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| 1 | Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol显示文摘 | Meifeng Yang Junye Miao Joshua Rizak Rongwei Zhai Zhengbo Wang Tanzeel Huma Ting Li Na Zheng Shihao Wu Yingwei Zheng Xiaona Fan Jianzhen Yang Jianhong Wang Shangchuan Yang Yuanye Ma Longbao Lü Rongqiao He Xintian Hu | 2014 | Journal of Alzheimer's Disease2014，，4： | 1 |
| 2 | Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder显示文摘Obsessive-compulsive disorder(OCD)is a chronic and debilitating psychiatric disorder that affects∼2%–3%of the population globally.Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder.In large rhesus monkey colonies,we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs)in individual-specific sequences that were repetitive,time-consuming and stable over prolonged periods.Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans.Brain imaging showed that monkeys with SMBs had larger gray matter(GM)volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum.The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs.Notably,exposure to a stressor(human presence)significantly increased SMBs.In addition,fluoxetine,a serotonergic medication commonly used for OCD,decreased SMBs in these monkeys.These findings provide a novel foundation for developing better understanding and treatment of OCD. | Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan JStein Zhi-Qi Xiong Zhen Wang | 2023 | National Science Review2023，10，11： | 1 |
| 3 | The effect of Typhoon Kalmaegi on the modal energy and period of internal waves near the Dongsha Islands(South China Sea)显示文摘The influence of Typhoon Kalmaegi on internal waves near the Dongsha Islands in the northeastern South China Sea was investigated using mooring observation data.We observed,for the first time,that the phenomenon of regular variation characteristics of the 14-d spring-neap cycle of diurnal internal tides(ITs)can be regulated by typhoons.The diurnal ITs lost the regular variation characteristics of the 14-d spring-neap cycle during the typhoon period owing to the weakening of diurnal coherent ITs,represented by O_(1)and K_(1),and the strengthening of diurnal incoherent ITs.Results of quantitative analysis showed that during the pre-typhoon period,timeaveraged modal kinetic energy(sum of Modes 1–5)of near-inertial internal waves(NIWs)and diurnal and semidiurnal ITs were 0.62 kJ/m^(2),5.66 kJ/m^(2),and 1.48 kJ/m^(2),respectively.However,during the typhoon period,the modal kinetic energy of NIWs increased 5.11 times,mainly due to the increase in high-mode kinetic energy.At the same time,the modal kinetic energy of diurnal and semidiurnal ITs was reduced by 68.9%and 20%,respectively,mainly due to the decrease in low-mode kinetic energy.The significantly reduced diurnal ITs during the typhoon period could be due to:(1)strong nonlinear interaction between diurnal ITs and NIWs,and(2)a higher proportion of high-mode diurnal ITs during the typhoon period,leading to more energy dissipation. | Rongwei Zhai Guiying Chen Chenjing Shang Xiaodong Shang Youren Zheng | 2023 | Acta Oceanologica Sinica2023，42，12： | 0 |
| 4 | Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys显示文摘Background Brain-derived neurotrophic factor(BDNF)is known to prevent methamphetamine(METH)-induced neurotoxicity and plays a role in various stages of METH addiction.However,there is a lack of research with longitudinal design on changes in plasma BDNF levels in active METH-dependent individuals.Aims The aim of the study was to investigate changes in BDNF levels during METH self-administration in monkeys.Methods This study measured plasma BDNF levels in three male rhesus monkeys with continuous METH exposure and four male control rhesus monkeys without METH exposure.Changes in plasma BDNF levels were then assessed longitudinally during 40 sessions of METH self-administration in the three monkeys.Results Repeated METH exposure decreased plasma BDNF levels.Additionally,plasma BDNF decreased with long-term rather than short-term accumulation of METH during METH self-administration.Conclusions These findings may indicate that the changes in peripheral BDNF may reflect the quantity of accumulative METH intake during a frequent drug use period. | Wenlei Zhang Jiahui Zhou Hang Su Xiaocheng Zhang Weichen Song Zijing Wang Chengjie Tang Kadir Uludag Min Zhao Zhi-Qi Xiong Rongwei Zhai Haifeng Jiang | 2023 | General Psychiatry2023，36，5： | 0 |
| 5 | Applicability evaluation of ERA5 wind and wave reanalysis data in the South China Sea显示文摘Wind and wave data are essential in climatological and engineering design applications.In this study,data from 15 buoys located throughout the South China Sea(SCS)were used to evaluate the ERA5 wind and wave data.Applicability assessment are beneficial for gaining insight into the reliability of the ERA5 data in the SCS.The bias range between the ERA5 and observed wind-speed data was-0.78-0.99 m/s.The result indicates that,while the ERA5 wind-speed data underestimation was dominate,the overestimation of such data existed as well.Additionally,the ERA5 data underestimated annual maximum wind-speed by up to 38%,with a correlation coefficient>0.87.The bias between the ERA5 and observed significant wave height(SWH)data varied from-0.24 to 0.28 m.And the ERA5 data showed positive SWH bias,which implied a general underestimation at all locations,except those in the Beibu Gulf and centralwestern SCS,where overestimation was observed.Under extreme conditions,annual maximum SWH in the ERA5 data was underestimated by up to 30%.The correlation coefficients between the ERA5 and observed SWH data at all locations were greater than 0.92,except in the central-western SCS(0.84).The bias between the ERA5 and observed mean wave period(MWP)data varied from-0.74 to 0.57 s.The ERA5 data showed negative MWP biases implying a general overestimation at all locations,except for B1(the Beibu Gulf)and B7(the northeastern SCS),where underestimation was observed.The correlation coefficient between the ERA5 and observed MWP data in the Beibu Gulf was the smallest(0.56),and those of other locations fluctuated within a narrow range from 0.82 to 0.90.The intercomparison indicates that during the analyzed time-span,the ERA5 data generally underestimated wind-speed and SWH,but overestimated MWP.Under non-extreme conditions,the ERA5 wind-speed and SWH data can be used with confidence in most regions of the SCS,except in the central-western SCS. | Rongwei ZHAI Caijing HUANG Wei YANG Ling TANG Wenjing ZHANG | 2023 | Journal of Oceanology and Limnology2023，41，2： | 0 |
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