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| 1 | Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis显示文摘AIM: Oxygen free radical mediated tissue damage is well established in pathogenesis of acute pancreatitis (AP).Whether nitric oxide (NO) plays a deleterious or a protective role is unknown. In alcohol-induced AP, we studied NO, lipooxidative damage and glutathione in pancreas, lung and circulation.METHODS: AP was induced in rats (n = 25) by injection of ethyl alcohol into the common biliary duct. A sham laparatomy was performed in controls (n = 15). After 24 h the animals were killed, blood and tissue sampling were done.RESULTS: Histopathologic evidence confirmed the development of AP. Marked changes were observed in the pulmonary tissue. Compared with controls, the AP group displayed higher values for NO metabolites in pancreas and lungs, and thiobarbituric acid reactive substances in circulation. Glutathione was lower in pancreas and in circulation. Glutathione and NO were positively correlated in pancreas and lungs of controls but negatively correlated in circulation of experimental group. In the experimental group, plasma thiobarbituric acid reactive substances were negatively correlated with pancreas thiobarbituric acid reactive substances but positively correlated with pancreas NO.CONCLUSION: NO increases in both pancreas and lungs in AP and NO contributes to the pathogenesis of AP under oxidative stress. | Gülnur Andican Remisa Gelisgen Ethem Unal Osman Baran Tortum Sergülen Dervisoglu Tayfun Karahasanoglu Gülden Bur(?)ak | 2005 | World Journal of Gastroenterology2005，11，15： | 18 |
| 2 | 更年期医学:欧洲男女更年期协会2004/2005关于围绝经期和绝经后激素补充治疗的立场声明显示文摘目前从大量的随机对照临床试验(RCT)中已得出结论性的证据:对于经历令人痛苦的更年期症状的围绝经期和绝经后妇女,任何形式的全身HRT均可以缓解症状,没有其它治疗手段能产生相似效果。尽管这种证据与日俱增,但如何提供最好的临床医疗以减轻绝经症状和预防较远期的绝经后退化性疾病,仍在争论之中。当提供更年期医药时,HRT的剂量和方案的个体化是基于与症状的严重程度和绝经时间相关的最低有效剂量的原则。然而,在有症状的妇女中,尚没有多少关于长期应用不同HRT方案的资料,同时赖以说明心血管疾病、乳腺癌和骨质疏松症的基线风险的影响。在大多数病例中,个体化的处方联同生活方式的调整就可能对更年期症状、生活质量、性问题和骨质疏松症产生最终有益的作用,罕见严重副反应。基于最近的流行病学研究,不少是来自WHI中单用雌激素组的结果,欧洲男女更年期协会(EMAS)支持在有症状的妇女中进行新的HRT方案的研究,以提高临床中受益和风险之间的平衡,包括生活质量方面特有的信息;并解释美国和欧洲之间在治疗模式上的传统差异,以及在BMI、生活方式和饮食习惯方面的不同所产生的影响。对于早绝经(<45岁)的妇女,现有的资料支持HRT所特有的总体益处。目前,具有骨质疏松性骨折高危险性的妇女可考虑应用较长期的全身HRT,尤其是当其它治疗措施既不恰当又疗效不佳时,因为此时收益大于风险。而对于泌尿生殖道症状,已认为长期的局部雌激素治疗可能安全和有效。 | Sven O.Skouby Farook Al-Azzawi David Barlow Joaquin Calaf-Alsina Erdogan Ert ungealp Anne Gompel Alessandra Graziottin Decebal Hudita Amos ines Serge Rozenberg Gran Samsioe John C.Stevenson 陈瑛 | 2005 | 国外医学(妇幼保健分册)2005，16，5： | 3 |
| 3 | Improvement of Rose varietal Creation in The World 显示文摘 | Serge G | 1999 | Acta hort1999，495，： | 1 |
| 4 | Optical flow based vehicle tracking- strengthened by statistical decisions显示文摘 | Fatemeh Karimi Nejadasl Ben G H Gorte Serge P Hoogendoorn | 2006 | ISPRS Jour nal of Photogram metry Remote Sensing2006，61，9： | 1 |
| 5 | Future internet re- search and eperimentatiun: the fire initiative 显示文摘 | ANASTASIUS G ART() K SERGE F | 2007 | Com- puter Communication Review2007，37，3： | 1 |
| 6 | The CAS-OB Process inthe Steelshop of Fos-Sur-Mer-Conception and First OperatingReslts 显示文摘 | Serge A Pierre G Jean P R | 1989 | MPT1989，12，6： | 1 |
| 7 | Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1显示文摘 | Cagatay G Serge L Alain P | 2000 | Cancer Res2000，60，： | 1 |
| 8 | Progress in clinical neurosciences:Canadian guidelines for the development of antidementia显示文摘 | Howard F Serge G Howard C | 2006 | Can J Newol Sci2006，33，： | 1 |
| 9 | Influence of Microarrays Experiments Missing Values on the Stability of Gene Groups by Hierarchical Clustering显示文摘 | Alexandre G B Serge H Alain M | 2004 | BMC Bioinformatics2004，5，： | 1 |
| 10 | Evaluation of the ulnopalmar arterial arches with pulse oximetry and plethysmography: Comparison with the Allen’s test in 1010 patients显示文摘 | Gérald R Barbeau Fran?ois Arsenault Louise Dugas Serge Simard Marie Mai Larivière | 2004 | American Heart Journal2004，，3： | 1 |
| 11 | Proteomic analysis of the ffects of ABA treatments on ripening Vitisvini fera berries显示文摘 | MARZIA G LAURENCE G Serge D | 2010 | Journal of Experimenta Botany2010，6，9： | 1 |
| 12 | High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis显示文摘 | Nathalie HV Chris P Serge G | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 13 | Room temperature molten salts as lithium battery electrolyte显示文摘 | Garcia B Serge L Perron G | 2004 | Electrochimica Acta2004，49，26： | 1 |
| 14 | Classification of aged wine distillates using fuzzy and neural network system 显示文摘 | Ni Y N Chen S H Serge K G | 2002 | Analytiea Chimica Acta2002，463，2： | 1 |
| 15 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Serge Andréfou?t Philip Kramer Damaris Torres-Pulliza Karen E Joyce Eric J Hochberg Rodrigo Garza-Pérez Peter J Mumby Bernhard Riegl Hiroya Yamano William H White Mayalen Zubia John C Brock Stuart R Phinn Abdulla Naseer Bruce G Hatcher Frank E Muller-Karg | 2003 | Remote Sensing of Environment2003，，1： | 1 |
| 16 | Comparison of spatial math models for tolerance analysis:tolerance-maps,deviation domain,and TTRS显示文摘 | Ameta G Serge S Giordano M | 2011 | ASME Journal of Computing and Information Science in Engineering2011，，11： | 1 |
| 17 | Room temperature molten salts as lithium battery electrolyte 显示文摘 | BEATRICE G SERGE L GERALD P | 2004 | Electrochimica Acta2004，49，： | 1 |
| 18 | Effect of graphite crystal structure on lithium electrochemical intercalation 显示文摘 | KATIA G ANNIE F B SERGE F | 1999 | J Electrochemical Society1999，146，10： | 1 |
| 19 | Simultaneous spectrophotometric determination of maltol, ethylmaltol, vaniUin and ethy vanillin in foods by multivariate calibration and art ificial neural networks 显示文摘 | Ni Y N Zhang G W Serge K | 2005 | Food Chemistry2005，89，3： | 1 |
| 20 | Alzheimer' s disease 显示文摘 | CLIVE B SERGE G ANNE C | 2011 | Lancet2011，377，9770： | 1 |
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