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| 1 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 2 | Improving intermittent androgen deprivation therapy: lessons learned from basic and translational research显示文摘断断续续的雄激素剥夺治疗(IADT ) 在有 nonmetastatic 疾病的前列腺癌症病人是连续雄激素剥夺治疗(ADT ) 的一种选择。ADT 与象热闪光,性机能障碍,贫血症,疲劳,肌肉质量的损失,骨质疏松症,新陈代谢的症候群和早熟的心血管的疾病那样的众多的副作用被联系。IADT 与改进生活并且到前列腺癌症的延期前进的质量到阉割抵抗的意愿被开发。由与 ADT 相比的 IADT 的生活的稍微改进的质量的好处在多重临床的试用被表明。IADT 被注意是到在有前列腺癌症,但是在与变形前列腺癌症在病人执行的研究的生物化学的复发的病人的 ADT 的 noninferior,结果是不确定的。我们的最近的研究建议 5 个 alpha-reductase 禁止者的管理能显著地在 IADT 的离开周期期间延长当离开周期持续时间是短的时,忍受雄激素敏感的前列腺肿瘤的老鼠的幸存。这评论在动物模型和这发现进诊所的潜在的翻译在 IADT 讨论 5 alpha-reductase 抑制的幸存利益。 | Rahul A Parikh Laura E Pascal Benjamin J Davieses Zhou Wang | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 3 | A novel tuning strategy for multi variable model predictive control 显示文摘 | RAHUL S DOUGLAS J C | 1998 | ISA Transactions1998，36，4： | 1 |
| 4 | Effects of bile salts on cholestan-3 6,5 α, 613-triol-induced apopto- sis in dog gallbladder epithelial cells显示文摘 | Tadashi Yoshida J Henriette Klinkspoor Rahul Kuver | 2001 | Biochimica et Biophys- ica Acta2001，1530，23： | 1 |
| 5 | Selenium and its role in health and disease 显示文摘 | Rahul S Geeta J | 2007 | Kuwait Medical Journal2007，39，1： | 1 |
| 6 | Arti- ficial bee colony (ABC) for multi-objective design optimi- zation of composite structures 显示文摘 | OMKAR S N SENTHILNATH J RAHUL K | 2011 | Applied Soft Compu- ting2011，11，1： | 1 |
| 7 | Exploiting mobility for energy efficient data collection in wireless sensor networks显示文摘 | SUSHANT J RAHUL C S WAYLON B | 2006 | Mobile Networks and Applications2006，11，3： | 1 |
| 8 | A Fourier-transform infrared spectroscopic analysis of organic matter degradation in a bench-scale solid substrate fermentation (composting) system 显示文摘 | Tseng D V Rahul V Sam J T | 1996 | Biotechnology and Bioengineering1996，52，6： | 1 |
| 9 | XORs in the air: Practical wireless network coding显示文摘 | KATTI S RAHUL H HU W J | 2008 | IEEE/ACM Transactions on Networking2008，16，3： | 1 |
| 10 | Shock attenuation of PMMA sandwich panels filled with soda-lime glass beads: A fluid-structure interaction continuum model simulation显示文摘 | George A. Christou Laurence R. Young Rahul Goel Andrew P. Vechart Antoine Jérusalem | 2012 | International Journal of Impact Engineering2012，，： | 1 |
| 11 | Laparoscopic Management of Advanced Renal Cell Carcinoma with Renal Vein and Inferior Vena Cava Thrombus显示文摘 | Rahul Kumar Bansal Hin Yu Vincent Tu Darrel Drachenberg Bobby Shayegan Edward Matsumoto J Paul Whelan Anil Kapoor | 2013 | Urology2013，，： | 1 |
| 12 | Recent advances in new structural classes of anti-tuberculosis agents显示文摘 | AMIT N RAHUL J | 2005 | Cult Med Chem2005，12，16： | 1 |
| 13 | Chemical mechanical polishing:process manufacturability显示文摘 | Rahul J Janos F Huang C K | 1994 | Solid State Technology1994，37，7： | 1 |
| 14 | Long-term efficacy of catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular dysp-Lasia/cardiomyopathy显示文摘 | Darshan D Rahul J Harikrishna T | 2007 | J Am Coll Cardiol2007，50，： | 1 |
| 15 | XORs in the air:Practical wireless network coding显示文摘 | S Katti H Rahul W Hu D Katabi M Medard J Crowcroft | 2008 | IEEE ACM Transactions on Networking2008，16，3： | 1 |
| 16 | XORs in the alr:Practical wire- less network coding 显示文摘 | Katti S Rahul H Hu W J | 2008 | IEEE/ACM Transactions on Networ- king2008，16，3： | 1 |
| 17 | Microsatellite sequences of mammals and their applications in genome analysis in pigs a review显示文摘 | Rahul B N Sheoran J B Tantia M S | 2002 | Asian-Australasian Journal of Animal Sciences2002，15，12： | 1 |
| 18 | Association of vascular endothelial growth factor single nucleotide polymorphisms on the prognosis of breast cancer patients 显示文摘 | Rani J Rahul B Ramesh G | 2014 | Indian J Cancer2014，51，4： | 1 |
| 19 | Biological and molecular characterization of chicken anaemia virus isolates of Indian origin 显示文摘 | Natesan S Kataria J M Dhama K Rahul S Baradhwaj N | 2006 | Virus Desearch2006，118，1： | 1 |
| 20 | Chemical mechanical polishing:process manufacturability显示文摘 | RAHUL J JANOS F HUANG C K | | 0，，07： | 1 |
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