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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?显示文摘AIM To investigate the correlation of iodine concentration(IC) generated by spectral computed tomography(CT) with micro-vessel density(MVD) and vascular endothelial growth factor(VEGF) expression in patients with advanced gastric carcinoma(GC).METHODS Thirty-four advanced GC patients underwent abdominal enhanced CT in the gemstone spectral imaging mode. The IC of the primary lesion in the arterial phase(AP) and venous phase(VP) were measured, and were then normalized against that in the aorta to provide the normalized IC(nI C). MVD and VEGF were detected by immunohistochemical assays, using CD34 and VEGF-A antibodies, respectively. Correlations of nI C with MVD, VEGF, and clinical-pathological features were analyzed.RESULTS Both nI Cs correlated linearly with MVD and were higher in the primary lesion site than in the normal control site, but were not correlated with VEGF expression. After stratification by clinical-pathological subtypes, nI C-AP showed a statistically significant correlation with MVD, particularly in the group with tumors at stage T4, without nodular involvement, of a mixed Lauren type, where the tumor was located at the antrum site, and occurred in female individuals. nI C-VP showed a positive correlation with MVD in the group with the tumor at stage T4 and above, had nodular involvement, was poorly differentiated, was located at the pylorus site, of a mixed and diffused Lauren subtype, and occurred in male individuals. nI C-AP and nI C-VP showed significant differences in terms of histological differentiation and Lauren subtype.CONCLUSION The IC detected by spectral CT correlated with the MVD. n IC-AP and n IC-VP can reflect angiogenesis in different pathological subgroups of advanced GC. | Xiao-Hua Chen Ke Ren Pan Liang Yaru Chai Kui-Sheng Chen Jian-Bo Gao | 2017 | World Journal of Gastroenterology2017，23，9： | 47 |
| 3 | Nitrogen Cycling and Losses Under Rice-Wheat Rotations with Coated Urea and Urea in the Taihu Lake Region显示文摘A lysimeter experiment with undisturbed soil profiles was carried out to study nitrogen cycling and losses in a paddy soil with applications of coated urea and urea under a rice-wheat rotation system in the Taihu Lake region from 2001 to 2003. Treatments for rice and wheat included urea at conventional, 300 (rice) and 250 (wheat) kg N ha-1, and reduced levels, 150 (rice) and 125 (wheat) kg N ha-1, coated urea at two levels, 100 (rice) and 75 (wheat) kg N ha-1, and 150 (rice) and 125 (wheat) kg N ha-1, and a control with no nitrogen arranged in a completely randomized design. The results under two rice-wheat rotations showed that N losses through both NH3 volatilization and runoff in the coated urea treatments were much lower than those in the urea treatments. In the urea treatments N runoff losses were significantly (P < 0.001) positively correlated (r = 0.851) with applied N. N concentration in surface water increased rapidly to maximum two days after urea application and then decreased quickly. However, if there was no heavy rain within five days of fertilizer application, the likelihood of N loss by runoff was not high. As the treatments showed little difference in N loss via percolation, nitrate N in the groundwater of the paddy fields was not directly related to N leaching. The total yield of the two rice-wheat rotations in the treatment of coated urea at 50% conventional level was higher than that in the treatment of urea at the conventional level. Thus, coated urea was more favorable to rice production and environmental protection than urea. | WANG Xiao-Zhi ZHU Jian-Guo GAO Ren H. YASUKAZU FENG Ke | 2007 | Pedosphere2007，17，1： | 31 |
| 4 | Deep carbon cycles constrained by a large-scale mantle Mg isotope anomaly in eastern China显示文摘Although deep carbon recycling plays an important role in the atmospheric CO_2 budget and climate changes through geological time,the precise mechanisms remain poorly understood.Since recycled sedimentary carbonate through plate subduction is the main light-δ^(26)Mg reservoir within deep-Earth,Mg isotope variation in mantle-derived melts provides a novel perspective when investigating deep carbon cycling.Here,we show that the Late Cretaceous and Cenozoic continental basalts from 13 regions covering the whole of eastern China have low δ^(26)Mg isotopic compositions,while the Early Cretaceous basalts from the same area and the island arc basalts from circum-Paciic subduction zones have mantle-like or heavy Mg isotopic characteristics.hus,a large-scale mantle low δ^(26)Mg anomaly in eastern China has been delineated,suggesting the contribution of sedimentary carbonates recycled into the upper mantle,but limited into the lower mantle.his large-scale spatial and temporal variation of Mg isotopes in the mantle places severe constraints on deep carbon recycling via oceanic subduction. | Shu-Guang Li Wei Yang Shah Ke Xunan Meng Hengci Tian Lijuan Xu Yongsheng He Jian Huang Xuan-Ce Wang Qunke Xia Weidong Sun Xiaoyong Yang Zhong-Yuan Ren Haiquan Wei Yongsheng Liu Fancong Meng Jun Yan | 2017 | National Science Review2017，4，1： | 23 |
| 5 | ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro显示文摘目的: 为糖尿病的可勃起的机能障碍(编辑) 的治疗的间充质的干细胞(MSC ) 的移植被移植房间的 apoptosis 妨碍。在糖尿病的编辑,有增加的氧化应力并且在阴茎海绵体,和反应的氧种类(ROS ) 不减少导致移植房间的 apoptosis。在这研究,我们检验了是否并且 autophagy 怎么涉及 MSCs.Methods 的导致 ROS 的 apoptosis : 老鼠 C3H10 MSC 与 H 2 在糖尿病的编辑房间生存能力模仿高氧化的条件的 O 2 用 MTT 被测量试金。Apoptosis 被流动 cytometry 分析。Apoptosis 相关、 autophagy 相关的蛋白质与西方的污点试金被检测。细胞内部的 autophagosome 累积用传播电子 microscopy.Results 被学习: 有 H 2 O 2(50-400 μ mol/L ) 在集中依赖者和时间依赖者礼貌禁止了房间生存能力。而且, H 2 O 2(300 μ mol/L ) 在 MSC 的导致的 apoptosis,以及激活的 autophagy。有 lysosome 禁止者 chloroquine 的预告的处理(10 μ mol/L ) 或 PI3K 禁止者 3-methyladenine (5 mmol/L ) 显著地提高了 H 2 O 2-induced 房间死亡。有 JNK 禁止者 SP600125 的预告的处理(10 μ mol/L ) 废除 H 2 LC3-II 的 O 2-induced 累积,和稀释 H 2 在 MSCs.Conclusion 的 Bcl-2 层次的 O 2-induced 减小: ROS 导致 autophagy 由 JNK 的激活在 MSC 抵抗 apoptosis。因此, autophagy 的扩大可以减少 apoptosis,延长 MSC 幸存并且改进为糖尿病的编辑的基于 MSC 的治疗学的功效。 | Guan-yu LIU Xiao-xue JIANG Xin ZHU Wei-yang HE You-lin KUANG Ke REN Yong LIN Xin GOU | 2015 | Acta Pharmacologica Sinica2015，36，12： | 20 |
| 6 | Curcumin inhibits hepatitis B virus infection by downregulating ccc DNA-bound histone acetylation显示文摘AIM To investigate the potential effect of curcumin on hepatitis B virus(HBV) covalently closed circular DNA(ccc DNA) and the underlying mechanism.METHODS A Hep G2.2.15 cell line stably transfected with HBV was treated with curcumin, and HBV surface antigen(HBs Ag) and e antigen(HBe Ag) expression levels were assessed by ELISA. Intracellular HBV DNA replication intermediates and ccc DNA were detected by Southern blot and real-time PCR, respectively. The acetylation levels of histones H3 and H4 were measured by Western blot. H3/H4-bound ccc DNA was detected by chromatin immunoprecipitation(Ch IP) assays. The deacetylase inhibitors trichostatin A and sodium butyrate were used to study the mechanism of action for curcumin. Additionally, short interfering RNAs(si RNAs) targeting HBV were tested along with curcumin.RESULTS Curcumin treatment led to time-and dose-dependent reductions in HBs Ag and HBe Ag expression and significant reductions in intracellular HBV DNA replication intermediates and HBV ccc DNA. After treatment with 20 μmol/L curcumin for 2 d, HBs Ag and ccc DNA levels in Hep G2.2.15 cells were reduced by up to 57.7%(P < 0.01) and 75.5%(P < 0.01), respectively, compared with levels in non-treated cells. Meanwhile, time-and dose-dependent reductions in the histone H3 acetylation levels were also detected upon treatment with curcumin, accompanied by reductions in H3-and H4-bound ccc DNA. Furthermore, the deacetylase inhibitors trichostatin A and sodium butyrate could block the effects of curcumin. Additionally, transfection of si RNAs targeting HBV enhanced the inhibitory effects of curcumin.CONCLUSION Curcumin inhibits HBV gene replication via downregulation of ccc DNA-bound histone acetylation and has the potential to be developed as a ccc DNA-targeting antiviral agent for hepatitis B. | Zhi-Qiang Wei Yong-Hong Zhang Chang-Zheng Ke Hong-Xia Chen Pan Ren Yu-Lin He Pei Hu De-Qiang Ma Jie Luo Zhong-Ji Meng | 2017 | World Journal of Gastroenterology2017，23，34： | 18 |
| 7 | Transcription Factor WRKY70 Displays Important but No Indispensable Roles in Jasmonate and Salicylic Acid Signaling显示文摘The transcription factor WRKY70 was previously reported to be a common component in salicylic acid(SA) and jasmonate(JA) mediated signal pathways in Arabidopsis.Here,we present that the inactivation of the WRKY70 gene in wrky70-1 mutant does not alter the responses of both JA and SA,and that wrky70 mutation is unable to restore the coi1 mutant in JA responses.However,overexpression of WRKY70 reduces JA responses such as expression of JA-induced genes and JA-inhibitory root growth,and activates expression of SA-inducible PR1.These data indicate that the WRKY70 is important but not indispensable for JA and SA signaling,and that other regulators may display the redundant role with WRKY70 in modulation of JA and SA responses in Arabidopsis.Furthermore,we showed that JA inhibits expression of WRKY70 and PR1 by both COI1-dependent and COI1-independent pathways. | Chun-Mei Ren Qi Zhu Bi-Da Gao Shao-Ying Ke Wan-Cong Yu Dao-Xin Xie Wen Peng | 2008 | Journal of Integrative Plant Biology2008，50，5： | 15 |
| 8 | Municipal wastewater treatment in China:Development history and future perspectives显示文摘China has the world's largest and still growing wastewater sector and water market,thus its future development will have profound influence on the world.The high-speed development of China's wastewater sector over the past 40 years has forged its global leading treatment capacity and innovation ability.However,many problems were left behind,including underdeveloped sewers and sludge disposal facilities,low sustainability of the treatment processes,questionable wastewater treatment plant(WWTP)effluent discharge standards,and lacking global thinking on harmonious development between wastewater management,human society and the nature.Addressing these challenges calls for fundamental changes in target design,policy and technologies.In this mini-review,we revisit the development history of China's municipal wastewater management and identify the remaining challenges.Also,we highlight the future needs of sustainable development and exploring China's own wastewater management path,and outlook the future from several aspects including targets of wastewater management,policies and technologies,especially the new concept WWTP.Furthermore,we envisage the establishment of new-generation WWTPs with the vision of turning WWTP from a site of pollutant removal into a plant of energy,water and fertilizer recovery and an integrated part urban ecology in China. | Jiuhui Qu Hongchen Wang Kaijun Wang Gang Yu Bing Ke Han-Qing Yu Hongqiang Ren Xingcan Zheng Ji Li Wen-Wei Li Song Gao Hui Gong | 2019 | Frontiers of Environmental Science & Engineering2019，13，6： | 13 |
| 9 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 10 | Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats显示文摘 | Wen-ya HUANG Xin ZOU Fu-er LU Hao SU Chu ZHANG Yan-lin REN Ke FANG Li-jun XU Kai- fu WANG Qing-jie CHEN Hui DONG | 2018 | Current Medical Science2018，38，4： | 13 |
| 11 | Uptake of HIV Self-testing among Men Who have Sex with Men in Beijing, China: a Cross-sectional Study显示文摘Objective To examine HIV self-testing uptake and its determinates among men who have sex with men(MSM) in Beijing, China. Methods A cross-sectional online survey was conducted in Beijing, China in 2016. Participants were users of a popular Chinese gay networking application and had an unknown or negative HIV status. Univariate and multivariate logistic regression analyses were conducted to examine factors associated with HIV self-testing based on adjusted odds ratio(AOR) and 95% confidence interval(CI). Results Among the 5,996 MSM included in the study, 2,383(39.7%) reported to have used HIV self-testing kits. Willingness to use an HIV self-test kit in the future was expressed by 92% of the participants. High monthly income(AOR = 1.49; CI = 1.10-2.02; P = 0.010), large number of male sex partners(≥ 2: AOR = 1.24; CI = 1.09-1.43; P = 0.002), sexual activity with commercial male sex partners(≥ 2: AOR = 1.94; CI = 1.34-2.82; P = 0.001), long-term drug use(AOR = 1.42; CI = 1.23-1.62; P < 0.001), and long-term HIV voluntary counseling and testing(VCT) attendance(AOR = 3.62; CI = 3.11-4.22; P < 0.001) were all associated with increased odds of HIV self-testing uptake. Conclusion The nearly 40% rate of HIV self-testing uptake among MSM in our sample was high. In addition, an over 90% willingness to use kits in the future was encouraging. HIV self-testing could be an important solution to help China achieve the global target of having 90% of all people living with HIV diagnosed by 2020. | REN Xian Long WU Zun You MI Guo Dong MCGOOGAN Jennifer ROU Ke Ming ZHAO Yan | 2017 | Biomedical and Environmental Sciences2017，30，6： | 13 |
| 12 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 13 | Preliminary evaluation of magnetic resonance fresh blood imaging for diagnosis of Budd-Chiari syndrome显示文摘背景 Budd-Chiari 症候群(英国计算机学会) 是稀罕疾病,门高血压由肝的静脉或劣等的静脉 cava (IVC ) 的阻塞引起了。Angiography 为诊断是“金色的标准”,但是它是侵略考试。相对英国计算机学会估计新鲜的血成像(FBI ) 的诊断价值,我们在这研究为英国计算机学会病人的外科手术前的评估与一个 FBI 序列使用了磁性的回声 angiography (MRA ) 。在他们被 B 超声检查了以后,被怀疑有英国计算机学会的五十个病人被学习的方法。2D 和 3D FBI 在 1.5T 上被执行超导的先生扫描仪。原来的图象用最大的紧张设计(MIP ) 被重建控制台上的方法。在他们听说了 angiography 结果以前,二位医生考察了所有图象。我们然后比较了从 FBI 和 angiography 结果获得评估 FBI.Results 的诊断价值的 diagnoses 41 个病人作为英国计算机学会被诊断并且 9 作为非英国计算机学会基于 angiography。FBI 正确地诊断了 38 个病人,不正确地诊断了 1 个病人,并且错过了在 3 个病人的诊断。因此, FBI 的诊断敏感是 93%(38/41 ) ,特性是 89%(8/9 ) 并且精确性是 92%(46/50 ) 。IVC 的 13 膜的 stenoses 的 FBI 图象显示出 IVC 的肝以后的片断的突然的狭窄。有 IVC 的膜的阻塞的 5 个病人的图象显示出 IVC 在 IVC 的 hepatic 以后片断变厚和血信号的缺席。有 IVC 的部分血栓的 4 个病人的图象在 IVC 显示出反常、断断续续的信号。有简单肝的静脉阻塞的 6 个病人的图象显示出妨碍的肝的静脉。有 IVC 和肝的静脉的狭窄的 6 个病人的图象显示出 IVC 的狭窄,在肝以内肝的静脉和补偿发行量的形成变厚。最后, 7 个病人的图象与狭窄或与 FBI 能显示出的一或二肝的 veins.Conclusions 的阻塞显示出 IVC 血栓的联合 IVC 的膜的狭窄,和阻塞和血栓。另外,它能也表明与慢血流动曲折肝的静脉和 intra 肝的补偿分支的发展变厚。因此,它能指导刺穿并且开为英国计算机学会病人涉及 interventional 治疗的肝的静脉。 | REN Ke XU Ke SUN Wen-ge CHEN Yu-shuai QI Xi-xun LI Ran-liang JIN An-yu | 2007 | Chinese Medical Journal2007，，2： | 12 |
| 14 | Preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells显示文摘Biodegradation of magnesium (Mg) based metals in body fluid can lead to a strong alkalinity as well as an increase of Mg2+ concentration in its surrounding environment. In vitro cytotoxic effects of the extracts of pure Mg with and without micro arc oxidation (MAO) coating on osteosarcoma U2-OS cells, a kind of bone cancer cells, were preliminarily studied, independently considering the increase of either alkalinity or Mg2+ concentration. The results indicated that the high alkalinity, i.e., a great increase of pH value, caused by the degradations of Mg with and without MAO coating in the culture medium all showed strong cytotoxic effects on U2-OS cells. However, the increase of Mg2+ concentration had no such cytotoxic effect. This finding may provide an alternative way to cure bone cancers through creating a high alkalinity surrounding the cancer cells. | Yu Zhang Ling Ren Mei Li Xiao Lin Huafu Zhao Ke Yang | 2012 | Journal of Materials Science & Technology2012，28，9： | 11 |
| 15 | Nickel-free Stainless Steel for Medical Applications显示文摘BIOSS4 steel is essentially a nickel-free austenitic stainless steel developed by the Institute of Metal Research, Chinese Academy of Sciences, in response to nickel allergy problems associated with nickel-containing stainless steels that are widely used in medical applications. The high nitrogen content of this steel effectively maintains the austenitic stability and also contributes to the high levels of corrosion resistance and strength. BIOSS4 steel possesses a good combination of high strength and toughness, better corrosion resistance, and better blood compatibility, in comparison with the medical 316L stainless steel. Potential applications of BIOSS4 steel can include medical implantation material and orthodontic or orthopedic devices, as well as jewelries and other decorations. | Yibin REN, Ke YANG, Bingchun ZHANG, Yaqing WANG and Yong LIANGInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2004 | Journal of Materials Science & Technology2004，20，5： | 11 |
| 16 | Bio-functional Design for Metal Implants,a New Concept for Development of Metallic Biomaterials显示文摘A new concept for development of metallic biomaterials is proposed in this article,i.e.,a certain bio-function can be realized for a metal implant through continuous release of a designed bio-functional metal element from surface of the metal implant in the body environment.This creative idea has been verified to be possible by several different in vitro and in vivo experimental evidences on the Cu-bearing stainless steels and magnesium based metals.It was indicated that a trace amount of Cu release from the Cu-bearing steels could have obvious bio-functions of reduction of the in-stent restenosis(ISR),anti-bacterial infection,inhibiting the inflammatory cells and even promoting the early osteogenesis.Furthermore,the degradation of magnesium based metals in bones could promote the new bone formation,enhance the bone mineral density for the osteoporosis modeled animal,and even have strong anti-bacterial ability and strong cytotoxicity to bone tumor cells due to the enhancement of pH.Special bio-function with satisfied load-bearing capacity for metallic biomaterials will bring higher application values for the implant made of this novel material.This is an attractive direction for research and development with many challenges,but the final success will be much beneficial to the majority of patients. | Ling Ren Ke Yang | 2013 | Journal of Materials Science & Technology2013，29，11： | 10 |
| 17 | Modified FOLFIRINOX for unresectable locally advanced or metastatic gallbladder cancer,a comparison with GEMOX regimen显示文摘Background:The first-line chemotherapy regimen for advanced gallbladder cancer(GBC)is gemcitabine plus platinum(GP),despite its efficacy is limited.The current investigation is a retrospective study to compare the safety and efficacy between the modified FOLFIRINOX(mFOLFIRINOX)and gemcitabine plus oxaliplatin(GEMOX)as the first-line chemotherapy for unresectable locally advanced or metastatic GBC.Methods:The data of patients with unresectable locally advanced or metastatic GBC,who were treated with mFOLFIRINOX or GEMOX as the first-line therapy between April 2014 and April 2018 at Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,were retrieved.This retrospective study evaluated the clinical characteristics,survival outcomes and adverse events.Results:A total of 44 patients(n=25 in mFOLFIRINOX,n=19 in GEMOX)were included.There were no significant differences between groups in baseline characteristics.The median progression free survival(mPFS)was 5.0 months in the mFOLFIRINOX group and 2.5 months in the GEMOX group[P=0.021;hazard ratio(HR),0.499;95%CI,0.266 to 0.937].The median overall survival(mOS)was 9.5 months in the mFOLFIRINOX group and 7.0 months in the GEMOX group(P=0.019;HR,0.471;95%CI,0.239 to 0.929).Disease control rate(DCR)was 76.0%in the mFOLFIRINOX group and 47.4%in the GEMOX group(P=0.051).The rate of grade 3-4 adverse events was 48%in the mFOLFIRINOX group and 36.8%in the GEMOX group(P=0.459).The incidence of grade 3-4 neutropenia and diarrhea were more common in the mFOLFIRINOX group,while the incidence of grade 3-4 thrombocytopenia and peripheral neuropathy were more common in the GEMOX group.Conclusions:mFOLFIRINOX might improve the poor prognosis of unresectable locally advanced or metastatic GBC,and the results need to be further verified by prospective clinical studies. | Xu-Ya Cui Xue-Chuan Li Jiu-Jie Cui Xiang-Song Wu Lu Zou Xiao-Ling Song Tai Ren Yi-Di Zhu Huai-Feng Li Yang Yang Ke Liu Xu-Sheng Han Zi-Yao Jia Wen-Guang Wu Xu-An Wang Wei Gong Li-Wei Wang Mao-Lan Li Ying-Bin Liu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 10 |
| 18 | Effect of Heat Treatment on Cu Distribution,Antibacterial Performance and Cytotoxicity of Ti-6Al-4V-5Cu Alloy显示文摘A copper-bearing Ti-6AI-4V-5Cu alloy was processed and subjected to different heat treatments to explore the relationship among microstructure,antibacterial performance,and cytocompatibility.Characterization of microstructure revealed that the solution treated alloy consisted of α phase,α' phase and(3 phase,while besides these phases,the aged alloy also contained the precipitations of intermetallic Ti_2Cu compound.The solution treated alloy showed better antibacterial performance with increasing the solution temperature.The Cu ions released from Ti—6AI—4V—5Cu alloy could effectively inhibit the formation of bacterial biofilm on the surface of alloy,and do not induce any cytotoxicity.The optimal heat treatment for Ti-6Al-4V-5Cu alloy was solution treated at 930 C,at which it could exhibit both promising antibacterial performance and no cytotoxicity. | Zheng Ma Ling Ren Rui Liu Ke Yang Yu Zhang Zhenhua Liao Weiqiang Liu Min Qi R.D.K.Misra | 2015 | Journal of Materials Science & Technology2015，31，7： | 10 |
| 19 | Antibacterial Performance of a Cu-bearing Stainless Steel against Microorganisms in Tap Water显示文摘Tap water is one of the most commonly used water resources in our daily life. However, the increasing water contamination and the health risk caused by pathogenic bacteria, such as Staphylococcus aureus and Escherichia coli have attracted more attention. The mutualism of different pathogenic bacteria may diminish antibacterial effect of antibacterial agents. It was found that materials used for making pipe and tap played one of the most important roles in promoting bacterial growth. This paper is to report the performance of an innovative type 304 Cu-bearing stainless steel(304Cu SS) against microbes in tap water. The investigation methodologies involved were means of heterotrophic plate count, contact angle measurements, scanning electron microscopy for observing the cell and subtract surface morphology,atomic absorption spectrometry for copper ions release study, and confocal laser scanning microscopy used for examining live/dead bacteria on normal 304 stainless steel and 304 Cu SS. It was found that the surface free energy varied after being immersed in tap water with polar component and Cu ions release.The results showed 304 Cu SS could effectively kill most of the planktonic bacteria(max 95.9% antibacterial rate), and consequently inhibit bacterial biofilms formation on the surface, contributing to the reduction of pathogenic risk to the surrounding environments. | Mingjun Li Li Nan Dake Xu Guogang Ren Ke Yang | 2015 | Journal of Materials Science & Technology2015，31，3： | 10 |
| 20 | Optimization of mechanical property, antibacterial property and corrosion resistance of Ti-Cu alloy for dental implant显示文摘Ti-Cu alloys with different Cu contents(3, 5 and 7 wt%) were fabricated and studied as novel antibacterial biomaterials for dental application. The Ti-Cu alloys were annealing treated at different temperatures(740℃, 830℃ and 910℃) in order to obtain three typical microstructures, β-Ti + Ti2Cu, β-Ti + transformed α-Ti, and transformed α-Ti. Mechanical, antibacterial and biocorrosion properties of Ti-Cu alloys with different microstructures were well analyzed by scanning electron microscopy(SEM),X-ray diffraction(XRD), transmission electron microscopy(TEM), tensile test, electrochemical test and antibacterial test. The results indicated that the Ti-Cu alloys with microstructure of β-Ti + Ti2 Cu showed the best ductility compared with other Ti-Cu alloys with microstructures of β-Ti + transformed α-Ti and complete transformed α-Ti, and meanwhile, increase of the Cu content significantly contributed to the decreased ductility due to the increasing amount of Ti2 Cu, which brought both solid solution strengthening and precipitation strengthening. Finally, the Ti-5 Cu alloy with microstructure of β-Ti + Ti2 Cu exhibited excellent ductility, antibacterial property and corrosion resistance, providing a great potential in clinical application for dental implants. | Jiewen Wang Shuyuan Zhang Ziqing Sun Hai Wang Ling Ren Ke Yang | 2019 | Journal of Materials Science & Technology2019，35，10： | 9 |
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