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| 1 | MiR-125a-5p Regulates Vitamin D Receptor Expression in a Mouse Model of Experimental Autoimmune Encephalomyelitis显示文摘Multiple sclerosis(MS)is a chronic and incurable autoimmune neurodegenerative disease of the central nervous system.Although the symptoms of MS can be managed by vitamin D3 treatment alone,this condition cannot be completely eradicated.Thus,there might be unknown factors capable of regulating the vitamin D receptor(VDR).Genome-wide analysis showed that miRNAs were associated with VDRs.We sought to determine the role and mechanism of action of miRNA-125a-5p and VDRs in a model of MS,mice with experimental autoimmune encephalomyelitis(EAE),which was induced by myelin oligodendrocyte glycoprotein 35–55 peptides.EAE mice showed decreased mean body weight but increased mean clinical scores compared with vehicle or control mice.And inflammatory infiltration was found in the lumbosacral spinal cord of EAE mice.In addition,VDR expression was significantly lower while the expression of miR-125a-5p was markedly higher in the spinal ventral horn of EAE mice than in vehicle or control mice.Importantly,activation of VDRs by paricalcitol or inhibition of miR-125a-5p by its antagomir markedly decreased the mean clinical scores in EAE mice.Interestingly,VDR and miR-125a-5p were co-localized in the same neurons of the ventral horn.More importantly,inhibition of miR-125a-5p remarkably blocked the decrease of VDRs in EAE mice.These results support a critical role for miR-125a-5p in modulating VDR activity in EAE and suggest potential novel therapeutic interventions. | Han-Chun Long Rui Wu Chun-Feng Liu Fei-Long Xiong Zu Xu Dian He Yi-Fan Zhang Bing Shao Ping-An Zhang Guang-Yin Xu Lan Chu | 2020 | Neuroscience Bulletin2020，36，2： | 6 |
| 2 | Endonuclease-rolling circle amplification-based method for sensitive analysis of DNA-binding protein显示文摘为微数组上的 DNA 有约束力的蛋白质的质的察觉的一条敏感途径被开发。一个部分双区域从一份 biotin 教材和圆单身者海滨 DNA (ssDNA ) 在被形成的 DNA 建筑群在一个微数组上被看到。endonuclease 识别地点(ERS ) 和 DNA 有约束力的地点(DBS ) 在双区域以内并排被安排。察觉系统的工作原则如下被描述:什么时候 DNA 有约束力的蛋白质俘获 DBS, endonuclease 不能在 DNA 建筑群属于 ERS,和使不能调动的教材能被卷圆扩大(RCA ) 沿着圆 ssDNA 扩大。当没有蛋白质保护 DBS 时, ERS 能被 endonuclease 攻击,随后,没有滚动的圆扩大发生。从而,我们能检测顺序特定的 DNA 有约束力的活动与由于 RCA 的信号扩大高敏感。 | Min Li Li Dong Rui Zhou Hong Zhao Jin Ke Wang Zu Hong Lu | 2009 | Chinese Chemical Letters2009，20，11： | 4 |
| 3 | Blocking peptides against HBV: PreS1 protein selected from a phage display library显示文摘 | Wei Wang Yang Liu Xiangyang Zu Rui Jin Gengfu Xiao | 2011 | Biochemical and Biophysical Research Communications2011，，4： | 2 |
| 4 | Graduation formula: a new method to construct belief reliability distribution under epistemic uncertainty显示文摘In reliability engineering,the observations of the variables of interest are always limited due to cost or schedule constraints.Consequently,the epistemic uncertainty,which derives from lack of knowledge and information,plays a vital influence on the reliability evaluation.Belief reliability is a new reliability metric that takes the impact of epistemic uncertainty into consideration and belief reliability distribution is fundamental to belief reliability application.This paper develops a new method called graduation formula to construct belief reliability distribution with limited observations.The developed method constructs the belief reliability distribution by determining the corresponding belief degrees of the observations.An algorithm is designed for the graduation formula as it is a set of transcendental equations,which is difficult to determine the analytical solution.The developed method and the proposed algorithm are illustrated by two numerical examples to show their efficiency and future application. | ZU Tianpei KANG Rui WEN Meilin | 2020 | Journal of Systems Engineering and Electronics2020，31，3： | 1 |
| 5 | Comparison of summer chlorophyll a concentration in the South China Sea and the Arabian Sea using remote sensing data显示文摘The South China Sea(SCS) and the Arabian Sea(AS) are both located roughly in the north tropical zone with a range of similar latitude(0°–24°N). Monsoon winds play similar roles in the upper oceanic circulations of the both seas. But the distinct patterns of chlorophyll a(Chl a) concentration are observed between the SCS and the AS.The Chl a concentration in the SCS is generally lower than that in the AS in summer(June–August); the summer Chl a concentration in the AS shows stronger interannual variation, compared with that in the SCS; Moderate resolution imaging spectroradiometer(MODIS)-derived data present higher atmospheric aerosol deposition and stronger wind speed in the AS. And it has also been found that good correlations exist between the index of the dust precipitation indicated by aerosol optical thickness(AOT) and the Chl a concentration, or between wind and Chl a concentration. These imply that the wind and the dust precipitation bring more nutrients into the AS from the sky, the sub-layer or coast regions, inducing higher Chl a concentration. The results indicate that the wind velocity and the dust precipitation can play important roles in the Chl a concentration for the AS and the SCS in summer. However aerosol impact is weak on the biological productivity in the west SCS and wind-induced upwelling is the main source. | YAO Jinglong YANG Lei SHU Yeqiang ZENG Lili SHI Rui CHEN Ju ZU Tingting CHEN Chuqun | 2017 | Acta Oceanologica Sinica2017，36，11： | 1 |
| 6 | Surface Acidic Properties of Loaded Heteropoly Acid and Preparation of Dimethylether by Catalyzed Dehydration of Methyl Alcohol显示文摘SurfaceAcidicPropertiesofLoadedHeteropolyAcidandPreparationofDimethyletherbyCatalyzedDehydrationofMethylAlcohol*HUARui-nian,W... | HUA Rui nian, WANG Yuan hong, GONG Jian, ZU Wei and QU Lun yu (Department of Chemistry, Northeast Normal University, Changchun, 130024) | 1997 | Chemical Research in Chinese Universities1997，13，1： | 0 |
| 7 | Structure-based development of potent and selective type-II kinase inhibitors of RIPK1显示文摘Receptor-interacting serine/threonine-protein kinase 1(RIPK1)functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases.A number of allosteric RIPK1 inhibitors(RIPK1i)have been developed,and some of them have already advanced into clinical evaluation.Recently,selective RIPK1i that interact with both the allosteric pocket and the ATP-binding site of RIPK1 have started to emerge.Here,we report the rational development of a new series of type-II RIPK1i based on the rediscovery of a reported but mechanistically atypical RIPK3i.We also describe the structure-guided lead optimization of a potent,selective,and orally bioavailable RIPK1i,62,which exhibits extraordinary efficacies in mouse models of acute or chronic inflammatory diseases.Collectively,62 provides a useful tool for evaluating RIPK1 in animal disease models and a promising lead for further drug development. | Ying Qin Dekang Li Chunting Qi Huaijiang Xiang Huyan Meng Jingli Liu Shaoqing Zhou Xinyu Gong Ying Li Guifang Xu Rui Zu Hang Xie Yechun Xu Gang Xu Zheng Zhang Shi Chen Lifeng Pan Ying Li Li Tan | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 8 | Analytical and numerical modeling of optical second harmonic generation in anisotropic crystals using #SHAARP package显示文摘Electric-dipole optical second harmonic generation(SHG)is a second-order nonlinear process that is widely used as a sensitive probe to detect broken inversion symmetry and local polar order.Analytical modeling of the SHG polarimetry of a nonlinear optical material is essential to extract its point group symmetry and the absolute nonlinear susceptibilities.Current literature on SHG analysis involves numerous approximations and a wide range of(in)accuracies.We have developed an open-source package called the Second Harmonic Analysis of Anisotropic Rotational Polarimetry(♯SHAARP.si)which derives analytical and numerical solutions of reflection SHG polarimetry from a single interface(.si)for bulk homogeneous crystals with arbitrary symmetry group,arbitrary crystal orientation,complex and anisotropic linear dielectric tensor with frequency dispersion,a general SHG tensor and arbitrary light polarization.♯SHAARP.si enables accurate modeling of polarimetry measurements in reflection geometry from highly absorbing crystals or wedge-shaped transparent crystals.The package is extendable to multiple interfaces. | Rui Zu Bo Wang Jingyang He Jian-Jun Wang Lincoln Weber Long-Qing Chen Venkatraman Gopalan | 2022 | npj Computational Materials2022，，1： | 0 |
| 9 | WORLD-CLASS UNIVERSITIES AND SUBJECTS EVALUATION REPORT(2021-2022)显示文摘LAbout CASEE The Chinese Academy of Science and Education Evaluation(CASEE),also known as the Chinese Academy of Evaluation Sciences(CAES),is a key evaluation and research institute established by Hangzhou DianziUniversity in 2017.Prof. | Rui Zhang JunPingQiu Wenling Zu Fei Shu ShuLiu | 2021 | 评价与管理2021，19，5： | 0 |
| 10 | Lithium Camphor initiated Anionic Polymerization of C_(60) and Styrene显示文摘A simple new method for the syntheses of a highly soluble noncross linked C 60 styrene copolymers by means of lithium camphor initiated anionic polymerization reaction is demonstrated. | WANG Jing xia, CHEN Yu, XU Xiao hong, CAI Rui fang ** and HUANG Zu en (Department of Chemistry, Fudan University, Shanghai 200433, P.R. China) (Received Jan. 25, 1999) | 1999 | Chemical Research in Chinese Universities1999，15，4： | 0 |
| 11 | The UV-VIS Studies of C_(60) Chemically Modified Polystyrene Film显示文摘The opticai properties of C,, chemicaiiy modified poiystyrene(C,, -PS copolymer) and the parent polystyrene (PS) films have been investigated.Addition of bulky C,, moiety, a special functional group, to the polystyrene by anovel organometallic reaction modified considerably the optical property of theparent polystyrene. The lattice periodicity of pure PS film is subject to someperturbation or distortion in varying degrees due to the covalent attachInent of bulkyC,, moiety to the polymer backbone. C,,-PS copolymer possesses a new energy ba-ndstructure with indirect forbidden band when compared with the parent PS. | Yu Chen Zu En Huang Rui Fang Cai Wei Wen Ma(Departfnent of Chemistry- Fudan University- Shanghai 200433)Zhong-Chi Wu(Department of Materials Science. Fudan University Shanghai 200433) | 1997 | Chinese Chemical Letters1997，8，5： | 0 |
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