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	题名	作者	年代	出处	被引量
1	胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。	Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉叶鹏	2017	中华高血压杂志2017，25，9：	2
2	New insights into the regulation of HDL metabolism and reverse cholesterol transport 显示文摘	Lewis GF Rader DJ	2005	Circ Res2005，96，12：	1
3	Translating molecular discoveries into new therapies for atherosclerosis显示文摘	Rader DJ Daugherty A	2008	Nature2008，451，7181：	1
4	Emerging therapies targeting high-density lip- oprotein metabolism and reverse cholesterol transport显示文摘	Dully D Rader DJ	2006	Circu- lation2006，113，11：	1
5	The metabolic syndrome:more than the sum of its parts显示文摘	Reilly MP Rader DJ	2003	Circulation2003，108，：	1
6	Laboratory assessment of HDL heterogenicity and function 显示文摘	Mowa R Rader DJ	2008	Clin Chem2008，54，5：	1
7	Endothelial lipase:a new member of the triglyceride lipase gene family显示文摘	Rader DJ Jaye M	2000	Curr Opin Lipidol2000，11，2：	1
8	Genes influencing HDL-c metabolism: new perspecfives and implications for atherosclerosis prevention显示文摘	Rader DJ Maugeais C	2000	Mole Med Today2000，6，：	1
9	Update on the role of endothelial lipase inhigh-density lipoprotein met -abolism, reverse cholesterol transport, and atherosc lerosis显示文摘	Yasuda T Ishida T Rader DJ	2010	Circ J2010，74，11：	1
10	Translating molecular discoveries into new therapies for atherosclerosis显示文摘	Rader DJ Daugherty A	2008	Nature2008，451，7181：	1
11	Pathophysiology and maenagement of low high-density lipoprotein cholesterol显示文摘	Rader DJ	1999	Am J cardiol1999，83，9：	1
12	Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases 显示文摘	Liu J Afroza H Rader DJ	2010	J Biol Chem2010，285，27：	1
13	Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I显示文摘	Jahangiri A Rader DJ Marchadier D	2005	J Lipid Res2005，46，7：	1
14	The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans 显示文摘	Shah A Rader DJ Millar JS	2010	Atherosclerosis2010，210，1：	1
15	Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study 显示文摘	Budoff MJ Rader DJ Reilly MP	2011	Am J Kidney Dis2011，58，4：	1
16	Emerging therapies targeting high density lipoprotein metabolism and reverse cholesterol transport显示文摘	Duffy D Rader DJ	2006	Circulation2006，113，：	1
17	Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol transport显示文摘	Duffy D Rader DJ	2006	Circulation2006，113，8：	1
18	From catalytic asymmetric synthesis to the transcriptional regulation of genes:in vivo and in vitro evolution of proteins 显示文摘	Barbas CF 3rd Rader C Segal DJ	2000	Adv Protein Chem2000，55，8：	1
19	Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I显示文摘	Rader DJ Marchadier D	2005	J Lipid Res2005，46，7：	1
20	Emerging therapies targeting high density lipoprotein metabolism and reverse cholesterol transport显示文摘	Duffy D Rader DJ	2006	Circulation2006，113，8：	1

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