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| 1 | Molecular regulation of sucrose catabolism and sugar transport for development~ defence and phloem function显示文摘Sucrose(Suc) is the major end product of photosynthesis in mesophyll cells of most vascular plants. It is loaded into phloem of mature leaves for long-distance translocation to non-photosynthetic organs where it is unloaded for diverse uses. Clearly,Suc transport and metabolism is central to plant growth and development and the functionality of the entire vascular system. Despite vast information in the literature about the physiological roles of individual sugar metabolic enzymes and transporters,there is a lack of systematic evaluation about their molecular regulation from transcriptional to post-translational levels.Knowledge on this topic is essential for understanding and improving plant development,optimizing resource distribution and increasing crop productivity. We therefore focused our analyses on molecular control of key players in Suc metabolism and transport,including:(i) the identification of promoter elements responsive to sugars and hormones or targeted by transcription factors and microRNAs degrading transcripts of target genes; and(ii)modulation of enzyme and transporter activities through protein-protein interactions and other post-translational modifications. We have highlighted major remaining questions and discussed opportunities to exploit current understanding to gain new insights into molecular control of carbon partitioning for improving plant performance. | Jun Li Limin Wu Ryan Foster Yong-Ling Ruan | 2017 | Journal of Integrative Plant Biology2017，59，5： | 8 |
| 2 | The Role of the p38 Pathway in Adaptive Immunity显示文摘Since its discovery in 1993,the mitogen-activated protein(MAP) kinase p38 has attracted much attention for its role in a wide range of cellular processes,many of which involve the immune system. Although p38 has been heavily implicated in the function of all type immune cells,research has tended focus on its role in innate immunity. In this review we attempt to highlight some of the major discoveries that have been made regarding p38's role in adaptive immunity,and also to discuss the possible future implications of these discoveries. | Ryan Cook Chia-Cheng Wu Young Jun Kang | 2007 | Cellular & Molecular Immunology2007，4，4： | 7 |
| 3 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 4 | Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes显示文摘Traumatic brain injury(TBI)is a global cause of morbidity and mortality.Initial management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available,noninvasive diagnostic biomarker.In particular,a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI(mTBI).Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue injury.By applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after TBI.Acoustofluidic isolation eliminated interference from other blood components,making it possible to detect exosomal biomarkers for TBI via flow cytometry.Flow cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma,indicating the potential of using circulating exosomes for the rapid diagnosis of TBI.Elevated levels of TBI biomarkers were only detected in the samples separated via acoustofluidics;no changes were observed in the analysis of the raw plasma sample.This finding demonstrated the necessity of sample purification prior to exosomal biomarker analysis.Since acoustofluidic exosome separation can easily be integrated with downstream analysis methods,it shows great potential for improving early diagnosis and treatment decisions associated with TBI. | Zeyu Wang Haichen Wang Ryan Becker Joseph Rufo Shujie Yang Brian E.Mace Mengxi Wu Jun Zou Daniel T.Laskowitz Tony Jun Huang | 2021 | Microsystems & Nanoengineering2021，7，2： | 3 |
| 5 | Autonomic responses to blast overpressure can be elicited by exclusively exposing the ear in rats显示文摘Blast overpressure has become an increasing cause of brain injuries in both military and civilian populations. Though blast's direct effects on the cochlea and vestibular organs are active areas of study, little attention has been given to the ear's contribution to the overall spectrum of blast injury. Acute autonomic responses to blast exposure, including bradycardia and hypotension, can cause hypoxia and contribute to blast-induced neurotrauma. Existing literature suggests that these autonomic responses are elicited through blast impacting the thorax and lungs. We hypothesize that the unprotected ear also provides a vulnerable locus for blast to cause autonomic responses. We designed a blast generator that delivers controlled overpressure waves into the ear canal without impacting surrounding tissues in order to study the ear's specific contribution to blast injury. Anesthetized adult rats' left ears were exposed to a single blast wave ranging from 0 to 110 PSI(0-758 kPa). Blast exposed rats exhibited decreased heart rates and blood pressures with increased blast intensity, similar to results gathered using shock tubes and whole-body exposure in the literature. While rats exposed to blasts below 50 PSI(345 kPa) exhibited increased respiratory rate with increased blast intensity, some rats exposed to blasts higher than 50 PSI(345 kPa) stopped breathing immediately and ultimately died. These autonomic responses were significantly reduced in vagally denervated rats, again similar to whole-body exposure literature. These results support the hypothesis that the unprotected ear contributes to the autonomic responses to blast. | David S.Sandlin Yue Yu Jun Huang Chunming Zhang Alberto A.Arteaga John K.Lippincott Erin O.H.Peeden Ryan R.Guyton Lan Chen Laura L.S.Beneke Jerome C.Allison Hong Zhu Wu Zhou | 2018 | Journal of Otology2018，13，2： | 2 |
| 6 | Overproduction of vascular endotheli- al growth factor related to yon Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas显示文摘 | Na X Wu G Ryan CK | 2003 | J Urol2003，170，21： | 1 |
| 7 | The Role of Social Pres-ence and Moderating Role of Computer Self Efficacy in Predicting the Continuance Usage of E-learning Systems显示文摘 | A Hayashi C Chen T Ryan J Wu | 2004 | Journal of Information Systems Education2004，15，2： | 1 |
| 8 | Macrophage contributions to ovarian function显示文摘 | Wu R van der Hock KH Ryan NK | 2004 | Hum Reprod Update2004，10，2： | 1 |
| 9 | Influence of social context and af-fect on individualsy implementation of information security safeguards显示文摘 | WU Y RYAN S WINDSOR J | 2009 | ICIS Proceedings2009，3336，： | 1 |
| 10 | Lactated Ringer’s Solution Reduces Systemic Inflammation Compared With Saline in Patients With Acute Pancreatitis显示文摘 | Bechien U. Wu James Q. Hwang Timothy H. Gardner Kathryn Repas Ryan Delee Song Yu Benjamin Smith Peter A. Banks Darwin L. Conwell | 2011 | Clinical Gastroenterology and Hepatology2011，，8： | 1 |
| 11 | Ovarian leukocyte distribution andcytokine/chemokine mRNA expression in follicular fluid cells in women with polycystic ovary syndrome显示文摘 | Fujii S Ryan NK et at | 2007 | Hum Repred2007，22，2： | 1 |
| 12 | Surgical treatment of gastrointestinal stromal tumors in the imatinib (STI-571) era显示文摘 | Wu PC Langerman A Ryan CW | 2003 | Surg2003，134，4： | 1 |
| 13 | Correction of sickle cell disease by homologous recombination in embryonic stem cells 显示文摘 | Wu LC Sun CW Ryan TM | 2006 | Blood2006，108，4： | 1 |
| 14 | Novel CLCN1 mutations with unique clinical and electrophysiological consequences显示文摘 | Wu FF Ryan A Devaney J | 2002 | Brain2002，125，： | 1 |
| 15 | Mitral Valve surgery Using the Classical ‘Heartport' Technique显示文摘 | Ryan WU Dewey TM Mack MJ | 2005 | The J of Heart Dis2005，14，： | 1 |
| 16 | Ovarian leukocyte distribution and cytokine/chemokine mRNA expression in follicular fluid cells in women with polycystic ovary syndrome 显示文摘 | Wu R Fujii S Ryan NK | 2007 | Hum Reprod2007，22，2： | 1 |
| 17 | Macrophage contributions to ovarian function显示文摘 | Wu R J Van der Hoek K H Ryan N K | 2004 | Hum Reprod Update2004，10，2： | 1 |
| 18 | Overproduction of vascular endothelial growth factor related to yon Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas 显示文摘 | Na X Wu G Ryan CK | 2003 | J Urol2003，170，21： | 1 |
| 19 | Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas显示文摘 | Na X Wu G Ryan CK | 2003 | J Urol2003，170，2： | 1 |
| 20 | Rewriting earnings history显示文摘 | Baruch Lev Stephen G. Ryan Min Wu | 2008 | Review of Accounting Studies2008，，4： | 1 |
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