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| 1 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 2 | Coning motion stability of wrap around fin rockets显示文摘Both the asymptotical stability criterion and the bounded stability criterion of the coning motion for wrap around fin(WAF) rockets are proposed through the analy-sis of coning motion equations,which can be easily used to determine the exis-tence of the coning motion during the rocket design. The correctness of the crite-rions is verified by mathematical simulation examples of a WAF rocket with differ-ent setting angles. It is also found that the setting angle of WAF has great effects on the rolling moment and side moment of the rocket. | MAO XueRui YANG ShuXing XU Yong | 2007 | Science China(Technological Sciences)2007，50，3： | 7 |
| 3 | Evaluation of hollow fiber T-type zeolite membrane modules for ethanol dehydration显示文摘This work presents the design of hollow fiber T-type zeolite membrane modules with different geometric configurations. The module performances were evaluated by pervaporation dehydration of ethanol/water mixtures. Strong concentration polarization was found for the modules with big membrane bundles. The concentration polarization was enhanced at high temperature due to the higher water permeation flux. The increase of feed flow could improve water permeation flux for the membrane modules with small membrane bundle.Computational fluid dynamics was used to visualize the flow field distribution inside of the modules with different configurations. The membrane module with seven bundles exhibited highest separation efficiency due to the uniform distribution of flow rate. The packing density could be 10 times higher than that of the tubular membrane module. The hollow fiber membrane module exhibited good stability for ethanol dehydration. | Xuerui Wang Ji Jiang Dezhong Liu Youquan Xue Chun Zhang Xuehong Gu | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 7 |
| 4 | Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2显示文摘现在的学习显示出 RNA 依赖的蛋白质 kinase (PKR ) 调整的那双 stranded 蛋白质表示水平和 Bcl-2 和戏的 phosphorylation 在人的 hepatocellular 癌房间(HepG2 ) 的一个 anti-apoptotic 角色。在房间的各种各样的类型,浸透了免费的丰满的酸(船边交货) 例如 palmitate,被显示了由几机制导致细胞的 apoptosis。Palmitate 下面调整 PKR 并且从而的活动减少 Bcl-2 蛋白质的水平,由 NF-魏 B 抄写因素的减少的激活部分地调停了。除了 Bcl-2 蛋白质的水平,在不同氨基酸残余的 Bcl-2 的 phosphorylation 例如 Ser70 和 Ser87,在调整细胞的 apoptosis 也是重要的。在在在到 palmitate 的暴露之上的 Ser70 的 Bcl-2 的 phosphorylation 的减少被 c6 月 N 终端 kinase (JNK ) 被 PKR 并且可能的抑制调停,而在 Ser87 的 Bcl-2 的 phosphorylation 由 palmitate 或 PKR 是未受影响的。在摘要, PKR 调停蛋白质水平和 Bcl-2 的 phosphorylation 地位的规定,在 HepG2 房间提供导致 palmitate 的 apoptosis 的新奇机制。 | Xuerui Yang | 2009 | Cell Research2009，19，4： | 5 |
| 5 | Attribution analysis based on Budyko hypothesis for land evapotranspiration change in the Loess Plateau, China显示文摘Land evapotranspiration(ET) is an important process connecting soil, vegetation and the atmosphere, especially in regions that experience shortage in precipitation.Since 1999, the implementation of a large-scale vegetation restoration project has significantly improved the ecological environment of the Loess Plateau in China.However, the quantitative assessment of the contribution of vegetation restoration projects to long-term ET is still in its infancy.In this study, we investigated changes in land ET and associated driving factors from 1982 to 2014 in the Loess Plateau using Budyko-based partial differential methods.Overall, annual ET slightly increased by 0.28 mm/a and there were no large fluctuations after project implementation.An attribution analysis showed that precipitation was the driving factor of inter-annual variability of land ET throughout the study period;the average impacts of precipitation, potential evapotranspiration, and vegetation restoration on ET change were 61.5%, 11.5% and 26.9%, respectively.These results provide an improved understanding of the relationship between vegetation condition change and climate variation on terrestrial ET in the study area and can support future decision-making regarding water resource availability. | HE Guohua ZHAO Yong WANG Jianhua GAO Xuerui HE Fan LI Haihong ZHAI Jiaqi WANG Qingming ZHU Yongnan | 2019 | Journal of Arid Land2019，11，6： | 5 |
| 6 | Progress,problems and prospects for standardization of greenhouse-related technologies显示文摘In recent years,the scale of greenhouse grows rapidly and steadily in China,which promotes the development of greenhouse technology and the demand for standardized technology.However,the standardization process of greenhouse industry in China has been facing with the problem of unbalanced development with the practical standard system for many years.To solve these problems,the most characteristic greenhouse designs used in China contributing to this work are presented in detail.And the development of standard system and the standardization efforts of them are summarized and analyzed in relationship to the data presented in this paper.In this way the origin of greenhouse standard system in China and context of the system development and standardization of greenhouse structure are clarified.It was also found that the development and iterative update of greenhouse standard system are under the influences of enterprises which as the participation of standard constitutors were proved to play an important role in promoting the standardization development of greenhouse.The outcome of this work may be utilized to perfect the greenhouse standardization system and improve the greenhouse standardization efficiency that dominate the facility agriculture in China. | Yanzhao Ren Minjuan Wang Iftikhar Ahmed Saeeda Xuerui Chen Wanlin Gao | 2018 | International Journal of Agricultural and Biological Engineering2018，11，1： | 4 |
| 7 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
| 8 | Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells显示文摘Dear Editor,Migrasomes are recently discovered vesicular organelles which form on the retraction fibers(RFs)of migrating cells.'Once detached from cells,migrasomes can rupture and release their luminal contents'in a process named migracytosis.Recently,migrasomes have been shown to play an important role in zebrafish organ morphogenesis by releasing chemokine signals to defined regions of the embryo.2 Thus,migracytosis is considered as a major mechanism for migrasomes to carry out their functions.It has been frequently observed that intact migrasomes can be engulfed by surrounding cells,'and this has been proposed as a potential mechanism for lateral transfer of cellular contents between cells.However,it is not clear whether the lateral transfer of cellular contents by migrasomes has functional consequences for the recipient cells. | Mingli Zhu Qin Zou Rongyao Huang Ying Li Xudong Xing Jianhuo Fang Liang Ma Lifei Li Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 3 |
| 9 | Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation显示文摘Fundamental processes such as ribosomal RNA synthesis and chromatin remodeling take place in the nucleolus,which is hyperactive in fast-proliferating cells.The sophisticated regulatory mechanism underlying the dynamic nucleolar structure and functions is yet to be fully explored.The present study uncovers the mutual functional dependency between a previously uncharacterized human long non-coding RNA,which we renamed LETN,and a key nucleolar protein,NPM1.Specifically,being upregulated in multiple types of cancer,LETN resides in the nucleolus via direct binding with NPM1.LETN plays a critical role in facilitating the formation of NPM1 pentamers,which are essential building blocks of the nucleolar granular component and control the nucleolar functions.Repression of LETN or NPM1 led to similar and profound changes of the nucleolar morphology and arrest of the nucleolar functions,which led to proliferation inhibition of human cancer cells and neural progenitor cells.Interestingly,this inter-dependency between LETN and NPM1 is associated with the evolutionarily new variations of NPM1 and the coincidental emergence of LETN in higher primates.We propose that this human-specific protein–lncRNA axis renders an additional yet critical layer of regulation with high physiological relevance in both cancerous and normal developmental processes that require hyperactive nucleoli. | Xianteng Wang Xiaolin Hu Wanlu Song Hui Xu Zhengtao Xiao Rongyao Huang Qingran Bai Fan Zhang Yongzhen Chen Yu Liu Jianhuo Fang Xin Li Qin Shen Haitao Zhao Xuerui Yang | 2021 | Cell Research2021，31，6： | 3 |
| 10 | Pathogenic mutations of nuclear genes associated with mitochondrial disorders显示文摘Mitochondrial 混乱是与 mitochondrial 机能障碍联系的临床的显型,它能被变化在 mitochondrial DNA (mtDNA ) 或原子基因引起。在这评论,我们总结了与 mitochondrial 混乱联系的原子基因的病原的变化。这些原子基因编码, mitochondrial 的部件翻译机械和氧化 phosphorylation 的集会因素,那建筑群。分子的机制,原子修饰词基因调制 mtDNA 变化的 phenotypic 表示,详细被讨论。 | Xiaoyu Zhu Xuerui Peng Min-Xin Guan Qingfeng Yan | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 3 |
| 11 | Defective Ni_(3)S_(2)nanowires as highly active electrocatalysts for ethanol oxidative upgrading显示文摘Electrochemical upgrading of biomass ethanol to value-added chemicals is promising for sustainable society.Here,we synthesize defective Ni_(3)S_(2) nanowires(NWs),which show high activity towards electrochemical oxidation of ethanol to acetate.The Ni_(3)S_(2) NWs are formed by the oriented attachment mechanism,and rich defects are introduced during the growth.A low onset potential of 1.31 V and high mass activity of 8,716 mA·mgNi^(-1) at 1.5 V are achieved using the synthesized Ni_(3)S_(2) NWs toward the ethanol electro-oxidation,which are better than the Ni(OH)2 NWs and the Ni_(3)S_(2) nanoparticles(NPs).And the selectivity for the acetate generation is ca.99%.The high activity of Ni_(3)S_(2) NWs is attributed to the easier oxidation of Ni(II)to the catalytically active Ni(III)species with the promotion from S component and rich defects.These results demonstrate that the defective NWs can be synthesized by the oriented attachment method and the defective Ni_(3)S_(2) NWs structure as the efficient nonnoble metal electrocatalysts for oxidative upgrading of ethanol. | Yufeng Zhang Wei Zhu Jinjie Fang Zhiyuan Xu Yanrong Xue Di Liu Rui Sui Qingqing Lv Xuerui Liu Yongsheng Wang Wei Chen Zhongbin Zhuang | 2022 | Nano Research2022，15，4： | 2 |
| 12 | Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms显示文摘Heart failure is the leading cause of death worldwide.Compound Danshen Dripping Pill(CDDP)or CDDP combined with simvastatin has been widely used to treat patients with myocardial infarction and other cardiovascular diseases in China.However,the effect of CDDP on hypercholesterolemia/atherosclerosis-induced heart failure is unknown.We constructed a new model of heart failure induced by hypercholesterolemia/atherosclerosis in apolipoprotein E(ApoE)and LDL receptor(LDLR)dual deficient(ApoE^(–/–)LDLR^(–/–))mice and investigated the effect of CDDP or CDDP plus a low dose of simvastatin on the heart failure.CDDP or CDDP plus a low dose of simvastatin inhibited heart injury by multiple actions including anti-myocardial dysfunction and anti-fibrosis.Mechanistically,both Wnt and lysine-specific demethylase 4A(KDM4A)pathways were significantly activated in mice with heart injury.Conversely,CDDP or CDDP plus a low dose of simvastatin inhibited Wnt pathway by markedly up-regulating expression of Wnt inhibitors.While the anti-inflammation and anti-oxidative stress by CDDP were achieved by inhibiting KDM4A expression and activity.In addition,CDDP attenuated simvastatin-induced myolysis in skeletal muscle.Taken together,our study suggests that CDDP or CDDP plus a low dose of simvastatin can be an effective therapy to reduce hypercholesterolemia/atherosclerosis-induced heart failure. | Yanfang Yang Ke Feng Liying Yuan Yuxin Liu Mengying Zhang Kaimin Guo Zequn Yin Wenjia Wang Shuiping Zhou He Sun Kaijing Yan Xijun Yan Xuerui Wang Yajun Duan Yunhui Hu Jihong Han | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 13 | IDH1 fine-tunes cap-dependent translation initiation显示文摘The metabolic enzyme isocitrate dehydrogenase 1(IDH1)catalyzes the oxidative decarboxylation of isocitrate to a-ketoglutarate(a-KG).Its mutation often leads to aberrant gene expression in cancer.IDH1 was reported to bind thousands of RNA transcripts in a sequence-dependent manner;yet,the functional significance of this RNA-binding activity remains elusive.Here,we report that IDH1 promotes mRNA translation via direct associations with polysome mRNA and translation machinery.Comprehensive proteomic analysis in embryonic stem cells(ESCs)revealed strikingenrichmentof ribosomal proteins and translation regulators in IDH1-bound protein interactomes.We performed ribosomal profiling and analyzed mRNA transcripts that are associated with actively translating polysomes.Interestingly,knockout of IDH1 in ESCs led to significant downregulation of polysome-bound mRNA in IDH1 targets and subtle upregulation of ribosome densities at the start codon,indicating inefficient translation initiation upon loss of IDH1.Tethering IDH1 to a luciferase mRNA via the MS2-MBP system promotes luciferase translation,independently of the catalytic activity of IDH1.Intriguingly,IDH1 fails to enhance luciferase translation driven by an internal ribosome entry site.Together,these results reveal an unforeseen role of IDH1 in fine-tuning cap-dependent translation via the initiation step. | Lichao Liu JYuyang Lu Fajin Li Xudong Xing Tong Li Xuerui Yang Xiaohua Shen | 2019 | Journal of Molecular Cell Biology2019，11，10： | 2 |
| 14 | Genetic mutations and molecular mechanisms of Fuchs endothelial corneal dystrophy显示文摘Background:Fuchs endothelial corneal dystrophy is a hereditary disease and the most frequent cause of corneal transplantation in the worldwide.Its main clinical signs are an accelerated decrease in the number of endothelial cells,thickening of Descemet’s membrane and formation of guttae in the extracellular matrix.The cornea’s ability to maintain stromal dehydration is impaired,causing painful epithelial bullae and loss of vision at the point when the amount of corneal endothelial cells cannot be compensated.At present,apart from corneal transplantation,there is no other effective treatment that prevents blindness.Main text:In this review,we first summarized the mutations of COL8A2,TCF4,TCF8,SLC4A11 and AGBL1 genes in Fuchs endothelial corneal dystrophy.The molecular mechanisms associated with Fuchs endothelial corneal dystrophy,such as endoplasmic reticulum stress and unfolded protein response pathway,oxidative stress,mitochondrial dysregulation pathway,apoptosis pathway,mitophagy,epithelial-mesenchymal transition pathway,RNA toxicity and repeat-associated non-ATG translation,and other pathogenesis,were then explored.Finally,we discussed several potential treatments related to the pathogenesis of Fuchs endothelial corneal dystrophy,which may be the focus of future research.Conclusions:The pathogenesis of Fuchs endothelial corneal dystrophy is very complicated.Currently,corneal transplantation is an important method in the treatment of Fuchs endothelial corneal dystrophy.It is necessary to continuously explore the pathogenesis of Fuchs endothelial corneal dystrophy and establish the scientific foundations for the development of next-generation corneal therapeutics. | Xuerui Liu Tao Zheng Chuchu Zhao Yi Zhang Hanruo Liu Liyuan Wang Ping Liu | 2021 | Eye and Vision2021，8，1： | 2 |
| 15 | Evaluation of leachate recirculation on nitrous oxide production in the Likang Landfill,China显示文摘 | Lee Chunman Lin Xuerui Lan Chongyu | 2002 | J Environ Qual2002，31，5： | 1 |
| 16 | Oxygen dependent oxidation of trimethoprim by sulfate radical:Kinetic and mechanistic investigations显示文摘Trimethoprim(TMP)is a typical antibiotic to treat infectious disease,which is among the most commonly detected antibacterial agents in natural waters and municipal wastewaters.In the present study,the impacts of dissolved oxygen(DO)on the oxidation efficiency and pathways of TMP by reaction with sulfate radicals(SO_(4)^(-1))were investigated.Our results revealed that the presence of DO was favourable for TMP degradation.Specifically,TMP would react initially with SO_(4)^(-1)via electron-transfer process to form a carbon-centered radical.In the absence of oxygen,the carbon-centered radical could undergo hydrolysis to produceα-hydroxytrimethoprim(TMPàOH),followed by the further oxidation which generatedα-ketotrimethoprim(TMP=O).However,in the presence of oxygen,the carbon-centered radical would alternatively combine with oxygen,leading to a sequential reaction in which peroxyl radical and a tetroxide were formed,and finally generated TMPàOH and TMP=O simultaneously.The proposed pathways were further confirmed by density functional theory(DFT)calculations.The results obtained in this study would emphasize the significance of DO on the oxidation of organic micropollutants by SO_(4)^(-1). | Xuerui Yang Xi Ding Lei Zhou Yuefei Ji Guangli Xiu | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 17 | A physical model of asymmetric vortices flow structure in regular state over slender body at high angle of attack显示文摘 | Deng Xueying Wang Gang Chen Xuerui | 2003 | Science in China (Series E)2003，46，6： | 1 |
| 18 | A physical model of asymmetric vortices flow structure in regular state over slender body at high angle of attack 显示文摘 | Deng Xueying Wang Gang Chen Xuerui | 2003 | Science in China (English Version)2003，46，6： | 1 |
| 19 | Gray relational analysis:a new statistical method of multifactorial analysis medicine显示文摘 | Tan xuerui Deng Julong | | 0，，01： | 1 |
| 20 | Precision Medicine:What Challenges Are We Facing?显示文摘Following the publication of the US National Research Council(NRC)report‘‘Toward Precision Medicine:Building a Knowledge Network for Biomedical Research and a New Taxonomy of Diseases'in 2011[1],several nations have announced that their national research programs would definitely head toward this direction.Now,precision medicine(PM)became a banner for many large-scale | Yu Xue Eric-Wubbo Lameijer Kai Ye Kunlin Zhang Suhua Chang Xiaoyue Wang Jianmin Wu Ge Gao Fangqing Zhao Jian Li Chunsheng Han Shuhua Xu Jingfa Xiao Xuerui Yang Xiaomin Ying Xuegong Zhang Wei-Hua Chen Yun Liu Zhang Zhang Kun Huang Jun Yu | 2016 | Genomics, Proteomics & Bioinformatics2016，14，5： | 1 |
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