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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 3 | The effect of local attachment of cationized antioxidant enzymes on experimental colitis in the rat 显示文摘 | Sigal B Ron K Paul B | 2000 | Pharm Res2000，17，9： | 1 |
| 4 | Organizational decision support system for effective R&D project selection 显示文摘 | TIAN Q MA J LIANG J RON C W K OU L | 2005 | Decision Support Systems2005，39，3： | 1 |
| 5 | 显示文摘 | Goebel Dan M Watkins Ron M Jameson Kristina K | 2007 | Propul Power2007，23，3： | 1 |
| 6 | Membrane lipid satu- ration activates endoplasmic reticulum unfolded protein response transducers through their transmembrane do- mains显示文摘 | Volmer R van der Ploeg K Ron D | 2013 | Proc Natl Acad Sci USA2013，，12： | 1 |
| 7 | Rising thyroid cancer incidence in the united states by demographic and tumor charactristics, 1980 : 2005 显示文摘 | Enewold L Zhu K Ron E | 2009 | Cancer Epidemiol Biomarkers Prey2009，18，3： | 1 |
| 8 | Switching characteristics of a gas trigatron operated in single and double trigger mode显示文摘 | NANU K RON P H IYENGAR S T | 1990 | IEEE Transactions on Electrical Insulation1990，25，2： | 1 |
| 9 | Effect of Cheyne-Stokes Respiration on Muscle Sympathetic Nerve Activity in Severe Congestive Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy显示文摘 | Philippe van de Borne Ron Oren Chadi Abouassaly Erling Anderson Virend K Somers | 1998 | The American Journal of Cardiology1998，，： | 1 |
| 10 | Implementing 5S within a Japanese context:an integrated management system显示文摘 | ROD G RON F KAORU K | 2008 | Management Decision2008，4，： | 1 |
| 11 | Rising thyroid cancer incidence in the United States by demographic and tumor characteristics,1980-2005显示文摘 | Enewold L Zhu K Ron E | | 0，，03： | 1 |
| 12 | Elevated serum squalene and cholesterol synthesis markers in pregnant obese women with ges- rational diabetes mellitus显示文摘 | Miettinen HE Rons K Koivusalo S | 2014 | J Lipid Res2014，55，12： | 1 |
| 13 | Implementing 5S within a Japanesecon-text: an integrated management system显示文摘 | Rod G Ron F Kaoru K | 2008 | Management Decision2008，2，4： | 1 |
| 14 | The benefit of an acute stroke unit in patients with intracranial haemorrhage: a controlled trial 显示文摘 | RONNING 0 M GULDVOG B STAVEM K | 2001 | J Neurol Neurosurg Psychiatry2001，70，5： | 1 |
| 15 | The prevalence of treatable left ventricular systolic dysfunction in patients who present with noncardiac vascular episodes:a case-control study显示文摘 | Anthony S Ron M W | 2002 | J Am Coll Cardiol2002，39，： | 1 |
| 16 | Rapid colorimetric detection of antibody-epitope recognition at a biomimetic membrane interface显示文摘 | RON K MARINA K | 2001 | Journal of the American Chemical Society2001，123，3： | 1 |
| 17 | Unplanned extubation in the ICU: Impact on outcome and nursing workload显示文摘 | Ayman K Ron B Claudio M | 2006 | Annals of Thoracic Medicine2006，1，2： | 1 |
| 18 | The high-volume return premium显示文摘 | Gervais S Ron K Mingelgrin D H | 2001 | Journal of Finance2001，56，： | 1 |
| 19 | Genetic study of the CD36 gene In a French diabetic population显示文摘 | F Leprêtre KJ Linton C Lacquemant V Vatin C Samson C Dina M Chikri S Ali P Scherer K Séron F Vasseur T Aitman P Froguel | 2004 | Diabetes and Metabolism2004，，5： | 1 |
| 20 | Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005显示文摘 | Enewold L Zhu K Ron E | 2009 | Cancer Epidemiol Biomarkers Prey2009，18，3： | 1 |
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