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| 1 | Trends in Waiting List Registration for Liver Transplantation for Viral Hepatitis in the United States显示文摘 | W. Ray Kim Norah A. Terrault Rachel A. Pedersen Terry M. Therneau Erick Edwards Andrew A. Hindman Carol L. Brosgart | 2009 | Gastroenterology2009，，5： | 1 |
| 2 | Amyloid-beta-dependent phosphorylation of collapsin response mediator protein-2 dissociates kinesin in Alzheimer's disease显示文摘Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles.Prior to the development of these characteristic pathological hallmarks of AD,anterograde axonal transport is impaired.However,the key proteins that initiate these intracellular impairments remain elusive.The collapsin response mediator protein-2(CRMP-2)plays an integral role in kinesin-1-dependent axonal transport and there is evidence that phosphorylation of CRMP-2releases kinesin-1.Here,we tested the hypothesis that amyloid-beta(Aβ)-dependent phosphorylation of CRMP-2 disrupts its association with the kinesin-1(an anterograde axonal motor transport protein)in AD.We found that brain sections and lysates from AD patients demonstrated elevated phosphorylation of CRMP-2 at the T555 site.Additionally,in the transgenic Tg2576 mouse model of familial AD(FAD)that exhibits Aβaccumulation in the brain with age,we found substantial co-localization of p T555CRMP-2and dystrophic neurites.In SH-SY5Y differentiated neuronal cultures,Aβ-dependent phosphorylation of CRMP-2 at the T555 site was also elevated and this reduced the CRMP-2 association with kinesin-1.The overexpression of an unphosphorylatable form of CRMP-2 in neurons promoted the re-establishment of CRMP-2-kinesin association and axon elongation.These data suggest that Aβ-dependent phosphorylation of CRMP-2 at the T555 site may directly impair anterograde axonal transport protein function,leading to neuronal defects. | Sara H.Mokhtar Min Joung Kim Kylie A.Magee Pei Mun Aui Speros Thomas Maha M.Bakhuraysah Amani A.Alrehaili Jae Young Lee David L.Steer Rachel Kenny Catriona Mc Lean Michael F.Azari Antonis Birpanagos Ewlina Lipiec Philip Heraud Bayden Wood Steven Petratos | 2018 | Neural Regeneration Research2018，13，6： | 1 |
| 3 | Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury显示文摘 | Hongmei Ruan Jian Li Shuxun Ren Jing Gao Guangping Li Rachel Kim Hong Wu Yibin Wang | | Journal of Molecular and Cellular Cardiology0，，： | 1 |
| 4 | Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice显示文摘 | Phil Lee Jieun Kim Rachel Williams Rajat Sandhir Eugene Gregory William M. Brooks Nancy E.J. Berman | 2011 | Experimental Neurology2011，，1： | 1 |
| 5 | MORC Family ATPases Required for Heterochromatin Condensation and Gene Silencing显示文摘 | Guillaume Moissiard Shawn J. Cokus Joshua Cary Suhua Feng Allison C. Billi Hume Stroud Dylan Husmann Ye Zhan Bryan R. Lajoie Rachel Patton McCord Christopher J. Hale Wei Feng Scott D. Michaels Alison R. Frand Matteo Pellegrini Job Dekker John K. Kim Steve | 2012 | Science . 2012 (6087)2012，，6087： | 1 |
| 6 | Trends in Waiting List Registration for Liver Transplantation for Viral Hepatitis in the United States显示文摘 | W. Ray Kim Norah A. Terrault Rachel A. Pedersen Terry M. Therneau Erick Edwards Andrew A. Hindman Carol L. Brosgart | 2009 | Gastroenterology2009，，5： | 1 |
| 7 | Do sovereign credit ratings influence regional stock and bond market interdependencies in emerging countries?显示文摘 | Rachel Christopher Suk-Joong Kim Eliza Wu | 2012 | Journal of International Financial Markets, Institutions & Money2012，，4： | 1 |
| 8 | Use of sirolimus in liver transplant recipients with renal insufficiency: A systematic review and meta‐analysis显示文摘 | Sumeet K. Asrani Michael D. Leise Colin P. West M. Hassan Murad Rachel A. Pedersen Patricia J. Erwin Jianmin Tian Russell H. Wiesner W. Ray Kim | 2010 | Hepatology2010，，4： | 1 |
| 9 | Systematic Radio Telescope Alignment Using Portable Fringe Projection Profilometry显示文摘In 2019,the Event Horizon Telescope(EHT)released the first-ever image of a black hole event horizon.Astronomers are now aiming for higher angular resolutions of distant targets,like black holes,to understand more about the fundamental laws of gravity that govern our universe.To achieve this higher resolution and increased sensitivity,larger radio telescopes are needed to operate at higher frequencies and in larger quantities.Projects like the next-generation Very Large Array(ngVLA)and the Square-Kilometer Array(SKA)require building hundreds of telescopes with diameters greater than 10 ms over the next decade.This has a twofold effect.Radio telescope surfaces need to be more accurate to operate at higher frequencies,and the logistics involved in maintaining a radio telescope need to be simplified to support them properly in large quantities.Both of these problems can be solved with improved methods for surface metrology that are faster and more accurate with a higher resolution.This leads to faster and more accurate panel alignment and,therefore,a more productive observatory.In this paper,we present the use of binocular fringe projection profilometry as a solution to this problem and demonstrate it by aligning two panels on a 3-m radio telescope dish.The measurement takes only 10 min and directly delivers feedback on the tip,tilt,and piston of each panel to create the ideal reflector shape. | Joel Berkson Justin Hyatt Nathan Julicher Byeongjoon Jeong Isaac Pimienta Rachel Ball Wyatt Ellis Jason Voris Diego Torres‑Barajas Daewook Kim | 2024 | Nanomanufacturing and Metrology2024，7，1： | 0 |
| 10 | Computational approaches to understanding protein aggregation in neurodegeneration显示文摘有毒的外国人蛋白质 conformers 的产生作为一个统一线程出现在象 Alzheimer'sdisease, Parkinson 的疾病,和 amyotrophic 那样的混乱之中侧面的硬化。关于动态变化的原子水平的详细那 facilitateprotein 聚集,以及大规模订的总数和可溶的外国人 oligomers 的结构的特征,将为细胞毒素的种类的 inhibitingformation 显著地作出贡献到这些复杂现象和提议潜力策略的当前的理解。然而,试验性的限制经常预防高分辨率的 structuraland 的获得为聚集系统的机械学的信息。计算方法,特别地,那些联合所有原子和 coarse-grainedsimulations 盖住大量时间和长度规模,因此为调查 proteinaggregation 作为关键工具出现了。这里,我们为蛋白质的学习考察计算方法论的当前的状态自己组装,与向在人的 neurodegenerative 混乱的蛋白质总数的理解的这些方法的申请上的 afocus。 | Rachel L. Redler David Shirvanyants Onur Dagliyan Feng Ding Doo Nam Kim Pradeep Kota Elizabeth A. Proctor Srinivas Ramachandran Arpit Tandon Nikolay V. Dokholyan | 2014 | Journal of Molecular Cell Biology2014，8，2： | 0 |
| 11 | 领导,员工并不想成为你的“好友”显示文摘很大程度上,社交媒体圈子是自己创造的。你可以选择关注谁,谁可以跟踪你,你'喜欢'什么,以及你的生活中哪些片段可以透露。但是,如果这些精心策划的描述突然出现在你的下一个季度考核中,该怎么办? | Rachel Kim Raczka 王梦菲(编译) | 2021 | 董事会2021，，11： | 0 |
| 12 | Advanced bioactive glue tethering Lubricin/PRG4 to promote integrated healing of avascular meniscus tears显示文摘Meniscus injuries are extremely common with approximately one million patients undergoing surgical treatment annually in the U.S. alone, but no regenerative therapy exist. Previously, we showed that controlled applications of connective tissue growth factor (CTGF) and transforming growth factor beta 3 (TGFβ3) via fibrin-based bio-glue facilitate meniscus healing by inducing recruitment and stepwise differentiation of synovial mesenchymal stem/progenitor cells. Here, we first explored the potential of genipin, a natural crosslinker, to enhance fibrin-based glue’s mechanical and degradation properties. In parallel, we identified the harmful effects of lubricin on meniscus healing and investigated the mechanism of lubricin deposition on the injured meniscus surface. We found that the pre-deposition of hyaluronic acid (HA) on the torn meniscus surface mediates lubricin deposition. Then we implemented chemical modifications with heparin conjugation and CD44 on our bioactive glue to achieve strong initial bonding and integration of lubricin pre-coated meniscal tissues. Our data suggested that heparin conjugation significantly enhances lubricin-coated meniscal tissues. Similarly, CD44, exhibiting a strong binding affinity to lubricin and hyaluronic acid (HA), further improved the integrated healing of HA/lubricin pre-coated meniscus injuries. These findings may represent an important foundation for developing a translational bio-active glue guiding the regenerative healing of meniscus injuries. | Solaiman Tarafder Jaskirti Ghataure David Langford Rachel Brooke Ryunhyung Kim Samantha Lewis Eyen Julian Bensadoun Jeffrey T.Felix James L.Cook Chang H.Lee | 2023 | Bioactive Materials2023，，10： | 0 |
| 13 | Biopsy-proven acute phosphate nephropathy:A case report显示文摘BACKGROUND Acute phosphate nephropathy(APN)is a disease that can occur when exposed to high doses of phosphate.The most common cause of APN is the use of oral sodium phosphate for bowel cleansing preparations.However,there are other less commonly known sources of phosphate that are equally important.To date,our literature search did not identify any report of excessive dietary phosphate as a cause of APN.CASE SUMMARY We report an unusual case of a 39-year-old diabetic male who presented with epigastric pain and oliguria.Work-up showed elevated serum creatinine,potassium,and calcium-phosphate product,and metabolic acidosis.The patient was admitted in the intensive care unit and received emergent renal replacement therapy.Kidney biopsy revealed tubular cell injury with transparent crystal casts positive for Von Kossa staining,which established the diagnosis of APN.CONCLUSION This case confirmed that APN may occur with other sources of phosphorus,highlighting the importance of good history taking and kidney biopsy in patients with predisposing factors for APN.Raising awareness on the possibility of APN and its timely recognition and management is imperative so that appropriate measures can be instituted to prevent or delay its progression to end stage renal disease. | Kristianne Rachel Palanca Medina-Liabres Bo Mi Kim Sejoong Kim | 2020 | World Journal of Clinical Cases2020，8，12： | 0 |
| 14 | 美国年轻人加入SPAC热潮显示文摘所谓的空白支票公司实际上是寻找投资机会的大量现金池,它们的发展轨迹正在掀起一波典型的华尔街狂欢。过去两年中,它们已经从面向金融专业人士的小众产品转变为在Twitter和CNBC上大肆宣传的大众市场现象。这些特姝目的收购公司(SPAC)中有近600家在纽约进行交易,对冲基金巨头比尔•阿克曼(Bill Ackman)、日本科技亿万富翁孙正义(Masayoshi Son)和花旗集团资深人士迈克尔•克莱因(Michael Klein)等知名金融家纷纷入场。 | Ben Scent Crystal Kim Eduardo Thomson Rachel Adams-Hearci 融汐(译) | 2021 | 商业周刊(中文版)2021，，19： | 0 |
| 15 | 机遇之地?显示文摘乐观者看到一幕转向大戏;悲观者称之为外国投资的坟墓
有没有哪个心智正常的企业高管愿意将大笔资金投入到一个中央计划的经济欠发达国家,一个以食品短缺、制造业落后和基础设施严重不足而闻名的地方? | Andy Sharp Sohee Kim Daniele Lepido Chris Anstey Serene Cheong Ben Bartenstein Rachel Chang Tomoko Yamazaki 永年(译) | 2018 | 商业周刊(中文版)2018，0，12： | 0 |
| 16 | COVID-19 among African Americans and Hispanics:Does gastrointestinal symptoms impact the outcome?显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)disproportionately affected African Americans(AA)and Hispanics(HSP).AIM To analyze the significant effectors of outcome in African American patient population and make special emphasis on gastrointestinal(GI)symptoms,laboratory values and comorbidities METHODS We retrospectively evaluated the medical records of 386 COVID-19 positive patients admitted at Howard University Hospital between March and May 2020.We assessed the symptoms,including the GI manifestations,comorbidities,and mortality,using logistic regression analysis.RESULTS Of these 386 COVID-19 positive patients,257(63.7%)were AAs,102(25.3%)HSP,and 26(6.45%)Whites.There were 257(63.7%)AA,102(25.3%)HSP,26(6.45%)Whites.The mean age was 55.6 years(SD=18.5).However,the mean age of HSP was the lowest(43.7 years vs 61.2 for Whites vs 60 for AAs).The mortality rate was highest among the AAs(20.6%)and lowest among HSP(6.9%).Patients with shortness of breath(SOB)(OR2=3.64,CI=1.73-7.65)and elevated AST(OR2=8.01,CI=3.79-16.9)elevated Procalcitonin(OR2=8.27,CI=3.95-17.3),AST(OR2=8.01,CI=3.79-16.9),ferritin(OR2=2.69,CI=1.24-5.82),and Lymphopenia(OR2=2.77,CI=1.41-5.45)had a high mortality rate.Cough and fever were common but unrelated to the outcome.Hypertension and diabetes mellitus were the most common comorbidities.Glucocorticoid treatment was associated with higher mortality(OR2=5.40,CI=2.72-10.7).Diarrhea was prevalent(18.8%),and GI symptoms did not affect the outcome.CONCLUSION African Americans in our study had the highest mortality as they consisted of an older population and comorbidities.Age is the most important factor along with SOB in determining the mortality rate.Overall,elevated liver enzymes,ferritin,procalcitonin and C-reactive protein were associated with poor prognosis.GI symptoms did not affect the outcome.Glucocorticoids should be used judiciously,considering the poor outcomes associated with it.Attention should also be paid to monitor liver function during COVID-19,especially in AA and HSP patients with higher disease severity. | Hassan Ashktorab Adeleye Folake Antonio Pizuorno Gholamreza Oskrochi Philip Oppong-Twene NuriTamanna Maryam Mehdipour Dalivand Lisa N Umeh Esther S Moon Abdoul Madjid Kone Abigail Banson Cassandra Federman Edward Ramos Eyitope Ola Awoyemi Boubini Jones Wonni Eric Otto Guttu Maskalo Alexandra Ogando Velez Sheldon Rankine Camelita Thrift Chiamaka Ekwunazu Derek Scholes LakshmiGayathri Chirumamilla Mohd Elmugtaba Ibrahim Brianna Mitchell Jillian Ross Julencia Curtis Rachel Kim Chandler Gilliard Joseph Mathew Adeyinka Laiyemo Angesum Kibreab Edward Lee Zaki Sherif Babak Shokrani Farshad Aduli Hassan Brim | 2021 | World Journal of Clinical Cases2021，9，28： | 0 |
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