点,而且在苗期,根和种子。扰乱 GA 动态平衡影响了表明基因 GID1 (赤霉素感觉迟钝的矮子 1 ) 的 GA 的表示, GID2 和 SLR1。有效地增加的 Eui 基因的转基因的 RNA 干扰种高度和改进标题性能。由对比,在米饭 GA 生合成基因 GA3ox2 和 GA20ox2 的倡导者下面的 Eui 的宫外的表示显著地减少了植物高度。这些结果证明 Eui 表示的细微增加能戏剧性地改变米饭形态学,显示在米饭的 Eui 基因的实际申请为一个高产潜力的分子的繁殖。 | Yingying Zhang Yongyou Zhu Yu Peng Dawei Yan Qun Li Jianjun Wang Linyou Wang Zuhua He | 2008 | Cell Research2008，18，3： | 10 |
| 7 | Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma显示文摘Background: According to the 7 th edition of the American Joint Committee on Cancer(AJCC) staging system, over50% of patients with nasopharyngeal carcinoma(NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively under-researched, and the metastasis risk of this group is not well-stratified. This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node(GTVnd) and pretreatment serum copy number of Epstein-Barr virus(EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of patients.Methods: The medical records of 787 newly diagnosed patients with nonmetastatic, histologically proven N1 NPC who were treated at Sun Yat-sen University Cancer Center between November 2009 and February 2012 were analyzed. Computed tomography-derived GTVnd was measured using the summation-of-area technique. Blood samples were collected before treatment to quantify plasma EBV DNA. The receiver operating characteristic(ROC) curve analysis was used to evaluate the cut-off point for GTVnd, and the area under the ROC curve was used to assess the predicted validity of GTVnd. The survival rates were assessed by Kaplan-Meier analysis, and the survival curves were compared using a log-rank test. Multivariate analysis was conducted using the Cox proportional hazard regression model.Results: The 5-year distant metastasis-free survival(DMFS) rates for patients with GTVnd > 18.9 vs.≤ 18.9 mL were82.2% vs. 93.2%(P < 0.001), and for patients with EBV DNA copy number > 4000 vs. < 4000 copies/mL were 83.5% vs.93.9%(P < 0.001). After adjusting for GTVnd, EBV DNA copy number, and T category in the Cox regression model, both GTVnd > 18.9 mL and EBV DNA copy number > 4000 copies/mL were significantly associated with poor prognosis(both P < 0.05). According to combination of GTVnd and EBV DNA copy number, all patients were divided into low-,moderate-, and high-risk groups, with the 5-year DMFS rates of 96.1,87.4, and 73.8%, respectively(P < 0.001). Multivariate analysis confirmed the prognostic value of this model for distant metastatic risk stratification(hazard ratio [HR],4.17; 95% confidence interval [CI] 2.34-7.59; P < 0.001).Conclusions: GTVnd and serum EBV DNA copy number are independent prognostic factors for predicting distant metastasis in NPC patients with N1 disease. The prognostic model incorporating GTVnd and EBV DNA copy number may improve metastatic risk stratification for this group of patients. | Ji‑Jin Yao Guan‑Qun Zhou Ya‑Qin Wang Si‑Yang Wang Wang‑Jian Zhang Ya‑Nan Jin Fan Zhang Li Li Li‑Zhi Liu Zhi‑Bin Cheng Jun Ma Zhen‑Yu Qi | 2017 | Chinese Journal of Cancer2017，36，12： | 9 |
| 8 | A DELLA protein complex controls the arbuscular mycorrhizal symbiosis in plants显示文摘 | Nan Yu Dexian Luo Xiaowei Zhang Junzhong Liu Wanxiao Wang Yue Jin Wentao Dong Jiyun Liu Huan Liu Weibing Yang Longjun Zeng Qun Li Zuhua He Giles E D Oldroyd Ertao Wang | 2014 | Cell Research2014，24，1： | 9 |
| 9 | Kinetics of the hydrogen absorption and desorption processes of hydrogen storage alloys: A review显示文摘High hydrogen absorption and desorption rates are two significant index parameters for the applications of hydrogen storage tanks.The analysis of the hydrogen absorption and desorption behavior using the isothermal kinetic models is an efficient way to investigate the kinetic mechanism.Multitudinous kinetic models have been developed to describe the kinetic process.However,these kinetic models were de-duced based on some assumptions and only appropriate for specific kinetic measurement methods and rate-controlling steps(RCSs),which sometimes lead to confusion during application.The kinetic analysis procedures using these kinetic models,as well as the key kinetic parameters,are unclear for many researchers who are unfamiliar with this field.These problems will prevent the kinetic models and their analysis methods from revealing the kinetic mechanism of hydrogen storage alloys.Thus,this review mainly focuses on the summarization of kinetic models based on different kinetic measurement methods and RCSs for the chemisorption,surface penetration,diffusion of hydrogen,nucleation and growth,and chemical reaction processes.The analysis procedures of kinetic experimental data are expounded,as well as the effects of temperature,hydrogen pressure,and particle radius.The applications of the kinetic models for different hydrogen storage alloys are also introduced. | Qian Li Xi Lin Qun Luo Yuʼan Chen Jingfeng Wang Bin Jiang Fusheng Pan | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，1： | 9 |
| 10 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 11 | Effects of Glutamine Supplementation on Patients Undergoing Abdominal Surgery显示文摘Objective To evaluate the effects of supplementation of glutamine (GLN) on maintaining glutathione (GSH) level, immune system function, liver function, and clinical outcome of patients receiving abdominal operation. Methods Forty patients undergoing elective abdominal surgical treatment were randomly divided into 2 groups: study group (n=20) and control group (n=20). All patients received total parenteral nutrition (TPN) for up to 7 days during perioperative period. The study group received TPN supplemented with GLN dipeptide while the control group received TPN without GLN dipeptide. Patients in both groups received equivalent nitrogen and caloric intake. Blood sample was taken on preoperative day, and the 1st,3rd,6th postoperative day to measure GSH level, immune indexes, and liver function indexes. Results The decrease of GSH level in plasma and red blood cell (RBC) in study group was less than that in control group during postoperative period. Ratio of GSH/glutathione disulfide (GSSG) in plasma in study group was higher than that in control group on the 3rd postoperative day (52.53±11.46 vs. 31.43±7.27, P=0.001). Albumin level in study group was higher than that in control group on the 3rd postoperative day (37.7±3.8g/L vs. 33.8±4.2g/P=0.02). There was no significant difference in the levels of immunoglobin (IgG,IgM,IgA) or T lymphocyte subgroup (CD4, CD8, CD4/CD8) in both groups during postoperative period. There was one case with infectious complication in control group, while none in study group. A trend of shortened hospital stay was observed in study group compared with control group (22.3± 2.1d vs.24.9±1.7d,P=0.32). Conclusions Supplementation of GLN-enriched TPN has beneficial effects on maintaining GSH levels in plasma and RBC, sustaining GSH/GSSG ratio and albumin level, and keeping antioxidant abilities during postoperative period in patients with abdominal operation, with the trends of decreasing incidence of infectious complication and shortening hospital stay. | Yue-Dina Fan Jian-chun Yu Wei-ming Kang Qun Zhang | 2009 | Chinese Medical Sciences Journal2009，24，1： | 7 |
| 12 | CIVB flashback analysis of hydrogen flame based on azimuthal vorticity at mixing zone exit显示文摘Swirl-premixed combustion systems exhibit potential to meet future regulations on pollution emissions. However, combustion induced vortex breakdown(CIVB) flashback is frequently observed in these systems, especially for high hydrogen content fuel. In this study, a swirl-premixed burner with diverging centerbody was used to investigate CIVB flashback based on azimuthal vorticity at mixing zone exit. Through 2D axisymmetric model, it was found that there was a maximal azimuthal vorticity at mixing zone exit for each equivalence ratio. The physical meaning of these maximal azimuthal vorticity values was the minimally required azimuthal vorticity to trigger CIVB flashback. At the same time, the required azimuthal vorticity declined with the increase of equivalence ratio since turbulent burning velocity started to control flashback. Nevertheless, azimuthal vorticity offered by heat release increased with the increase of equivalence ratio, which promoted flame propagating upstream continually. | TIAN Xiao Jing XING Shuang Xi CUI Yu Feng FANG Ai Bing NIE Chao Qun | 2014 | Science China(Technological Sciences)2014，57，12： | 7 |
| 13 | Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7721 cells显示文摘N-acetylglucosaminyltransferase V (GnT-V ) 是重要 tumorigenesis 和联系转移的酶。为了学习它的简历,工作, GnT-V 稳定地压制了房间线(GnT-V-AS/7,721 ) 在以前的学习从 7,721 个 hepatocarcinoma 房间被构造。在这研究, cDNA 数组基因表示侧面在 GnT-V-AS/7,721 之间被比较并且父母 7,721 个房间。数据显示 GnT-V-AS/7,721 显示出与 ER 压力一致的一个典型表达式模式。ER 压力的分子的机制被分析在二展开的蛋白质回答(UPR ) 在关键分子上在 GnT-V-AS/7,721 探索小径。为 ATF6 和 Ire1/XBP-1 小径,它被 BIP 的起来规定在 mRNA 和蛋白质证实 XBP-1 的拼接的形式的水平,和外观。至于 PERK/eIF2alpha 小径,激活嗯 eIF2alpha kinase 津贴被观察。从 GnT-V-AS/7,721 房间证实结果,在 UPR 的关键分子在 7,721 个房间再被检验由特定的 RNAi 处理防碍 GnT-V。结果与从 GnT-V-AS/7721 的那些是类似的,显示那块 GnT-V 能明确地激活嗯在 7,721 个房间的应力。率(3 )H 人加入与率改正了(3 ) 在 GnT-V-AS/7,721 的 H 列伊加入与控制相比极大地是下面调整的,它表明了综合的酶的缺乏的功能在堵住的 GnT-V 以后的 N-glycans。而且,与 underglycosylation 联系的女伴 GRP94 的更快的移居形式,和细胞内部的 glycoproteins 的广泛地改变的 N-glycans 结构是也在 GnT-V-AS/7,721 检测了。这些结果支持了机制损害的那块 GnT-V 表达式女伴和 N-glycan-synthesizing 酶工作,它在 vivo 引起了 UPR。 | Huan Fang Wei Huang Ying Ying Xu Zong Hou Shen Chao Qun Wu Shou Yi Qiao Yan Xu Long Yu Hui Li Chen | 2006 | Cell Research2006，16，1： | 7 |
| 14 | Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats显示文摘Amyloid β-peptide(Aβ) has been implicated as a key molecule in the neurodegenerative cascades of Alzheimer 's disease(AD). Humanin(HN) is a secretory peptide that inhibits the neurotoxicity of Aβ. However, the mechanism(s) by which HN exerts its neuroprotection against Aβ-induced ADlike pathological changes and memory deficits are yet to be completely defined. In the present study,we provided evidence that treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory deficits induced by Aβ1-42. HN also attenuated Aβ1-42-induced tau hyperphosphorylation,apparently by inhibiting the phosphorylation of Tyr307 on the inhibitory protein phosphatase-2A(PP2A)catalytic subunit and thereby activating PP2 A. HN also inhibited apoptosis and reduced the oxidativestress induced by Aβ1-42. These findings provide novel mechanisms of action for the ability of HN to protect against Aβ1-42-induced AD-like pathological changes and memory deficits. | Gao-Shang Chai Dong-Xiao Duan Rong-Hong Ma Jian-Ying Shen Hong-Lian Li Zhi-Wei Ma Yu Luo Lu Wang Xin-Hua Qi Qun Wang Jian-Zhi Wang Zelan Wei Darrell D.Mousseau Li Wang Gongping Liu | 2014 | Neuroscience Bulletin2014，30，6： | 7 |
| 15 | Identification of a Ubiquitin-Binding Structure in the S-Locus F-Box Protein Controlling S-RNase-Based Self-Incompatibility显示文摘在 flowering 植物,自我障碍(SI ) 作为重要 intraspecific 服务繁殖障碍支持快。在从 Solanaceae, Plantaginaceae 和 Rosaceae, S-RNase 和 SLF (S 地点 F 盒子) 蛋白质的种类被显示了分别地控制 SI 的女、男的特性。然而,很少除了它的保存 F 盒子领域对 SLF 蛋白质的结构特征被知道。这里,我们证明 SLF C 终端区域拥有结构在 SLF 蛋白质家庭之中保存了的一个新奇 ubiquitin 有约束力的领域(UBD ) 。由使用 Nicotiana benthamiana 的一个 ex vivo 系统,我们发现 UBD 调停由 ubiquitin–proteasome 小径的 SLF 蛋白质周转。而且,我们检测了 SLF 蛋白质直接涉及 S-RNase 降级。一起拿,我们的结果提供新奇卓见进 SLF 结构并且在 S-RNase-based 自我障碍加亮 SLF 蛋白质稳定性和降级的一个潜在的角色。 | Guang Chen BinZhang Lijing Liu Qun Li Yu'e Zhang Qi Xie Yongbiao Xue | 2012 | Journal of Genetics and Genomics2012，39，2： | 7 |
| 16 | Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules显示文摘Diabetes is a serious public health problem affecting 422 million people worldwide. Traditional diabetes management often requires multiple daily insulin injections, associated with pain and inadequate glycemia control. Herein, we have developed an ultrasound-triggered insulin delivery system capable of pulsatile insulin release that can provide both long-term sustained and fast on-demand responses. In this system, insulin-loaded poly(lactic-co-glycolic acid) (PLGA) nanocapsules are encapsulated within chitosan microgels. The encapsulated insulin in nanocapsules can passively diffuse from the nanoparticle but remain restricted within the microgel. Upon ultrasound treatment, the stored insulin in microgels can be rapidly released to regulate blood glucose levels. In a chemically-induced type 1 diabetic mouse model, we demonstrated that this system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner. | Jin Di Jicheng Yu Qun Wang Shanshan Yao Yanqi Ye Matthew Pless Yong Zhu Yun Jing Zhen Gu | 2017 | Nano Research2017，10，4： | 6 |
| 17 | Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy显示文摘在这研究,我们在场有 NH 4+2 ultrathin nanosheets 的准备 > 用一个自底向上的热水的方法和在导致光的 photothermal 癌症的这材料的潜在的申请的置闰治疗。我们的结果表明有 150 nm 的一种尺寸的 nanosheets 在宽广在红外线附近的波长区域是高度吸水、展出的强壮的轻吸收和优秀 photostability。在里面 vitro 试验性的结果显示了 nanosheets 的好 biocompatibility。更尤其是,我们的在里面 vivo antitumor 实验说明了从有 808 nm 激光的 2 nanosheets 能高效地杀死的 1T-WS 的照耀发源的那导致光的 photothermal 脱离肿瘤房间;这些效果不仅在细胞的水平而且在老鼠的生活机关被获得。这结果可以在新奇 photothermal 治疗导致二维的分层的材料的新应用,另外的 photothermal 联系领域。 | Qin Liu Chunyang Sun Qun He Adnan Khalil Ting xiang Daobin Liu Yu Zhou Jun Wang Li Song | 2015 | Nano Research2015，8，12： | 6 |
| 18 | CD163 promotes hematoma absorption and improves neurological functions in patients with intracerebral hemorrhage显示文摘Clinical outcomes are positively associated with hematoma absorption.The monocyte-macrophage scavenger receptor,CD163,plays an important role in the metabolism of hemoglobin,and a soluble form of CD163 is present in plasma and other tissue fluids;therefore,we speculated that serum CD163 affects hematoma absorption after intracerebral hemorrhage.Patients with intracerebral hemorrhage were divided into high-and low-level groups according to the average CD163 level(1,977.79 ± 832.91 ng/m L).Compared with the high-level group,the low-level group had a significantly slower hematoma absorption rate,and significantly increased National Institutes of Health Stroke Scale scores and modified Rankin Scale scores.These results suggest that CD163 promotes hematoma absorption and the recovery of neurological function in patients with intracerebral hemorrhage. | Wen-jing Xie Hong-quan Yu Yu Zhang Qun Liu Hong-mei Meng | 2016 | Neural Regeneration Research2016，11，7： | 6 |
| 19 | Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation显示文摘Excessive activation of NLRP3 inflammasome is associated with the pathogenesis of inflammatory diseases.Pristimerin(Pri)is a quinonoid triterpene derived from traditional Chinese medical herb Celastraceae and Hippocrateaceae.Pri has shown antifungal,antibacterial,antioxidant,and anticancer activities.In this study we investigated whether NLRP3 inflammasome was associated with the anti-inflammatory activity of Pri.We showed that Pri(0.1−0.4μM)dose-dependently blocked caspase-1 activation and IL-1βmaturation in LPS-primed mouse bone-marrow-derived macrophages(BMDMs).Pri specifically inhibited NLRP3 inflammasome activation,had no visible effects on NLRC4 and AIM2 inflammasome activation.Furthermore,we demonstrated that Pri blocked the assembly of the NLRP3 inflammasome via disturbing the interaction between NEK7 and NLRP3;theα,β-unsaturated carbonyl moiety of Pri was essential for NLRP3 inflammasome inactivation.In LPS-induced systemic inflammation mouse model and MSU-induced mouse peritonitis model,preinjection of Pri(500μg/kg,ip)produced remarkable therapeutic effects via inhibition of NLRP3 inflammasome in vivo.In HFD-induced diabetic mouse model,administration of Pri(100μg·kg^(−1)·d^(−1),ip,for 6 weeks)reversed HFD-induced metabolic disorders via suppression of NLRP3 inflammasome activation.Taken together,our results demonstrate that Pri acts as a NLRP3 inhibitor,suggesting that Pri might be useful for the treatment of NLRP3-associated diseases. | Qun Zhao Yun Bi Jian Guo Ying-xiang Liu Jing Zhong Long-rui Pan Yan Tan Xian-jun Yu | 2021 | Acta Pharmacologica Sinica2021，42，6： | 6 |
| 20 | Response of macrophages in rat skeletal muscle after eccentric exercise显示文摘PurposeMacrophages 被知道众多的受伤纸巾取决于为愈合重要他们响应不同刺激的功能的显型。这研究的目的是揭示涉及导致锻练的骨胳的肌肉损害的巨噬细胞 phenotypic 变化, regeneration.MethodsAdult 男性 Sprague-Dawley 老鼠经历了下坡的跑的一个会议(有超过 0.95 的最低的记录的相对的腐殖的酸流动(HAF ) 的 16ouling 性质。在另一方面, PVA-ZnO 加入改进了腐殖的酸拒绝直到 96.03 吗?4 th 等级,他们在部分理解上被估计并且进一步分类就象对没有困难?? | Qun Zuo Shu-Chen Wang Xin-Kai Yu Wei-Wei Chao | 2018 | Chinese Journal of Traumatology2018，21，2： | 6 |
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