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| 1 | Nitrate Transport, Sensing, and Responses in Plants显示文摘氮(N) 是影响植物生长和开发的必要 macronutrient。N 是叶绿素,氨基酸, nucleic 酸,和第二等的代谢物的一个重要部件。硝酸盐是在土壤的最丰富的 N 来源之一。因为硝酸盐和其它 N 营养素经常正在限制,植物开发了复杂机制在可变环境保证营养素的足够的供应。硝酸盐全神贯注于根并且由硝酸盐 transporters 动员了到另外的机关。硝酸盐察觉到激活局部地并且在整个植物水平在分子、新陈代谢、生理、发展的回答之上侵犯的发信号的小径。与 genomics 技术和基因工具的来临,在我们硝酸盐和另外的 N 滋养的回答的理解的重要进展在过去的十年被完成了。而且,从单个种利用在分叉的个人在场的自然多型性的技术在揭开是必要的新部件。然而,仍然在我们硝酸盐发信号怎么在植物影响生物过程的理解有差距。而且,我们仍然缺乏识别的所有规章的因素怎么交往的一个综合看法或串音安排植物典型地展出的无数 N 回答。在这评论,我们提供由哪个硝酸盐全部被察觉到并且搬运植物的机制的更新的概述。我们讨论发信号的部件并且怎么在植物局部地并且全球性为发展回答与神经质的小径察觉到串音的硝酸盐。理解硝酸盐怎么在植物影响植物新陈代谢,生理学,和生长和开发对为持续农业改进庄稼关键。 | Jose A. O'Brien Andrea Vega Eleonore Bouguyon Gabriel Krouk Alain Gojon Gloria Coruzzi Rodrigo A. Gutierrez | 2016 | Molecular Plant2016，9，6： | 32 |
| 2 | Intraoperative cell salvage with autologous transfusion in liver transplantation显示文摘Liver transplant(LT) is the primary treatment for patients with end-stage liver disease. About 25000 LTs are performed annually in the world. The potential for intraoperative bleeding is quite variable. However, massive bleeding is common and requires blood transfusion. Allogeneic blood transfusion has an immunosuppressive effect and an impact on recipient survival, in addition to the risk of transmission of viral infections and transfusion errors, among others.Techniques to prevent excessive bleeding or to use autologous blood have been proposed to minimize the negative effects of allogeneic blood transfusion.Intraoperative reinfusion of autologous blood is possible through previous selfdonation or blood collected during the operation. However, LT does not normally allow autologous transfusion by prior self-donation. Hence, using autologous blood collected intraoperatively is the most feasible option. The use of intraoperative blood salvage autotransfusion(IBSA) minimizes the perioperative use of allogeneic blood, preventing negative transfusion effects without negatively impacting other clinical outcomes. The use of IBSA in patients with cancer is still a matter of debate due to the theoretical risk of reinfusion of tumor cells. However, studies have demonstrated the safety of IBSA in several surgical procedures, including LT for hepatocellular carcinoma. Considering the literature available to date, we can state that IBSA should be routinely used in LT, both in patients with cancer and in patients with benign diseases. | Marcelo A Pinto Marcio F Chedid Leo Sekine Andre P Schmidt Rodrigo P Capra Carolina Prediger Jo?o E Prediger Tomaz JM Grezzana-Filho Cleber RP Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，1： | 16 |
| 3 | Metabolic complications in liver transplant recipients显示文摘The metabolic syndrome(MS), which includes obesity,dyslipidaemia, hypertension and hyperglycaemia according to the most widely accepted definitions now used, is one of the most common post-transplant complications, with a prevalence of 44%-58%. The MS, together with the immunosuppression, is considered the main risk factor for the development of cardiovascular disease(CVD) in transplant recipients, which in turn accounts for 19%-42% of all deaths unrelated to the graft. The presence of MS represents a relative risk for the development of CVD and death of 1.78. On the other hand, non-alcoholic fatty liver disease(NAFLD), considered as the manifestation of the MS in the liver, is now the second leading reason for liver transplantation in the United States after hepatitis C and alcohol. NAFLD has a high rate of recurrence in the liver graft and a direct relation with the worsening of other metabolic disorders, such as insulin resistance or diabetes mellitus. Consequently, it is vitally important to identify and treat as soon as possible such modifiable factors as hypertension, overweight, hyperlipidaemia or diabetes in transplanted patients to thus minimise the impact on patient survival. Additionally, steroid-free regimens are favoured, with minimal immunosuppression to limit the possible effects on the development of the MS. | Miguel Jiménez-Pérez Rocío González-Grande Edith Omonte Guzmán Víctor Amo Trillo Juan Miguel Rodrigo López | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 4 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 5 | Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection: Time Trends in a Spanish Multicenter Study of 1000 Patients显示文摘 | Javier P. Gisbert ángeles Pérez-Aisa Fernando Bermejo Manuel Castro-Fernández Pedro Almela Jesús Barrio ángel Cosme Inés Modolell Felipe Bory Miguel Fernández-Bermejo Luis Rodrigo Jesús Ortu?o Pilar Sánchez-Pobre Sam Khorrami Alejandro Franco Albert Tomas | 2013 | Journal of Clinical Gastroenterology2013，，2： | 5 |
| 6 | Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline显示文摘 | Cesare Hassan Enrique Quintero Jean-Marc Dumonceau Jaroslaw Regula Catarina Brand?o Stanislas Chaussade Evelien Dekker Mario Dinis-Ribeiro Monika Ferlitsch Antonio Gimeno-García Yark Hazewinkel Rodrigo Jover Mette Kalager Magnus Loberg Christian Pox Bjorn | 2013 | Endoscopy2013，，10： | 3 |
| 7 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 8 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 9 | Coffee oil as a potential feedstock for biodiesel production显示文摘 | Leandro S O Adriana S F Rodrigo R S C | 2008 | Bioresource Technology2008，，99： | 1 |
| 10 | COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse显示文摘 | Andrea Moura Rodrigues Manoel Jo?o Batista Castello Gir?o Ismael Dale Cotrim Guerreiro Silva Marair Gracio Ferreira Sartori Karina de Falco Martins Rodrigo de Aquino Castro | 2008 | International Urogynecology Journal2008，，11： | 1 |
| 11 | A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer显示文摘 | Covadonga Huidobro Rocío G. Urdinguio Ramón María Rodríguez Cristina Mangas Vincenzo Calvanese Pablo Martínez-Camblor Cecilia Ferrero Adolfo Parra-Blanco Luis Rodrigo álvaro J. Obaya Laura Suárez-Fernández Aurora Astudillo Henar Hernando Esteban Ballestar | 2011 | European Journal of Cancer2011，，14： | 1 |
| 12 | Evaluation of chemical mediators and cellular response during acute and chronic gut inflammatory response induced by dextran sodium sulfate in mice显示文摘 | Allisson Freire Bento Daniela Ferraz Pereira Leite Rodrigo Marcon Rafaela Franco Claudino Rafael Cypriano Dutra Maíra Cola Alessandra Cadete Martini Jo?o B. Calixto | 2012 | Biochemical Pharmacology2012，，11： | 1 |
| 13 | A meta-analysis of the effects of ipratropium bromide in adults with acute asthma显示文摘 | Rodrigo G Rodrigo C Burschtin O | 1999 | Am Med1999，107，： | 1 |
| 14 | Acute liver failure-in- duced death of rats is delayed or prevented by blocking NMDA receptors in brain显示文摘 | Cauli O Rodrigo R Boix J | 2008 | Am J Physiol Gastrointest Liver Physiol2008，295，3： | 1 |
| 15 | Isolation and culture of adult mouse cardiac myocytes显示文摘 | O'Connell TD Rodrigo MC Simpson PC | 2007 | Methods Mol Biol2007，357，： | 1 |
| 16 | Synthesis of 9-deoxo-9a-aza- 9a-homoerythromycin A 11, 12-hydrogen borate and azithromycin 11,12-hydrogen borate: a new procedure to obtain azithromycin dihydrate显示文摘 | Miguel B J Rodrigo J C Fernando L O | 1997 | Journal of Organic Chemistry1997，62，21： | 1 |
| 17 | A meta-analysis of the effects of ipratropium bromide in adults with acute asthma显示文摘 | Rodrigo G Rodrigo C Burschtin O | 1999 | American Journal of Medicine1999，107，4： | 1 |
| 18 | Creep behavior of two Cu-2vol% TiC alloys obtained by reaction milling and extrusion显示文摘 | Rodrigo H Palma Aquiles O Sepijlveda | 2013 | Materials Scienceand Engineering A2013，588，： | 1 |
| 19 | Structure–activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity显示文摘 | Bibiana Monson de Souza Marcia Perez dos Santos Cabrera Paulo Cesar Gomes Nathalia Baptista Dias Rodrigo Guerino Stabeli Natalia Bueno Leite Jo?o Ruggiero Neto Mario Sergio Palma | 2015 | Peptides2015，，： | 1 |
| 20 | The interaction of encapsulated pharmaceutical drugs with a silica matrix显示文摘 | Everton C. Morais Gabriel G. Correa Rodrigo Brambilla Claudio Radtke Ione Maluf Baibich Jo?o Henrique Z. dos Santos | 2013 | Colloids and Surfaces B: Biointerfaces2013，，： | 1 |
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