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| 1 | Association of Cytokines with Alanine Aminotransferase, Hepatitis B Virus Surface Antigen and Hepatitis B Envelope Antigen Levels in Chronic Hepatitis B显示文摘 | Ming-Hui Li Yao Lu Lu Zhang Xing-Yue Wang Chong-Ping Ran Hong-Xiao Hao Dan Zhang Xiao-Jing Qu Ge Shen Shu-Ling Wu Wei-Hua Cao Tian-Lin Qi Ru-Yu Liu Lei-Ping Hu Min Chang Wen-Hao Hua Shun-Ai Liu Gang Wan Yao Xie | 2018 | Chinese Medical Journal2018，，15： | 17 |
| 2 | Plasmacytoid Dendritic Cell Function and Cytokine Network Profiles in Patients with Acute or Chronic Hepatitis B Virus Infection显示文摘 | Ming-Hui Li Lu Zhang Dan Zhang Wei-Hua Cao Tian-Lin Qi Hong-Xiao Hao Xing-Yue Wang Chong-Ping Ran Xiao-Jing Qu Shun-Ai Liu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping Hu Wen-Hao Hua Gang Wan Jun Cheng Yao Xie | 2018 | Chinese Medical Journal2018，，1： | 16 |
| 3 | CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6显示文摘睫是毛一般的细胞器从房间表面延长与重要感觉并且活动性功能。睫的缺点能导致作为 ciliopathies 知道的大量人的疾病。然而,控制 ciliogenesis 的分子的机制仍然保持糟糕定义。这里,我们显示出那 cylindromatosis (CYLD ) ,怀有 deubiquitinase 活动的肿瘤 suppressor 蛋白质,在多重机关在主要、能动的睫的集会起一个关键作用。CYLD 猛烈老鼠 polydactyly 展出并且各种各样的睫的缺点,例如在基础身体抛锚和基础身体和 axenomes 的组织的破坏的失败。CYLD 的睫的功能部分从 70 kDa (Cep70 ) 的 centrosomal 蛋白质被归因于它 polyubiquitin 链的 deconjugation,为 Cep70 到的一个要求与 γ 交往;导管素并且在中心体本地化。另外, histone deacetylase 的调停 CYLD 的抑制 6 (HDAC6 ) ,它支持导管素 acetylation,为 CYLD 的睫的功能组成另一机制。HDAC6 的小分子的禁止者能部分在 CYLD 猛烈老鼠救睫的缺点。这些调查结果在 ciliogenesis 的调整强调蛋白质 ubiquitination 的重要性,作为这个过程的一个关键管理者识别 CYLD,并且建议在 ciliopathies 的 CYLD 缺乏的参与。 | Yunfan Yang Jie Ran Min Liu Dengwen Li Yuanyuan Li Xingjuan Shi Dan Meng Junmin Pan Guangshuo Ou Rim Aneja Sbao-Cong Sun Jun Zhou | 2014 | Cell Research2014，24，11： | 8 |
| 4 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 5 | Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2显示文摘AIM:To investigate the biological features of hepatitis B virus(HBV)-transfected HepG2.2.15 cells. METHODS:The cell ultrastructure,cell cycle and apoptosis,and the abilities of proliferation and invasion of HBV-transfected HepG2.2.15 and the parent HepG2 cells were examined by electron microscopy,flow cytometry, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and trans-well assay.Oncogenicity of the two cell lines was compared via subcutaneous injection and orthotopic injection or implantation in nude mice,and the pathological analysis of tumor formation was performed.Two cytoskeletal proteins were detected by Western blotting. RESULTS:Compared with HepG2 cells,HepG2.2.15 cells showed organelle degeneration and filopodia disappearance under electron microscope.HepG2.2.15 cells proliferated and migrated slowly in vitro,and hardly formed tumor and lung metastasis in nude mice.Flow cytometry showed that the majority of HepG2.2.15 cells were arrested in G1 phase,and apoptosis was minor in both cell lines.Furthermore,the levels of cytoskeletal proteins F-actin and Ezrin were decreased in HepG2.2.15 cells. CONCLUSION:HepG2.2.15 cells demonstrated a lower proliferation and invasion ability than the HepG2 cells due to HBV transfection. | Ran Zhao Tian-Zhen Wang Dan Kong Lei Zhang Hong-Xue Meng Yang Jiang Yi-Qi Wu Zu-Xi Yu Xiao-Ming Jin | 2011 | World Journal of Gastroenterology2011，17，9： | 5 |
| 6 | Reliability Study on Quantitative Detection of Extensor Digi- torum Brevis Strength with Needle Electromyography and Nerve Conduction显示文摘Objective To study the objectivity and reliability of needle electromyography and nerve conduction for detection of musculus extensor digitorum brevis strength, which may provide a basis for establishing a quantitative detection of muscle strength in forensic clinical study. Methods Forty-four healthy people were enrolled as the subjects, and during toe dorsiflexion, the following items including needle electromyography indexes, motor unit potential(MUP) amplitude, MUP count, recruitment reaction type, and nerve conduction detection indexes, compound muscle action potential(CMAP) amplitude, CMAP latent period and motor nerve conduction velocity(MNCV), were simultaneously detected under the cooperation and disguise condition. Results Under the cooperation condition, regardless of the same operator or different operators, there were good test-retest reliabilities in MUP amplitude, CMAP amplitude, CMAP latent period and MNCV, while there were normal test-retest reliabilities in MUP count and recruitment reaction type and the repeatability of the same operator was slightly better than the repeatability between different operators. Under the disguise condition, test-retest reliabilities of MUP amplitude, CMAP amplitude, CMAP latent period and MNCV were relatively high, while test-retest reliabilities of MUP count and recruitment reaction type were relatively low. Conclusion There are good test-retest reliabilities in MUP amplitude, CMAP amplitude, CMAP latent period and MNCV, which can be conducive to comparison between different operators and results at various times; MUP count and recruitment reaction type, which can be easily affected by subjectivity of operators and examinees, can be used to differentiate whether an examinee disguises or not. The indexes used to objectively judge muscle strength remain to be further investigated. | GAO Dong XIA Qing RAN Dan TIAN Dong ZHU Guang-you FAN Li-hua | 2013 | 法医学杂志2013，29，6： | 4 |
| 7 | Slightly ruthenium doping enables better alloy nanoparticle exsolution of perovskite anode for high-performance direct-ammonia solid oxide fuel cells显示文摘Fuel flexibility is one of the most distinguished advantages of solid oxide fuel cells(SOFCs)over other low-temperature fuel cells.Furthermore,the combination of ammonia fuel and SOFCs technology should be a promising clean energy system after considering the high energy density,easy transportation/storage,matured synthesis technology and carbon-free nature of NH_(3) as well as high efficiency of SOFCs.However,the large-scale applications of direct-ammonia SOFCs(DASOFCs)are strongly limited by the inferior anti-sintering capability and catalytic activity for ammonia decomposition reaction of conventional nickel-based cermet anode.Herein,a slightly ruthenium(Ru)doping in perovskite oxides is proposed to promote the alloy nanoparticle exsolution,enabling better DA-SOFCs with enhanced power outputs and operational stability.After treating Ru-doped Pr_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.75)Ru_(0.05)O_(3-δ) single-phase perovskite in a reducing atmosphere,in addition to the formation of two layered Ruddlesden-Popper perovskites and Pr_(2)O_(3) nanoparticles(the same as the Ru-free counterpart,Pr_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_(3-δ)),the exsolution of CoFeRu-based alloy nanoparticles is remarkably promoted.Such reduced Pr_(0.6)Sr0.4Co_(0.2)Fe_(0.75)Ru_(0.05)O_(3-δ) composite anode shows superior catalytic activity and stability for NH_(3) decomposition reaction as well as anti-sintering capability in DA-SOFCs to those of reduced Pr0.6Sr0.4Co0.2Fe0.8O_(3-δ)due to the facilitated nanoparticle exsolution and stronger nanoparticle/substrate interaction.This work provides a facile and effective strategy to design highly active and durable anodes for DA-SOFCs,promoting large-scale applications of this technology. | Xiandong Xiong Jian Yu Xiaojian Huang Dan Zou Yufei Song Meigui Xu Ran Ran Wei Wang Wei Zhou Zongping Shao | 2022 | Journal of Materials Science & Technology2022，，30： | 3 |
| 8 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 9 | How Users Search the Mobile Web:A Model for Understanding the Impact of Motivation and Context on Search Behaviors显示文摘Purpose:This study explores how search motivation and context influence mobile Web search behaviors.Design/methodology/approach:We studied 30 experienced mobile Web users via questionnaires,semi-structured interviews,and an online diary tool that participants used to record their daily search activities.SQLite Developer was used to extract data from the users' phone logs for correlation analysis in Statistical Product and Service Solutions(SPSS).Findings:One quarter of mobile search sessions were driven by two or more search motivations.It was especially difficult to distinguish curiosity from time killing in particular user reporting.Multi-dimensional contexts and motivations influenced mobile search behaviors,and among the context dimensions,gender,place,activities they engaged in while searching,task importance,portal,and interpersonal relations(whether accompanied or alone when searching) correlated with each other.Research limitations:The sample was comprised entirely of college students,so our findings may not generalize to other populations.More participants and longer experimental duration will improve the accuracy and objectivity of the research.Practical implications:Motivation analysis and search context recognition can help mobile service providers design applications and services for particular mobile contexts and usages.Originality/value:Most current research focuses on specific contexts,such as studies on place,or other contextual influences on mobile search,and lacks a systematic analysis of mobile search context.Based on analysis of the impact of mobile search motivations and search context on search behaviors,we built a multi-dimensional model of mobile search behaviors. | Dan Wu Man Zhu Aihua Ran | 2016 | Journal of Data and Information Science2016，1，1： | 2 |
| 10 | Silk Fibroin‑Based Wearable All‑Fiber Multifunctional Sensor for Smart Clothing显示文摘Wearable sensing technology enables the interaction between the physical world and the digital world,as takes an irreplaceable role in development of the Internet of Things(IoT),and artificial intelligence(AI).However,increasing requirements posed by rapid development of wearable electronic information technology bring about many for wearable sensing technology,such as the demands for ultrahigh flexibility,air permeability,excellent biocompatibility,and multifunctional integration.Herein,we propose a wearable all-fiber multifunctional sensor(AFMS)based on a biocompatible material,i.e.,silk fibroin.A simple two-layer configuration of a silk fiber film and an interdigital Ag nanowires(AgNWs)electrode was designed to construct the AFMS,in which silk fibroin simultaneously serves as a fundamental supporting component and a functional sensing component.Electrospinning and spray coating technologies were introduced to process the silk fiber film and the AgNWs electrode.The all-fiber configuration allows AFMS to possess ultrahigh flexibility and good air permeability,and silk fibroin enables the AFMS to have excellent biocompatibility.More importantly,benefiting from the all-fiber structure and the environmentally sensitive dielectric property of silk fibroin,the AFMS presented multiple sensing characteristics,including pressure sensing,temperature sensing,and humidity sensing.Among them,the pressure sensing function reached a high sensitivity of 2.27 pF/kPa(7.5%/kPa)and a remarkable resolution of~26 Pa in the low pressure range.Additionally,the outstanding mechanical reliability and sensing stability of AFMS were proven by a systematic experiment.In addition,the AFMS was successfully applied for smart mask for breathing monitoring and a smart glove for bending angle recognition of finger joints.Multiple sensing characteristics combined with prominent fundamental features enable the AFMS tremendous potential in the smart sensing field,e.g.,smart clothing. | Dan‑Liang Wen Yu‑Xing Pang Peng Huang Yi‑Lin Wang Xin‑Ran Zhang Hai‑Tao Deng Xiao‑Sheng Zhang | 2022 | Advanced Fiber Materials2022，4，4： | 2 |
| 11 | Long-term functional reconstruction of segmental tracheal defect by pedicled tissue-engineered trachea in rabbits显示文摘 | Xusong Luo Yi Liu Zhiyong Zhang Ran Tao Yu Liu Aijuan He Zongqi Yin Dan Li Wenjie Zhang Wei Liu Yilin Cao Guangdong Zhou | 2013 | Biomaterials2013，，13： | 2 |
| 12 | Spectrum of toxic hepatitis following intentional paraquat ingestion: analysis of 187 cases显示文摘 | Chin‐Jung Yang Ja‐Liang Lin Dan‐Tzu Lin‐Tan Cheng‐Hao Weng Ching‐Wei Hsu Shen‐Yang Lee Shwu‐Hua Lee Chia‐Ming Chang Wey‐Ran Lin Tzung‐Hai Yen | 2012 | Liver Int2012，，9： | 1 |
| 13 | Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcomes显示文摘 | Dan Ran Mario Schubert Larissa Pietsch Isabel Taubert Patrick Wuchter Volker Eckstein Thomas Bruckner Margot Zoeller Anthony D. Ho | 2009 | Experimental Hematology2009，，12： | 1 |
| 14 | NSUN2-mediated mRNA m^(5)C Modification Regulates the Progression of Hepatocellular Carcinoma显示文摘RNA modifications affect many biological processes and physiological diseases.The 5-methylcytosine(m^(5)C)modification regulates the progression of multiple tumors.However,its characteristics and functions in hepatocellular carcinoma(HCC)remain largely unknown.Here,we found that HCC tissues had a higher m^(5)C methylation level than the adjacent normal tissues.Transcriptome analysis revealed that the hypermethylated genes mainly participated in the phosphokinase signaling pathways,such as the Ras and PI3K-Akt pathways.The m^(5)C methyltransferase NSUN2 was highly expressed in HCC tissues.Interestingly,the expression of many genes was positively correlated with the expression of NSUN2,including GRB2,RNF115,AATF,ADAM15,RTN3,and HDGF.Real-time PCR assays further revealed that the expression of the mRNAs of GRB2,RNF115,and AATF decreased significantly with the down-regulation of NSUN2 expression in HCC cells.Furthermore,NSUN2 could regulate the cellular sensitivity of HCC cells to sorafenib via modulating the Ras signaling pathway.Moreover,knocking down NSUN2 caused cell cycle arrest.Taken together,our study demonstrates the vital role of NSUN2 in the progression of HCC. | Dan Song Ke An Wenlong Zhai Luyao Feng Yingjie Xu Ran Sun Yueqin Wang Yun-Gui Yang Quancheng Kan Xin Tian | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 15 | Null genotypes of GSTM1 and GSTT1 contribute to hepatocellular carcinoma risk: Evidence from an updated meta-analysis显示文摘 | Bin Wang Gang Huang Dan Wang Aijun Li Zhipeng Xu Ran Dong Deqiang Zhang Weiping Zhou | 2010 | Journal of Hepatology2010，，3： | 1 |
| 16 | Long-term functional reconstruction of segmental tracheal defect by pedicled tissue-engineered trachea in rabbits显示文摘 | Xusong Luo Yi Liu Zhiyong Zhang Ran Tao Yu Liu Aijuan He Zongqi Yin Dan Li Wenjie Zhang Wei Liu Yilin Cao Guangdong Zhou | 2013 | Biomaterials2013，，13： | 1 |
| 17 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 18 | Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction显示文摘 | Bo Lagerqvist Ole Fr?bert G?ran K. Olivecrona Thórarinn Gudnason Michael Maeng Patrik Alstr?m Jonas Andersson Fredrik Calais J?rg Carlsson Olov Collste Matthias G?tberg Peter H?rdhammar Dan Ioanes Anders Kallryd Rickard Linder Anders Lundin Jacob Odensted | 2014 | The New England Journal of Medicine2014，，： | 1 |
| 19 | Operation management of green ports and shipping networks: overview and research opportunities显示文摘Global ports and maritime shipping networks are important carriers for global supply chain networks, but they are also the main sources of energy consumption and pollution. To limit ship emissions in ports and offshore areas, the International Maritime Organization, as well as some countries, has issued a series of policies. This study highlights the importance and necessity of investigating emergent research problems in the operation management of green ports and maritime shipping networks. Considerable literature related to this topic is reviewed and discussed. Moreover, a comprehensive research framework on green port and shipping operation management is proposed for future research opportunities. The framework mainly comprises four research areas related to emission control and grading policies. This review may provide new ideas to the academia and industry practitioners for improving the performance and efficiency of the operation management of green ports and maritime shipping networks. | Lu ZHEN Dan ZHUGE Liwen MURONG Ran YAN Shuaian WANG | 2019 | Frontiers of Engineering Management2019，6，2： | 1 |
| 20 | Prediction of system performance based on component jitter and noise budgets 显示文摘 | Dan Oh Frank Lambrecht Jihong Ran | 2007 | IEEE Transaction on Signal Proceeding2007，25，6： | 1 |
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