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| 1 | Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro显示文摘Dear Editor,In December 2019,a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan,a city of 11 million people in central China.The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27,2020,the Chinese authorities reported 2835 confirmed cases in China's Mainland,including 81 deaths.Additionally,19 confirmed cases were identified in Hong Kong,Macao and Taiwan,and 39 imported cases were identified in Thailand,Japan,South Korea,United States,Vietnam,Singapore,Nepal,France,Australia and Canada.The pathogen was soon identified as a novel coronavirus(2019-nCoV),which is closely related to sever acute respiratory syndrome CoV(SARS-CoV).2 Currently,there is no specific treatment against the new virus.Therefore,identifying effective antiviral agents to combat the disease is urgently needed. | Manli Wang Ruiyuan Cao Leike Zhang Xinglou Yang Jia Liu Mingyue Xu Zhengli Shi Zhihong Hu Wu Zhong Gengfu Xiao | 2020 | Cell Research2020，30，3： | 563 |
| 2 | Early screening and diagnosis strategies of pancreatic cancer:a comprehensive review显示文摘Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis.Most pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to its highly aggressive characteristics and lack of typical early symptoms.Thus,an early diagnosis of pancreatic cancer is crucial for improving its prognosis.Currently,screening is often applied in high-risk individuals to achieve the early diagnosis of pancreatic cancer.Fully understanding the risk factors of pancreatic cancer and pathogenesis could help us identify the high-risk population and achieve early diagnosis and timely treatment of pancreatic cancer.Notably,accumulating studies have been undertaken to improve the detection rate of different imaging methods and the diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)which is the golden standard for pancreatic cancer diagnosis.In addition,there are currently no biomarkers with sufficient sensitivity and specificity for the diagnosis ofpancreatic cancer to be applied in the clinic. As the only serum biomarkerapproved by the United States Food and Drug Administration, carbohydrateantigen 19-9 (CA19-9) is not recommended to be used in the early screeningof pancreatic cancer because of its limited specificity. Recently, increasingnumbers of studies focused on the discovering of novel serum biomarkersand exploring their combination with CA19-9 in the detection of pancreaticcancer. Besides, the application of liquid biopsy involving circulating tumor cells(CTCs), circulating tumor DNA (ctDNA), microRNAs (miRNAs), and exosomesin blood and biomarkers in urine, and saliva in pancreatic cancer diagnosis aredrawing more and more attention. Furthermore, many innovative technologiessuch as artificial intelligence, computer-aided diagnosis system, metabolomicstechnology, ion mobility spectrometry (IMS) associated technologies, and novelnanomaterials have been tested for the early diagnosis of pancreatic cancer andhave shown promising prospects. Hence, this review aims to summarize therecent progress in the development of early screening and diagnostic methods,including imaging, pathological examination, serological examination, liquidbiopsy, as well as other potential diagnostic strategies for pancreatic cancer. | Jinshou Yang Ruiyuan Xu Chengcheng Wang Jiangdong Qiu Bo Ren Lei You | 2021 | Cancer Communications2021，41，12： | 23 |
| 3 | Application of autocorrelation method on ionospheric short--term forecasting in China显示文摘Adopting the autocorrelation method in the ionospheric short-term forecasting, we put for- ward a simple and practical forecasting method― the sectional autocorrelation method, that is, for pre- dictions of one hour to four hours ahead the auto- correlation coefficient of RDF with the “iteration” method is selected, for prediction of more than four hours ahead, the autocorrelation coefficient of f0F2 with the “at once” method is used. The prediction precisions have been quantitatively estimated based on the data from Chongqing and Guangzhou Ionos- onde Stations. It is shown that the method is much improved for the predictions of one hour to four hours ahead. For the predictions of more than four hours ahead the prediction error reaches a saturation value, which is still lower than that of the “median” method. This new method could also be applied to the short-term forecasting of other ionospheric parame- ters. | LIU Ruiyuan LIU Shunlin XU Zhonghua WU Jian WANG Xianyi ZHANG Beichen HU Hongqiao | 2006 | Chinese Science Bulletin2006，51，3： | 17 |
| 4 | The role of histone methylation in the development of digestive cancers:a potential direction for cancer management显示文摘Digestive cancers are the leading cause of cancer-related death worldwide and have high risks of morbidity and mortality.Histone methylation,which is mediated mainly by lysine methyltransferases,lysine demethylases,and protein arginine methyltransferases,has emerged as an essential mechanism regulating pathological processes in digestive cancers.Under certain conditions,aberrant expression of these modifiers leads to abnormal histone methylation or demethylation in the corresponding cancer-related genes,which contributes to different processes and phenotypes,such as carcinogenesis,proliferation,metabolic reprogramming,epithelial–mesenchymal transition,invasion,and migration,during digestive cancer development.In this review,we focus on the association between histone methylation regulation and the development of digestive cancers,including gastric cancer,liver cancer,pancreatic cancer,and colorectal cancer,as well as on its clinical application prospects,aiming to provide a new perspective on the management of digestive cancers. | Yuan Chen Bo Ren Jinshou Yang Huanyu Wang Gang Yang Ruiyuan Xu Lei You Yupei Zhao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 5 | Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis:a comprehensive and systematic显示文摘Research on obesity-and diabetes mellitus(DM)-related carcinogenesis has expanded exponentially since these two diseases were recognized as important risk factors for cancers.The growing interest in this area is prominently actuated by the increasing obesity and DM prevalence,which is partially responsible for the slight but constant increase in pancreatic cancer(PC)occurrence.PC is a highly lethal malignancy characterized by its insidious symptoms,delayed diagnosis,and devastating prognosis.The intricate process of obesity and DM promoting pancreatic carcinogenesis involves their local impact on the pancreas and concurrent wholebody systemic changes that are suitable for cancer initiation.The main mechanisms involved in this process include the excessive accumulation of various nutrients and metabolites promoting carcinogenesis directly while also aggravating mutagenic and carcinogenic metabolic disorders by affecting multiple pathways.Detrimental alterations in gastrointestinal and sex hormone levels and microbiome dysfunction further compromise immunometabolic regulation and contribute to the establishment of an immunosuppressive tumor microenvironment(TME)for carcinogenesis,which can be exacerbated by several crucial pathophysiological processes and TME components,such as autophagy,endoplasmic reticulum stress,oxidative stress,epithelialmesenchymal transition,and exosome secretion.This review provides a comprehensive and critical analysis of the immunometabolic mechanisms of obesity-and DM-related pancreatic carcinogenesis and dissects how metabolic disorders impair anticancer immunity and influence pathophysiological processes to favor cancer initiation. | Rexiati Ruze Jianlu Song Xinpeng Yin Yuan Chen Ruiyuan Xu Chengcheng Wang Yupei Zhao | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 6 | Preparation and properties of hollow fibre nanofiltration membrane with continuous coffee-ring structure显示文摘Polyamide(PA)hollow fibre composite nanofiltration(NF)membranes with a coffee-ring structure and beneficial properties were prepared by adding graphene oxide(GO)into the interfacial polymerization process.The presentation of the coffee-ring structure was attributed to the heterogeneous,finely dispersed multiphase reaction system and the“coffee-stain”effect of the GO solution.When the piperazine concentration was 0.4 wt-%,the trimesoyl chloride concentration was 0.3 wt-%,and the GO concentration was 0.025 wt-%,the prepared NF membranes showed the best separation properties.The permeate flux was 76 L·m^(−2)·h^(−1),and the rejection rate for MgSO4 was 98.6%at 0.4 MPa.Scanning electron microscopy,atomic force microscopy,and attenuated total reflectance-Fourier transform infrared spectroscopy were used to characterize the chemical structure and morphology of the PA/GO NF membrane.The results showed that GO was successfully entrapped into the PA functional layer.Under neutral operating conditions,the PA/GO membrane showed typical negatively charged NF membrane separation characteristics,and the rejection rate decreased in the order of Na2SO_(4)>MgSO_(4)>MgCl_(2)>NaCl.The PA/GO NF membrane showed better antifouling performance than the PA membrane. | Xiuzhen Wei Xufeng Xu Yi Chen Qian Zhang Lu Liu Ruiyuan Yang Jinyuan Chen Bosheng Lv | 2021 | Frontiers of Chemical Science and Engineering2021，15，2： | 2 |
| 7 | The evolving view of thermogenic fat and its implications in cancer and metabolic diseases显示文摘The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has reached pandemic levels worldwide and increased gradually.Most of them are listed on the table of high-risk factors for malignancy,and metabolic disorders systematically or locally contribute to cancer progression and poor prognosis of patients.Importantly,adipose tissue is fundamental to the occurrence and development of these metabolic disorders.White adipose tissue stores excessive energy,while thermogenic fat including brown and beige adipose tissue dissipates energy to generate heat.In addition to thermogenesis,beige and brown adipocytes also function as dynamic secretory cells and a metabolic sink of nutrients,like glucose,fatty acids,and amino acids.Accordingly,strategies that activate and expand thermogenic adipose tissue offer therapeutic promise to combat overweight,diabetes,and other metabolic disorders through increasing energy expenditure and enhancing glucose tolerance.With a better understanding of its origins and biological functions and the advances in imaging techniques detecting thermogenesis,the roles of thermogenic adipose tissue in tumors have been revealed gradually.On the one hand,enhanced browning of subcutaneous fatty tissue results in weight loss and cancer-associated cachexia.On the other hand,locally activated thermogenic adipocytes in the tumor microenvironment accelerate cancer progression by offering fuel sources and is likely to develop resistance to chemotherapy.Here,we enumerate current knowledge about the significant advances made in the origin and physiological functions of thermogenic fat.In addition,we discuss the multiple roles of thermogenic adipocytes in different tumors.Ultimately,we summarize imaging technologies for identifying thermogenic adipose tissue and pharmacologic agents via modulating thermogenesis in preclinical experiments and clinical trials. | Xinpeng Yin Yuan Chen Rexiati Ruze Ruiyuan Xu Jianlu Song Chengcheng Wang Qiang Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 8 | An Approach for User’s Trajectory Prediction Based on the Trajectory Cluster显示文摘The existing user's trajectory prediction methods considered little about the interrelation among users and would fail if the user historical trajectory data were lack. This paper presents a user's trajectory prediction model and corresponding algorithms by the historical trajectories of users based on the trajectory cluster. The experimental results on MDC dataset show that the proposed method has great improvement in efficiency, accuracy, and scalability comparing with the traditional methods, and it also be applied to the situation where user's historical trajectory data are lacked. | LI Ruiyuan NIE Wenhui LI Zhihao WANG Tian XU Yating ZENG Cheng | 2012 | Wuhan University Journal of Natural Sciences2012，17，5： | 0 |
| 9 | Ce doped polyaniline nanoparticles for absorption and photoacoustic imaging response to GSH in vitro and in vivo显示文摘Glutathione(GSH)is an important biological thiol in cells,which is involved in many physiological processes in the organism and regulates pathological processes of cells.Rapid and accurate monitoring of GSH in vitro and in vivo is quite needed in investigating important biochemical events.In this contribution,innovative cerium(Ce)doped polyaniline(Ce–Fe@PANI NPs)were prepared via Fe(III)induced oxidization polymerization method.Upon addition of GSH,the absorption of Ce–Fe@PANI NPs red shifted from the visible to the NIR region,con-firming the excellent absorption response to GSH.Moreover,Ce–Fe@PANI NPs exhibited excellent photoacoustic(PA)imaging enhancement in tube and shifted the PA intensity peak from 680 nm to 820 nm upon addition of GSH.In vitro and in vivo experiment verified that Ce–Fe@PANI NPs can monitor GSH in deep tissues via PA imaging technology.Collectively,this research provides Ce–Fe@PANI NPs would serve as a powerful nano-platform to realize PA imaging detection of GSH in vitro and in vivo. | Yulin Kuang Nanbo Liu Sheng Ye Xiang Li Xuyuan Chen Li Qi Ping Zhu Ruiyuan Liu Xu Wu | 2022 | Bioactive Materials2022，7，11： | 0 |
| 10 | Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro显示文摘The recent outbreak of novel coronavirus pneumonia(COVID-19)caused by a new coronavirus has posed a great threat to public health.Identifying safe and effective antivirals is of urgent demand to cure the huge number of patients.Virusencoded proteases are considered potential drug targets.The human immunodeficiency virus protease inhibitors(lopinavir/ritonavir)has been recommended in the global Solidarity Trial in March launched by World Health Organization.However,there is currently no experimental evidence to support or against its clinical use.We evaluated the antiviral efficacy of lopinavir/ritonavir along with other two viral protease inhibitors in vitro,and discussed the possible inhibitory mechanism in silico.The in vitro to in vivo extrapolation was carried out to assess whether lopinavir/ritonavir could be effective in clinical.Among the four tested compounds,lopinavir showed the best inhibitory effect against the novel coronavirus infection.However,further in vitro to in vivo extrapolation of pharmacokinetics suggested that lopinavir/ritonavir could not reach effective concentration under standard dosing regimen[marketed as Kaletraò,contained lopinavir/ritonavir(200 mg/50 mg)tablets,recommended dosage is 400 mg/10 mg(2 tablets)twice daily].This research concluded that lopinavir/ritonavir should be stopped for clinical use due to the huge gap between in vitro IC50 and free plasma concentration.Nevertheless,the structure–activity relationship analysis of the four inhibitors provided further information for de novel design of future viral protease inhibitors of SARS-CoV-2. | Leike Zhang Jia Liu Ruiyuan Cao Mingyue Xu Yan Wu Weijuan Shang Xi Wang Huanyu Zhang Xiaming Jiang Yuan Sun Hengrui Hu Yufeng Li Gang Zou Min Zhang Lei Zhao Wei Li Xiaojia Guo Xiaomei Zhuang Xing-Lou Yang Zheng-Li Shi Fei Deng Zhihong Hu Gengfu Xiao Manli Wang Wu Zhong | 2020 | Virologica Sinica2020，35，6： | 0 |
| 11 | Rational design and synthesis of nanosheets self-assembled hierarchical flower-ball-like CuFeS_(2)for boosted wide temperature sodium-ion batteries显示文摘Nano-structure designs with conductive networks have been demonstrated as an efficient strategy to boost sodium storage properties for transition metal sulfides.Herein,an exquisite nanosheets self-assembled hierarchical flower-ball-like CuFeS_(2)embedded into the reduced graphene oxide(RGO)nanosheet matrix(F-CuFeS_(2)@RGO)is fabricated via a concise two-step solvothermal method.Such a well-designed architecture affords increased active reaction interfaces and enhanced mixed ionic/electronic conductivity.Meanwhile,the external RGO matrix can effectively alleviate the volume expansion and create a stable structure during long cycles.As a result,the composite material exhibits a high reversible capacity of 559 mAh·g^(-1)at 0.1 A·g^(-1),a superior rate capability of 455 mAh·g^(-1)at 5 A·g^(-1)and excellent cyclic stability with 96%capacity retention after 4800 cycles at 5 A·g^(-1),among the best in the state-of-the-art transition metal sulfide anodes.Especially,F-CuFeS_(2)@RGO delivers outstanding low-temperature performances with a high capacity retention of 100%and 91%at-20 and-40℃,respectively,over 200 cycles.The proposed hierarchical structure fabrication paves a new direction in the design of high-performance electrodes for all-temperature energy storage applications. | Ge Sun Hezhe Lin Ruiyuan Tian Zhixuan Wei Xiaoqi Wang Xu Jin Shiyu Yao Gang Chen Zexiang Shen Fei Du | 2023 | Nano Research2023，16，7： | 0 |
| 12 | Lipid metabolism in pancreatic cancer:emerging roles and potential targets显示文摘Pancreatic cancer is one of the most serious health issues in developed and developing countries,with a 5-year overall survival rate currently<9%.Patients typically presentwith advanced disease due to vague symptoms or lack of screening for early cancer detection.Surgical resection represents the only chance for cure,but treatment options are limited for advanced diseases,such as distant metastatic or locally progressive tumors.Although adjuvant chemotherapy has improved long-term outcomes in advanced cancer patients,its response rate is low.So,exploring other new treatments is urgent.In recent years,increasing evidence has shown that lipid metabolism can support tumorigenesis and disease progression as well as treatment resistance through enhanced lipid synthesis,storage,and catabolism.Therefore,a better understanding of lipid metabolism networks may provide novel and promising strategies for early diagnosis,prognosis estimation,and targeted therapy for pancreatic cancer patients.In this review,we first enumerate and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in pancreatic cancer.In addition,we summarize preclinical studies and clinical trials with drugs targeting lipid metabolic systems in pancreatic cancer.Finally,we highlight the challenges and opportunities for targeting lipid metabolism pathways through precision therapies in pancreatic cancer. | Xinpeng Yin Ruiyuan Xu Jianlu Song Rexiati Ruze Yuan Chen Chengcheng Wang Qiang Xu | 2022 | Cancer Communications2022，42，12： | 0 |
| 13 | Chlorophyll Fluorescence Response of Persimmon Plants under Salt Stress显示文摘[Objectives]To study the photosynthetic response mechanism of persimmon seedlings to salt stress.[Methods]The chlorophyll fluorescence parameters of Diospyros virginiana and Diospyros lotus seedlings under 4%salt stress were studied by pot culture salt control method,including the minimal fluorescence(F_(0)),maximum fluorescence(F_(m)),potential activity of PS II(F_(v)/F_(0)),maximum photochemical efficiency of PS II(F_(v)/F_(m)),electron transport rate(ETR),actual photochemical efficiency of PS II(Y II),and photochemical quenching coefficient(q_(p)).[Results]Under 4%salt stress,the maximum fluorescence(F_(m)),maximum photochemical efficiency of PS II(F v/F m),and photochemical quenching coefficient(q_(p))of two persimmon plants decreased with time.The potential activity of PS II(F_(v)/F_(0)),actual photochemical efficiency of PS II(Y_(II)),and electron transport rate(ETR)decreased under salt stress.[Conclusions]This study indicates that the PS II reaction center in the persimmon leaves was damaged and the electron transport at the acceptor side was damaged under salt stress.It is expected to lay a foundation for the analysis of salt-tolerance mechanism of persimmon plants. | Xining GENG Lihua XIE Jingwen XU Ruiyuan WANG | 2023 | Medicinal Plant2023，14，5： | 0 |
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