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| 1 | MELD score,insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease显示文摘AIM:To determine the contributions of insulin-like growth factor 1 (IGF-1),cytokines and liver disease severity to bone mineral density in patients pre-transplantation.METHODS:Serum IGF-1,tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6) were measured and the Model for End-Stage Liver Disease (MELD) score calculated in 121 adult patients referred to a single centre for liver transplantation.Bone mineral density (BMD) of the lumbar spine and femoral neck were assessed via dual energy X-ray absorptiometry.Demographics,liver disease etiology,medication use and relevant biochemistry were recorded.RESULTS:A total of 117 subjects were included,with low BMD seen in 68.6%,irrespective of disease etiol-ogy.In multivariable analysis,low body mass index (BMI),increased bone turnover and low IGF-1 were independent predictors of low spinal bone density.At the hip,BMI,IGF-1 and vitamin D status were predictive.Despite prevalent elevations of TNFα and IL-6,levels did not correlate with degree of bone loss.The MELD score failed to predict low BMD in this pre-transplant population.CONCLUSION:Osteopenia/osteoporosis is common in advanced liver disease.Low serum IGF-1 is weakly predictive but serum cytokine and MELD score fail to predict the severity of bone disease. | Rebecca Mitchell Jill McDermid Mang M Ma Constance L Chik | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 2 | Assessing adequacy of emergency provider documentation among interhospital transferred patients with acute aortic dissection显示文摘BACKGROUND: Acute aortic dissection(AoD) is a hypertensive emergency often requiring the transfer of patients to higher care hospitals; thus, clinical care documentation and compliance with the Emergency Medical Treatment and Active Labor Act(EMTALA) is crucial. The study assessed emergency providers(EP) documentation of clinical care and EMTALA compliance among interhospital transferred AoD patients.METHODS: This retrospective study examined adult patients transferred directly from a referring emergency department(ED) to a quaternary academic center between January 1, 2011 and September 30, 2015. The primary outcome was the percentage of records with adequate documentation of clinical care(ADoCC). The secondary outcome was the percentage of records with adequate documentation of EMTALA compliance(ADoEMTALA). RESULTS: There were 563 electronically identified patients with 287 included in the final analysis. One hundred and five(36.6%) patients had ADoCC while 166(57.8%) patients had ADoEMTALA. Patients with inadequate documentation of EMTALA(IDoEMTALA) were associated with a higher likelihood of not meeting the American Heart Association(AHA) ED Departure SBP guideline(OR 1.8, 95% CI 1.03–3.2, P=0.04). Male gender, handwritten type of documentation, and transport by air were associated with an increased risk of inadequate documentation of clinical care(IDoCC), while receiving continuous infusion was associated with higher risk of IDoEMTALA.CONCLUSION: Documentation of clinical care and EMTALA compliance by Emergency Providers is poor. Inadequate EMTALA documentation was associated with a higher likelihood of patients not meeting the AHA ED Departure SBP guideline. Therefore, Emergency Providers should thoroughly document clinical care and EMTALA compliance among this critically ill group before transfer. | Mark Rose Carina Newton Benchaa Boualam Nancy Bogne Adam Ketchum Umang Shah Jordan Mitchell Safura Tanveer Tucker Lurie Walesia Robinson Rebecca Duncan Stephen Thom Quincy Khoi Tran | 2019 | World Journal of Emergency Medicine2019，10，2： | 5 |
| 3 | Cloning, Human Chromosomal Assignment, and Adipose and Hepatic Expression of the CL-6/INSIG1 Gene显示文摘 | Yong Peng Emily J. Schwarz Mitchell A. Lazar Anna Genin Nancy B. Spinner Rebecca Taub | 1997 | Genomics1997，，3： | 1 |
| 4 | 显示文摘 | Andrew C. Barrett Charles D. Cook Jolan M. Terner Rebecca M. Craft Mitchell J. Picker | 2001 | Psychopharmacology2001，，2： | 1 |
| 5 | Ecology and evolution of plant-pollinator interactions 显示文摘 | Randall J Mitchell Rebecca E Irwin Rebecca J Flanagan Jeffrey D Karron | 2009 | Annals of Botany2009，103，： | 1 |
| 6 | Affordancesand Limitations of Immersive Participatory AugmentedReality Simulations for Teaching and Learning显示文摘 | Chris Dede Matt Dunleavy Rebecca Mitchell | 2009 | Journal of science Education and Technology2009，，2： | 1 |
| 7 | Health and lifestyle risk factors for falls in a large population-based sample of older people in Australia显示文摘 | Rebecca J. Mitchell Wendy L. Watson Andrew Milat Amy Z.Q. Chung Stephen Lord | 2013 | Journal of Safety Research2013，，： | 1 |
| 8 | Updated Standardized Endpoint Definitions for Transcatheter Aortic Valve Implantation显示文摘 | A. Pieter Kappetein Stuart J. Head Philippe Généreux Nicolo Piazza Nicolas M. van Mieghem Eugene H. Blackstone Thomas G. Brott David J. Cohen Donald E. Cutlip Gerrit-Anne van Es Rebecca T. Hahn Ajay J. Kirtane Mitchell W. Krucoff Susheel Kodali Michael J. | 2012 | Journal of the American College of Cardiology2012，，： | 1 |
| 9 | Affordances and Limitations of Immersive Participatory Augmented Reality Simulations for Teaching and Learning显示文摘 | Chris Dede Matt Dunleavy Rebecca Mitchell | 2009 | Journal of science Education and Technology2009，，2： | 1 |
| 10 | Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis显示文摘Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple sclerosis. While immune mechanisms are key participants in the pathogenesis of relapsing remitting multiple sclerosis, the mechanisms underlying the development of progressive multiple sclerosis are less well understood. Putative mechanisms behind progressive multiple sclerosis have been put forth: insufficient energy production via mitochondrial dysfunction, activated microglia, iron accumulation, oxidative stress, activated astrocytes, Wallerian degeneration, apoptosis, etc. Furthermore, repair processes such as remyelination are incomplete. Experimental therapies that strive to improve metabolism within neurons and glia, e.g., oligodendrocytes, could act to counter inadequate energy supplies and/or support remyelination. Most experimental approaches have been examined as standalone interventions; however, it is apparent that the biochemical steps being targeted are part of larger pathways, which are further intertwined with other metabolic pathways. Thus, the potential benefits of a tested intervention, or of an established therapy, e.g., ocrelizumab, could be undermined by constraints on upstream and/or downstream steps. If correct, then this argues for a more comprehensive, multifaceted approach to therapy. Here we review experimental approaches to support neuronal and glial metabolism, and/or promote remyelination, which may have potential to lessen or delay progressive multiple sclerosis. | Rebecca M.Heidker Mitchell R.Emerson Steven M.Le Vine | 2017 | Neural Regeneration Research2017，12，8： | 1 |
| 11 | Propranolol treatment of infantile hemangioma endothelial cells: A molecularanalysis显示文摘 | Jessica Stiles Clarissa Amaya Robert Pham Rebecca Rowntree Mary Lacaze Arlynn Mulne Joyce Bischoff Victor Kokta Laura Boucheron Dianne Mitchell Brad Bryan | 2012 | Experimental and Therapeutic Medicine2012，，4： | 1 |
| 12 | Selective internal radiation therapy with 90yttrium microspheres for extensive colorectal liver metastases显示文摘 | Richard S. Stubbs M.D. F.R.C.S. (Eng) F.R.A.C.S. Mr. Rebecca J. Cannan M.Sc. Alex W. Mitchell Ph.D | 2001 | Journal of Gastrointestinal Surgery2001，，3： | 1 |
| 13 | Learning to Decode Cognitive States from Brain Images显示文摘 | Tom M. Mitchell Rebecca Hutchinson Radu S. Niculescu Francisco Pereira Xuerui Wang Marcel Just Sharlene Newman | 2004 | Machine Learning (-)2004，，1： | 1 |
| 14 | Knowledge creation measurement methods显示文摘 | Rebecca Mitchell Brendan Boyle | 2010 | Journal of knowledge management2010，，1： | 1 |
| 15 | Refractive errors in an older population显示文摘 | KARIN ATTEBO REBECCA Q PAUL MITCHELL | 1999 | Ophthalmology1999，106，： | 1 |
| 16 | How management style moderates the relationship between abusive supervision and workplace deviance: An uncertainty management theory perspective显示文摘 | Stefan Thau Rebecca J. Bennett Marie S. Mitchell Mary Beth Marrs | 2008 | Organizational Behavior and Human Decision Processes2008，，1： | 1 |
| 17 | Refractive errors in an older population显示文摘 | Karin Attebo Rebecca Q Ivers Paul Mitchell | 1999 | Ophthalmology1999，，6： | 1 |
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