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| 1 | Pancreatic cancer and its stroma: A conspiracy theory显示文摘Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has received little attention until recent times. Given that treatments focusing on pancreatic cancer cells alone have failed to significantly improve patient outcome over many decades, research efforts have now moved to understanding the pathophysiology of the stromal reaction and its role in cancer progression. In this regard, our Group was the first to identify the cells(pancreatic stellate cells, PSCs) that produced the collagenous stroma of pancreatic cancer and to demonstrate that these cells interacted closely with cancer cells to facilitate local tumour growth and distant metastasis. Evidence is accumulating to indicate that stromal PSCs may also mediate angiogenesis, immune evasion and the well known resistance of pancreatic cancer to chemotherapy and radiotherapy. This review will summarise current knowledge regarding the critical role of pancreatic stellate cells and the stroma in pancreatic cancer biologyand the therapeutic approaches being developed to target the stroma in a bid to improve the outcome of this devastating disease. | Zhihong Xu Srinivasa P Pothula Jeremy S Wilson Minoti V Apte | 2014 | World Journal of Gastroenterology2014，20，32： | 10 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | Chemical associations of lead, cadmium, copper and zinc in street dusts and roadside soils显示文摘 | Harrison R M Laxen D P H Wilson S J | 1981 | Environmental Science and Technology1981，15，11： | 2 |
| 4 | Reliability of ultrasound ovarian-adnexal reporting and data system amongst less experienced readers before and after training显示文摘BACKGROUND The 2018 ovarian-adnexal reporting and data system(O-RADS)guidelines are aimed at providing a system for consistent reports and risk stratification for ovarian lesions found on ultrasound.It provides key characteristics and findings for lesions,a lexicon of descriptors to communicate findings,and risk characterization and associated follow-up recommendation guidelines.However,the ORADS guidelines have not been validated in North American institutions or amongst less experienced readers.AIM To evaluate the diagnostic accuracy and inter-reader reliability of ultrasound ORADS risk stratification amongst less experienced readers in a North American institution with and without pre-test training.METHODS A single-center retrospective study was performed using 100 ovarian/adnexal lesions of varying O-RADS scores.Of these cases,50 were allotted to a training cohort and 50 to a testing cohort via a non-randomized group selection process in order to approximately equal distribution of O-RADS categories both within and between groups.Reference standard O-RADS scores were established through consensus of three fellowship-trained body imaging radiologists.Three PGY-4 residents were independently evaluated for diagnostic accuracy and inter-reader reliability with and without pre-test O-RADS training.Sensitivity,specificity,positive predictive value,negative predictive value(NPV),and area under the curve(AUC)were used to measure accuracy.Fleiss kappa and weighted quadratic(pairwise)kappa values were used to measure inter-reader reliability.Statistical significance was P<0.05.RESULTS Mean patient age was 40±16 years with lesions ranging from 1.2 to 22.5 cm.Readers demonstrated excellent specificities(85%-100%pre-training and 91%-100%post-training)and NPVs(89%-100%pre-training and 91-100%post-training)across the O-RADS categories.Sensitivities were variable(55%-100%pre-training and 64%-100%post-training)with malignant ORADS 4 and 5 Lesions pre-training and post-training AUC values of 0.87-0.95 and 0.94-098,respectively(P<0.001).Nineteen of 22(86%)misclassified cases in pre-training were related to mischaracterization of dermoid features or wall/septation morphology.Fifteen of 17(88%)of posttraining misclassified cases were related to one of these two errors.Fleiss kappa inter-reader reliability was‘good’and pairwise inter-reader reliability was‘very good’with pre-training and post-training assessment(k=0.76 and 0.77;and k=0.77-0.87 and 0.85-0.89,respectively).CONCLUSION Less experienced readers in North America achieved excellent specificities and AUC values with very good pairwise inter-reader reliability.They may be subject to misclassification of potentially malignant lesions,and specific training around dermoid features and smooth vs irregular inner wall/septation morphology may improve sensitivity. | Prayash Katlariwala Mitchell P Wilson Yeli Pi Baljot S Chahal Roger Croutze Deelan Patel Vimal Patel Gavin Low | 2022 | World Journal of Radiology2022，14，9： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Comparison of numbers and enzymatic activities in surface soils and subsoils using various techniques显示文摘 | TAYLOR J P WILSON B MILLS M S | 2002 | Soil Biology Biochemical2002，34，： | 1 |
| 7 | Comparison of micro bial numbers and enzymatic activities in surface soils and sub soils using various techniques显示文摘 | Taylor T P Wilson B Mills M S | 2002 | Soil Biology and Biochemis try2002，34，： | 1 |
| 8 | Species competitive ability and position along a natural stress/disturbance gradient显示文摘 | Wilson S D Keddy P A | 1986 | Ecology1986，67，： | 1 |
| 9 | Opportunistic beamforming and scheduling for OFDMA systems显示文摘 | SVEDMAN P WILSON S K CIMINI J | 2007 | IEEE Transactions on Communications2007，55，5： | 1 |
| 10 | Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering显示文摘 | BONETTI P O WILSON S H RODRIGUEZ-POR- CEL M | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 11 | Direct gas detection using wavelet energy absorption显示文摘 | Peters S W Lichman E Wilson P H | 2003 | Expanded Abstract of EAGE 65^th Annual Conference2003，32，： | 1 |
| 12 | Trace gas emissions from Melbourne, Australia, based on AGAGE observations at Cape Grim, Tasmania, 1995-2000 显示文摘 | DUNSE B L STEELE L P WILSON S R | 2005 | Atmos Environ2005，39，34： | 1 |
| 13 | Relationship between placental vascular endothelial growth factor expression and placental/endometrial vascularity in the pig 显示文摘 | Vonnahme K A Wilson M E Ford S P | 2001 | Biol Reprod2001，64，6： | 1 |
| 14 | Early tactile experience of low birth weight children: links to later mental health and social adaptation显示文摘 | Weiss S Wilson P St Jonn-Seed M | 2001 | Infant Child Dev2001，10，： | 1 |
| 15 | Model predictive control of multilevel cascaded H-bridge inverters显示文摘 | Cortes P Wilson A Kouro S | 2010 | IEEE Transactions on Industrial Electronics2010，57，8： | 1 |
| 16 | Laboratory investigation of a passive acoustic method for measurenlent of underwater gas seep ebullition显示文摘 | GREENE C A WILSON P S | 2012 | The Journal of Ihe Acoustical So-ciety of America2012，131，1： | 1 |
| 17 | Comparison of microbial numbers and enzymatic activities in surface soils and subsoils using various techniques显示文摘 | Taylor J P Wilson B Mills M S | 2002 | Soil Biology & Biochemistry2002，34，3： | 1 |
| 18 | Relation between diacylglycerol acyltransferase activity and oil concentration in soybean显示文摘 | SETTLAGE S B KWAN YUEN P WILSON R F | 1998 | JAOCS1998，75，7： | 1 |
| 19 | SUIF:An Infra-structure for Research on Parallelizing and Optimizing Com- pilers显示文摘 | Wilson R P French R S Wilson C S | 1994 | ACM Sigplan Notices1994，29，12： | 1 |
| 20 | Landscape management through integration of existing tools and emerging technologies显示文摘 | McCarter J B Wilson J S Baker P J | 1998 | Journal of Forestry1998，96，6： | 1 |
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