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| 1 | Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer显示文摘Oxaliplatin 是在 colorectal 癌症(CRC ) 的化疗的关键药。然而,它的功效由于癌症房间的药抵抗是未得到满足的。在这研究,我们测试了是否一个自然代理人, ursolic 酸,能为 CRC 提高 oxaliplatin 的功效。当在 vitro 模型,和 SW620 异种皮移植老鼠模型被使用在,包括 SW480, SW620, LoVo,和 RKO 的四根 CRC 房间线被使用进一步在里面 vivo 学习。我们发现 ursolic 酸禁止了增长并且导致了所有四个房间的 apoptosis 并且提高了 oxaliplatin 的 cytotoxicity。这效果与 Bcl-xL 的下面规定被联系, Bcl-2 , survivin , caspase-3 的激活, 8 , 9 ,并且 MAPK 的 KRAS 表示和 BRAF , MEK1/2 , ERK1/2 , p-38 , JNK , AKT , IKK , IB ,和 p65 phosphorylation 的抑制, PI3K/AKT ,并且 NF-B 发信号小径。二个代理人也在 vivo 对肿瘤生长显示出 synergistic 效果。另外, ursolic 酸恢复了与 oxaliplatin 对待的鼠标的肝函数和身体重量。因此,我们断定 ursolic 酸能在 vitro 并且在 vivo 对 CRC 提高 oxaliplatin 的治疗学的效果,它提供有效策略最小化导致 oxaliplatin 的不利事件的负担并且提供地基让新临床的策略对待 CRC。 | Jianzhen Shan Yanyan Xuan QiZhang Chunpeng Zhu Zhen Liu Suzhan Zhang | 2016 | Protein & Cell2016，7，8： | 11 |
| 2 | Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging显示文摘Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy(DN)is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies.In the present study,a spatial-resolved metabolomics approach based on air flowassisted desorption electrospray ionization(AFADESI)and matrix-assisted laser desorption ionization(MALDI)integrated mass spectrometry imaging(MSI)was proposed to investigate tissue-specific metabolic alterations in the kidneys of high-fat diet-fed and streptozotocin(STZ)-treated DN rats and the therapeutic effect of astragalosideⅣ,a potential anti-diabetic drug,against DN.As a result,a wide range of functional metabolites including sugars,amino acids,nucleotides and their derivatives,fatty acids,phospholipids,sphingolipids,glycerides,carnitine and its derivatives,vitamins,peptides,and metal ions associated with DN were identified and their unique distribution patterns in the rat kidney were visualized with high chemical specificity and high spatial resolution.These region-specific metabolic disturbances were ameliorated by repeated oral administration of astragaloside Ⅳ(100 mg/kg)for 12 weeks.This study provided more comprehensive and detailed information about the tissue-specific metabolic reprogramming and molecular pathological signature in the kidney of diabetic rats.These findings highlighted the promising potential of AFADESI and MALDI integrated MSI based metabolomics approach for application in metabolic kidney diseases. | Zhonghua Wang Wenqing Fu Meiling Huo Bingshu He Yaqi Liu Lu Tian Wanfang Li Zhi Zhou Baili Wang Jianzhen Xia Yanhua Chen Jinfeng Wei Zeper Abliz | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 7 |
| 3 | A^2.5 Ga magmatic event at the northern margin of the Yangtze craton:Evidence from U-Pb dating and Hf isotope analysis of zircons from the Douling Complex in the South Qinling orogen显示文摘The poorly studied Douling Complex is a crystalline basement that developed in the Neoproterozoic-Paleozoic weakly metamorphosed to non-metamorphosed strata at the South Qinling tectonic belt.Five banded dioritic-granitic gneiss samples from the Douling Complex were chosen for LA-MC-ICPMS U-Pb zircon dating,which yielded protolith emplacement ages of 2469±22Ma,2479±12 Ma,2497±21 Ma,2501±17 Ma and 2509±14 Ma,respectively.An important peak age of^2.48 Ga was also obtained for a metasedimentary rock in the same region.These discoveries suggest the occurrence of magmatic activity of2.51–2.47 Ga at the northern margin of the Yangtze craton.The age-correctedεHf(t)values obtained from in situ zircon Hf isotopic analysis are mainly between 5.5 and+0.3,and the two-stage zircon Hf model ages range from 3.30 to 2.95 Ga.Considering two important periods of^3.3–3.2 Ga and^2.95–2.90 Ga for the continental crustal growth in the Yangtze craton,we infer that the dioritic-granitic gneisses from the Douling Complex are the products of reworking of Paleo-to Mesoarchean crust at the northern margin of the Yangtze craton at^2.5 Ga.In addition,metamorphic ages of 837±8 Ma and 818±10 Ma were obtained for zircon overgrowth rims from a dioritic gneiss and a metasedimentary rock,indicating that the main phase amphibolite facies metamorphism of the Doulng Complex occurred during the Neoproterozoic,although its geological meaning remains ambiguous. | HU Juan LIU XiaoChun CHEN LongYao QU Wei LI HuaiKun GENG JianZhen | 2013 | Chinese Science Bulletin2013，58，28： | 6 |
| 4 | Study on the Metallogenetism of Sub-mantle Plume and Mantle Branches in the Gold Mineralization Concentration Area of Northwest Jiaodong Peninsula显示文摘The northwest of Jiaodong peninsula is characterized by its greatest gold concentration area, enormous gold reserves and limited time interval(115±5Ma) of gold mineralization in China. Studies show that the east area of north China began its mantle plume evolution since the Yanshanian movement, and the Laiyang sub-mantle plume and its surrounding mantle branches such as those in Guojiadian, Aishan and Panshidian were formed in the mineralization concentration area of northwestern Jiaodong peninsula. With the development of mantle plume → sub-mantle plume → mantle branch → favorable expending structures, the deep-derived hydrothermal fluid moved up to the favorable places, such as brittle-ductile or ductile-brittle shearing zones, the internal and external contact zones of intrusions, dense fracturing zones and the contact zones between dikes and countryrocks, and concentrated into deposits. Then the gold mineralization concentration zones that are centralized on mantle branches were formed. This study takes Guojiadian mantle branch as an example to discuss their metallogenetism and conclude the metallogenetic mode. | NIU Shuyin CHENG Guangsuo ZHANG Jianzhen SUN Aiqun MA Baojun ZHANG Fuxiang WANG Baode XU Meng WU Jichun ZHAO Rongxin WANG Shanfei | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 4 |
| 5 | Silicon lithium-ion battery anode with enhanced performance: Multiple effects of silver nanoparticles显示文摘Silicon has been regarded as one of the most promising next generation lithium-ion battery anode. However, the poor cyclic stability of the Si based anode has severely limited its practical applications, which is even worse with high mass loading density(>1 mg cm^(-2)). A new concept has been developed to enhance the electrochemical performance of the Si nanoparticle anode. Silver nanoparticles are composited with the silicon nanoparticles in a facile way for the first time. It is found that the mechanical properties of the Si electrode have been significantly improved by the incorporation of the silver nanoparticles, leading to enhanced cyclic performance. With the Si/Ag mass ratio of 4:1, the reversible specific discharge capacity is retained as 1156 m A h g^(-1) after 100 cycles at 200 mA g^(-1), which is more than three times higher than that of the bare silicon(318 mA h g^(-1)). The rate performance has been effectively improved as well due to excellent electron conductivity of the silver nanoparticles. | Shanshan Yin Qing Jia Xiuxia Zuo Shuang Xie Kai Fang Yonggao Xia Jinlong Li Bao Qiu Meimei Wang Jianzhen Ban Xiaoyan Wang Yi Zhang Ying Xiao Luyao Zheng Suzhe Liang Zhaoping Liu Cundong Wang Ya-Jun Cheng | 2018 | Journal of Materials Science & Technology2018，34，10： | 4 |
| 6 | Growth of Carbon Nanocoils by Porous α-Fe2O3/SnO2 Catalyst and Its Buckypaper for High Efficient Adsorption显示文摘High-purity(99%)carbon nanocoils(CNCs)have been synthesized by using porousα-Fe2O3/SnO2 catalyst.The yield of CNCs reaches 9,098%after a 6 h growth.This value is much higher than the previously reported data,indicating that this method is promising to synthesize high-purity CNCs on a large scale.It is considered that an appropriate proportion of Fe and Sn,proper particle size distribution,and a loose-porous aggregate structure of the catalyst are the key points to the high-purity growth of CNCs.Benefiting from the high-purity preparation,a CNC Buckypaper was successfully prepared and the electrical,mechanical,and electrochemical properties were investigated comprehensively.Furthermore,as one of the practical applications,the CNC Buckypaper was successfully utilized as an efficient adsorbent for the removal of methylene blue dye from wastewater with an adsorption efficiency of 90.9%.This study provides a facile and economical route for preparing high-purity CNCs,which is suitable for large-quantity production.Furthermore,the fabrication of macroscopic CNC Buckypaper provides promising alternative of adsorbent or other practical applications. | Yongpeng Zhao Jianzhen Wang Hui Huang Tianze Cong Shuaitao Yang Huan Chen Jiaqi Qin Muhammad Usman Zeng Fan Lujun Pan | 2020 | Nano-Micro Letters2020，12，2： | 3 |
| 7 | Timing of mineralization at the Shihu gold deposit in the middle segment of the Taihang Mountain, China显示文摘The Shihu gold deposit, located in the middlesouth section of the core of the Fuping mantle branch structure, is hosted in the Archean Fuping Group and adjacent to the quartz diorite porphyrite. The gold deposit is the only large gold deposit with reserves of more than 30 tons gold discovered in western Hebei Province so far. In order to constrain the timing of mineralization of this ore deposit, this paper focuses on the isotopic dating of zircon and pyrite. Zircons in gold-bearing quartz veins are magmatic in origin and no hydrothermal zircon has been found in such quartz veins, indicating that zircons were derived from the wall rocks. U–Pb ages of zircons fall mainly in the two domains: 2492 ± 82 and 136 ± 4 Ma, respectively,indicative of the contribution of the Fuping-Group TTG gneiss and Yanshanian igneous rocks, respectively. The Re–Os isotopic compositions of pyrites in the gold-bearing quartz veins yield an isochron age of 127 ± 31 Ma. Combined with other dating results, we suggest that the main metallogenic age of the Shihu gold deposit is 120–127 Ma. | Chao Chen Shuyin Niu Fang Wang Fuxiang Zhang Qinglian Zhang Baojun Ma Aiqun Sun Jianzhen Zhang Yaqi Cao Xiaoqing Zhang | 2018 | Acta Geochimica2018，37，1： | 3 |
| 8 | Study on the ore-forming and ore-controlling structure of the Mujicun Cu (Mo) ore deposit, Hebei Province, China显示文摘The Mujicun Cu (Mo) ore deposit at Laiyuan, Hebei Province, is a currently proven large-sized Cu (Mo) polymetallic ore deposit and it is located in the second-ordered fault depression basin of the ditachment belt on the hanging-wall on the western side at the juncture of the Laiyuan dumbell-shaped complex in the northern part of the Fuping mantle-branch structure. Metallogenesis is controlled by diorite porphyrite in intrusive relation with the fault depression basin and other relevant fault structure systems and intenstive wall-rock alteration zones. This study, in conjunction with the most recent exploration data, analyzed the geological background of metallogenesis of this deposit, summaried the geological characteristics of typical ore deposits, determined the alteration zonation of the deposit, investigated regional metallogenesis and the genesis of typical ore deposits, discussed the regional ore-forming and ore-controlling structures, and generalized the regional ore-controlling model and metallogenic model of the deposit. It is considered that the Mujicun porphry Cu (Mo) deposit, the Tieling, Futuyu, Xiaoligou and other skarn-type Fe-Cu deposits and the He'ergou hydrothermal-type Pb-Zn-Ag deposit jointly constitute a three-in-one polymetallic orefield, with the characteristics of typical metallogenic series. | NIU Shuyin MA Guoxi CHEN Zhikuan WANG Baode CHEN Lijing SUN Aiqun MA Xiaofeng ZHANG Jianzhen MA Baojun CHEN Chao LU Hongpeng | 2012 | Chinese Journal Of Geochemistry2012，31，1： | 2 |
| 9 | Eco-economic control mode and benefit analysis of rock desertification region in Huajiang Karst Valley of Guizhou Province显示文摘It is difficult to afforest in rock desertification region and is the key area for eco-environment treatment. To speed up the comprehensive treatment of rock desertification, several anti-rock desertification modes implemented in Dingtan region, located on the right bank of Huajiang Grand Valley in Beipanjiang Town, are introduced as examples. This paper first analyzes the natural and environmental conditions, the development of rock desertification in the Dingtan region, then the detail of the treatment modes, such as “Chinese wingleaf pricklyash – pig breeding – marsh gas” (Mode One), “amomum villosum – pig breeding – marsh gas” mode (Mode Two), “traditional grain and economic crop (corn, peanut) – amomum villosum or Chinese wingleaf pricklyash” (Mode Three), etc. The eco-economic effects, potential and shortcomings of the above mentioned modes are analyzed and compared. It is proved that Mode One and Mode Two are of good economic effect, but Mode Three of better ecological effect. Solutions to the shortcomings of the modes are also put forward. | Su Weici He Tairong Teng Jianzhen | 2006 | Ecological Economy2006，2，3： | 2 |
| 10 | Analysis of the ore-controlling role of Guojiadian mantle branch structure,Northwest Shandong Peninsula,China显示文摘Metallogenesis in the gold ore-concentrated zone of Northwest Shandong Peninsula is closely related to deep processes.The region in the eastern part of North China entered into the stage of mantle plume evolution during the Yanshanian movement,following the long-time stage of stable platform evolution during Paleozoic time.At that time,the ore-concentrated zone of Northwest Shandong Peninsula just entered into the development-evolution stage of the Laiyang sub-mantle plume and the Guojiadian mantle branch structure in its periphery.The core-mantle-source gold was present in the gas-liquid form,and it migrated through mantle plume→sub-mantle plume→mantle branch structure→favorable tectonic expansion zone to the favorable loci of the mantle branch structure,where gold was deposited as ores,thereafter constituting a series of large-to medium-sized gold deposits distributed around the Guojiadian mantle branch structure.This study also dealt with the Jiaojia fault as the main detachment(fault altered rock) belt on the northwestern margin of the mantle branch structure and also presented a basic cognition about the fact that the Sanshandao fault as the listric fault on the hanging wall of the detachment belt.Furthermore,on this basis,this study also pointed out the orientation for further ore prospecting in this region. | NIU Shuyin Sun Aiqun ZHANG Jianzhen MA Baojun WANG Baode CHEN Chao ZHANG Fuxiang LIU Cheng ZHANG Xiaofei | 2012 | Chinese Journal Of Geochemistry2012，31，4： | 2 |
| 11 | The chemical composition of inorganic and carbonaceous materials in PM25 in Nanjing, China 显示文摘 | YANG Hong YU Jianzhen STEVEN Sai Hang Ho | 2005 | Atmospheric Environment2005，39，20： | 1 |
| 12 | Characterization of a chitin synthase cDNA and its increased mRNA level associated with decreased chitin synthesis in Anopheles quadrimaculatus exposed to diflubenzuron显示文摘 | Jianzhen Zhang Kun Yan Zhu | 2006 | Insect Biochemistry and Molecular Biology2006，，9： | 1 |
| 13 | Thermal Analysis of Rapid Charging Nickel/Metal Hydride Batteries 显示文摘 | Shi Jianzhen Wu Feng Chen Shi | 2006 | Joumal of Power Sources2006，，157： | 1 |
| 14 | Feasibility of collection and analysis of airborne carbonyls by on-sorbent derivatization and thermal desorption 显示文摘 | HO S S H YU Jianzhen | 2002 | Anal Chem2002，74，6： | 1 |
| 15 | Thermal analysis of rapid charging nickel/metal hydride batteries显示文摘 | SHI Jianzhen WU Feng | 2006 | Journal of Power Sources2006，，157： | 1 |
| 16 | Insulin-like growth factor 3 is involved in oocyte maturation in zebrafish 显示文摘 | Li Jianzhen Liu Zhihao Wang Deshou | 2011 | Biol Reprod2011，84，3： | 1 |
| 17 | Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol显示文摘 | Meifeng Yang Junye Miao Joshua Rizak Rongwei Zhai Zhengbo Wang Tanzeel Huma Ting Li Na Zheng Shihao Wu Yingwei Zheng Xiaona Fan Jianzhen Yang Jianhong Wang Shangchuan Yang Yuanye Ma Longbao Lü Rongqiao He Xintian Hu | 2014 | Journal of Alzheimer's Disease2014，，4： | 1 |
| 18 | Extraction kinetics of copper, zinc, iron, and manganese from contaminated sediment using Disodium Ethylenediaminetetraacetate显示文摘 | Jianzhen Yu Doug Klarup | 1994 | Water Air & Soil Pollution (-)1994，，3： | 1 |
| 19 | Priority-based Hierarchical Application Layer Multicast Management Model显示文摘 | Xu Jianzhen Xu Mihua Zhang Fuyan | 2007 | International Journal Computer Science and Network Security2007，7，4： | 1 |
| 20 | Nanostructured tungvSten oxide-Properties, synthesis andapplications 显示文摘 | Zheng Haidong Ou Jianzhen Michael S Strano | 2011 | Adv Funct Mater2011，21，12： | 1 |
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