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| 1 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 2 | Active greeting technique: a mother-and-child catheter based technique to facilitate retrograde wire externalization in recanalization of coronary chronic total occlusion显示文摘Although retrograde approach has greatly improved the success rate of percutaneous coronary intervention(PCI) for coronary chronic total occlusion(CTO), retrograde wire externalization still remains challenging and time-consuming in some cases. Cases utilizing ‘‘Active Greeting Technique(AGT)', a mother-and-child catheter based technique to facilitate retrograde wire externalization, were extracted from Chronic Total Occlusion Club, China(CTOCC) database. AGT was performed by deep intubation a mother-and-child catheter(GuidezillaTMextension, 4 or 5 Fr inner catheter, and etc.) in combination with either reverse controlled antegrade or retrograde subintimal tracking(CART) technique or retrograde wire crossing technique. A total of 111 patients with 112 CTO lesions treated with this technique were retrospectively analyzed. Reverse CART technique and retrograde wire crossing technique were performed in 90.2% and 9.8% of all procedures. The utilization of GuidezillaTMextension, 4 Fr, and 5 Fr inner catheter accounted for 94.6%, 3.6%, and 1.8%, respectively. Externalization of retrograde wire was successful in all cases. No procedural complications were adjudicated to AGT. Complications independent of AGT included two target vessel perforations and two collateral perforations. No in-hospital major adverse cardiac events were found. AGT is a feasible and safe technique that facilitates retrograde wire externalization. | Junbo Ge Lei Ge Bin Zhang Xin Zhong Jianying Ma Leisheng Ru Tao Hu Juying Qian 无 | 2018 | Science Bulletin2018，63，23： | 10 |
| 3 | Endocrine Disruption Activity of 30-day Dietary Exposure to Decabromodiphenyl Ethane in Balb/C Mouse显示文摘Objective This study aimed to evaluate the hepatotoxicity,metabolic disturbance activity and endocrine disrupting activity of mice treated by Decabromodiphenyl ethane(DBDPE).Methods In this study,Balb/C mice were treated orally by gavage with various doses of DBDPE.After 30 days of treatment,mice were sacrificed; blood,livers and thyroid glands were obtained,and hepatic microsomes were isolated.Biochemical parameters including 8 clinical chemistry parameters,blood glucose and hormone levels including insulin and thyroid hormone were assayed.The effects of DBDPE on hepatic cytochrome P450(CYP) levels and activities and uridinediphosphate-glucuronosyltransferase(UDPGT) activities were investigated.Liver and thyroid glands were observed.Results There were no obvious signs of toxicity and no significant treatment effect on body weight,or liver-to-body weight ratios between treatment groups.The levels of ALT and AST of higher dose treatment groups were markedly increased.Blood glucose levels of treatment groups were higher than those of control group.There was also an induction in TSH,T3,and f T3.UDPGT,PROD,and EROD activities were found to have been increased significantly in the high dose group.Histopathologic liver changes were characterized by hepatocyte hypertrophy and cytoplasmic vacuolization.Our findings suggest that DBDPE can cause a certain degree of mouse liver damage and insufficiency.Conclusion DBDPE has the activity of endocrine disruptors in Bal/C mice,which may induce drug-metabolizing enzymes including CYPs and UDPGT,and interfere with thyroid hormone levels mediated by Ah R and CAR signaling pathways.Endocrine disrupting activity of DBDPE could also affect the glucose metabolism homeostasis. | SUN Ru Bao SHANG Shuai ZHANG Wei LIN Ben Cheng WANG Qiang SHI Yun XI Zhu Ge | 2018 | Biomedical and Environmental Sciences2018，31，1： | 7 |
| 4 | Cytotoxicity and Apoptosis Induction in Human HepG2 Hepatoma Cells by Decabromodiphenyl Ethane显示文摘Objective To investigate the toxic effects of decabromodiphenyl ethane (DBDPE), used as an alternative to decabromodiphenyl ether in vitro. Methods HepG2 cells were cultured in the presence of DBDPE at various concentrations (3.125-100.0 mg/L) for 24, 48, and 72 h respectively and the toxic effect of DBDPE was studied. Results As evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and lactate dehydrogenase assays and nuclear morphological changes, DBDPE inhibited HepG2 viability in a time- and dose-dependent manner within a range of 12.5 mg/L to 100 mg/L and for 48 h and 72 h. Induction of apoptosis was detected at 12.5-100 mg/L at 48 h and 72 h by propidium iodide staining, accompanied with overproduction of reactive oxygen species (ROS). Furthermore, N-acetyl-L-cysteine, a widely used ROS scavenger, significantly reduced DBDPE-induced ROS levels and increased HepG2 cells viability. Conclusion DBDPE has cytotoxic and anti-proliferation effect and can induce apoptosis in which ROS plays an important | SUN Ru Bao XI Zhu Ge YAN Jun YANG Hong Lian | 2012 | Biomedical and Environmental Sciences2012，25，5： | 6 |
| 5 | Prevalence and Risk Factors Associated with Adverse Drug Reactions among Previously Treated Tuberculosis Patients in China显示文摘我们与 anti-TB 药估计了不利的药反应(ADR ) 的发生并且为在中国在以前对待的肺结核病人开发 ADR 评估了风险因素。所有病人是由国家指南推荐了收到了首要的 anti-TB 政体(2HREZS/6HRE ) 。临床并且实验室评估一个月被执行一次。从 354 个参加者,(74.0%) 262 经历了象 hyperuricemia 那样的 ADR (65.0% , 230/354 ) , hepatotoxicity (6.2% , 22/354 ) 并且听觉骚乱(4.8% , 17/354 ) 。ADR 显著地与糖尿病 mellitus 被联系[或(95% CI ) :15.5 (2.07-115.87 )] ;然而,重量超过 50 kg [或(95% CI ) :0.41 (0.22-0.85 )] 是为 ADR 的出现的一个保护的因素。Hyperuricemia 是最普通的不利事件但是,有 hyperuricemia 的大多数病人为高尿的酸层次显示出增加的忍耐。低身体重量和糖尿病 mellitus 在 anti-TB 治疗期间增加了 ADR 的出现的风险。 | HAN Xi Qin PANG Yu MA Yan LIU Yu Hong GUO Ru SHU Wei HUANG Xue Rui GE Qi Ping DU Jian GAO Wei Wei | 2017 | Biomedical and Environmental Sciences2017，30，2： | 5 |
| 6 | First record of the golden potato nematode Globodera rostochiensis in Yunnan and Sichuan provinces of China显示文摘The potato cyst nematodes(PCN) Globodera rostochiensis(Wollenweber) Skarbilovich,1959 is considered the most damaging nematode pest of potato worldwide that causes significant yield losses,and this nematode is recognized and listed as a quarantine nematode in many countries(EPPO 2017).China is currently the largest producer of potato in the world. | JIANG Ru PENG Huan LI Yun-qing LIU Hui ZHAO Shou-qi LONG Hai-bo HU Xian-qi GE Jian-jun LI Xing-yue LIU Miao-yan SHAO Bao-lin PENG De-liang | 2022 | Journal of Integrative Agriculture2022，21，3： | 4 |
| 7 | Recent advances in nanorobotic manipulation inside scanning electron microscopes显示文摘A scanning electron microscope(SEM)provides real-time imaging with nanometer resolution and a large scanning area,which enables the development and integration of robotic nanomanipulation systems inside a vacuum chamber to realize simultaneous imaging and direct interactions with nanoscaled samples.Emerging techniques for nanorobotic manipulation during SEM imaging enable the characterization of nanomaterials and nanostructures and the prototyping/assembly of nanodevices.This paper presents a comprehensive survey of recent advances in nanorobotic manipulation,including the development of nanomanipulation platforms,tools,changeable toolboxes,sensing units,control strategies,electron beam-induced deposition approaches,automation techniques,and nanomanipulation-enabled applications and discoveries.The limitations of the existing technologies and prospects for new technologies are also discussed. | Chaoyang Shi Devin K Luu Qinmin Yang Jun Liu Jun Chen Changhai Ru Shaorong Xie Jun Luo Ji Ge Yu Sun | 2016 | Microsystems & Nanoengineering2016，2，1： | 4 |
| 8 | Subacute Effect of Decabromodiphenyl Ethane on Hepatotoxicity and Hepatic Enzyme Activity in Rats显示文摘Information regarding decabromodiphenyl ethane(DBDPE)effects on hepatotoxicity and metabolism is limited.In the present study,Wistar rats were given oral DBDPE at different doses.DBDPE induced oxidative stress,elevated blood glucose levels,increased CYP2B2 mRNA,CYP2B1/2protein,7-pentoxyresorufin O-depentylase(PROD)activity,and induced CYP3A2 mRNA,CYP3A2protein,and luciferin benzylether debenzylase(LBD)activity.UDPGT activity increased with its increasing exposure levels,suggesting that oral DBDPE exposure induces drug-metabolizing enzymes in rats via the CAR/PXR signaling pathway.The induction of CYPs and co-regulated enzymes of phase II biotransformation may affect the homeostasis of endogenous substrates,including thyroid hormones,which may,in turn,alter glucose metabolism. | SUN Ru Bao XI Zhu Ge ZHANG Hua Shan ZHANG Wei | 2014 | Biomedical and Environmental Sciences2014，27，2： | 4 |
| 9 | On the temperature characteristics of phase measurement in homodyne fiber interferometer显示文摘Different from the traditional way of using piezoelectric (PZT) phase shifter to measure phase difference,a new method is designed to calculate it between signals in the two arms of a homodyne fiber interferometer. A simple homodyne fiber interferometer system is then established to measure the interference photocurrent and the photocurrents from the two fiber arms generated by the signal power on a temperature control plat. The homodyne fiber interferometer system is composed of fiber and sensitive to the variation of temperature. Thus,is necessary to study the temperature characteristics in the phase measurement of homodyne fiber interferometer. The experimental results show that the variation of the phase difference of signals in the two fiber arms is proportional to the variation of temperature. | GAO Bo,TIAN Xiao-jian ,WU Ge,RU Yu-xing,WANG Qing College of Electronic Science and Engineering ,State Key Laboratory of Integrated Optoelectronics,Jilin University ,Changchun 130012,China | 2010 | The Journal of China Universities of Posts and Telecommunications2010，17，2： | 3 |
| 10 | Trace determination of hexabromocyclododecane diastereomers in water samples with temperature controlled ionic liquid dispersive liquid phase microextraction显示文摘新奇温度控制了散液体阶段 microextraction (TCIL-DLPME ) 结合了的离子的液体快速的分辨率液体 chromatographyelectrospray 双人脚踏车团 spectrometry (RRLCESI-MSMS ) 在水样品为三 hexabromocyclododecane diastereomers (HBCD ) 的丰富和决心被开发了。格林溶剂离子的液体(IL ) 被用作抽取溶剂而不是有毒的器官的溶剂。这种技术也避免了散溶剂的用法。可能影响抽取效率的一些重要参数被优化。在最佳下面,条件,好线性关系,敏感和重制度被获得。为三 diastereomers 的察觉的所有限制是 0.1 ng/mL。线性范围为三 HBCD diastereomers 的全部的数量在 1100 ng/mL 的范围被获得。分析真实的环境水样品,恢复从 77.2% ~ 99.3%是令人满意的。方法的主要优点是有毒的器官没有溶剂。 | Ru Song Zhao Xia Wang Jin Peng Yuan Shan Shan Wang Chuan Ge Cheng | 2011 | Chinese Chemical Letters2011，22，1： | 3 |
| 11 | Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese显示文摘Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects.Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615subjects.The mean value of left and right BaPWV was analyzed.BaPWV was defined as high when it was?1 752.5 cm/s(the upper quartile)either side.Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level(P<0.05).The prevalence of elevated BaPWV was significantly higher in subjects of the second,third and highest quartiles than in those of the lowest quartile(26.9%,28.4%,and 33.2%vs23.7%,P=0.0116,P=0.0004,and P<0.0001).Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32-fold higher in subjects of the highest quartile than in those of the lowest quartile(OR=1.32,95%CI:1.08-1.60).Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness,independent of conventional risk factors,in middle-aged and elderly Chinese subjects. | DENG Xin Ru ZHANG Yin Fei WANG Tian Ge XU Bai Hui SUN Ji Chao ZHAO Lie Bin XU Min CHEN Yu Hong WANG Wei Qing BI Yu Fang LU Jie Li | 2014 | Biomedical and Environmental Sciences2014，27，8： | 2 |
| 12 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 13 | Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese显示文摘Objective Calibrated Automated Thrombogram(CAT) is a test to monitor the generation of thrombin. It can be described by four parameters: lag time, peak thrombin, endogenous thrombin potential(ETP) and time to peak(ttPeak). This study aims to determine the normal ranges of CAT parameters in Chinese, and evaluate whether thrombin generation is correlated with the concentration of heparin/low molecular weight heparin. Methods Plasma from 120 healthy subjects were collected to determine the normal rangea of CAT parameters in Chinese. Normal plasma pool(NPP, n=25) spiked with different concentrations of heparin or enoxaparin were used to detecte CAT parameters. The overall and age specific normal ranges of CAT parameters were calculated using descriptive statistics method with mean±2SD. The correlation between CAT parameters and age or concentrations of heparin, enoxaparin were analyzed with linear regression model. Results The normal ranges for lag time, peak thrombin, ETP, ttPeak in the subjects were 3.648±2.465 min, 367.39±151.93 nmol/L, 2277±1030 nmol/L·min and 6.372±4.280 min respectively. Age was linearly correlated with lag time(r=-0.6583, P<0.0001), peak thrombin(r=0.4863, P<0.0001), ETP(r=0.3608, P<0.0014) and ttPeak(r=-0.6313, P<0.0001). The values of ETP/peak ratio were linearly correlated with concentrations of heparin. Conclusion The normal ranges of four CAT parameters for Chinese were determined. CAT parameters are associated with age. ETP/peak ratio could be used to monitor the process of anticoagulation therapy. | WU Jun ZHAO Hui Ru ZHANG Hui Ying GE Yan Ling QIU Shuang ZHAO Jie SONG Ying ZHAO Jing Zhong LU Song Song | 2014 | Biomedical and Environmental Sciences2014，27，5： | 2 |
| 14 | Simultaneous quantification of 12 bioactive components of Ligusticum chuanxiong Hort. by high-performance liquid chromatography显示文摘 | Ru Yan Song-Lin Li Hoi-Sing Chung Yun-Kau Tam Ge Lin | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，，1： | 1 |
| 15 | Role of glycogen synthase kinase 3β in protective effect of propofol against hepatic ischemia–reperfusion injury显示文摘 | Ge Zhao Hongwei Ma Xin Shen Gao-Feng Xu Yu-Lin Zhu Baoying Chen Ru Tie Ping Qu Yi Lv Haifeng Zhang Jun Yu | 2013 | Journal of Surgical Research2013，，： | 1 |
| 16 | Applying System Thinking to Learn from Accident of Modern Automatic Control Systems显示文摘Modern societies increasingly rely on automatic control systems. These systems are hardly pure technical systems; instead they are complex socio-technical systems, which consist of technical elements and social components. It is necessary to have a systematic approach to analyze these systems because it is growing evidence that accidents from these systems usually have complex causal factors which form an interconnected network of events,rather than a simple cause-effect chain. We take railway Train control systems(TCS) as an example to demonstrate the importance of the socio-technical approach to analyze the system. The paper presents an investigation of recent high-speed railway accident by applying STAMP – one of the most notable socio-technical system analysis techniques, outlines improvements to the system which could avoid similar accidents in the future. We also provide our valuable feedback for the use of STAMP. | NIU Ru CAO Yuan GE Xiaocheng TANG Tao | 2014 | Chinese Journal of Electronics2014，23，2： | 1 |
| 17 | Functional and pathological improvements of the hearts in diabetes model by the combined therapy of bFGF-loaded nanoparticles with ultrasound-targeted microbubble destruction显示文摘 | Ying-Zheng Zhao Xin-Qiao Tian Ming Zhang Lu Cai Ao Ru Xiao-Tong Shen Xi Jiang Rong-Rong Jin Lei Zheng Kyle Hawkins Subrata Charkrabarti Xiao-Kun Li Qian Lin Wen-Ze Yu Shuping Ge Cui-Tao Lu Ho Lun Wong | 2014 | Journal of Controlled Release2014，，： | 1 |
| 18 | High fill factor over 82%enabled by a biguanide doping electron transporting layer in planar perovskite solar cells显示文摘N-type doping in electron transport materials is an effective way to improve the electron collection and enhance the performance of the perovskite solar cells (PSCs).Here,for the first time,an antibiotic and antimicrobial compound of 1-(o-Tolyl)biguanide (oTb) is used to dope the electron transport material of phenyl- C61-butyric acid methyl ester (PCBM).The oTh doping into the PCBM can increase the conductivity and reduce the work function of the PCBM.The oTb doping can significantly enhance the fill factor (FF)of the perovskite solar cells with the structure of glass/ITO/NiO]MAPbI3/(oTb)PCBM/(PEIE)/Ag.For the cells without PEIE (polyethylenimine ethoxylated)coating,the oTb doping increases the FF from 0.57 to 0.73.S-shaped of the current density-voltage (J-V)characteristic under illumination is removed after the oTb doping.For the cells with PEIE coating between the (oTb)PCBM and Ag,the oTb doping increases the FF from 0.70 to 0.82.These results show the potential of the oTb as an n-dopant in the applications of perovskite solar cells. | Ru GE Fei QIN Lin HU Sixing XIONG Yinhua ZHOU | 2018 | Frontiers of Optoelectronics2018，11，4： | 1 |
| 19 | Serum Fetuin-A Levels and Thyroid Function in Middle-aged and Elderly Chinese显示文摘Serum fetuin-A levels are reportedly elevated in hyperthyroidism. However, there are few relevant epidemiologic studies. We conducted a cross-sectional study in Songnan community, China in 2009 to investigate the association between serum fetuin-A concentrations and thyroid function. A total of 2,984 participants aged 40 years and older were analyzed. Multivariable linear regression analysis revealed that serum fetuin-A concentrations were positively associated with log(free triiodothyronine) and were inversely associated with log(thyroid peroxidase antibody) after adjustment(both P < 0.05). Compared with the participants in the lowest tertile of free triiodothyronine and free thyroxine level, those in the highest tertile had higher fetuin-A concentrations. Additionally, high serum fetuin-A concentrations were related to high thyroid function(odds ratio 1.27, 95% confidence interval 1.01-1.61), after adjustment for conventional risk factors. | DENG Xin Ru DING Lin WANG Tian Ge XU Min LU Jie Li LI Mian ZHAO Zhi Yun CHEN Yu Hong BI Yu Fang XU Yi Ping XU Yu | 2017 | Biomedical and Environmental Sciences2017，30，6： | 1 |
| 20 | Fluorescence Responses of the Protonation and Deprotonation Processes between Phenolate and Phenol within Rosamine显示文摘有 pyronine 酚骨骼的二基于 rosamine 的 pH 探针 1a 和 1b 被简单一步舞反应设计并且综合。pH 滴定实验向氢离子在 550-750 nm 附近在在离开上荧光回答附近显示出那探针 1a 和 1b 展览。pK 探查 1a 的 是 8.29,当因为氢,探查 1b 的增加到 12.1 时,在它内结合。选择、竞争的实验显示普通离子和氨基酸没介入他们有氢离子的排放。而且,共焦荧光灯成像证明探查 1a 能在 HeLa 和 Ges-1 房间作为线粒体 biomarker 被服务。 | Ling Yang Jinyun Niu Yanhua Zhan Yujie Xu Ru Sun Jianfeng Ge | 2018 | Chinese Journal of Chemistry2018，36，1： | 1 |
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