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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Angiotensin Ⅱ and the fibroproliferative response to acute lung injury显示文摘 | Richard P M Peter G Rachel C | 2004 | Am J Physiol Lung Cell Mol Physiol2004，286，： | 2 |
| 3 | School-based intervention for adolescents with social anxiety disorder:Result of a controlled study显示文摘 | Carrie Masia-Warner Rachel G Klein Heather C Dent | 2005 | Journal of Abnormal Child Psychology2005，33，6： | 1 |
| 4 | Changes in the intra- metropolitan loca- tion of producer services in the France (1978--1997) : Do informa- tion technologies promote a more dispersed spatial pattern? 显示文摘 | ORAIN C B RACHEl G | 2004 | Ur- ban Geography2004，25，6： | 1 |
| 5 | A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland显示文摘 | Katrina E G Bert B Rachel S C | 2000 | Breast Cancer Res2000，2，3： | 1 |
| 6 | A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland 显示文摘 | KATRINA E G BERT B RACHEL S C | 2000 | Breast Cancer Res2000，2，3： | 1 |
| 7 | Adoption of Environmental Innova- tions: Analysis from the Waipara Wine Industry 显示文摘 | Sharon L F Ross C Rachel G | 2013 | Wine Economies and Policy2013，2，1： | 1 |
| 8 | Personal involvement as a determinant of argument-based persuasion 显示文摘 | Petty R E John T C Rachel G | 1981 | Journal of Personality and Social Psychology1981，41，5： | 1 |
| 9 | Clinic pathologic, histological,and toxicological findings in 70 cats inadvertently exposed to pet food contaminated with melamine and cyanuric acid显示文摘 | Rachel E C Karyn B Joseph G E | 2008 | Sci Reports2008，233，5： | 1 |
| 10 | Parameters guiding selection of best embryos for transfer after cryopreservation:a reappraisal显示文摘 | Fabrice G Rachel B Veronique C | 2002 | Hum Reprod2002，17，5： | 1 |
| 11 | Parameters guiding selection of best embryos for transfer after cryopreservation: a reappraisal 显示文摘 | Fabrice G Rachel B Veronique C | 2002 | Hum deprod2002，17，5： | 1 |
| 12 | Effect of glyphosate on the tripartite symbiosis formed by Glomus intraradices,Bradyrhizobium japonicum,and genetically modified soybean显示文摘 | Jeff R P Rachel G C Kari E D | 2009 | Applied Soil Ecology2009，41，1： | 1 |
| 13 | Clonogenicity of human endometrial epithelial and stromal cells显示文摘 | RACHEL W S C KJIANA ES CAROLINE E G | 2004 | Biology of Reproduction2004，70，： | 1 |
| 14 | Fluorene based conjugated polyeleetrolyte/silica nanocomposites: charge mediated phase agregation at the organic-inorganic interface显示文摘 | Rachel C E Andreia G M Swapna P | 2010 | Advance Mate- rial2010，22，28： | 1 |
| 15 | Using CT perfusion during the early baseline period in aneurysmal subarachnoid hem- orrhage to assess for development of vasospasm显示文摘 | Pina C Austin J Rachel G | 2011 | Neuro- radiology2011，53，6： | 1 |
| 16 | Parameters guiding selection of best embryos for transfer after cryopreservation:a reappraisal显示文摘 | Fabrice G Rachel B Veronique C | 2002 | Hum Reprod2002，17，5： | 1 |
| 17 | Systematic review and meta analysis of evidence for increasing numbers of drugs in antiretroviral combination therapy显示文摘 | Rachel J Lisa G Carole C | 2002 | British Med2002，324，7340： | 1 |
| 18 | Systematic review and meta-analysis of evidence for increasing numbers of drugs in antiretroviral combination therapy显示文摘 | Rachel J Lisa G Carole C | 2002 | British Med2002，324，： | 1 |
| 19 | Parameters guiding selection of best embryos for transfer after cryopreservation :a reappraisal显示文摘 | Fabrice G Rachel B Veronique C | 2002 | Hum Reprod2002，17，5： | 1 |
| 20 | Prenatal Exposure to Butylbenzyl Phthalate and Early Eczema in an Urban Cohort显示文摘 | Just Allan C Whyatt Robin M Perzanowski Matthew S Calafat Antonia M Perera Frederica P Goldstein Inge F Chen Qixuan Rundle Andrew G Miller Rachel L | 2012 | EN2012，，10： | 1 |
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