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| 1 | Intrahepatic cholestasis of pregnancy:When should you look further?显示文摘Pruritis with abnormal liver function tests is the classical presentation of intrahepatic cholestasis of pregnancy(ICP),a condition associated with significant fetal complications.Although the etiology of ICP is unclear in many cases,certain features of the clinical presentation should alert the practitioner to the possibility of an underlying metabolic defect, which may not only affect subsequent pregnancies, but may be an indicator of more serious subsequent liver disease.We report a kindred of Anglo-Celtic descent,among whom many members present with ICP,gallstones or cholestasis related to use of oral contraception.Genetic studies revealed a novel mutation in the ABCB4 gene,which codes for a phospholipid transport protein.The clinical significance of this mutation and the importance of identifying such patients are discussed. | Winita Hardikar Shivani Kansal Ronald P J Oude Elferink Peter Angus | 2009 | World Journal of Gastroenterology2009，15，9： | 22 |
| 2 | Observation of ocean current response to 1998 Hurricane Georges in the Gulf of Mexico显示文摘The ocean current response to a hurricane on the shelf-break is examined. The study area is the DeSoto Canyon in the northeast Gulf of Mexico, and the event is the passage of 1998 Hurricane Georges with a maximum wind speed of 49 m/s. The data sets used for analy- sis consist of the mooring data taken by the Field Program of the DeSoto Canyon Eddy Intrusion Study, and simultaneous winds ob- served by NOAA (National Oceanic and Atmospheric Administration) Moored Buoy 42040. Time-depth ocean current energy density images derived from the observed data show that the ocean currents respond almost immediately to the hurricane with important differ- ences on and off the shelf. On the shelf, in the shallow water of 100 m, the disturbance penetrates rapidly downward to the bottom and forms two energy peaks, the major peak is located in the mixed layer and the secondary one in the lower layer. The response dissipates quickly after external forcing disappears. Off the shelf, in the deep water, the major disturbance energy seems to be trapped in the mixed layer with a trailing oscillation; although the disturbance signals may still be observed at the depths of 500 and 1 290 m. Verti- cal dispersion analysis reveals that the near-initial wave packet generated off the shelf consists of two modes. One is a barotropic wave mode characterized by a fast decay rate of velocity amplitude of 0.020 s-1, and the other is baroclinic wave mode characterized by a slow decay rate of 0.006 9 s-1. The band-pass-filtering and empirical function techniques are employed to the frequency analysis. The results indicate that all frequencies shift above the local inertial frequency. On the shelf, the average frequency is 1.04f in the mixed layer, close to the diagnosed frequency of the first baroclinic mode, and the average frequency increases to 1.07f in the thermocline. Off the shelf, all frequencies are a little smaller than the diagnosed frequency of the first mode. The average frequency decreases from 1.035f in the mixed layer to 1.02f in the thermocline, implying a trend for the shift in frequency of the oscillations towards f with the depth. | ZHENG Quanan LAI Ronald J HUANG Nortlen E PAN Jiayi LIU W Timothy | 2006 | Acta Oceanologica Sinica2006，25，1： | 20 |
| 3 | Variation and mechanisms of clastic reservoir quality in the Paleogene Shahejie Formation of the Dongying Sag, Bohai Bay Basin, China显示文摘Reservoir quality varies greatly in the Shahejie Formation in the Dongying Sag. It is essential to analyze the variation and mechanisms of reservoir quality for determining the controlling factors based on cores, porosity measurements and fluid inclusion techniques and so on. The sandstones in the fluvial,(fan) delta-front have the best reservoir quality due to the depositional conditions mechanically controlling the petrology configuration and the primary porosity, and chemically influencing the diagenesis and development of secondary pores. The activity of the boundary faults and the sedimentary facies dominate the variation of reservoir quality in different areas and intervals. The reservoir quality varies with the position of sandstone beds in different vertical models of sandstone and mudstone. This mainly arose from the strong cementation or strong dissolution in the sandstone caused by the diagenesis evolution of adjacent mudstone. With higher oil saturation reservoir quality is better because the hydrocarbon charge favors dissolution and restricts cementation. Diagenesis, depositional conditions and tectonic setting are the key controls of reservoir quality in the Shahejie Formation of the Dongying Sag. | Zhang Qin Zhu Xiaomin Ronald J Steel Zhong Dakang | 2014 | Petroleum Science2014，11，2： | 16 |
| 4 | 85岁及以上老年冠心病患者经皮冠状动脉支架治疗的临床观察显示文摘目的探讨85~94岁冠心病患者经皮冠状动脉支架治疗的疗效和预后。方法回顾性分析90例85岁以上冠心病患者经皮冠状动脉支架治疗的临床和造影特点、住院期间和长期疗效。结果90例中,21例应用金属裸支架(BMs),69例应用药物洗脱支架(DES)。三支病变41例,2支病变21例,单支病变28例。手术成功率为94.4%,术前与术后TIMI-3级血流比例分别为72.2%和94.4%。手术相关并发症为15.6%,主要为冠脉夹层(11.1%)。住院期间主要心血管不良事件(MACE)为7.8%,其中DES组住院期间MACE为5.8%,BMS组为14.3%。DES组出现2例严重出血。86例患者随访1年时,总的MACE为4.6%,其中DES组为6.0%,BMS组没有任何MACE。DES组出现1例脑卒中和1例严重出血。47例患者随访2年时,总的MACE为14.9%,其中DES组MAcE为19.4%,BMS组无任何MACE。DES组1例发生严重出血,BMS组1例发生脑卒中。多因素C0x回归分析表明,肌酐水平和高血压是影响长期预后的重要因素。结论85岁以上冠心病患者经皮冠状动脉支架治疗手术成功率较高,住院期间和长期的MACE事件发生率较低,并存高血压和严重肾功能不全的患者MACE的发生率相对较高。 | 马涵英 周玉杰 Ronald J Dick 赵迎新 吴小滢 梁静 杨丽霞 张琳琳 | 2008 | 中华老年医学杂志2008，27，7： | 8 |
| 5 | 牧草如何生长——植物生长与放牧管理之关联(英文)显示文摘适当管理饲料饲草资源的基本原则是理解多年生牧草如何生长。长期以来 ,对根系生长有了基本的了解 ,对去叶和环境对根系生长的影响也知之甚多。然而 ,对去叶、干旱及其他环境因素对多年生牧草的影响以及这些牧草对去叶的反应缺乏应有的理解。从牧草返青到开花 ,植物处于短枝阶段 ,适度放牧并不对多年生牧草的健康和活力造成危害 ,因为植物会弥补其失去的叶片。然而 ,当牧草从短枝向长枝阶段 (节间伸长和开花期 )转移时 ,碳水化合物主要用于节间伸长和开花过程。在开花后和休眠前期 ,碳水化合物主要向茎基和植物基部转移 ,以供来年新枝条的发育。因此 ,在花后和休眠前期 ,放牧系统必须被调节到“无放牧”状态。“无放牧”状态 ,如休息、轮牧、延迟轮牧和快速轮牧制 ,其价值在于这种定期的禁牧可提高多年生牧草的活力 ,改善草地的健康状况 ,并且在不利的环境条件下 。 | Ronald E Sosebee David B Wester J Carlos Villalobos Carlton M Britton Changgui Wan Hisham Nofal | 2005 | 草业学报2005，14，1： | 8 |
| 6 | Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction显示文摘AIM:To investigate the molecular mechanism and functional consequences of heme oxygenase-1(HO-1) activation by lansoprazole in endothelial cells and macrophages. METHODS:Expression of HO-1 mRNA was analyzed by Northern blotting.Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species(ROS) formation was measured with lucigenin-enhanced chemiluminescence.HO-1 promoter activity in mouse fibroblasts,stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed using in vivo bioluminescence imaging. RESULTS:Lansoprazole increased HO-1 mRNA levels in endothelial cells and HO-1 protein levelsin macrophages.In addition,lansoprazole-induced ferritin protein levels in both cell systems.Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation.The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor,chromium mesoporphyrin IX.Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However,the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter activity. CONCLUSION:Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002. | Stephanie Schulz-Geske Kati Erdmann Ronald J Wong David K Stevenson Henning Schrder Nina Grosser | 2009 | World Journal of Gastroenterology2009，15，35： | 7 |
| 7 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 8 | Long-term outcome of patients of over 85 years old with acute coronary syndrome undergoing percutaneous coronary stenting: a comparison of bare metal stent and drug eluting stent显示文摘超过 85 年的背景病人在经皮的冠的干预(一种总线标准) 是未被充分代表的尽管有为一种总线标准的工作分派的增加的试用。在有急性冠的症候群(交流) 的超过 85 年的病人的经皮的冠的 stenting 的长期的安全和功效仍然保持不清楚。而且是否在这特殊 population.Methods 赤裸的金属 stent (BMS ) 和药 eluting stent (DES ) 之间有差别,是未知的,有交流的 80 个病人的一个总数在经历 stenting (BMS 组 n=21 对 DES 组 n=59 ) 的 85 年变老回顾地被学习。在里面医院,一年和包括心脏的死亡的主要不利心脏的事件(权标)的全面临床的后续( 12-36 月),心肌的梗塞,目标损害 revascularization ( TLR )和象击并且另外的主要流血一样的目标容器 revascularization ( TVR )在全部队在二 groups.Results 之间被比较,过程成功率与在93.8%容器一种总线标准以后的 TIMI-3 冠的流动是93.8%,过程联系了复杂并发症是17.5%。在 BMS 组的在里面医院权标的发生更高(14.3% 对 6.8% , P=0.30 ) 。当在 BMS 组没有向时,在 DES 组的权标的 1 年的发生是 7.0% 。为 12-36 月的临床的后续证明从向免费的全面幸存是 82.9% ,在 BMS 组的向的发生更低(5.3% 对 21.1% , P=0.20 ) 。Multivariate 回归分析证明 creatinine 铺平(OR:1.013;95%C1:1.006-1.020;P=0.004 ) 并且高血压(OR:3.201;95%C1:1.000-10.663; P=0.04 ) 是二个主要因素影响在超过 85 年的病人的长期的 MACE.Conclusions 经皮的冠的 stenting 是安全的并且提供好短、长期的功效。有肾的机能障碍和高血压的病人可以有向的相对高的发生。 | MA Han-ying ZHOU Yu-jie Ronald J Dick SHI Dong-mei LIU Yu-yang CHENG Wan-jun GUO Yong-he WANG Jian-long GE Hai-long | 2008 | Chinese Medical Journal2008，，10： | 5 |
| 9 | 他汀药物预治疗对高龄冠心病患者支架术预后的影响显示文摘目的 探讨术前他汀类药物治疗对高龄冠心病患者经皮冠状动脉支架治疗近期和远期预后的影响.方法 回顾性分析90例85岁以上冠心病患者术前他汀应用情况,观察其对预后的影响.结果 90例患者中,33例经皮冠状动脉介入(PCI)术前接受他汀治疗,57例PCI术前未接受他汀治疗.80例(88.9%)为急性冠状动脉综合征.术前接受他汀治疗组血脂异常、既往心肌梗死病史、既往PCI、开口病变、药物涂层支架(DES)植入比例比例略高.住院期间主要心血管不良事件(MACE)发生率要低于术前未接受他汀治疗组(3.0%比10.5%,P=0.05).随访1年时MACE发生率两组相似(6.1%与3.8%,P=0.07).整个研究人群1年生存率较高.结论 他汀预治疗对高龄冠心病支架术后可能降低住院期间MACE,而不一定能改善1年预后. | 马涵英 赵铁夫 张银凤 史宏志 韩红亚 周玉杰 Ronald J Dick | 2010 | 中华医学杂志2010，90，32： | 5 |
| 10 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 11 | Nicotine and inflammatory neurological disorders显示文摘香烟烟是显著地包括肺癌症和呼吸感染增加疾病的发生的一个主要健康风险因素。然而,正在增加吸烟者们有煽动性的一些和 neurodegenerative 疾病的更低的发生的证据。烟碱是香烟烟的主要抑制免疫力的成分,它两个都禁止天生、适应的有免疫力的回答。不同于香烟烟,烟碱还没被认为是致癌物并且事实上,可以作为 neuroprotective 和反煽动性的代理人有治疗学的潜力。这评论提供在免疫系统上总结烟碱的效果的一个提要并且它的(烟碱) 在各种各样的神经病学的疾病上影响。 | Wen-Hua PIAO Denise CAMPAGNOLO Carlos DAYAO Ronald J LUKAS Jie WU Fu-D ong SHI | 2009 | Acta Pharmacologica Sinica2009，30，6： | 3 |
| 12 | Angiotensin Type 1 Receptor Blockers Induce Peroxisome Proliferator–Activated Receptor-γ Activity显示文摘 | Michael Schupp Jürgen Janke Ronald Clasen Thomas Unger Ulrich Kintscher | 2004 | Circulation: Journal of the American Heart Association2004，，17： | 3 |
| 13 | AN OVERVIEW OF CMIP5 AND THE EXPERIMENT DESIGN显示文摘 | Taylor Karl E Stouffer Ronald J Meehl Gerald A | 2012 | EN2012，，4： | 3 |
| 14 | 肾功能不全与高龄冠脉支架治疗的预后分析显示文摘目的 探讨不同肾功能对高龄冠心病患者经皮冠状动脉支架治疗住院期间和长期预后的影响.方法 回顾性分析90例85岁以上冠心病接受冠脉支架治疗患者主要心血管不良事件和病死率.根据入院时估算的肾小球滤过率水平,患者分为eGFR≥60组(肾功能正常或轻度不全组;n=62)和eGFR〈60组(中重度肾功能不全组;n=28),观察肾功能不全对高龄冠脉介入治疗预后的影响.结果 eGFR〈60组高血压病、目前吸烟状态、既往心肌梗死病史、三支病变、C型病变、术前TIMI0级血流比例略高.住院期间主要心血管不良事件发生率eGFR〈60组要明显高于eGFR≥60组(14.3%vs4.8%;P〈0.05).随访1年时全因死亡率两组相似(4.9%vs4.0%;P〉0.05),但MACE发生率eGFR〈60组仍高于eGFR≥60组(8.0%vs3.3%;P=0.05).整体研究人群1年生存率较高.结论 中重度肾功能不全是影响高龄冠脉支架治疗预后的一个重要危险因素,围手术期应积极地改善患者的肾功能从而改善预后. | 马涵英 赵铁夫 张维君 杨清 刘睿方 柴萌 张鸥 Ronald J Dick | 2011 | 中国急救复苏与灾害医学杂志2011，6，10： | 3 |
| 15 | Plant vintage, technology, and environmental regulation显示文摘 | Wayne B Gray Ronald J Shadbegian | 2003 | Journal of Environmental Economics and Management2003，，3： | 3 |
| 16 | Mortality Risk for Dialysis Patients With Different Levels of Serum Calcium, Phosphorus, and PTH: The Dialysis Outcomes and Practice Patterns Study (DOPPS)显示文摘 | Francesca Tentori Margaret J. Blayney Justin M. Albert Brenda W. Gillespie Peter G. Kerr Jürgen Bommer Eric W. Young Tadao Akizawa Takashi Akiba Ronald L. Pisoni Bruce M. Robinson Friedrich K. Port | 2008 | American Journal of Kidney Diseases2008，，3： | 3 |
| 17 | Epidemiology of Cryptosporidium : transmission, detection and identification显示文摘 | Ronald Fayer Una Morgan Steve J Upton | 2000 | International Journal for Parasitology2000，，12： | 3 |
| 18 | Management of the Open Abdomen: From Initial Operation to Definitive Closure显示文摘 | Vargo Daniel Richardson J David Campbell Andre Chang Michael Fabian Timothy Franz Michael Kaplan Mark Moore Frederick Reed R Lawrence Scott Bradford Silverman Ronald | 2009 | The American Surgeon2009，，11： | 2 |
| 19 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 20 | Chemical and pharmacological evaluation of Hypericum perforation extracts显示文摘KEY WORDS Hypericum perforation; High pressure liquid chromatography; serotonin uptake inhibitors; tree radicals; antioxidants; hyperforin; hypericin; quercetin; rutinABSTRACTAIM: To determine the concentrations of chemical characteristic to extracts of leaves and flowers of Hypericum perforatnm (St John’s wort) in a number of selected samples and, following chemical characterization, to investigate the effects of these extracts on several pharmacological properties including effects of the extracts on inhibition of 5-hydroxytryptamine (5-HT) uptake and on an-tioxidant properties. METHODS: The samples were analyzed for the presence of characteristic chemicals by high performance liquid chromatography (HPLC) directly coupled to ultraviolet wavelength absorbance and positive or negative mode electrospray mass spectrometric detection. The effects of extracts on 5-HT uptake were determined by quantifying 3H-5-HT incorporation into rat hip-pocampal prisms. Estimates of effects of extracts on free radical | B Duff SLOLEY Liana J URICHUK LING Lei GU Lie-Dong Ronald T COUTTS Peter K T PANG Jacqueline J SHAN | 2000 | Acta Pharmacologica Sinica2000，21，12： | 2 |
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