|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tissue-specific alterations in expression and function of P-glycoprotein in streptozotocin-induced diabetic rats显示文摘瞄准: 在导致 streptozocin 的糖尿病的老鼠的服的外皮,马头鱼尾的怪兽,肝,肠的 mucosa 和肾调查表达式的变化和 P-glycoprotein (P-GP ) 的功能。 | Lu-lu ZHANG Liang LU Shi JIN Xin-yue JING Dan YAO Nan HU Li LIU Ru DUAN Xiao-dong LIU Guang-ji WANG Lin XIE | 2011 | Acta Pharmacologica Sinica2011，32，7： | 15 |
| 2 | Spatial–temporal distribution and potential ecological risk assessment of nonylphenol and octylphenol in riverine outlets of Pearl River Delta, China显示文摘The aquatic environments of the Pearl River Delta in Southern China are subjected to contamination with various industrial chemicals from local industries. In this paper, the occurrence, seasonal variation and spatial distribution of alkylphenol octylphenol(OP) and nonylphenol(NP) in river surface water and sediments in the runoff outlets of the Pearl River Delta were investigated. NP and OP were detected in all water and sediment samples and their mean concentrations in surface water during the dry season ranged from 810 to 3366 ng/L and85.5 to 581 ng/L, respectively, and those in sediments ranged from 14.2 to 95.2 ng/g dw and 0.4to 3.0 ng/g dw, respectively. In surface water, much higher concentrations were detected in the dry season than those in the wet season. In sediments, the concentrations in the dry season were also mostly higher. High concentrations of NP and OP were found in Humen outlet, likely due to high levels of domestic and industrial wastewater discharges. An ecological risk assessment with the use of hazard quotient(HQ) was also carried out and the HQ values ranged from 3.6 × 10-5to 35 and 64% of samples gave a HQ > 1, indicating that the current levels of NP and OP pose a significant risk to the relevant aquatic organisms in the region. | Ru Chen Pinghe Yin Ling Zhao Qiming Yu Aihua Hong Shunshan Duan | 2014 | Journal of Environmental Sciences2014，26，11： | 11 |
| 3 | Associations between the physical environment and park-based physical activity:A systematic review显示文摘Background:With an increase in the evidence for the associations between park-based physical activity(PA)and physical environments(especially park and neighborhood environments),researchers face an important challenge in interpreting and summarizing the evidence to develop environ?mental change interventions.An updated review is needed to better inform policymaking and environmental interventions.The current study aimed to systematically review the research on the associations of park-based PA with park and neighborhood environmental characteristics.Methods:We targeted English peer-reviewed articles from 5 electronic databases using keywords related to park-based PA,park environments,and neighborhood environments.Of the 4071 identified papers,25 studies published between 2008 and 2016 met all the eligibility criteria and were included in this review.Results:The characteristics of physical environment that received consistent support included paths/trails,lighting,and incivilities(e.g.,broken glasses and litter).Mixed findings were revealed for 6 park environmental factors(unspecified active facilities,playgrounds and skating areas,fit?ness stations,picnic areas,greenness,and park size)and 2 neighborhood environmental factors(park density and park proximity).Conclusion:It can be concluded that paths/trails,lighting,and incivilities are 3 key physical environmental attributes of park-based PA.Given the inconsistent findings on park and neighborhood environmental factors,more robust designs such as prospective investigation are required. | Ru Zhang Hagen Wulff Yanping Duan Petra Wagner | 2019 | Journal of Sport and Health Science2019，8，5： | 7 |
| 4 | Effects of Bushen Yiqi Huoxue Decoction in Treatment of Patients with Diminished Ovarian Reserve:A Randomized Controlled Trial显示文摘Objective:To explore the therapeutic effect of Bushen Yiqi Huoxue Decoction BYHD)in patients with diminished ovarian reserve(DOR).Methods:A total of 180 patients with DOR diagnosed from December2013 to December 2014 were equally assigned into progynova and duphaston(E+D)group,Zuogui Pill group and BYHD group with 60 cases in each by computerized randomization.Patients received E+D,Zuogui Pill or BYHD for 12 months,respectively.Follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),anti-Mullerian hormone(AMH),antral follicle count(AFC),ovarian volume,endometrial thickness,and the resistance indices(Rls)of ovarian arteries and uterine arteries were observed before and after treatment.Results:Nine women(4 from the E+D group,3 from the Zuogui Pill group,and 2 from the BYHD group)withdrew from the study.After 6 months,Zuogui Pill and BYHD significantly decreased FSH and LH and increased endometrial thickness and AMH(all P<0.01),BYHD also resulted in E2 elevation(P<0.05),ovary enlargement(P<0.05),AFC increase(P<0.01),and RI of ovarian arteries decrease(P<0.05).After 12 months,further improvements were observed in the Zuogui Pill and BYHD groups(all P<0.01),but BYHD showed better outcomes,with lower FSH,larger ovaries and a thicker endometrium compared with the Zuogui Pill group(all P<0.01).However,E+D only significantly increased endometrial thickness(P<0.01)and no significant improvements were observed in the RI of uterine arteries in the three groups.Conclusions:BYHD had a favorable therapeutic effect in patients with DOR by rebalancing hormone levels,promoting ovulation,and repairing the thin endometrium.The combination of tonifying Shen(Kidney),benefiting qi and activating blood circulation may be a promising therapeutic strategy for DOR. | ZHOU Jing PAN Xin-yao LIN Jin ZHOU Qi LAN Li-kun ZHU Jun DUAN Ru WANG Lan SUN Yan WANG Ling | 2022 | Chinese Journal of Integrative Medicine2022，28，3： | 7 |
| 5 | Smart elasto-magneto-electric (EME) sensors for stress monitoring of steel structures in railway infrastructures显示文摘Steel structures are widely used in railway infrastructures.Their stress state is the most important determinant of the safety of these structures.The elasto-magnetic (EM) sensor is the most promising for stress monitoring of in-service steel structures.Nevertheless,the necessity of magnetic excitation to saturation due to the use of a secondary coil for signal detection,keeps from its engineering application.In this paper,a smart elasto-magneto-electric (EME) sensor using magneto-electric (ME) sensing units to take the place of the secondary coil has been exploited for the first time.The ME sensing unit is made of ME laminated composites,which has an ultrahigh ME voltage coefficient and can measure the magnetic induction simply and precisely.Theoretical analysis and characterization experiments firstly conducted on the ME laminated composites showed that the ME sensing units can be applied in the EM sensor for improved performance in stress monitoring.A tension test of a steel bar was carried out to characterize our smart EME sensor and the results showed high accuracy and sensitivity.The present smart EME sensor is a promising tool for stress monitoring of steel structures in railway and other civil infrastructures. | Yuan-feng DUAN Ru ZHANG Yang ZHAO Siu-wing OR Ke-qing FAN Zhi-feng TANG | 2011 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2011，12，12： | 4 |
| 6 | Efficient 16 Boolean logic and arithmetic based on bipolar oxide memristors显示文摘The physically separated memory and logic units in traditional von Neumann computers place essential limits on the performance and cause increased energy consumption,and hence in-memory computing is required to overcome this bottleneck.Here,a new bipolar memristor based in-memory logic approach is proposed,which is capable of achieving all 16 possible Boolean logic functions in a single device in less than3 steps.This approach does not require initialization and can facilitate logic cascading,and the calculation taking place in-situ is showcased by 1-bit full adder and 2-bit multiplier with improved efficiency,thus showing a great prospect in future in-memory computing architecture. | Rui YUAN Mingyuan MA Liying XU Zhenhua ZHU Qingxi DUAN Teng ZHANG Yu ZHU Yu WANG Ru HUANG Yuchao YANG | 2020 | Science China(Information Sciences)2020，63，10： | 3 |
| 7 | Concentrating partially entangledW-class states on nonlocal atoms using low-Q optical cavity and linear optical elements显示文摘Entanglement plays an important role in quantum information science, especially in quantum communications. Here we present an efficient entanglement concentration protocol(ECP) for nonlocal atom systems in the partially entangled W-class states, using the single-photon input-output process regarding low-Q cavity and linear optical elements. Compared with previously published ECPs for the concentration of non-maximally entangled atomic states, our protocol is much simpler and more efficient as it employs the Faraday rotation in cavity quantum electrodynamics(QED) and the parameter-splitting method. The Faraday rotation requires the cavity with low-Q factor and weak coupling to the atom, which makes the requirement for entanglement concentration much less stringent than the previous methods, and achievable with current cavity QED techniques. The parameter-splitting method resorts to linear-optical elements only. This ECP has high efficiency and fidelity in realistic experiments, and some imperfections during the experiment can be avoided efficiently with currently available techniques. | Cong Cao Xi Chen YuWen Duan Ling Fan Ru Zhang TieJunWang Chuan Wang | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，10： | 3 |
| 8 | Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease显示文摘The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in rodents.Both are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be elucidated.In this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD spectrum.We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice.Moreover,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus non-converters.Thus,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD. | Lin Zhu Zan Wang Zhanhong Du Xinyang Qi Hao Shu Duan Liu Fan Su Qing Ye Xuemei Liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin Wang Li Lin Shijiang Li Ying Han Liping Wang Zhijun Zhang | 2020 | Neuroscience Bulletin2020，36，8： | 2 |
| 9 | Steel Stress Monitor- ing Sensor Based on Elasto-Magnetic Effect and Using Magneto- Electric Laminated Composite 显示文摘 | Duan Yuanfeng Zhang Ru Zhao Yang | 2012 | American Institute of Physics2012，，4： | 1 |
| 10 | Mi- croRNA- 29b inhibits peritoneal fibrosis in a mouse model of peritoneal dialysis显示文摘 | Jian- Wen Yu Wen- Juan Duan Xiao- Ru Huang | 2014 | Lab Invest2014，94，9： | 1 |
| 11 | Human bone marrow stromal cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats 显示文摘 | Zhao Li Ru Duan Wei Ming Reyes M | 2002 | Expe Neurol2002，174，： | 1 |
| 12 | Steel Stress Monitor- ing Sensor Based on Elasto-Magnetic Effect and Using Magneto- electric Laminated Composite显示文摘 | Duan Yuangeng Zhang Ru Zhao Yang | 2012 | American Institute of Physics2012，，4： | 1 |
| 13 | Patient empowerment 显示文摘 | Duan She - xia Guo Xiu - ru Kong Juan | 1999 | Foreign Medical Sciences1999，18，9： | 1 |
| 14 | Molecular characterization of a novel reovirus isolated from SARS patients with distinct S1 segment显示文摘We reported a novel mammalian reovirus, designed BYD1, isolated from throat swabs of patients with severe acute respiratory syndrome (SARS), in 2003. In the present study, we firstly compared the genome electrophoretic migration patterns of reovirus BYD1 with 3 prototype reovirus strains by polyacrylamide gel electrophoresis (PAGE) and determined the complete nucleotide sequence of the S1 gene segment of BYD1 by single primer amplification technique. The electropherogram of BYD1 was different from those of the 3 prototype strains and any other reovirus isolates reported before. The entire S1 segment sequence of BYD1 is 1437 bp long with two meaningful open reading frames (ORFs). The longest ORF encodesσ1, the cell attachment protein, and the second longest ORF supposedly encodesσ1s, an important nonstructural virulence factor. The terminal sequences of S1 segment are 5'GCUA and 3'UCAUC, which are consistent with those of other mammalian reoviruses. The highest homology of deducedσ1 amino acid sequence is 64% identity with known mammalian reoviruses. Phylogenetic analysis of both S1 nucleotide sequence andσ1 amino acid sequence indicated the BYD1 isolate belonged to a new clade of serotype 2 group. The results of this study showed that the BYD1 S1 segment was markedly different from those of isolates reported before and BYD1 was a novel human reovirus isolate. | LI HUA SONG JUN HE HONG ZHU YU XIN SU RU TONG HUANG HONG YUAN DUAN PAN YONG MAO QING DUAN | 2006 | Journal of Microbiology and Immunology2006，4，4： | 1 |
| 15 | Cenozoic Uplift of the Central Yunnan Fragment, Southwestern China, Revealed by Apatite(U-Th)/He Dating显示文摘The age of central Yunnan fragment uplift has long been debated, with estimates ranging from the Late Eocene to about 1 Ma. To determine the central Yunnan fragment uplift time in the Cenozoic, apatite(U-Th)/He(AHe) was used to analyze the low-temperature thermochronology of samples from the Jiaozi Mountain area of the eastern central Yunnan fragment. The sampling area is located in the Dongchuan District of Kunming, Yunnan Province, near the Xiaojiang fault zone. The results show that AHe ages from the eastern part of central Yunnan fragment were mainly concentrated around 25.7–37.9 Ma, and intensive uplift had happened before 36.5 Ma. Together with previous low-temperature thermochronology research on the western and eastern central Yunnan fragment, we concluded that the Yunnan Plateau uplifted prior to 36.5 Ma, in a west to east sequence. The uplift caused a change in paleo-geographical terrain, which may have altered the ancient river systems of the southeast Tibetan Plateau. | Ke Wu Youpu Dong Jiaxin Duan Xin Ru Dongyue Zhang Dan Wang | 2020 | Journal of Earth Science2020，31，4： | 0 |
| 16 | Clinical manifestations of respiratory syncytial virus infection and the risk of wheezing and recurrent wheezing illness:a systematic review and meta‑analysis显示文摘Background Respiratory syncytial virus(RSV)infection in infants is a global health priority.We aimed to investigate the common manifestations of RSV infection by age group and human development index(HDI)level and to assess its association with the development of wheezing and recurrent wheezing illness.Methods We searched the literature published between January 1,2010 and June 2,2022 in seven databases.Outcomes included common manifestations and long-term respiratory outcomes of RSV infection in children.Random-and fixed-effect models were used to estimate the effect size and their 95%confidence intervals.Subgroup analysis was conducted by age and HDI levels.This review was registered in PROSPERO(CRD42022379401).Results The meta-analysis included 47 studies.The top five manifestations were cough(92%),nasal congestion(58%),rhinorrhea(53%),shortness of breath(50%),and dyspnea(47%).The clinical symptoms were most severe in infants.In our analysis,compared to very high and high HDI countries,fewer studies in medium HDI countries reported related manifestations,and no study in low HDI countries reported that.The RSV-infected infants were more likely to develop wheezing than the non-infected infants[odds ratio(OR),3.12;95%CI,2.59–3.76]and had a higher risk of developing wheezing illnesses after recovery(OR,2.60;95%CI,2.51–2.70).Conclusions Cough and shortness of breath are common manifestations of RSV infection.More attention should be given to infants and areas with low HDI levels.The current findings confirm an association between RSV infection and wheezing or recurrent wheezing illness. | Ming‑Yue Jiang Yu‑Ping Duan Xun‑Liang Tong Qiang‑Ru Huang Meng‑Meng Jia Wei‑Zhong Yang Lu‑Zhao Feng | 2023 | World Journal of Pediatrics2023，19，11： | 0 |
| 17 | ERF5.1 modulates carotenoid accumulation by interacting with CCD4.1 in Lycium显示文摘Carotenoids are important natural pigments and have medical and health functions for humans.Carotenoid cleavage dioxygenase 4(CCD4)and ethylene responsive factor(ERF)participate in carotenoid metabolism,but their roles in Lycium have not been discovered.Here,we annotated LbCCDs from the Lycium reference genome and found that LbCCD4.1 expression was significantly correlated with the carotenoid metabolites during Lycium five fruit developmental stages.Over-expression of LbCCD4.1 in NQ’s leaves resulted in a series of significantly lower contents of carotenoid metabolites,includingβ-carotene andβ-cryptoxanthin.Moreover,LbERF5.1,a transcription factor belonging to the ERF family that was located in the nucleus,was isolated.Significant reductions in the carotenoids,especially lutein,violaxanthin and their derivatives,were observed in over-expressing ERF5.1 transgenic NQ’s leaves.Over-expression or virus-induced gene silencing of LbERF5.1 in NQ’s leaves induced a consistent up-or down-expression,respectively,of LbCCD4.1.Furthermore,yeast one-hybrid and dual-luciferase reporter assays showed that ERF5.1 interacted with the promoter of CCD4.1 to increase its expression,and LbERF5.1 could bind to any one of the three predicted binding sites in the promoter of LbCCD4.1.A transcriptome analysis of LbERF5.1 and LbCCD4.1 over-expressed lines showed similar global transcript expression,and geranylgeranyl diphosphate synthase,phytoene synthase,lycopeneδ-cyclase cytochrome,cytochrome P450-type monooxygenase 97A,cytochrome P450-type monooxygenase 97C,and zeaxanthin epoxidase in the carotenoid biosynthesis pathway were differentially expressed.In summary,we uncovered a novel molecular mechanism of carotenoid accumulation that involved an interaction between ERF5.1 and CCD4.1,which may be used to enhance carotenoid in Lycium. | Jianhua Zhao Yuhui Xu Haoxia Li Xinlei Zhu Yue Yin Xiyan Zhang Xiaoya Qin Jun Zhou Linyuan Duan Xiaojie Liang Ting Huang Bo Zhang Ru Wan Zhigang Shi Youlong Cao Wei An | 2023 | Horticulture Research2023，10，12： | 0 |
| 18 | Biphasic regulation of P-glycoprotein function and axpression by NO donors in Caco-2 cells显示文摘瞄准: 调查氮的氧化物的效果(没有) 在 Caco-2 房间的 P-glycoprotein (P-gp ) 的功能和表示上的施主。 | Ru DUAN Nan HU Hai-yan LIU Jia LI Hai-fang GUO Can LIU Li LIU Xiao-dong LIU | 2012 | Acta Pharmacologica Sinica2012，33，6： | 0 |
| 19 | 通过^(1)H(^(15)O,p)^(15)O弹性散射来研究^(16)F的能级性质显示文摘The understanding of open quantum systems in unbound nuclei is a challenge to the nuclear structure research[1].The continuum coupling effect may lead to a reordering of the shells in such systems[2].A way to study this effect is to compare the level schemes of two mirror nuclei involving an unbound and a bound nucleus such as 16F and 16N[3].Here we report an experiment of studying the level properties of 16F using the resonant elastic scattering with an 15O radioactive beam delivered by the Radioactive Ion Beam Line at Lanzhou(RIBLL)[4]. | Ru Longhui Hu Jun Liu Enqiang Bai Zhen Duan Fangfang Fang Xiao Hou Suqing Hu Qiang Ji Liancheng Jin Shuya Li Kuoang Li Yiyang Li Ruojie Ma Peng Ma Junbing Sun Xinxin Shi Guozhu Tang Xiaodong Wang Xinyu Wang Jiansong Wang Yufeng Wu Jiatong Xu Xiaodong Xu Shiwei Xin Wenyu Yang Kaiping Yang Yanyun NMichel | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 20 | Response Mechanisms to Flooding Stress in Mulberry Revealed by Multi-Omics Analysis显示文摘Abiotic stress,including flooding,seriously affects the normal growth and development of plants.Mulberry(Morus alba),a species known for its flood resistance,is cultivated worldwide for economic purposes.The transcriptomic analysis has identified numerous differentially expressed genes(DEGs)involved in submergence tolerance in mulberry plants.However,a comprehensive analyses of metabolite types and changes under flooding stress in mulberry remain unreported.A non-targeted metabolomic analysis utilizing liquid chromatographytandem mass spectrometry(LC-MS/MS)was conducted to further investigate the effects of flooding stress on mulberry.A total of 1,169 metabolites were identified,with 331 differentially accumulated metabolites(DAMs)exhibiting up-regulation in response to flooding stress and 314 displaying down-regulation.Pathway enrichment analysis identified significant modifications in many metabolic pathways due to flooding stress,including amino acid biosynthesis and metabolism and flavonoid biosynthesis.DAMs and DEGs are significantly enriched in the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways for amino acid,phenylpropanoid and flavonoid synthesis.Furthermore,metabolites such as methyl jasmonate,sucrose,and D-mannose 6-phosphate accumulated in mulberry leaves post-flooding stress.Therefore,genes and metabolites associated with these KEGG pathways are likely to exert a significant influence on mulberry flood tolerance.This study makes a substantial contribution to the comprehension of the underlying mechanisms implicated in the adaptation of mulberry plants to submergence. | Jingtao Hu Wenjing Chen Yanyan Duan Yingjing Ru Wenqing Cao Pingwei Xiang Chengzhi Huang Li Zhang Jingsheng Chen Liping Gan | 2024 | Phyton-International Journal of Experimental Botany2024，93，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员