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5篇 您的检索式：作者名="Robert Pollard"

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		题名	作者	年代	出处	被引量
	1	The Pattern of Arteriosclerotic Narrowing of the Celiac and Superior Mesenteric Arteries显示文摘	JOHN R. DERRICK HARRY S. POLLARD ROBERT M. MOORE	1959	Annals of Surgery1959，，5：	1
	2	Green Marketing and Ajzen's Theory of Planned Behavior:a Cross-Market Examination显示文摘	Stavros P Kalafatis Michael Pollard Robert East Markos H Tsogas	1999	The Journal of Consumer Marketing1999，16，5：	1
	3	New cement slurry properties and save cost显示文摘	Robert Pollard Jeff Hibbeler		SPE0，，：	1
	4	Islet Auto transplanlation following total pancreatectomy 显示文摘	M' Balu A Pollard BSe Robert Gregory	2008	Pancreas2008，37，3：	1
	5	An integrative approach of digital image analysis and transcriptome profiling to explore potential predictive biomarkers for TGFβblockade therapy显示文摘Increasing evidence suggests that the presence and spatial localization and distribution pattern of tumor infiltrating lymphocytes(TILs)is associate with response to immunotherapies.Recent studies have identified TGFβactivity and signaling as a determinant of T cell exclusion in the tumor microenvironment and poor response to PD-1/PD-L1 blockade.Here we coupled the artificial intelligence(AI)-powered digital image analysis and gene expression profiling as an integrative approach to quantify distribution of TILs and characterize the associated TGFβpathway activity.Analysis of T cell spatial distribution in the solid tumor biopsies revealed substantial differences in the distribution patterns.The digital image analysis approach achieves 74%concordance with the pathologist assessment for tumor-immune phenotypes.The transcriptomic profiling suggests that the TIL score was negatively correlated with TGFβpathway activation,together with elevated TGFβsignaling activity observed in excluded and desert tumor phenotypes.The present results demonstrate that the automated digital pathology algorithm for quantitative analysis of CD8 immunohistochemistry image can successfully assign the tumor into one of three infiltration phenotypes:immune desert,immune excluded or immune inflamed.The association between“cold”tumor-immune phenotypes and TGFβsignature further demonstrates their potential as predictive biomarkers to identify appropriate patients that may benefit from TGFβblockade.	Robert Pomponio Qi Tang Anthony Mei Anne Caron Bema Coulibaly Joachim Theilhaber Maximilian Rogers-Grazado Michele Sanicola-Nadel Souad Naimi Reza Olfati-Saber Cecile Combeau Jack Pollard Tun Tun Lin Rui Wang	2022	Acta Pharmaceutica Sinica B2022，12，9：	0

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