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| 1 | Variation and heritability of morphological and physiological traits among Leymus chinensis genotypes under different environmental conditions显示文摘Intraspecific trait variation and heritability in different environmental conditions not only suggest a potential for an evolutionary response but also have important ecological consequences at the population, community, and ecosystem levels. However, the contribution of quantitative trait variation within a grassland species to evolutionary responses or ecological consequences is seldom documented. Leymus chinensis is an important dominant species in semi-arid grasslands of China, which has seriously suffered from drought and high temperature stresses in recent decades. In the present study, we measured variation and heritability of 10 quantitative traits, namely the number of tillers, maximum shoot height, number of rhizomes, maximum rhizome length, rhizome mass, aboveground mass, root mass, maximum net photosynthetic rate(Pmax), specific leaf area(SLA), and leaf length to leaf width ratio(LL/LW), for 10 genotypes of L. chinensis under one non-stress(Ck) condition and three environmental stress conditions(i.e., drought(Dr), high temperature(Ht), and both drought and high temperature(DrHt)). Result indicated that(1) the interaction of genotype and environmental condition(G×E) was significant for 6 traits but not significant for the other 4 traits as shown by two-way analysis of variance(ANOVA), suggesting that different selection forces were placed for different traits on the factors dominating phenotypic responses to different environmental conditions. Moreover, these significant G×E effects on traits indicated significantly different phenotypic adaptive responses among L. chinensis genotypes to different environmental conditions. Additionally, individuals could be grouped according to environmental condition rather than genotype as shown by canonical discriminant analysis, indicating that environmental condition played a more important role in affecting phenotypic variation than genotype;(2) by one-way ANOVA, significant differences among L. chinensis genotypes were found in all 10 traits under Ck and Dr conditions, in 8 traits under Dr Ht condition and only in 4 traits under Ht condition; and(3) all 10 traits showed relatively low or non-measurable broad-sense heritability(H_2) under stress conditions. However, the lowest H_2 value for most traits did not occur under DrHt condition, which supported the hypothesis of 'unfavorable conditions have unpredictable effects' rather than 'unfavorable conditions decrease heritability'. Results from our experiment might aid to improve predictions on the potential impacts of climate changes on L. chinensis and eventually species conservation and ecosystem restoration. | YANG Xue LI Junpeng ZHAO Tingting MO Lidong ZHANG Jianli REN Huiqin ZHAO Nianxi GAO Yubao | 2019 | Journal of Arid Land2019，11，1： | 4 |
| 2 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 3 | Perceived resource support for chronic illnesses among diabetics in north-western China显示文摘社会支持的高水平能改进长期的糖尿病自我管理。从单身的来源的支持被评估了。这研究试图分析支持从多重并且为由使用长期的病资源的糖尿病的病人的 multilevel 来源调查(CIRS ) 。影响 CIRS 的利用的因素也被评估。有糖尿病的 297 个病人的一个总数用 CIRS 被调查并且在 Shihezi 城市里察觉了糖尿病自我管理规模,中国。描述的统计被用来解释规模的人口统计的变量和分数。影响长期的病资源的利用的因素通过 univariate 分析被决定然后由 multivariate 检验了逻辑回归分析。调查的 297 个糖尿病的病人, 67% 没能到达利用长期的病资源的标准(超过 3 个点) 。而且,长期的病资源的利用中等断然与糖尿病的自我管理被相关(r = 0.75, P < 0.05 ) 。根据 multivariate 逻辑回归分析,变老(或, 3.42;95%CI, 1.19-9.84 ) 并且每月的收入(或, 5.27;95%CI, 1.86-14.90 ) 断然显著地与 CIRS 分数被联系。有高中的个人(或, 2.61;95%CI, 1.13-6.05 ) 并且学院(或, 3.02;95%CI, 1.13-8.04 ) 度与小学教育比那些在调查获得了更高的分数。结果显示了为长期的病自我管理,特别地个人的调整和组织的资源和支持的那利用,不在在西北的中国的社区的糖尿病患者之中是理想的。长期的病资源的改进利用为合适的糖尿病自我管理是导致的。而且,长期的病资源的利用的水平与年龄,有文化水平,和每月的收入增加了。 | Huiqin Zhong Ya Shao Ling Fan Tangshen Zhong Lu Ren Yan Wang | 2016 | Frontiers of Medicine2016，10，2： | 3 |
| 4 | The effect of pore size and porosity of Ti6Al4V scaffolds on MC3T3-E1 cells and tissue in rabbits显示文摘Electron beam melting(EBM) allows the fabrication of specific porous titanium implants, whereas their in vitro and in vivo biological performance should be further investigated. In this study, we examined the porous Ti6 Al4 V scaffolds(low, 334.1 μm pore size with 55.4% porosity;middle, 383.2 μm pore size with 65.2% porosity;and high, 401.6 μm pore size with 78.1%porosity) fabricated through EBM. The structural characterization and mechanical properties of porous Ti6 Al4 V scaffolds were measured through micro-computed tomography(micro-CT), scanning electron microscopy, and a material testing system.MC3 T3-E1 cells were used to assess the proliferation and differentiation of the cells on different scaffolds at day 7 and day 14 based on the expression levels of genes, including alkaline phosphatase, bone morphogenetic protein-2, osteopontin and runtrelated transcription factor-2. Rabbits with distal femoral defects were utilized to evaluate bone ingrowth in the porous titanium.All of the samples were subjected to micro-CT and histological analysis after 12 weeks. Results showed that compressive Young’s modulus of 0.3–1.1 GPa was similar to the trabecular bone. The three types of porous Ti6 Al4 V scaffolds were inclined to promote cell proliferation, whereas cell differentiation and bone ingrowth into the porous scaffolds were biased to the porous titanium with relatively large pores and porosity(middle and high). This study implied that the present porous implant design,which had the combined advantages of different pore sizes and porosity, might be meaningful and promising for trabecular bone defect restoration. | LUAN HuiQin WANG LiTing REN WeiYan CHU Zhao Wei HUANG YunFei LU ChengLin FAN YuBo | 2019 | Science China(Technological Sciences)2019，62，7： | 2 |
| 5 | Effect of space flight factors on alfalfa seeds显示文摘 | Ren Weibo Zhang Yunwei Deng Bo Guo Huiqin Chen Li- bo Liu Yaxue | 2010 | African Journal of Biotechnology2010，9，43： | 1 |
| 6 | The bone alterations in hind limb amputation rats in vivo显示文摘Osteoporosis,which is characterized by bone loss,increases the risk of fractures and s and seriously affected the amputee’s health.Muscle mass is an important factor affecting bone mineral density(BMD).Muscular atrophy and decreased muscle mass can cause BMD to fall.The bone quantity and quality are used to assess by Microcomputer tomography(micro-CT)with non-destructive.To investigate the performance of micro-CT in evaluating amputation-induced osteopenia in rats,the micro-CT was used to evaluate the change of the microstructure in trabecular bone and cortical bone of amputation.Muscle morphology was analyzed by micro-CT and transmission electron microscopy.Female Sprague–Dawley rats(8 week old)were divided into two groups:control(CON)groups and left hind limb amputation(LHLA).At 35 days,microstructure and volumetric bone mineral density(vBMD)of the tibia and femur were detected through micro-CT.The results showed:(1)the trabecular and cortical vBMD of the proximal tibia and distal femur in the LHLA group were significantly lower than those in the CON group.(2)Compared with the CON group,the trabecular number,bone volume fraction and trabecular thickness of proximal tibia and distal femur in LHLA group decreased significantly,whereas the trabecular separation,structure model index and bone surface/bone volume increased significantly in LHLA group.(3)The whole cross-sectional area(CSA)of whole calf muscles of left limb in LHLA group decreased significantly compared with CON group.In general,hind limb amputation could cause bone loss,changes in the microstructure of trabecular bone and muscle atrophy.Micro-CT is sensitive in evaluating bone microstructure destruction caused by amputation,and can be used for early diagnosis or monitor the development of bone loss in amputation in vivo. | Huiqin Luan Huiru gu Zhongjun Mo Weiyan Ren Huan Guo Zhaowei Chu Yubo Fan | 2020 | Medicine in Novel Technology and Devices2020，，4： | 0 |
| 7 | Effects of different concentrations of TiAl6V4 particles on MC3T3-E1 cells and bone in rats显示文摘Three-dimensional(3D)-printed porous Ti6Al4V implants have good mechanical properties and excellent biocompatibility.As such,these implants are widely used in orthopedics.Particles adhere between the sintered and nonsintered interfaces of the porous samples during 3D printing.These excess particles can be cleaned by blowing the particles and via ultrasound,but the excess internal particles of complex structural parts are difficult to remove.During long-term cyclic loading,stress and strain can cause residual Ti6Al4V particles in the pores of the implant to shed.These detached Ti6Al4V particles are in extensive contact with osteoblasts and scattered around the implant.In this study,we examined the effects of different concentrations of Ti6Al4V particles on osteoblasts and bones.MC3T3-E1 cells were used to evaluate the effects of different concentrations of Ti6Al4V particles on cells after 72 h on the basis of the expression levels of genes,involving osteopontin,alkaline phosphatase,bone morphogenetic protein-2 and runt-related transcription factor-2.Microtubule-associated protein 1 light chain 3 was used to detect the autophagy of MC3T3-E1 with different concentrations of Ti6Al4V particles.The distal femoral defects of rats were examined to examine bone growth with different concentrations of Ti6Al4V particles.All rats were accepted by micro-CT and biochemical analyses after 12 weeks.The results indicated that 10 and 100μg/ml of Ti6Al4V particles may improve osteogenic differentiation.Micro-CT revealed that low concentrations of Ti6Al4V particles may improve the osteogenesis of the rats.However,the(cortical and trabecular)BMD of middle and high dose groups was no significant change compared with control group.In conclusion,low-dose residual particles do not inhibit osteoblast differentiation and do not decrease the bone mineral density of rats. | Huiqin Luan Zhanyong Yu Jian Li Jingfang Bi Zhongjun Mo Weiyan Ren Zengyong Li | 2020 | Medicine in Novel Technology and Devices2020，，3： | 0 |
| 8 | Inhibition of lysine-specific demethylase 1(LSD1)prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma显示文摘Lysine-specific demethylase 1(LSD1),as a histone lysine demethylase,demethylates monomethyl and dimethyl of histone H3 on lysine 4(H3K4)and lysine 9(H3K9).Studies have reported that high LSD1 expression promotes cell proliferation,migration,and invasion by regulating chromatin morphology and gene expression,and is closely related to the development of non-small cell lung cancer(NSCLC).1 However,the underlying mechanism of LSD1 on cell proliferation and migration remains unclear. | Pengxing He Linna Du Pan Hao Han Yang Yufei Ren Huiqin Kang Yanli Ding Wen Zhao Yichao Xu Hongmin Liu | 2023 | Genes & Diseases2023，10，5： | 0 |
| 9 | TIGER:A Web Portal of Tumor Immunotherapy Gene Expression Resource显示文摘Immunotherapy is a promising cancer treatment method;however,only a few patients benefit from it.The development of new immunotherapy strategies and effective biomarkers of response and resistance is urgently needed.Recently,high-throughput bulk and single-cell gene expression profling technologies have generated valuable resources.However,these resources are not well organized and systematic analysis is difficult.Here,we present TIGER,a tumor immunotherapy gene expression resource,which contains bulk transcriptome data of 1508 tumor samples with clinical immunotherapy outcomes and 11,057 tumor/normal samples without clinical immunotherapy outcomes,as well as single-cell transcriptome data of 2,116,945 immune cells from 655 samples.TIGER provides many useful modules for analyzing collected and user-provided data.Using the resource in TIGER,we identified a tumor-enriched subset of CD4^(+)T cells.Patients with melanoma with a higher signature score of this subset have a significantly better response and survival under immunotherapy.We believe that TIGER will be helpful in understanding anti-tumor immunity mechanisms and discovering effective biomarkers. | Zhihang Chen Ziwei Luo Di Zhang Huiqin Li Xuefei Liu Kaiyu Zhu Hongwan Zhang Zongping Wang Penghui Zhou Jian Ren An Zhao Zhixiang Zuo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，2： | 0 |
| 10 | SOLUTION FOR TWO-POINT BOUNDARY VALUE PROBLEM OF THE SEMILINEAR FRACTIONAL DIFFERENTIAL EQUATION显示文摘In this paper, we establish the existence result of solution and positive solution for two-point boundary value problem of a semilinear fractional differential equation by using the Leray-Schauder fixed-point theorem. The discussion is based on the system of integral equations on a bounded region. | Caixia Guo Yugang Ren Jianmin Guo Shugui Kang Yaqiong Cui Huiqin Chen | 2017 | Annals of Applied Mathematics2017，33，2： | 0 |
| 11 | A new spectral index for the quantitative identification of yellow rust using fungal spore information显示文摘Yellow rust(Puccinia striiformis f.sp.Tritici)is a frequently occurring fungal disease of winter wheat(Triticum aestivum L.).During yellow rust infestation,fungal spores appear on the surface of the leaves as yellow and narrow stripes parallel to the leaf veins.We analyzed the effect of the fungal spores on the spectra of the diseased leaves to find a band sensitive to yellow rust and established a new vegetation index called the yellow rust spore index(YRSI).The estimation accuracy and stability were evaluated using two years of leaf spectral data,and the results were compared with eight indices commonly used for yellow rust detection.The results showed that the use of the YRSI ranked first for estimating the disease ratio for the 2017 spectral data(R^(2)=0.710,RMSE=0.097)and outperformed the published indices(R^(2)=0.587,RMSE=0.120)for the validation using the 2002 spectral data.The random forest(RF),k-nearest neighbor(KNN),and support vector machine(SVM)algorithms were used to test the discrimination ability of the YRSI and the eight commonly used indices using a mixed dataset of yellow-rust-infested,healthy,and aphid–infested wheat spectral data.The YRSI provided the best performance. | Yu Ren Huichun Ye Wenjiang Huang Huiqin Ma Anting Guo Chao Ruan Linyi Liu Binxiang Qian | 2021 | Big Earth Data2021，5，2： | 0 |
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